دانلود مقالات ISI درباره سود عملکرد + ترجمه فارسی

ناهمگنی بالینی بیماری کاندیدیازیس مزمن غدد درون ریز متورم: ارائه به عنوان کاندیدیازیس مقاوم به درمان و بیماری مزمن ریه

Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and chronic lung disease

Keywords: سود عملکرد; GOF; Gain-of-function; STAT1; Signal transducer and activator of transcription 1; CMCD; Chronic mucocutaneous candidiasis disease; CCD; Coiled-coiled domain; DBD; DNA-binding domain; LOF; Loss-of-function; AR; Autosomal recessive; AD; Autosomal dominant

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

تقاطع خودکارآموزی و کمبود ایمنی: درسهایی از ویژگیهای پلی¬گنیک و نقایص مونوژنیک

The crossroads of autoimmunity and immunodeficiency: Lessons from polygenic traits and monogenic defects

Keywords: سود عملکرد; Autoimmunity; primary immunodeficiency diseases; B cells; T cells; AID; Activation-induced cytidine deaminase; AIHA; Autoimmune hemolytic anemia; AIRE; Autoimmune regulator; ALPS; Autoimmune lymphoproliferative disease; ANA; Anti-nuclear autoantibody; AP

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions

Keywords: سود عملکرد; PCSK9; Lipidomics; Lipoproteins; Atherosclerosis; Sphingolipids; Drug therapy; CAD; coronary artery disease; CE; cholesteryl ester; Cer; ceramide; DAG; diacylglycerol; Gb3; globotriasoylceramide; Glc/GalCer; glucosyl/galactosylceramide; GOF; gain-of-funct

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles

Keywords: سود عملکرد; Connexin43; Transcriptional regulation; Cardiac development; Cardiac electrophysiology; Wnt signaling, Ventricular tachycardia; SHF; Second heart field; RV; Right ventricle; LV; Left ventricle; ACM; Arrhythmogenic cardiomyopathy; GOF; Gain-of-function; LO

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

ReviewThe S4-­­S5 linker - gearbox of TRP channel gating

Keywords: سود عملکرد; Transient receptor potential channel; S4-S5 linker; Gain-of-function; TRP channelopathies; Gating elements; Channel conformation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Force regulated conformational change of integrin αVβ3

Keywords: سود عملکرد; Ab; antibody; BFP; biomembrane force probe; BSA; bovine serum albumin; Fg; fibrinogen; FNIII7-10; fibronectin module III domain 7-10; GOF; gain-of-function; MT; mutant; SA; streptavidin; WT; wild type; Biomechanics; Integrin αVβ3; Integrin conformat

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53

Keywords: سود عملکرد; Mutant p53; Gain-of-function; Transcriptome; Colorectal cancer; Floxuridine; Chemoresistance

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations

Keywords: سود عملکرد; GOF; Gain-of-function; AML; Acute myeloid leukemia; LSK; HSC-enriched Lin− Sca-1+ c-Kit+ cells; LT-HSC; Long-term hematopoietic stem cell; ST-HSC; Short-term hematopoietic stem cell; MPP; Multipotent progenitor; CMP; Common myeloid progenitor; GMP; Gra

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Free thiol groups in von Willebrand factor (VWF) are required for its full function under physiological flow conditions

Keywords: سود عملکرد; ADAMTS-13; a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; DTT; dithiothreitol; ECM; extracellular matrix; ELISA; enzyme linked immunosorbent assay; FVIII; coagulation factor VIII; GOF; gain-of-function; GPIb; glycoprote

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

Keywords: سود عملکرد; Autophagy; Mutant p53; Gain-of-function; Cancer; mTOR; AMPK;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Common variable immunodeficiency, impaired neurological development and reduced numbers of T regulatory cells in a 10-year-old boy with a STAT1 gain-of-function mutation

Keywords: سود عملکرد; CMC; chronic mucocutaneous candidiasis; CVID; common variable immunodeficiency; FOXP3; forkhead-box protein 3; GOF; gain-of-function; STAT; signal transducer and activator of transcription; Immunodeficiency; STAT transcription factor; Cytokine signaling;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2016 سفارش ترجمه

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome

Keywords: سود عملکرد; Arrhythmia; Timothy syndrome; LQT8; Cav1.2; Gain-of-function;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Negative and positive temperature dependence of potassium leak in MscS mutants: Implications for understanding thermosensitive channels

Keywords: سود عملکرد; CP; specific heat capacity; GOF; gain-of-function; LOF; loss-of-function; MS; mechanosensitive; NTD; negative temperature dependent; PTD; positive temperature dependent; TM; transmembrane helix; Bacteria; Channel; Mechanosensitive; Potassium; Thermosensit

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Transmission of influenza A viruses

Keywords: سود عملکرد; Influenza virus; Transmission; Virus lineage; HA; PB2; NA; Receptor-binding; Gain-of-function;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Relationship Between ABCB1 Polymorphisms, Thromboelastography and Risk of Bleeding Events in Clopidogrel-Treated Patients With ST-Elevation Myocardial Infarction

Keywords: سود عملکرد; ADP; adenosine diphosphate; STEMI; ST-elevation myocardial infarction; PCI; percutaneous coronary intervention; PR; platelet reactivity; LOF; loss-of-function; GOF; gain-of-function; ABCB1; ATP-binding cassette, sub-family B, member 1, also called MDR1; S

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks

Keywords: سود عملکرد; Mutant p53; microRNA; miRNA; Let-7; miR-130b; miR-128-2; miR-155; miR-223; miR-27a; miR-205; Gain-of-function; Invasion; Metastasis; Cancer;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis

Keywords: سود عملکرد; Demyelinating disease; Autoimmune disease; T cell differentiation; Gain-of-function; Genetic association

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewMendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity

Keywords: سود عملکرد; AD; autosomal dominant; AR; autosomal recessive; BCG; bacillus Calmette-Guérin; CGD; chronic granulomatous disease; CMC; chronic mucocutaneous candidiasis; EM; environmental mycobacteria; GOF; gain-of-function; HSCT; hematopoietic stem cell transplantati

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Ex vivo electroporation of retinal cells: A novel, high efficiency method for functional studies in primary retinal cultures

Keywords: سود عملکرد; electroporation; retina; photoreceptor; in vitro; culture; chick; gain-of-function; loss-of-function

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes

Keywords: سود عملکرد; Polycomb; Silencing; E(z); Histone methyltransferase; Gain-of-function

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males

Keywords: سود عملکرد; mating behavior; C. elegans; CaMKII; ether-a-go-go K+ channels; starvation; cholinergic signaling; ACh; acetylcholine; ARE; arecoline; CFP; cyan fluorescent protein; EAG; ether-a-go-go; EGL; egg-laying defective; ERG; ether-a-go-go related gene; fog; femi

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

La protoporphyrie érythropoïétique : une maladie, deux gènes et trois mécanismes moléculaires

Keywords: سود عملکرد; Protoporphyrie érythropoïétique; Récessivité; Dominance; Pénétrance incomplète; Gain de fonction; Ferrochélatase; ALA synthaseErythropoietic protoporphyria; Recessive inheritance; Dominant inheritance; Gain-of-function; Incomplete penetrance; Ferrochelata

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Betanodavirus non-structural protein B1: A novel anti-necrotic death factor that modulates cell death in early replication cycle in fish cells

Keywords: سود عملکرد; Betanodavirus; B1 protein; Gain-of-function; Anti-sense RNA; Mitochondria; Anti-necrotic gene

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly

Keywords: سود عملکرد; CeAJ; C. elegans apical junction; DAC; DLG-1-AJM-1 complex; dsRNA; double-stranded RNA; Emo; endomitotic oocyte; gof; gain-of-function; GUK; guanylate kinase; IP3; inositol 1,4,5-triphosphate; lof; loss-of-function; MAGUK; membrane-associated guanylate

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity

Keywords: سود عملکرد; RGS; Gain-of-function; GPCR; G protein;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

A role for N-cadherin in mesodermal morphogenesis during gastrulation

Keywords: سود عملکرد; Mesoderm; Muscle; Notochord; Cell adhesion; N-Cadherin; Gain-of-function; Gastrulation;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2007 سفارش ترجمه

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo

Keywords: سود عملکرد; Neurodegenerative disease; Neurodegeneration; Dominant; Gain-of-function; RNAi therapy; Transgenic mice; Inducible; Regulatable; Cre-lox; Motor neuron

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه