کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426212 | 1295913 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat
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کلمات کلیدی
NeuNNeuronal specific enolase2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-onephosphate-buffered saline containing 0.05% Tween 20PD98059U0126ACDPBS-TPRLCA3MPFCaCSFS.E.M.ERKOPAEGTABLADABPBSFITCCA13,3′-diaminobenzidine - 3،3'-diaminobenzidinebasolateral amygdala - amygdala basolateralAUC - AUCDMSO - DMSOMAPK - MAPKo-Phthalaldehyde - o-فتالالدئیدPBS-Tx - PBS-TXcornu ammonis area 1 - آمون طبقه بال 1ACh - آهEDTA - اتیلن دی آمین تترا استیک اسید Ethylenediaminetetraacetic acid - اتیلینیدامین تتراستیک اسیدAcetylcholine - استیل کولینAcetylcholine release - انتشار استیل کولینCornu Ammonis area 3 - بال 3 طبقه آمونanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceShort term memory - حافظه کوتاه مدتstandard error of the mean - خطای استاندارد میانگینdentate gyrus of the hippocampus - دندانه دار کردن قارچ از هیپوکامپdimethylsulphoxide - دی متیل سولفوکسیدphosphate-buffered saline containing 0.3% Triton X-100 - فسفات بافر حاوی 0.3٪ تریتون X-100 استFluorescein - فلورسئینinfralimbic cortex - قشر infralimbicmedial prefrontal cortex - قشر غده پروسترولprelimbic cortex - قشر پیش از قاعدگیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیMEK - مجاهدین خلقPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریarea under the curve - منطقه تحت منحنیventral hippocampus - هیپوکامپ شکمیExtracellular regulated protein kinase - پروتئین کیناز تنظیم شده خارج سلولیhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراglutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It has been demonstrated that the forebrain cholinergic system and the extracellular regulated kinase signal transduction pathway are involved in the mechanisms of learning, encoding, and storage of information. We investigated the involvement of the cholinergic and glutamatergic systems projecting to the medial prefrontal cortex and ventral hippocampus and of the extracellular regulated kinase signal transduction pathway in the acquisition and recall of the step-down inhibitory avoidance response in the rat, a relatively simple behavioral test acquired in a one-trial session. To this aim we studied by microdialysis the release of acetylcholine and glutamate, and by immunohistochemistry the activation of extracellular regulated kinase during acquisition, encoding and recall of the behavior. Cholinergic, but not glutamatergic, neurons projecting to the medial prefrontal cortex and ventral hippocampus were activated during acquisition of the task, as shown by increase in cortical and hippocampal acetylcholine release. Released acetylcholine in turn activated extracellular regulated kinase in neurons located in the target structures, since the muscarinic receptor antagonist scopolamine blocked extracellular regulated kinase activation. Both increased acetylcholine release and extracellular regulated kinase activation were necessary for memory formation, as administration of scopolamine and of extracellular regulated kinase inhibitors was followed by blockade of extracellular regulated kinase activation and amnesia. Our data indicate that a critical function of the learning-associated increase in acetylcholine release is to promote the activation of the extracellular regulated kinase signal transduction pathway and help understanding the role of these systems in the encoding of an inhibitory avoidance memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 136, Issue 1, 2005, Pages 15-32
Journal: Neuroscience - Volume 136, Issue 1, 2005, Pages 15-32
نویسندگان
M.G. Giovannini, M. Pazzagli, P. Malmberg-Aiello, L. Della Corte, A.D. Rakovska, F. Cerbai, F. Casamenti, G. Pepeu,