Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development
Keywords: Hair follicle; Shh; RAS; FGF; Morphogen; Signal strength; Amplitude;
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PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively
Keywords: ECM; extracellular matrix; EGF; epidermal growth factor; FGF; fibroblast growth factor; GEF; guanine nucleotide exchange factor; HGF; hepatocyte growth factor; MMP; matrix metalloproteinase; PAK; p21-activated kinase; PI3K; phosphoinositide 3-kinase; PTEN
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins
Keywords: APC; adenomatous polyposis coli; BMS; Basso Mouse Scale; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; FGF; fibroblast growth factor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDNF; glial cell line-derived neurotrophi
MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31
Keywords: 3â²UTR; 3â² untranslated region; ALP; Alkaline phosphatase; AP-1; Activator protein 1; ATF4; Activating transcription factor 4; BGLAP; Bone gamma-carboxyglutamate (gla) protein; BMP; Bone morphogenetic protein; COL1A1; Collagen, type I, alpha 1; FBS; Fe
Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice
Keywords: HS; heparan sulfate; BMP; bone morphogenetic protein; FGF; fibroblast growth factor; HSPGs; heparan sulfate proteoglycans; Ihh; Indian hedgehog; HME; Hereditary Multiple Exostoses; MMP-13; matrix metalloprotease 13; VEGFs; vascular endothelial growth fact
Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate
Keywords: AFM; atomic force microscopy; CS; chondroitin sulfate; DMMB; 1,9-dimethylmethylene blue; DS; dermatan sulfate; DSMFS; dynamic SMFS; ECM; extracellular matrix; FGF; fibroblast growth factor; GAG; glycosaminoglycan; GlcA; glucuronic acid; GlcNAc; N-acetylgl
Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition
Keywords: Glycoconjugated bile acids; Tauroconjugated bile acids; Ileum; Liver; Nuclear receptor; ACA; allocholic acid; BA; bile acid; BSEP; bile salt export pump; CDCA; chenodeoxycholic acid; CA; cholic acid; DCA; deoxycholic acid; FGF; fibroblast growth factor; F
Early axonal damage and progressive myelin pathology define the kinetics of CNS histopathology in a mouse model of multiple sclerosis
Keywords: B6; C57BL/6; CFA; complete Freund's adjuvant; CNS; central nervous system; CST; corticospinal tract; DC; dorsal column; EAE; experimental autoimmune encephalomyelitis; FGF; fibroblast growth factor; IFA; incomplete Freund's adjuvant; MBP; myelin basic pro
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Keywords: Cell commitment; Cell survival; Endocannabinoids; Membrane receptors; Niche cues; Protein kinases; Transcription factors; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; BDNF; brain derived neurotrophic factor; CBD; cannabidiol; CBG; cannab
FGF12 is a candidate Brugada syndrome locus
Keywords: BrS; Brugada syndrome; CTD; C-terminal domain; ECG; electrocardiogram; FGF; fibroblast growth factor; FHF; fibroblast growth factor homologous factor; GFP; green fluorescent protein; JPH2; junctophilin-2; KD; knocked down; Q; glutamine; qPCR; quantitative
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling
Keywords: RA; rheumatoid arthritis; FLS; fibroblast-like synoviocytes; ACPA; anti-citrullinated peptide antibody; DKK1; dickkopf-1; 11β-HSD1; 11beta-hydroxysteroid dehydrogenase type 1; PADI4; peptidylarginine deiminase-4; hTERT; human telomerase reverse transcrip
BMP signaling in development and diseases: A pharmacological perspective
Keywords: BMP; Wnt; FGF; Cartilage; Bone
The role of angiogenic and wound-healing factors after spinal cord injury in mammals
Keywords: Angiogenesis; Spinal cord injury; VEGF; Wound healing; Mammals; FGF
Developing a sense of taste
Keywords: CVP, circumvallate papilla; RTK, tyrosine kinase receptorMouse; Zebrafish; Molecular genetics; Sox2; Wnt; Shh; Notch; Fgf; miR-200
Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Keywords: Clinical Trial; Metabolic Syndrome; Treatment; Obesity; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BA; bile acid; C4; 7α-hydroxy-4-cholesten-3-one; FGF; fibroblast growth factor; FXR; farnesoid X receptor; GIR; glucose infusion rate;
Perspectives on cancer stem cells in osteosarcoma
Keywords: Osteosarcoma; Cancer stem cell; Tumor initiating cell; Mesenchymal tumors; Bone cancer; Sox2; FGF; Wnt signaling
FGFR signalling in women's cancers
Keywords: FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; HS; heparan sulfate; RTK; receptor tyrosine kinase; ER; oestrogen receptor; PR; progesterone receptor; IDC; invasive ductal carcinoma; FISH; fluorescence in situ hybridisation; TMA; t
Spry1 and Spry2 are necessary for eyelid closure
Keywords: Eyelids; Sprouty; FGF; ERK; C-Jun; Wnt; Foxc1; Foxc2
Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression
Keywords: Baculovirus; Expression system; RNAi; EGFP-fusion protein; ORF33; ORF34; FGF; Ubiquitin; Budded virus
Host Matrix Modulation by Tumor Exosomes Promotes Motility and Invasiveness
Keywords: ASML; BSp73ASML; ASML-CD44vkd; ASML cells with a stable knockdown of CD44v4-v7; CM; conditioned medium; CM-exo; exosome-depleted CM; coll; collagen; ECM; extracellular matrix; EGF; epidermal growth factor; FGF; fibroblast growth factor; FN; fibronectin; H
Effects of the polysaccharide from Pholiota nameko on human cytokine network in serum
Keywords: EGF; epidermal growth factor; FGF; fibroblast growth factors; Fit; Fit-3 ligand; G-CSF; granulocyte colony stimulating factor; GM-CSF; granulocyte-macrophage-colony stimulating factor; GRO; growth related oncogene; INF; Interferon; IL; interleukin; IP-1
Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro
Keywords: Diabetic foot ulcer; Radix Astragali; Radix Rehmanniae; Angiogenesis; VEGF; FGF; MAPK; Wound healing; Zebrafish embryos;
Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation
Keywords: BHT; butylated hydroxytoluene; DMSO; dimethyl sulfoxide; EBM-2; endothelial basal medium; EGM-2; endothelial growth medium; EGF; epidermal growth factor; FBS; fetal bovine serum; FGF; fibroblast growth factor; Hep3B; a human hepatoma cell line; HUVEC; hum
Candidate-gene exclusion in a family with inherited non-syndromic dental disorders
Keywords: AI; Amelogenesis imperfecta; ADAI; Amelogenesis imperfecta with autosomal dominant inheritance; ARAI; Amelogenesis imperfecta with autosomal recessive inheritance; X-linked AI; Amelogenesis imperfecta related to X chromosome; ENAM; Enamelin; DLX3; Distal-
Research reportInvolvement of GPR12 in the induction of neurite outgrowth in PC12 cells
Keywords: FGF; fibroblast growth factor; NGF; nerve growth factor; cAMP; cyclic AMP; PKA; protein kinase A; GPCR; G protein-coupled receptor; SYP; synaptophysin; MAP-2; microtubule-associated protein-2; GPR12; Phosphor-Erk1/2; Synaptophysin; Bcl-xL; Bcl-2;
Odontoblast-targeted Bcl-2 overexpression promotes dentine damage repair
Keywords: α-MEM; alpha-minimum essential medium; BCA; bicinchoninic acid assay; Bcl-2; B-cell lymphoma-2; hBcl-2; human Bcl-2; mBcl-2; mouse Bcl-2; mBax; mouse Bcl-2-associated X protein; βGP; beta-glycerophosphate; BMP; bone morphogenetic protein; BSA; bovine se
The genetic association of DUSP6 with bipolar disorder and its effect on ERK activity
Keywords: BD; bipolar disorder; COMT; catechol-O-methyltransferase; DIGS; Diagnostic Interview for Genetic Studies; DISC1; disrupted in schizophrenia 1; DMEM; Dulbecco's modified Eagle's medium; DNA; deoxyribonucleic acid; DUSP; dual-specificity phosphatase; ERK; e
Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea
Keywords: Colon; Malabsorption; Liver; Metabolism; BA; bile acid; BAM; bile acid malabsorption; BMI; body mass index; C4; 7α-hydroxy-4-cholesten-3-one; FGF; fibroblast growth factor; FGFR4; fibroblast growth factor receptor 4; HV; healthy volunteers; IBS; irritabl
Conditions that influence the response to Fgf during otic placode induction
Keywords: Zebrafish; Fgf; Pax2/5/8; Foxi1; Cranial placodes; Otic competence; Heat shock
Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus
Keywords: CNTF; ciliary neurotrophic factor; CNTFRα; ciliary neurotrophic factor receptor alpha; LIFRÃ; leukocyte inhibitory factor receptor beta; SON; supraoptic nucleus; PVN; paraventricular nucleus; VP; vasopressinergic; OT; oxytocinergic; NL; neural lobe; ROD
Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis
Keywords: 8-MOP; 8-methoxypsoralen; CCL2; chemokine (C-C motif) ligand; CD; cluster of differentiation; ECP; extracorporeal photochemotherapy; EGF; epidermal growth factor; ELISA; enzyme-linked immunosorbent assay; ENA; extractable nuclear antigen; FGF; fibroblast
Prostate cancer stem cells: Are they androgen-responsive?
Keywords: ABC; ATP-binding cassette; ADT; androgen deprivation therapy; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukaemia; AR; androgen receptor; BM; basement membrane; CaP; prostate cancer; CARN; castration-resistant nkx3.1-expressing cells; CB; committed
Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration
Keywords: BMP; bone morphogenic protein; EHD; extrahepatic duct; EPD; extrapancreatic duct; FGF; fibroblasts growth factor; GB; gall bladder; HNF; hepatocyte nuclear factor; HPD; hepatopancreatic ductal system; IHD; intrahepatic ducts; IPD; intrapancreatic ducts; S
Associate Editor: C.N. PopeFunctional consequences of repeated organophosphate exposure: Potential non-cholinergic mechanisms
Keywords: CPF; chlorpyrifos; DFP; diisopropylfluorophosphate; FGF; fibroblast growth factor; GWI; Gulf War Illness; NGF; nerve growth factor; OP; organophosphate; Pesticide; Cholinesterase inhibitor; Chronic; Memory; Cognition;
Mechanisms of FGFR-mediated carcinogenesis
Keywords: FGF; FGFR; Receptor tyrosine kinase; Signalling; Cancer; Cancer therapy
Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo
Keywords: Mouse; Embryo; Mesoderm; FGF; Elongation
Effects of osteogenic growth factors on bone marrow stromal cell differentiation in a mineral-based delivery system
Keywords: Coprecipitation; Biomineralization; Biomimetic material; SBF (simulated body fluids); BMP; FGF
FGF signaling transforms non-neural ectoderm into neural crest
Keywords: Neural crest; FGF; Non-neural ectoderm; Induction; Pax7
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
Keywords: EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; IGF; insulin-like growth factor; IGF-IR; type 1 IGF receptor; IR; insulin receptor; IRS; insulin receptor substrate; PI 3-kinase; phosphatidylinositol
Targeting angiogenesis in ovarian cancer
Keywords: Ovarian cancer; Angiogenesis; Clinical trials; VEGF; PDGF; FGF; Angiopoietin
Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis
Keywords: Ciona intestinalis; Heart development; Gene regulatory network; Fgf; Ets; Map kinase; Chordate
Neurotrophins and their role in the cochlea
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; CI; cochlear implant; CNTF; ciliary neurotrophic factor; eABR; electrically evoked auditory brainstem response; eCAP; electrically evoked compound action
Research ReportBehavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster
Keywords: NMJ; neuro-muscular junction; SMA; spinal muscular atrophy; SMN; survival motor neuron; UAS; upstream activating sequence; RNAi; RNA interference; FGF; fibroblast growth factor; BMP; bone morphogenetic protein; GluR; glutamate receptor; Drosophila; Motor
Defects in Gallbladder Emptying and Bile Acid Homeostasis in Mice With Cystic Fibrosis Transmembrane Conductance Regulator Deficiencies
Keywords: Enterohepatic Circulation; Cholehepatic Shunt; Bicarbonate Secretion; Bile Acid Transporters; Asbt; apical sodium-dependent bile salt transporter; BA; bile acid; cAMP; adenosine 3â²,5â²-cyclic monophosphate; Cck; cholecystokinin; CF; cystic fibrosis; CF
Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration: A review
Keywords: ATDC5; murine chondrogenic cell line; BMP; bone morphogenetic protein; CM; chitin carboxymethyl chitin; DA; degree of acetylation; DD; degree of deacetylation; DPBS; Dulbecco's phosphate-buffered saline; ECM; extracellular matrix; EDC; 1-ethyl-3-(3-dimeth
Specificity of peripheral nerve regeneration: Interactions at the axon level
Keywords: AKT/PKB; protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CAMs; cell adhesion molecules; Cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; ChAT; choline acetyltransferase
Single-domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1
Keywords: FGF; fibroblast growth factor; FGFR1; fibroblast growth factor receptor 1; VHH; heavy chain variable domain; Single-domain antibodies; Llama VHH; Fibroblast growth factor receptor 1; Competitive elution; Receptor internalization; MCF7 cells;
Establishment of Hertwig's epithelial root sheath cell line from cells involved in epithelial-mesenchymal transition
Keywords: CK14; cytokeratin14; EGFr; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; Fgf; fibroblast growth factor; HERS; Hertwig's epithelial root sheath; IGF-Ir; insulin-like growth factor-I receptor; PN; postnatal; RT; room temperat
Investigating the mechanism of the assembly of FGF1-binding heparan sulfate motifs
Keywords: Heparan sulfate; FGF; GAGOSOMES; Biosynthesis; Sulfotransferase; Enzymatic modification; Proteoglycan; Signaling
Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
Keywords: Fgf; Fgf20b; Cranial neural crest; Pharyngeal arch; Ectomesenchyme; Zebrafish;