Keywords: گلوکوزیلسرامید سنتاز; 27-HC; 27-Hydroxycholesterol; 3PO; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; ABCG1; ATP-binding cassette subfamily G1; ACBA1; ATP-binding cassette subfamily A1; ACC1; Acetyl-Co-A carboxylase-1; AKAP4; A-kinase anchoring protein 4; ALDO; Aldolase; AM
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Keywords: گلوکوزیلسرامید سنتاز; HMG-CoA reductase; 3-hydroxy-methylglutaryl CoA reductase; Emodin; 3-methyl-1,6,8-trihydroxyanthraquinone; CL; Cardiolipin; Cer; ceramide; Ch; cholesterol; DAG; Diacylglycerol; ER; endoplasmic reticulum; EGFR; epidermal growth factor receptor; EGCG; epiga
Keywords: گلوکوزیلسرامید سنتاز; 4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; aCDase; acid ceramidase; Akt; Akt/protein kinase B; aSMase; acid sphingomyelinase; CalA; calyculin A; CAPP; ceramide activated protein phosphatase; CDase; ceramidase; Cer; ceramide; Des
Keywords: گلوکوزیلسرامید سنتاز; AL; Ad libitum; CR; Calorie restriction; SPT; Serine palmitoyl transferase; GCS; Glucosylceramide synthase; CGT; Ceramide galactosyl transferase; CERK; Ceramide kinase; SMS1; Sphingomyelin synthase 1; SMS2; Sphingomyelin synthase 2; SPK1; Sphingosine kina
Keywords: گلوکوزیلسرامید سنتاز; AD; Alzheimer's disease; CGT; UDP-galactose ceramide galactosyltransferase; CNS; central nervous system; CST; cerebroside sulfotransferase; GalCer; galactosylceramide; GlcCer; glucosylceramide; GCS; glucosylceramide synthase; GPI; glycosylphosphatidylinos
Keywords: گلوکوزیلسرامید سنتاز; SL; sphingolipid; S1P; sphingosine 1-phosphate; GCS; glucosylceramide synthase; GC; glucosylceramide; AC; ceramidase; SphK; sphingosine kinase; PPMP; D-threo-1-phenyl-2-hexadecanoylamino-3-morpholino-1-propanol; PDMP; D-threo-1-phenyl-2-decanoylamino-3-mo
Keywords: گلوکوزیلسرامید سنتاز; ARCI; autosomal recessive congenital ichthyosis; CE; cornified envelope; Cer; ceramide; CerS1-6; ceramide synthase 1-6; CLE; corneocyte lipid envelope; ELOVL1-7; elongation of very long chain fatty acids 1-7; ER; endoplasmic reticulum; FA; fatty a
Keywords: گلوکوزیلسرامید سنتاز; ADR; Adriamycin-resistant; AFM; Atomic force microscopic; CTAB; Cetyltrimethylammonium bromide; DMAB; Didodecyldimethylammonium bromide; ERC; Endocytic recycling compartment; ERCC1; Excision repair cross-complementation group 1; GCS; Glucosylceramide synt
Effect of tamoxifen on the sphingolipid biosynthetic pathway in the different intraerythrocytic stages of the apicomplexa Plasmodium falciparum
Keywords: گلوکوزیلسرامید سنتاز; Plasmodium falciparum; Tamoxifen; Glycosphingolipids; Glucosylceramide synthase;
Excessive interferon-α signaling in autoimmunity alters glycosphingolipid processing in B cells
Keywords: گلوکوزیلسرامید سنتاز; Autoimmunity; B cell; iNKT cell; Interferon-α; Glycosphingolipid; GSL metabolism; IFN; interferon; TNF; tumour necrosis factor; IL; interleukin; iNKT; invariant natural killer T; GSL; glycosphingolipid; Cer; ceramide; LacCer; lactosylceramide; GCS; gluco
Long-chain glucosylceramides crosstalk with LYN mediates endometrial cell migration
Keywords: گلوکوزیلسرامید سنتاز; Cer; ceramide; GlcCer; glycosylceramide; HESC; human endometrial stromal cell; GCS; glucosylceramide synthase; LC-MS/MS; liquid chromatography-tandem mass spectrometry; SDF-1α; stromal cell-derived factor 1alpha; CXCR4; CXC chemokine receptor 4; Glycosyl
Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR
Keywords: گلوکوزیلسرامید سنتاز; Paclitaxel resistance; Human prostate cancer cell line; SPHK1; Glucosylceramide synthase; Sphingomyelinase; Sphingolipid rheostat; ACDase; acid ceramidase; ASMase; acid sphingomyelinase; DNR; daunorubicin; GCS; glucosylceramide synthase; LC-MS/MS; liquid
Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer
Keywords: گلوکوزیلسرامید سنتاز; C6-ceramide; N-hexanoyl-d-erythrosphingosine; GC; glucosylceramide; GCS; glucosylceramide synthase; SK; sphingosine kinase; S1-P; sphingosine 1-phosphate; PPMP; d-threo-1-phenyl-2-decanoylamino-3-morpholino-propanol; PPPP; 1-phenyl-2-palmitoylamino-3-pyrr
Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease
Keywords: گلوکوزیلسرامید سنتاز; CDX; 2-hydroxypropyl-β-cyclodextrin; GCS; glucosylceramide synthase; GSH-EE; GSH ethyl ester; mGSH; mitochondrial GSH; NAC; N-acetylcysteine; NPC; Niemann Pick type C disease; SMS; sphingomyelin synthase; Ceramide; Sphingolipids, Mitochondrial GSH; Cereb
N-butyldeoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV
Keywords: گلوکوزیلسرامید سنتاز; NB-DNJ; N-butyldeoxynojirimycin; GCS; glucosylceramide synthase; GSL; glycosphingolipid; CMH; ceramide monohexoside; CDH; ceramide dihexoside; GBA2; glucocerebrosidase; NPC; Niemann-Pick type C; SRT; substrate reduction therapy; Mucolipidosis type IV; Mig
Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility
Keywords: گلوکوزیلسرامید سنتاز; AS; antisense oligonucleotide; GCS; glucosylceramide synthase; GCSI; glucosylceramide synthase inhibitor; GM3S; ganglioside GM3 synthase; IGF-1; insulin-like growth factor-1; IGF1R; insulin-like growth factor-1 receptor; IR; insulin receptor; M2D3; GM2/GD
Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme
Keywords: گلوکوزیلسرامید سنتاز; Niemann-Pick disease type C; Cholesterol; Glucosylceramide synthase; Sphingomyelin; Vesicular trafficking; NPC; Niemann-Pick disease type C; SM; sphingomyelin; GSLs; glycosphingolipids; GlcCer; glucosylceramide; LacCer; lactosylceramide; GCase; glucocereb
Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity
Keywords: گلوکوزیلسرامید سنتاز; AD; Alzheimer disease; FAD; familial AD; Aβ; amyloid-β peptide; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme 1; PDMP; dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; DMAPP; (1S,2R-d-erythro-2-N-myristoylamino)-1-phenyl-1
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells
Keywords: گلوکوزیلسرامید سنتاز; Gb3; Globotriaosylceramide; GCS; Glucosylceramide synthase; GSL; Glycosphingolipid; MDR1; Multidrug resistance 1/P-glycoprotein; MPM; Malignant pleural mesothelioma (MPM); MRP1; Multidrug resistance-associated protein 1; NSCLC; Non-small cell lung cancer;
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics
Keywords: گلوکوزیلسرامید سنتاز; DMT; N-desmethyltamoxifen; AC; acid ceramidase; AML; acute myelogenous leukemia; SphK1; sphingosine kinase 1; S1-P; sphingosine 1-phosphate; GC; glucosylceramide; 4-HPR; fenretinide; GCS; glucosylceramide synthase; P-gp; P-glycoprotein; ATCC; American Typ
Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells
Keywords: گلوکوزیلسرامید سنتاز; SRSF1; serine/arginine-rich splicing factor 1; PP1; protein phosphatase 1; GCS; glucosylceramide synthase; MBO-asGCS; mixed backbone oligonucleotide against glucosylceramide synthase; PDMP; d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol; SMase;
Selective chaperone effect of aminocyclitol derivatives on G202R and other mutant glucocerebrosidases causing Gaucher disease
Keywords: گلوکوزیلسرامید سنتاز; BBB; blood-brain barrier; CBE; conduritol β-epoxide; Cer; ceramide; D-MEM; Dulbeco Eagle's minimal essential medium; ERT; enzyme replacement therapy; GBA1; lysosomal glucocerebrosidase; GBA2; non-lysosomal glucocerebrosidase; GlcCer; glucosylceramide;
Inhibitors of specific ceramide synthases
Keywords: گلوکوزیلسرامید سنتاز; Ceramide synthase; Ceramide; Inhibitor; Ceramide synthase activity assay; BSA; bovine serum albumin; Cer; ceramide; dhCer; dihydroceramide; CerS; (dihydro)ceramide synthase; DES; dihydroceramide desaturase; EDC; 1-ethyl-3-[3-dimethylaminopropyl]carbodiimi
Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice
Keywords: گلوکوزیلسرامید سنتاز; Niemann–Pick type C disease; Substrate reduction therapy; Lysosomal storage disease; Glucosylceramide; GBA2 gene; Glucosylceramide synthase
The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase
Keywords: گلوکوزیلسرامید سنتاز; Myelosuppression; Doxorubicin; Glucosylceramide synthase; Breast cancer stem cells; Bone marrow;
Dietary sericin enhances epidermal levels of glucosylceramides and ceramides with up-regulating protein expressions of glucosylceramide synthase, β-glucocerebrosidase and acidic sphingomyelinase in NC/Nga mice
Keywords: گلوکوزیلسرامید سنتاز; AD; atopic dermatitis; aSMase; acidic sphingomyelinase; β-GlcCer'ase; β- glucocerebrosidase; Cer; ceramide; CDase; ceramidase; GlcCer; glucosylceramide; GlcCer synthase; glucosylceramide synthase; SM; sphingomyelin; SMase; sphingomyelinase; SM synthase;
Fumonisin B1 and the kidney: Modes of action for renal tumor formation by fumonisin B1 in rodents
Keywords: گلوکوزیلسرامید سنتاز; AP; aminopentol; aSMase; acid sphingomyelinase; FB1; fumonisin B1; JNK; c-Jun N-terminal kinase; CYP; cytochrome P450 superfamiliy; ERK; extracellular regulated kinase; GCS; glucosylceramide synthase; GSH; glutathione; HFB1; hydrolyzed FB1; MAPK; mitogen-
Sphingolipids and expression regulation of genes in cancer
Keywords: گلوکوزیلسرامید سنتاز; C1P; ceramide 1-phosphate; CAPP; ceramide-activated protein phosphatase; CerK; ceramide kinase; CerS; ceramide synthase; CERT; ceramide transfer protein; COX-2; cyclooxygenase-2; CPPase; ceramide phosphate phosphatase; CSC; cancer stem cell; ES; embryo st
Modulation of ceramide metabolism in mouse primary macrophages
Keywords: گلوکوزیلسرامید سنتاز; BMD; bone marrow-derived; Cer; ceramide; CERK; ceramide kinase; GCS; glucosylceramide synthase; IFN-γ; interferon gamma; M-CSF; macrophage colony stimulation factor; MΦ; macrophage; LPS; lipopolysaccharide; NBD; N-[7-(4-nitrobenzo-2-oxa-l,3-diazole)]; S
The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism
Keywords: گلوکوزیلسرامید سنتاز; C6-NBD ceramide; 6-((N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino) hexanoyl) sphingosine; Ac-DEVD-AMC; Ac-Asp-Glu-Val-Asp-aminomethylcoumarin; FCS; fetal calf serum; GCS; glucosylceramide synthase; GlcCer; glucosylceramide; MTT; 3-(4,5-dimethylthiazol-2-yl)
Overexpression of glucosylceramide synthase in associated with multidrug resistance of leukemia cells
Keywords: گلوکوزیلسرامید سنتاز; Glucosylceramide synthase; Leukemia; Drug resistance; Apoptosis; Bcl-2; Bax; PPMP
Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury
Keywords: گلوکوزیلسرامید سنتاز; Iminosugars; Glucosylceramide synthase; N-butyldeoxynojirimycin; Ganglioside; Antibody; Neuropathy
Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons
Keywords: گلوکوزیلسرامید سنتاز; Alzheimer's disease; Ceramide; Cerebellar granule cells; Glucosylceramide synthase; P4 inhibitor; Primary neurons
Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species
Keywords: گلوکوزیلسرامید سنتاز; Apoptosis; Breast cancer; Ceramide; Ceramidase; Glucosylceramide synthase; Reactive oxygen species
4-IBP, a Ï1 Receptor Agonist, Decreases the Migration of Human Cancer Cells, Including Glioblastoma Cells, In Vitro and Sensitizes Them In Vitro and In Vivo to Cytotoxic Insults of Proapoptotic and Proautophagic Drugs
Keywords: گلوکوزیلسرامید سنتاز; Cancer cell migration; a receptor; Rho GDI; glucosylceramide synthase; orthotopic xenografts;
Ceramide response post-photodamage is absent after treatment with HA14-1
Keywords: گلوکوزیلسرامید سنتاز; Apoptosis; Ceramide; Glucosylceramide synthase; HA14-1; PDT; Serine palmitoyl-transferase; Sphingomyelin synthase
Glycosphingolipids and drug resistance
Keywords: گلوکوزیلسرامید سنتاز; Multidrug resistance; Glycosphingolipids; Glucosylceramide synthase; P-glycoprotein
Synthesis and biological evaluation of novel PDMP analogues
Keywords: گلوکوزیلسرامید سنتاز; Sphingolipids; C–C coupling; PDMP; Glucosylceramide synthase; Inhibitor
A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates
Keywords: گلوکوزیلسرامید سنتاز; Antisense morpholino oligo; Fluorescent substrate; Gene knockdown; Glycosphingolipid; Glucosylceramide synthase; High-performance liquid chromatography; Lactosylceramide synthase; Zebrafish;
Fenretinide: A p53-independent way to kill cancer cells
Keywords: گلوکوزیلسرامید سنتاز; Ceramide; Gadd153; Glucosylceramide synthase; GD3; Retinoids;