کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10870217 1073993 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
چکیده انگلیسی
MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 588, Issue 16, 19 August 2014, Pages 2610-2615
نویسندگان
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