EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition
Keywords: Erk; EGFR; Cell-cell contacts; wound healing;
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Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes
Keywords: Chemopreventive agent; Dithiolethiones; Nrf2; ERK
Protective effect of benzothiazole derivative KHG21834 on amyloid β-induced neurotoxicity in PC12 cells and cortical and mesencephalic neurons
Keywords: Aβ, amyloid beta; AD, Alzheimer's disease; ERK, extracellular signal-regulated kinase; PD, Parkinson's disease; TH, tyrosine hydroxylaseKHG21834; Amyloid beta; PC12 cells; Mesencephalic neurons; Cortical neurons; ERK
PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation
Keywords: PI3K; Erk; ErbB; Xenopus; Gastrulation
C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton
Keywords: C3G; PP2A; ERK; Actin cytoskeleton; Transformation suppression
Extracellular ATP-dependent upregulation of the transcription cofactor LMO4 promotes neuron survival from hypoxia
Keywords: LMO4; ATP; Stat3; hypoxia; cIAP2; ERK; CREB
Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK
Keywords: Anisomycin; ERK; p38; JNK; Hypoxia; Delta-opioid receptor
Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase
Keywords: retinoic acid; RAR; RXR; MAPK; ischemia; ATRA; all-trans retinoic acid; CA; cornu ammonis; DG; dentate gyrus; ERK; extracellular signal-regulated kinase; Hanks' BSS; Hanks' balanced salt solution; JNK; c-jun-N-terminal kinase; MAPK; mitogen-activated
Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells
Keywords: 12-HHT; ERK; Thromboxane receptor; Thromboxane synthase; Prostate cancer;
TNFR1-induced NF-κB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
Keywords: caspase; cysteine-aspartate-directed proteases; cPLA2; cytosolic phospholipase A2; DD; death domain; ERK; extracellular signal-regulated kinase; hr-GFP; humanised renilla green fluorescent protein; HUVEC; human umbilical endothelial cells; ICAM; intracell
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells
Keywords: ERK; IEC-18 cells; T84 cells; Carbachol;
Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo
Keywords: AgIIR; angiotensin II receptor; cAMP; cyclic adenosine monophosphate; EC; endothelial cells; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptor; IGFR; insulin-like growth factor receptor;
RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus
Keywords: EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; ER; endoplasmic reticulum; ERK; extracellular-signal-regulated protein kinase; FBS; fetal bovine serum; JNK; c-Jun N-terminal kinase; PARP; poly(ADP-ribose) polymerase; PBS; phosphate
Alternative pathway of transcriptional induction of p21WAF1/Cip1 by cyclosporine A in p53-deficient human glioblastoma cells
Keywords: ERK; extracellular signal-regulated kinase; JNK; c-Jun kinase; MAPK; mitogen-activated protein kinase; MKK1; MAP kinase kinase 1; cell cycle inhibitor; ERK/MAP kinases; c-Jun transcription factor; AP-1 complex; Sp1 transcription factor; glioblastoma cells
Injury and nucleotides induce phosphorylation of epidermal growth factor receptor: MMP and HB-EGF dependent pathway
Keywords: wound healing; epithelium; P2YR; ERK; EGFR; cell migration
FGF8/17/18 functions together with FGF9/16/20 during formation of the notochord in Ciona embryos
Keywords: Mesoderm; Notochord; FGF; ERK; Ascidian; Ciona;
Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup
Keywords: Pain; Development; Hyperalgesia; Mustard oil; Capsaicin; ERK
G-CSF protects dopaminergic neurons from 6-OHDA-induced toxicity via the ERK pathway
Keywords: Granulocyte colony-stimulating factor; 6-Hydroxydopamine; Dopaminergic neurons; ERK; Bad; Bcl-xL; Caspase-3
Regulation of preimplantation embryo development by brain-derived neurotrophic factor
Keywords: Apoptosis; BDNF; Blastocyst; ERK; NT-4/5; PI3K; TrkB
c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells
Keywords: HGF; Brain; Endothelial cells; Migration; JNK; ERK; Pyk-2; Src; Raf; MEK
Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells
Keywords: Multiple myeloma; Cell growth; AMPK; ERK; P70S6K; Proliferation
ERK implication in cell cycle regulation
Keywords: MEK; ERK; Signaling cascade; Cell Cycle; Phosphorylation; Cancer
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective
Keywords: MP1; p14; Scaffold; Actin; Microtubule dynamics; Calpains; Rho; PAK; MEK; ERK;Ste5; Cell migration
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway
Keywords: PTX; Pertussis toxin; BMDM; bone marrow-derived macrophages; C1P; ceramide 1-phosphate; C2-; acetyl; M-CSF; macrophage colony stimulating factor; MAPK; mitogen-activated protein kinase; ERK; extracellular regulated kinase; MEK; MAPK/ERK kinase; MTS; [3-(4
Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes
Keywords: ACh; acetylcholine; BCC; bovine chromaffin cells; BDNF; brain-derived neurotrophic factor; BMAP1/2; Brain Molecular Anatomy Project clone sets 1 and 2; BMPR2; bone morphogenic protein receptor, type II (serine/threonine kinase); Btg2; B-cell translocation
Insulin-like growth factor-II regulates the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and phosphatidylinositol 3-kinase pathways
Keywords: IGF-II; insulin-like growth factor II; 12-LOX; 12-lipoxygenase; MAPK; mitogen-activated protein kinase; ERK; extracellular regulatory kinase; PI3K; phosphatidylinositol 3-kinase; 12-HETE; 12-hydroxyeicosatetraenoic acid; 12-Lipoxygenase; 12-hydroxyeicosat
Ebola virus-like particle-induced activation of NF-κB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain
Keywords: Ebola virus; Filovirus; Dendritic cell; Signaling; NF-kB; Erk; MAP kinase; Transcription factor; Cytokine; Proinflammatory; Inhibitor
Arrestin Mobilizes Signaling Proteins to the Cytoskeleton and Redirects their Activity
Keywords: GPCR, G protein-coupled receptor; MT, microtubule; WT, wild-type; SDSL, site-directed spin labeling; EPR, electron paramagnetic resonancearrestin; microtubules; ERK; Mdm2; G-protein coupled receptor
Role of caspases in CD95L- and TRAIL-induced non-apoptotic signalling in pancreatic tumour cells
Keywords: Pancreatic cancer; CD95; TRAIL; Caspases; Apoptosis; ERK; NFκB;
Egr3, a synaptic activity regulated transcription factor that is essential for learning and memory
Keywords: Learning; Memory; Transcriptional regulation; Plasticity; MAPK; Erk; Mouse
RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line
Keywords: RhoE; Retinoblastoma protein; Proliferation; Apoptosis; Cyclin D1; ERK
Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells
Keywords: ERK; extracellular regulated kinase; FACS; flourescence activated cell sorter; Treg; T regulatory; nTreg; naturally-occurring Treg; PBMCs; peripheral blood mononuclear cells; PI3′K; phosphatidyl inositide-3 kinase; PHA; phytohemagglutinin; MAPK; Ras/ mito
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
Keywords: Bad phosphorylation; JNK; Akt; SP600125; bpV(pic); Cerebral ischemia; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; ERK; Extracellular signal regulated kinase; PKA; protein kinase A; RTK; receptor t
Vascular injury and modulation of MAPKs: A targeted approach to therapy of restenosis
Keywords: Intimal hyperplasia; Vascular remodeling; Angioplasty; Signaling; Coronary artery bypass graft; Smooth muscle cells; Endothelial cells; Endothelium; Extracellular-regulated kinases; ERK; JNK; p38MAPK; FGF; TGF; MMP; Thrombin; Inflammation; Topical inhibit
Involvement of the ERK/MAP kinase signalling pathway in milli-calpain activation and myogenic cell migration
Keywords: BCA; bicinchoninic acid; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; DTT; DL-dithiothreitol; EGF; epidermal growth factor; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; ERK; extracellular-signal regulat
Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth
Keywords: DIC; differential interference contrast; ERK; extracellular signal-regulated kinase; IκB; inhibitor of nuclear factor κB; ISOL; in situ oligo ligation; KSR1; kinase suppressor of Ras-1; LGG; Lactobacillus rhamnosus GG; LGG-CM; LGG-conditioned cell cultu
The MEK/ERK cascade: From signaling specificity to diverse functions
Keywords: MAPK; ERK; MEK; Signaling specificity
Enhanced Recruitment of CX3CR1+ T Cells by Mucosal Endothelial Cell-Derived Fractalkine in Inflammatory Bowel Disease
Keywords: Ab; antibody; ERK; extracellular signal-regulated kinase; FKN; fractalkine; HIMEC; human intestinal microvascular endothelial cell; ICAM-1; intercellular adhesion molecule 1; IFN; interferon; IL; interleukin; MAP; mitogen-activated protein; MCP-1; monocyt
Nuclear factor activation by FcγR in human peripheral blood neutrophils detected by a novel flow cytometry-based method
Keywords: FcγRIIA; FcγRIIIB; Fc receptor; NF-κB; ERK; Elk-1
Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide
Keywords: cerebellar development; granule cell; neuronal cell migration; cAMP; rate of cell movement; desensitization; E; embryonic day; EGL; external granular layer; Erk; extracellular signal-regulated; GalR1; galanin receptor 1; GRK; G-protein-coupled receptor ki
Apoptosis and the cardiac action of insulin-like growth factor I
Keywords: Insulin-like growth factor; Apoptosis; Myocardium; Ischaemia; Reperfusion injury; Signaling; ARC; apoptotic repressor with CARD; ATP; adenosine triphosphate; bFGF; basic fibroblast growth factor (also known as FGF2); BAK; Bcl-2 antagonist/killer protein;
Gene expression profiling reveals complex changes following MEK-EE expression in cardiac myocytes
Keywords: MAPK; mitogen-activated protein kinases; ERK; extracellular signal regulated kinase; JNK; c-Jun N-terminal kinase; ANF; atrial natriuretic factor; BNP; brain natriuretic peptide; MEK; MAPK or ERK kinase; MEK-EE; MEK made constitutively active by two point
Id-1 promotes TGF-β1-induced cell motility through HSP27 activation and disassembly of adherens junction in prostate epithelial cells
Keywords: Id-1; TGF-β1; HSP27; Phosphorylation; ERK; E-cadherin; N-cadherin; Cell motility; Prostate epithelial cells
The Lysophosphatidic Acid Type 2 Receptor Is Required for Protection Against Radiation-Induced Intestinal Injury
Keywords: BrdU; bromodeoxyuridine; BSA; bovine serum albumin; CHX; cycloheximide; EDG; endothelial differentiation gene; ERK; extracellular signal-regulated kinase; KO; knockout; LPA; lysophosphatidic acid; LPP; lipid phosphate phosphatase; MEK; mitogen-activated
PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells
Keywords: HR; histamine receptor; GPCR; G-protein coupled-receptor; ERK1/2; extracellular signal-regulated kinases; PI3K; phosphoinositide 3-kinase; DMEM; Dulbecco's modified Eagle's medium; PBS; phosphate-buffered saline; DMEM/F12; Dulbecco's modified Eagle's medi
The CART receptors: Background and recent advances
Keywords: CART signaling; GPCR; AtT20; ERK
Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes
Keywords: VIP; vasoactive intestinal peptide; GPCR; G protein-coupled receptor; VPAC1; type 1 VIP receptor; VPAC2; type 2 VIP receptor; T cell; T lymphocyte; LPA; lysophosphatidic acid; S1P; sphingosine 1-phosphate; LPA1; type 1 LPA receptor; iNOS; inducible nitric
Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting
Keywords: MAP Kinase; Transfection; ERK; Suprachiasmtaic; Circadian
Activation of extracellular signal-regulated kinase signaling by chronic electroconvulsive shock in the rat frontal cortex
Keywords: Electroconvulsive shock; ERK; BDNF