Keywords: High glucose; Endothelial to mesenchymal transition; TGF-β1; PD98059; NAC;
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Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells
Keywords: RES; resveratrol; RCC; renal cell carcinoma; EMT; epithelial-mesenchymal transition; MMP; matrix metalloproteinase; ECM; extracellular matrix; ERK; extracellular signal-regulated protein kinase; MAPK; mitogen-activated protein kinases; DMEM; Dulbecco's
T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation
Keywords: AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; BSA; bovine serum albumin; CQ; chloroquine; EC; endothelial cell; eIF2α; eukaryotic translation initiation factor 2α; ER; endoplasmic reticulum; Erk1/2; extracellular signal-regulated kinase;
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells
Keywords: KSHV; Kaposi's sarcoma-associated herpesvirus; B; butyrate; ERK; Extracellular Signal-regulated Kinase; MAPKs; Mitogen-Activated Protein Kinases; PD98059; ERK inhibitor; PEL; Primary Effusion Lymphoma; PKCs; protein kinases C; Q; quercetin; ROS; reactive
Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2)
Keywords: BDNF; brain-derived neurotropic factor; cAMP; cyclic adenosine monophosphate; CGS21680; 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid - selective adenosine A2A agonist; Cyt.
Original ResearchEffect of PPARδ Agonist on Stearoyl-CoA Desaturase 1 in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway
Keywords: PD98059; Î9-desaturase; fatty acids; GW0742; pancreatic neoplasms; PPARδ; PD98059; Î9-désaturase; acides gras; GW0742; néoplasmes pancréatiques; PPARδ;
Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3â²,4â²-dihydroxyflavonol
Keywords: Flavonol; Myocardial ischemia/reperfusion injury; Oxidative stress; Survival kinases; ERK1/2; Akt; PD98059; LY294002;
Differential expression profiles and roles of inducible DUSPs and ERK1/2-specific constitutive DUSP6 and DUSP7 in microglia
Keywords: Microglia; DUSP6; DUSP7; PD98059; FR180204; BCI;
PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells
Keywords: PARP-1; phospho-ERK; C6 glioma cells; GP8.3 cells; PJ-34; PD98059;
ERK 5/MAPK pathway has a major role in 1α,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells
Keywords: 1,25D; 1α,25(OH)2 vitamin D3; AML; acute myeloid leukemia; CC; cell cycle; VDD; vitamin D derivative; BIX; BIX02189; PD; PD98059; U0; U0126; XMD; XMD8-92; Vitamin D derivatives; ERK5; ERK1/2; MAPK inhibitors; Acute myeloid leukemia (AML); Cell differenti
Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2
Keywords: Dynasore; PD98059; BFA; SecinH3; LY294002; QS11; PBP10ARF, ADP-ribosylation factor; PI, phosphatidylinositol; PI3K, PI 3-kinase; PIP2, PI 4,5-bisphosphate; PIP3, PI 3,4,5-trisphosphate; ERK, extracellular-signal regulated kinase; MAPKK, mitogen-activated
Hepatitis C virus core protein enhances HIV-1 replication in human macrophages through TLR2, JNK, and MEK1/2-dependent upregulation of TNF-α and IL-6
Keywords: APCs; antigen-presenting cells; ERK; extracellular signal-regulated protein kinase 1/2; HKLM; heat killed Listeria monocytogenes; IL-6; interleukin 6; JNK; c-Jun amino-terminal kinase; MDMs; primary monocyte derived macrophages; p38; p38 MAP kinase; PD980
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells
Keywords: DHE; dihydroethidium; DHR; dihydrorodamine 123; HG; high glucose; LY; LY294002; LPO; lipid peroxidation; NBT; nitrotetrazolium blue; PC; protein carbonylation; U1; PD98059; U2; U0126; WT; wortmannin; Glial cells; Hyperglycemia; Oxidative-nitrosative stres
The role of Src protein in the process formation of PC12 cells induced by the proteasome inhibitor MG-132
Keywords: Cy3; Â a fluorophor cyanin dye; DMEM; Â Dulbecco's Modified Eagle's Medium; DMSO; Â dimethyl-sulfoxyde; EDTA; Â ethylenediaminetetraacetic acid; EGTA; Â ethylene glycol tetraacetic acid; ERK1/2; Â extracellular signal-regulated kinase 1 and 2; H-Ras;
Increase of oxidative stress by a novel PINK1 mutation, P209A
Keywords: AD; Alzheimer disease; ERK; extracellular signal-regulated kinase; MTT; 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolum bromide; HO-1; heme oxygenase-1; LDH; lactate dehydrogenase; LY294002; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; MEM; mini
Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2
Keywords: P2X7R; P2X7 receptor channels; LPS; lipopolysaccharide; IL-1β; interleukin-1β; TNFα; tumor necrosis factor α; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinase; ERK1/2; extracellular regulated kinases 1 and 2; MAPKs; mitogen-activated protein
C-peptide induces human renal mesangial cell proliferation in vitro, activating Src-kinase, PI-3 kinase and ERK1/2
Keywords: CDK4; cyclin-dependent kinase 4; DAPI; 4â²,6-diamidino-2-phenylindole; ERK1/2; extracellular-signal-regulated kinases; LY294002; PI-3 kinase inhibitor; MC; mesangial cells; PD98059; MAP/ERK kinase inhibitor; PDGF; platelet derived growth factor; PP2; pro
Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway
Keywords: BK; large (big) conductance Ca2+-activated K+ channels; DPCPX; 1,3-dipropyl-8-cyclopentylxanthine; GUO; guanosine; GSK-3β; glycogen synthase kinase 3β; H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; HO-1; heme oxygenase-1; LY294002; 2-(4-morpholinyl)
Activation of corticotropin releasing factor receptor type 2 in the heart by corticotropin releasing factor offers cytoprotection against ischemic injury via PKA and PKC dependent signaling
Keywords: CRF; corticotrophin releasing factor; CRFR; corticotrophin releasing factor receptor; MEK½; mitogen activated protein kinase; PKC; protein kinase C; PKA; protein kinase A; ACTH; adrenocorticotropic hormone; UCN; urocortin; ERK½; extracellular signal-reg
Low-power laser irradiation (LPLI) promotes VEGF expression and vascular endothelial cell proliferation through the activation of ERK/Sp1 pathway
Keywords: HUVEC-CS; human umbilical vein endothelial cells subline; HEK 293T; human embryonic kidney 293T; LPLI; low-power laser irradiation; ERK; extracellular signal-regulated kinase; Sp1; specificity protein 1; VEGF; vascular endothelial growth factor; EGF; epid
Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells
Keywords: DHK; dihydrokainate; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DTT; 1,4-dithiothreitol; EAAC1; excitatory amino acid carrier 1; EBSS; Earle's balanced salt solution; EAAT1-2-3; excitatory amino acid transporter 1-2-3; FBS;
Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model
Keywords: ADAM12; disintegrin and metalloproteinase domain-containing protein 12; α9β1; integrin receptor composed of α9 and β1 sub-units; C2C12; a clonal cell derived from mouse skeletal muscle; EC50; effective concentration 50%; ELISA; enzyme-linked immunosor
Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophophate; ATP; adenosine triphosphate; MI; myocardial infarction; ENTPD-1 CD39; ectonucleoside triphosphate diphosphohydrolase 1; Akt; serine/threonine protein kinase; ERK 1/2; extracellular signal-regulated
MEK5/ERK5/mef2: A novel signaling pathway affected by hepatitis C virus non-enveloped capsid-like particles
Keywords: HCVne; Hepatitis C non-enveloped capsid-like particles; EGF; epidermal growth factor; MAPKs; Mitogen Activated Protein Kinases; UO126; Selective inhibitor of both MEK1 and MEK2; PD98059; Specific inhibitor of the activation of mitogen-activated protein ki
Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells
Keywords: AKT/PKB; protein kinase B; BrDU; 5-bromo-2â²-deoxyuridine; CRC; colorectal cancer; DCFH; 2â²,7â²-dichlorofluorescin diacetate; DTT; dithiothreitol; EC; epicatechin; ECG; epicatechin gallate; EGCG; epigallocatechin-3-gallate; ERK; extracellular regulate
Cellular mechanisms of acute decrease of glutamate release induced by raloxifene in rat cerebral cortex
Keywords: Raloxifene; Glutamate release; Synaptosomes; Voltage-dependent Ca2+ channels; ERK; Synapsin I; 4-AP; 4-aminopyridine; [Ca2+]C; cytosolic free Ca2+ concentration; DiSC3(5); 3â²,3â²,3â²-dipropylthiadicarbocyanine iodide; DL-TBOA; DL-threo-beta-benzyl-oxy
Involvement of aquaporin in thromboxane A2 receptor-mediated, G12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells
Keywords: dbcAMP; dibutyryl adenosine 3â²,5â²-monophosphate; EIPA; 5-(N-Ethyl-N-isopropyl)amiloride; GF109203X; (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide;3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion
A novel diffusion cell model for the in vitro assessment of transcutaneous breast cancer therapeutics: Effect of permeants on MCF-7 cells cultured within the receptor compartment
Keywords: Breast cancer; Topical drug delivery; 4-Hydroxytamoxifen; EGFR inhibitors; PD98059; LY294002; Eicosapentaenoic acid; Cyclopore track etched membrane; Franz diffusion cell; Skin; Composite model
TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes
Keywords: VEGF; vascular endothelial growth factor; VEGFR; vascular endothelial growth factor receptor; TSU-16; (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; CYP; cytochrome P450; AhR; aryl hydrocarbon receptor; OMP; omeprazole; 3MC; 3-methylcholanthr
STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling
Keywords: Epstein-Barr virus; Latent membrane protein 1; Nasopharyngeal carcinoma; Signal transducer and activator of transcription 3; Vascular endothelial growth factor; Janus kinase 3; Extracellular signal-regulated kinase 1/2; PD98059; WHI-P131; Invasion abili
Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model
Keywords: TSC; mTOR; ERK/MAPK; rapamycin; PD98059
ERK/BCL-2 Pathway in the Resistance of Pancreatic Cancer to Anoikis
Keywords: anoikis; BCL-2; ERK1/2; PD98059; pancreatic cancer; metastasis
Unique MAP Kinase binding sites
Keywords: MAP kinases; Inhibitor binding; FXFP; Sulindac; PD98059; X-ray crystallographyCD-domain, Common docking domain; D-Motif, Docking motif or docking site in MAP kinase substrates and MAP kinase processing enzymes; DFG-out, unusual conformation in well conser
Interaction of epithelial cell membrane rafts with Paracoccidioides brasiliensis leads to fungal adhesion and Src-family kinase activation
Keywords: Membrane microdomains; Paracoccidioides brasiliensis; Host-pathogen interactions; Adhesions; Src-Family Kinases; ERK MAP kinases; Brij®98; polyoxyethylene(20) oleyl ether; BSA; bovine serum albumin; CTB; cholera toxin subunit B; DAPI; 2-(4-amidinophenyl)
Mechanisms of glutamate release from astrocytes
Keywords: 2-APB; 2-aminoethoxydiphenyl borate; 2DG; 2-deoxy-d-glucose; 2MeSADP; 2-methylthio-adenosine diphosphate; αβ mATP; α,β-methylene ATP; A3P5PS; adenosine 3â²-phosphate; 5â²-phosphosulfate; AMPA; α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid;
Immune responses of mussel hemocyte subpopulations are differentially regulated by enzymes of the PI 3-K, PKC, and ERK kinase families
Keywords: Mollusc; Signal transduction; Innate immunity; Phagocytosis; Respiratory burst; Wortmannin; Staurosporine; PD98059; Professional phagocytes
Severity of alcohol-induced painful peripheral neuropathy in female rats: Role of estrogen and protein kinase (A and Cε)
Keywords: ethanol; hyperalgesia; estrogen; second messenger signaling; CD; control diet; DMSO; dimethyl sulfoxide; ED; ethanol (6.5%, v:v) diet; ERK; extracellular-signal related kinase; IF; gonad-intact female; IM; gonad-intact male; MEK; mitogen and extracellular
Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation
Keywords: Hypoxia; Akt; Erk; PD98059; LY294002; SDF-1; CXCR4; Transmigration; HL-60
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α
Keywords: LPA; lysophosphatidic acid; MAPK; mitogen-activated protein kinases; siRNA; small interfering RNA; PTX; pertussis toxin; PD; PD98059; SB; SB203580; U0; U0126; ERK; extracellular signal-regulated kinase; JNK; c-Jun/N terminal kinases; IGF; insulin-like gro
Ischemic preconditioning via epsilon protein kinase C activation requires cyclooxygenase-2 activation in vitro
Keywords: neuroprotection; ERK1/2; mixed cortical neuron/astrocyte cell cultures; organotypic hippocampal slice cultures; ischemia; oxygen/glucose deprivation; BSA; bovine serum albumin; CCD; charge-device-based; cell cultures; mixed cortical neuron/astrocyte cell
The role of progestin receptors and the mitogen-activated protein kinase pathway in δ opioid receptor facilitation of female reproductive behaviors
Keywords: Lordosis; Progesterone; δ Opioid receptors; MAPK; PD98059; DPDPE; RU486
PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells
Keywords: Endoplasmic reticulum stress; PI3K-Akt pathway; LY294002; Wortmannin; PD98059; CHOP
The entorhinal cortex plays a role in extinction
Keywords: Learning; Memory; Extinction; Entorhinal cortex; AP5; NMDA; Anisomycin; Protein synthesis; KN-93; CaMKII; PD98059; ERK1/2
Regulation of C/EBPβ isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3
Keywords: Vitamin D; Monocytic differentiation; C/EBP transcription factors; MEK1-ERK MAP kinase pathway; Subcellular localization; PD98059; SB203580
MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation
Keywords: G receptor kinase 2; ERK1/2 kinase; Degradation; Proteasome; PD98059; Lactacystin; 7TM; GPRC;
Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes
Keywords: GST; GSH S-transferase; MEK-1; extracellular-regulated kinase kinase-1; PI 3-K; phosphotidyl inositol 3-kinase; PD; PD98059; SP; SP600125; SB; SB203580; Wt; wortmannin; ARE; antioxidant-responsive element; CDNB; 1-chloro-2, 4-dinitrobenzene; GAPDH; glycer
HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells
Keywords: AP-1; activator protein-1; EMSA; electrophoretic mobility shift assay; EpRE; electrophile response element; ERK; extracellular signal-regulated kinase; HNE; 4-hydroxynonenal; HO-1; heme oxygenase-1; HRP; horseradish peroxidase; JNK; c-Jun N-terminal kinas
Neuroprotective effects of inhibiting N-methyl-d-aspartate receptors, P2X receptors and the mitogen-activated protein kinase cascade: A quantitative analysis in organotypical hippocampal slice cultures subjected to oxygen and glucose deprivation
Keywords: propidium iodide; PD98059; MK-801; suramin; ischemia; stroke; BME; basal medium Eagle's solution; DMSO; dimethyl sulfoxide; ECF; Enhanced Chemi-Fluorescence; ERK; extracellular signal-regulated kinase; FD; fascia dentata; HBSS; Hanks' balanced salt so
Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat
Keywords: acetylcholine release; glutamate; medial prefrontal cortex; ventral hippocampus; MAPK; short term memory; ACd; anterior dorsal cingulate cortex; ACh; acetylcholine; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; AUC; area under the cur