Keywords: منطقه چارچوب; CDR; complementarity-determining region; Fab; fragment antigen-binding; Fc; fragment crystallizable; FR; framework region; Fv; fragment variable; RMSD; root-mean-square deviation; Antibody conformational changes; Complementarity determining regions; Compu
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Keywords: منطقه چارچوب; APR; aggregation-prone region; FR; framework region; CDR; complementarity-determining region; RALS; right angle light scattering; FDA; US Food and Drug Administration; PDB; Protein Data Bank; MASS; mutant aggregation and stability spectrum; SEC; size-excl
Keywords: منطقه چارچوب; 2D; two-dimensional; 3D; three-dimensional; CDR; complementarity determining region; CMC; chemistry, manufacturing and control; CPCA; composite protein for clinical applications; CS; canonical structure; EMBL-EBI; EMBL European Bioinformatics Institute; F
Keywords: منطقه چارچوب; scFv; single-chain fragment variable; Fab; fragment antigen binding; PBMC; peripheral blood mononuclear cell; V; variable; VH; variable heavy chain; VL; variable light chain; Vκ; variable kappa light chain; Vλ; variable lambda light chain; PPE; periplas
Protein de novo sequencing by top-down and middle-down MS/MS: Limitations imposed by mass measurement accuracy and gaps in sequence coverage
Keywords: منطقه چارچوب; Fourier transform; Ion cyclotron resonance; ICR; FT-ICR; FTMS; Mass accuracy; Antibody; mAb; Complementarity-determining region; CDR; Framework region; FR;
Immunoglobulin heavy chain variable region analysis in dairy goats
Keywords: منطقه چارچوب; Ig; immunoglobulin; VH; immunoglobulin heavy chain variable region variable gene; DH; immunoglobulin heavy chain variable region diversity gene; JH; immunoglobulin heavy chain variable region joining gene; V(D)J; junction of immunoglobulin heavy chain var
Construction of humanized anti-HER2 single-chain variable fragments (husFvs) and achievement of potent tumor suppression with the reconstituted husFv-Fdt-tBid immunoapoptotin
Keywords: منطقه چارچوب; HER2; Immunogenicity; Humanized scFv; Immunoapoptotin; Targeted cancer therapy; Apoptosis; HER2; human epidermal growth factor receptor 2; scFv; single-chain variable fragment; husFv; humanized e23sFv; VL; light chain variable region; VH; heavy chain vari
A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders
Keywords: منطقه چارچوب; CDR; complementarity-determining region; FR; framework region; sdAb; single-domain antibody; VL; variable light chain immunoglobulin domain; Tm; melting temperature; Single-domain antibody; Protein engineering; Human VL; Phage display; Disulfide bond; The
In vitro selection of bispecific diabody fragments using covalent bicistronic DNA display
Keywords: منطقه چارچوب; Bispecific antibody; Cell-free protein synthesis; Display technology; Disulfide stabilization; PURE system; bsAb; bispecific antibody; scFv; single-chain Fv; taFv; tandem scFv; dsDb; disulfide-stabilized diabody; CDR; complementarity-determining region; F
IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren's syndrome reveals molecular markers of Ro/La diversification
Keywords: منطقه چارچوب; BCR; B-cell receptor; CDR; complementary determining regions; CIEP; counterimmunoelectrophoresis; D; diversity; EBV; Epstein Barr virus; FR; framework region; H; heavy; IgV; immunoglobulin variable-region; IMGT; ImMunoGeneTics; J; joining; L; light; MS; m
Selection and characterization of single domain antibodies against human CD20
Keywords: منطقه چارچوب; RTX; rituximab; SdAb; single domain antibody; CDR; complementarity determining region; FR; framework region; Bt; biotinylated; NA-PE; NeutrAvidin-phycoerythrin conjugate; Ab; antibody; CDC; complement-dependent cytotoxicity; CD20; Single domain antibody
Contribution of secondary Igkappa rearrangement to primary immunoglobulin repertoire diversification
Keywords: منطقه چارچوب; RSS; recombination signal sequence; BCR; B-cell antigen receptors; Ag; antigen; cRS; cryptic recombination signal; FWR; framework region; SE; signal end; CDR3; complementarity-determining region 3; Ab; antibody; SHM; somatic hypermutation; AID; activation
Human B-cell isotype switching origins of IgE
Keywords: منطقه چارچوب; IgE; isotype switching; direct; indirect; antibody; BÂ cell; repertoire; high-throughput DNA sequencing; CDR3; Complementarity determining region 3; FR; Framework region; IGH; Immunoglobulin heavy chain gene;
A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation
Keywords: منطقه چارچوب; H4K20me1; histone H4 Lys20 monomethylation; Mintbody; modification-specific intracellular antibody; scFv; single-chain variable fragment; PCNA; proliferating cell nuclear antigen; FR; framework region; Xi; inactive X chromosome; Histone modification; Inac
Ligation-based assembly for constructing mouse synthetic scFv libraries by chain shuffling with in vivo-amplified VH and VL fragments
Keywords: منطقه چارچوب; LYS; hen egg lysozyme; BSA; bovine serum albumin; S.A.; streptavidin; EMCS; N-(6-maleimidocaproyloxy) succinimide; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CDR; complementarity determining region; HCDR; VH-CDR; Fw; framework region
Structural and functional characterization of the single-chain Fv fragment from a unique HCV E1E2-specific monoclonal antibody
Keywords: منطقه چارچوب; CDR; complementarity-determining region; DAAs; direct-acting antivirals; ELISA; enzyme-linked immunoabsorbent assay; FR; framework region; GT; genotype; HCV; hepatitis C virus; HCVsp; serum-derived HCV particles; HRP; horseradish peroxidase; IgG; immunogl
Innate autoreactive B cells as antigen-presenting cells in the induction of tolerance to conserved keratin polypeptide
Keywords: منطقه چارچوب; BCRs; B cell receptors; APC; antigen presenting cells; AK auto-Ab; anti-keratin autoantibody; LN; lymph nodes; TCR; T-cell antigen receptor; Ig; immunoglobulin; CDR; complementary determining region; FR; framework region; NHSB; N-hydroxysuccinimido-biotin
Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability
Keywords: منطقه چارچوب; CDR; complementary determining region; CH; constant domain heavy chain; CL; constant domain light chain; ELISA; enzyme-linked immunosorbent assay; FR; framework region; KD; dissociation constant; RMSD; root mean square deviation; SCM; spectra center of ma
Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy
Keywords: منطقه چارچوب; Immunotherapy; IgG4; Phl p 7; blocking antibody; CDR; Complementarity-determining region; FWR; Framework region; HBS; HEPES-buffered saline; ISU; ISAC standardized units; SPR; Surface plasmon resonance;
Molecular analysis of multicatalytic monoclonal antibodies
Keywords: منطقه چارچوب; ELISA; enzyme-linked immunosorbent assay; FR; framework region; HRP; horseradish peroxidase; mAb; monoclonal antibody; catAbs; abzymes, catalytic antibodies PBS, phosphate-buffered saline; scFv; single chain Fv; VH; variable heavy chain; VL; variable ligh
A new subgroup of immunoglobulin heavy chain variable region genes for the assessment of clonality in feline B-cell lymphomas
Keywords: منطقه چارچوب; Cat; Lymphoma; Clonality; Immunoglobulin; Heavy chain; Complementarity determining region; Framework region
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
Keywords: منطقه چارچوب; Ig; immunoglobulin; EBV; Epstein-Barr virus; FWR; framework region; CDR; complementarity determining region; ANA; anti-nuclear antibody.; Antibody; Single cell PCR; Self-reactivity; Polyreactivity;
Antibodies to the superantigenic site of HIV-1 gp120: Hydrolytic and binding activities of the light chain subunit
Keywords: منطقه چارچوب; Ab; antibody; AMC; 7-amino-4-methylcoumarin; BCR; B cell receptor; BSA; bovine serum albumin; CDR; complementary determining region; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid; EP; electrophile; FR; framework region; gp120SAg; su
Clonal diversification in OspA-specific antibodies from peripheral circulation of a chronic Lyme arthritis patient
Keywords: منطقه چارچوب; Bb; Borrelia burgdorferi; OspA; Outer Surface Protein A; Ig; Immunoglobulin; scFv; single chain variable region fragment; H; heavy; L; light; V; variable; PBMC; peripheral blood mononuclear cell; R; replacement; S; silent; CDR; complementarity determining
Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice
Keywords: منطقه چارچوب; CDR-IMGT; complementarity determining region; FR-IMGT; framework region; IG; immunoglobulin; PBMC; peripheral blood mononuclear cells; Somatic hypermutation; Human IG transgenes; Immunoglobulin; Hybridomas; Monoclonal antibodies;
Biased use of VH5 IgE-positive B cells in the nasal mucosa in allergic rhinitis
Keywords: منطقه چارچوب; Human; allergic rhinitis; VH5; superantigen; B lymphocyte; mucosa; CDR; Complementarity-determining region; FWR; Framework region; R/S; Replacement/silent mutation ratio;
Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2
Keywords: منطقه چارچوب; aa; amino acid(s); BLAST; basic local alignment search tool; CDR; complementarity determining region; E2; envelope protein 2; eIF2α; eukaryotic initiation factor 2α; FR; framework region; HCV; hepatitis C virus; Ig; immunoglobulin; HVR1; hypervariable r
Affinity maturation of a VHH by mutational hotspot randomization
Keywords: منطقه چارچوب; CDR; complementarity-determining region; Fab; antigen-binding fragment; FR; framework region; KD; dissociation constant; PBS; phosphate-buffered saline; PCR; polymerase chain reaction; PTH; parathyroid hormone; RIA; radioimmunoassay; scFv; single-chain va
Structural analysis of substitution patterns in alleles of human immunoglobulin VH genes
Keywords: منطقه چارچوب; Ab; antibody; CDR; complementarity determining region; FR; framework region; Ig; immunoglobulin; R/S ratio; replacement/silent ratio; R/S ratio; Amino acid substitution pattern; Molecular recognition; Antibody repertoires;
Humanization and epitope mapping of the H23 anti-MUC1 monoclonal antibody reveals a dual epitope specificity
Keywords: منطقه چارچوب; BSA; bovine serum albumin; CDR; complementarity determining region; DIP; delayed infectivity panning; ELISA; enzyme-linked immunosorbent assay; FITC; fluorescein isothiocyanate; FR; framework region; HumH23-MBP-scFv; humanized H23 in the form of a single-
Developmental progression of immunoglobulin heavy chain diversity in sheep
Keywords: منطقه چارچوب; CDR; complementarity determining region; CDR-IMGT; complementarity determining region as defined by IMGT; FR; framework region; FR-IMGT; framework region as defined by IMGT; HMS; hyper-mutated subset; IGHD; D heavy chain genes; IGHJ; J heavy chain gen