Keywords: Temporal lobe epilepsy; Seizures; Glycine transporter 1; GlyT1; Antiepileptic drugs; Histopathology;
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Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Keywords: GlyT1; Schizophrenia; NMDAr; N-Methyl-d-aspartate receptor; Glycine uptake inhibition;
Glycine Transporter-1 and glycine receptor mediate the antioxidant effect of glycine in diabetic rat islets and INS-1 cells
Keywords: AUCs; areas under the curve; BSA; bovine serum albumin; CAT; catalase; DCFH-DA; 2,7-Dichlorodi fluorescein; DM; diabetes mellitus; GlyR; glycine receptor; GlyT1; glycine transporter-1; GSH; glutathione; HG; high glucose; Nox; NADPH oxidase; OGTT; oral glu
Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia
Keywords: ANCOVA; analysis of covariance; CDSS; Calgary Depression Scale Score; CGI-I; Clinical Global Impressions-Improvement; CGI-S; Clinical Global Impressions-Severity; CSF; cerebrospinal fluid; C-SSRS; Columbia-Suicide Severity Rating Scale; GlyT1; glycine tra
Time-dependent impact of glutamatergic modulators on the promnesiant effect of 5-HT6R blockade on mice recognition memory
Keywords: 5-HT6R; serotonin type 6 receptor; NMDAR; N-methyl-D-aspartate receptor; GlyT1; glycine transporter type 1; ISI; inter-session interval; SB-271046 (PubChem CID: 5312149); CGS 19755 (PubChem CID: 68736); NFPS (PubChem CID: 5311283); Serotonin type 6 recept
Presynaptic facilitation of glycinergic mIPSC is reduced in mice lacking α3 glycine receptor subunits
Keywords: AC; adenylate cyclase; aCSF; artificial cerebrospinal fluid; ALS; amyotrophic lateral sclerosis; EGFP; Green fluorescent protein; GlyR α3; α3 subunit of the glycine receptor; GlyT1; glycine transporter 1; GlyT2; glycine transporter 2; KCC2; K+-CLâ c
Advances in understanding the functions of native GlyT1 and GlyT2 neuronal glycine transporters
Keywords: Glycine transporters; GlyT1; GlyT2; Glycine uptake; Transporter-mediated release; Glycine homoexchangeBoNT, botulinum toxin; GlyT1, glycine transporter 1; GlyT2, glycine transporter 2; HEK293, human embryonic kidney; NFPS (ALX 5407), N-[(3R)-3-([1,1′-biph
Structural insights into the benzophenanthridines binding to human glycine transporter GlyT1
Keywords: Sanguinarine (PubChem CID: 5154); Chelerythrine (PubChem CID: 2703); Benzophenanthridine; Sanguinarine; Chelerythrine; Neurotransmitter; Glycine transporter; GlyT1;
Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity
Keywords: Brain preconditioning; Neuroprotection; Neurotransmission; Glycine transporter type 1; ACSF; artificial cerebrospinal fluid; EAAT; excitatory amino-acid transporter; GC-MS; gas chromatography - mass spectrometry; GlyT1; glycine transporters type 1; Gl
Glycine transporters GlyT1 and GlyT2 are differentially modulated by glycogen synthase kinase 3β
Keywords: Glycinergic neurotransmission; GSK3β; GlyT1; GlyT2; Pharmacological inhibitors; Hereditary hyperekplexia; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CNS; central nervous system; COS-7; CV-1 (simian) in origin and carrying the SV40 genet
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead
Keywords: GlyT1; Scaffold hopping; Transporter; Schizophrenia;
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres
Keywords: GlyT1; Scaffold hopping; Transporter; Schizophrenia;
Effect of phosphomimetic mutations on the C-terminal sensitivity of glycine transporter GlyT1 to calpain
Keywords: Glycine transporter; GlyT1; Calpain;
Forebrain glycine transporter 1 deletion enhances sensitivity to CS–US discontiguity in classical conditioning
Keywords: Conditioned freezing; GlyT1; Memory; NMDA receptor; SLC6A9; Trace conditioning
Molecular basis for differential glycine transporters sensitivity to sanguinarine
Keywords: Neurotransmitter; Transporter; GlyT1; Sanguinarine; Cysteine;
Synthesis and biological evaluation of (4H-1,2,4-triazol-4-yl)isoquinoline derivatives as selective glycine transporter 1 inhibitors
Keywords: GlyT1; GlyT2; The NMDA receptors; Schizophrenia; Triazole;
Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters
Keywords: Neurotransmitter; Transporter; Glycine; Protein kinase C; PKC; GlyT1; GlyT2; Chelidonium majus; Inhibitor; Pain; Chelerythrine; Sanguinarine; Benzophenanthridine; Alkaloid; Ouabain
Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1
Keywords: GlyT1; NMDAr; NMDA; Glycine; Transporter; Inhibitor; Schizophrenia
Discovery of benzoylisoindolines as a novel class of potent, selective and orally active GlyT1 inhibitors
Keywords: GlyT1; Inhibitor; Schizophrenia; Benzoylisoindoline; hERG
Glycine and l-arginine transport in cultured Müller glial cells (TR-MUL)
Keywords: Glycine; l-Arginine; GlyT1; System A; CAT1; Müller cells
Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose
Keywords: GlyT1; Addiction; Drug abuse; Glycine; Motivation; Nicotine; NMDA; NMDA receptor; Reinforcement; Relapse
Calcium dependent modification of distal C-terminal sequences of glycine transporter GlyT1
Keywords: Neurotransmitter; Transporter; Glycine; Protein kinase C; PKC; GlyT1; Calpain; Caspase; Calcium
Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test
Keywords: GlyT, glycine transporter; MED, minimum effective dose; MEST, maximum electroshock threshold; NFPS, N-[3-(4′-Fluorophenyl)-3-(4′-phenylphenoxy)propyl]sarcosineGlycine; Transporter; GlyT1; Anticonvulsant; MEST
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors
Keywords: GlyT1; Schizophrenia; NMDA receptor; Inhibitor; N-{[1-(Propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties
Keywords: GlyT1; Schizophrenia; NMDA pharmacokinetics; Cassette dosing
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors
Keywords: Schizophrenia; Glycine transporter; GLYT1; Bioavailable; Inhibitor; NMDA; Pharmacokinetics;
Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains
Keywords: Glycine transporter; Membrane rafts; Fluorescence resonance energy transfer; Fluorescence life time imaging; Cholesterol; Co-localization; Glycine transport; GLYT1
Characteristics of glycine transport across the inner blood–retinal barrier
Keywords: Glycine; GlyT1; System A; Inner blood–retinal barrier
Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1
Keywords: GlyT1; NMDA receptor; latent inhibition; learning; psychopharmacology; schizophrenia; aCSF; artificial cerebrospinal fluid; ALX5407; (R)-N[3-(4-fluorophenyl)-3-(4-phenyl-phenoxy)propyl]-sarcosine; AMPAR; AMPA receptor; ANCOVA; analysis of covariance; ANOV
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
Keywords: GlyT1; Glycine; Transporter; Inhibitor; Schizophrenia; NMDA; Benzoylpiperazine
Functional expression of release-regulating glycine transporters GLYT1 on GABAergic neurons and GLYT2 on astrocytes in mouse spinal cord
Keywords: Glycine transporters; GLYT1; GLYT2; GABA release; Synaptosomes; Gliosomes;
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake
Keywords: GlyT1; PI3 kinase; LY 294002; Glycine uptake; ALX 5407;
A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies
Keywords: Glycine; GlyT1; Schizophrenia; Autoradiography;
Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: The therapeutic potentials for schizophrenia
Keywords: Glycine; NMDA; D-serine; Schizophrenia; Asc-1; D-amino acid oxidase; Glyt1; Glyb site; Allosteric modulation
Discovery and SAR studies of novel GlyT1 inhibitors
Keywords: Glycine transporter; GlyT1; GlyT2; Schizophrenia
Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile
Keywords: GlyT1; GlyT2; NMDA; Schizophrenia; Transporter; Spiropiperidine
4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters
Keywords: GlyT1; GlyT2; NMDA; Schizophrenia; Transporter; Glycine; Spiropiperidine
Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability
Keywords: GlyT1; GlyT2; NMDA; Schizophrenia; Transporter; Glycine; Spiropiperidine
Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors
Keywords: GlyT1; GlyT2; NMDA; Schizophrenia; Transporter; Glycine; Spiropiperidine
Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides
Keywords: Schizophrenia; GlyT1; Inhibitor; Piperidine
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors
Keywords: GlyT1; GlyT2; NMDA; Schizophrenia; Transporter; Glycine; Spiropiperidine;