کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8303500 | 1537808 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α
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کلمات کلیدی
EGFIGFJnkSB203580ERKPD98059U0126PTXGCKLPAMAPK - MAPKSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAlysophosphatidic acid - اسید لیسفسفیدیدpertussis toxin - سموم سورافنیepidermal growth factor - عامل رشد اپیدرمیInsulin-like growth factor - فاکتور رشد مانند انسولینCell migration - مهاجرت سلولیextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیmitogen-activated protein kinases - کیناز پروتئین فعال MitogenReceptors - گیرنده ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α](/preview/png/8303500.png)
چکیده انگلیسی
Prostate cancer cell migration is an essential event both in the progression of prostate cancer and in the steps leading to metastasis. We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA1 receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). Our results demonstrate that parallel activation of ERK1/2 and p38, but not JNK, is responsible for LPA-stimulated PC3 cell migration. Furthermore, using small interfering RNA (siRNA) technology, and overexpressing dominant-negative mutants of p38 MAPK isotypes of α, β, γ and δ, we have identified that the activation of ERK2 (p42) and p38α, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration. Our study provides the first evidence for a functional role of p42 and p38α in LPA-induced mammalian cell migration, and also demonstrates, for the first time, that the receptor LPA1 mediates prostate cancer cell migration. The results of the present study suggest that LPA, the receptor LPA1, ERK2 and p38α are important regulators for prostate cancer cell invasion and thus could play a significant role in the development of metastasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1771, Issue 7, July 2007, Pages 883-892
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1771, Issue 7, July 2007, Pages 883-892
نویسندگان
Feng Hao, Mingqi Tan, Xuemin Xu, Jiahuai Han, Duane D. Miller, Gabor Tigyi, Mei-Zhen Cui,