Keywords: آنتاگونیست گیرنده گلوکاگون; GCGR; glucagon receptor; cAMP; cyclic-adenosine monophosphate; T2DM; type 2 diabetes mellitus; SGLT-2; sodium-glucose cotransporter-2; HGP; hepatic glucose production; GPCRs; G-protein coupled receptors; SAR; structure-activity relationship; Ser; Serine;