کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1377177 | 981972 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
N-Alkyl and N,N-dialkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P (ADGP) were synthesized and found to inhibit growth of human pathogenic fungi (MICs in the 0.08–0.625 mg mL−1 range for the most active compounds). It was thus shown that N-alkylation of ADGP provides novel inhibitors of a fungal enzyme, glucosamine-6P synthase, exhibiting higher antifungal activity than the parent compound, due to the increased lipophilicity and better uptake by fungal cells.
N-Alkylation of d-glucosaminitol-6P affords compounds that inhibit Candida albicans glucosamine-6P synthase and exhibit antifungal activity (MIC = 0.08 − 0.625 mg mL−1).Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6602–6606
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 23, 1 December 2007, Pages 6602–6606
نویسندگان
Anna Melcer, Izabela Łącka, Iwona Gabriel, Marek Wojciechowski, Beata Liberek, Andrzej Wiśniewski, Sławomir Milewski,