7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues
Keywords: WHO; World Health Organization; nor-BNI; norbinaltorphimine; GNTI; 5â²-guanidinonaltrindole; GTPγS; guanosine 5â²-O-[γ-thio]-triphosphate; HPLC; high performance liquid chromatography; 7β-Methyl-nepenthone analogues; KOR ligands; Concept of hybridiza