“Pinching” the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage
Keywords: گلوکوزامین 6-فسفات سنتاز; CTP synthase; Mutagenesis; Molecular gate; Ammonia tunnel; Kinetics, catalytic synchronization; CD; circular dichroism; CPS; carbamoyl phosphate synthase; CTPS; CTP synthase; Gln; l-glutamine; dH; mean hydrodynamic diameter; DON; 6-diazo-5-oxo-l-norleucin