کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341717 | 1295844 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
JnkPBS-Tphosphorylated p38Retinoid X receptorssDNARARRXROGDc-Jun-N-terminal kinaseMKP-1p-ERKp-p38ERK9-cis RAatRA - ATRASingle-stranded DNA - DNA تک رشته ایMAPK - MAPKp-Jnk - p-jnkTris-buffered saline containing 0.1% Tween-20 - Tris-buffered saline حاوی 0.1٪ Tween-20 استall-trans retinoic acid - آل – ترانس رتینوئیک اسیدIschemia - ایسکمیcornu ammonis - بال آمونRetinoic acid - رتینوئیک اسیدReperfusion - رپرفیوژنdentate gyrus - شکنج دندانه دارOxygen and glucose deprivation - محرومیت از اکسیژن و گلوکزHanks’ balanced salt solution - محلول نمک متعادل هانکسRep - هرزهMitogen-activated protein kinase phosphatase-1 - پروتئین پروتئین Mitogen-fosinase phosphatase-1mitogen-activated protein kinase - پروتئین کیناز فعال با mitogenPropidium iodide - پروتئین یدیدphosphorylated extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال تنظیم شده خارج سلولی فسفورید شدهextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیRetinoic acid receptor - گیرنده اسید رتینوئیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase](/preview/png/4341717.png)
چکیده انگلیسی
Retinoic acids (RAs), including all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA), play fundamental roles in a variety of physiological events in vertebrates, through their specific nuclear receptors: retinoic acid receptor (RAR) and retinoid X receptor (RXR). Despite the physiological importance of RA, their functional significance under pathological conditions is not well understood. We examined the effect of ATRA on oxygen/glucose-deprivation/reperfusion (OGD/Rep)-induced neuronal damage in cultured rat hippocampal slices, and found that ATRA significantly reduced neuronal death. The cytoprotective effect of ATRA was observed not only in cornu ammonis (CA) 1 but also in CA2 and dentate gyrus (DG), and was attenuated by selective antagonists for RAR or RXR. By contrast, in the CA3 region, no protective effects of ATRA were observed. The OGD/Rep also increased phosphorylated forms of c-jun-N-terminal kinase (P-JNK) and p38 (P-p38) in hippocampus, and specific inhibitors for these kinases protected neurons. ATRA prevented the increases in P-JNK and P-p38 after OGD/Rep, as well as the decrease in NeuN and its shrinkage, all of which were inhibited by antagonists for RAR or RXR. These findings suggest that the ATRA signaling via retinoid receptors results in the inhibition of JNK and p38 activation, leading to the protection of neurons against OGD/Rep-induced damage in the rat hippocampus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 147, Issue 1, 15 June 2007, Pages 153-163
Journal: Neuroscience - Volume 147, Issue 1, 15 June 2007, Pages 153-163
نویسندگان
Y. Shinozaki, Y. Sato, S. Koizumi, Y. Ohno, T. Nagao, K. Inoue,