Keywords: گیرندههای جفتشونده با پروتئین جی; 2-AS, 2-(9-anthroyloxy)stearic acid; 12-AS, 12-(9-anthroyloxy)stearic acid; BODIPY, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; GPCR, G protein-coupled receptor; 8-OH-DPAT, 8-hydroxy-2(di-N-propylamino)tetralin; 5-PC, 1-palmitoyl-2-(5-doxyl)stearoyl-sn-gl
مقالات ISI گیرندههای جفتشونده با پروتئین جی (ترجمه نشده)
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Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; CF, cell-free; β1AR, beta1-adrenergic receptor; Brij35, polyoxyethylene-(23)-lauryl-ether; Brij58, polyoxyethylene-(20)-cetyl-ether; Brij78, polyoxyethylene-(20)-stearyl-ether; CHS, cholesteryl-hemisuccinate; LMPG, 1-myri
Keywords: گیرندههای جفتشونده با پروتئین جی; CHH, Crustacean Hyperglycemic Hormone; MIH, Molt Inhibiting Hormone; ITP, Ion Transport Peptide; FPKM, Fragments Per Kilobase per Million mapped reads; ORF, Open Reading Frame; GPCR, G Protein-Coupled Receptor; SARA, Smad Anchor for Receptor ActivationPro
Keywords: گیرندههای جفتشونده با پروتئین جی; b/d-Bth, β-(3-benzothienyl)-d-alanine; GPCR, G protein-coupled receptor; iv, intravenously; MRM, multiple reaction monitoring; MS, mass spectrometry; Pam, palmitic acid; PEG2, poly(ethylene glycol) 2 kDa; TAMRA, carboxytetramethylrhodamineGhrelin receptor
Keywords: گیرندههای جفتشونده با پروتئین جی; Bradykinin; Myometrium; Arrestin; Migration; Myometrial contraction; B2 receptorB2R, bradykinin B2 receptor; [Ca2+]i, intracellular calcium concentration; ERK, extracellular signal-regulated kinase; GPCR, G protein-coupled receptor; GRK, G protein-coupled
Keywords: گیرندههای جفتشونده با پروتئین جی; 17R-HDHA, 17R-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid; AT, aspirin-triggered; AT-RvD3, 4S,11R,17R-trihydroxydocosa-5Z,7E,9E,13Z,15E,19Z-hexaenoic acid; GPCR, G protein-coupled receptor; LC–MS–MS, liquid chromatography–tandem mass spectrometry;
Keywords: گیرندههای جفتشونده با پروتئین جی; di-8-ANEPPS, 4-(2-(6-(dioctylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)-pyridinium inner salt; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; GPCR, G protein-coupled receptor; HM, hippocampal membranes; LUV, large unilamellar vesicle; MβCD, meth
Keywords: گیرندههای جفتشونده با پروتئین جی; cAMP, cyclic AMP; EGF(R), epidermal growth factor (receptor); EMT, epithelial to mesenchymal transition; FITC, fluorescein isothiocyanate; FAK, focal adhesion kinase; GPCR, G protein-coupled receptor; mAb, monoclonal antibody; PI3, phosphatidyl-inositide
Keywords: گیرندههای جفتشونده با پروتئین جی; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; MEK, MAPK/ERK kinase; GPCR, G protein-coupled receptor; PLCβ, phospholipase Cβ; IP3, inositol trisphosphate; DAG, diacylglycerol; PKC, protein kinase C; CaM, calmodulin; P
The membrane as the gatekeeper of infection: Cholesterol in host–pathogen interaction
Keywords: گیرندههای جفتشونده با پروتئین جی; CFU, colony forming unit; CRAC, cholesterol recognition/interaction amino acid consensus; GPCR, G protein-coupled receptor; HMG-CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase; MβCD, methyl-β-cyclodextrinCARC; CRAC; Host–pathogen interactio
Design synthesis and structure–activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands
Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; MOR, Mu opioid receptor; DOR, delta opioid receptor; Boc, tert-butyloxycarbonyl; NaOtBu, sodium tert-butoxide; Et3N, triethylamine; HCl, hydrochloric acid; BH3-SMe2, borane dimethylsulfide; DHP, dihydropyran; PPTS, pyridi
Molecular characterization of a short neuropeptide F signaling system in the tsetse fly, Glossina morsitans morsitans
Keywords: گیرندههای جفتشونده با پروتئین جی; sNPF, short neuropeptide F; sNPFR, short neuropeptide F receptor; GPCR, G protein-coupled receptor; CHO, Chinese hamster ovary; NPF, neuropeptide FInsect; Tsetse fly; Glossina morsitans morsitans; Neuropeptide; Short neuropeptide F; G protein-coupled rece
Molecular cloning and pharmacological characterization of giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor
Keywords: گیرندههای جفتشونده با پروتئین جی; amMC4R, giant panda (Ailuropoda melanoleuca) melanocortin-4 receptor; GPCR, G protein-coupled receptor; MC4R, melanocortin-4 receptor; MSH, melanocyte-stimulating hormone; NDP-MSH, [Nle4, D-Phe7]-α-MSH; PCR, polymerase chain reaction; THIQ, [(N-[(3R)-1,2,
Identification and pharmacological analyses of eight naturally occurring caprine melanocortin-1 receptor mutations in three different goat breeds
Keywords: گیرندههای جفتشونده با پروتئین جی; EL, extracellular loop; ERK1/2, extracellular signal-regulated kinases 1 and 2; gMC1R, goat MC1R; GPCR, G protein-coupled receptor; IL, intracellular loop; LD, linkage disequilibrium; MC1R, melanocortin-1 receptor; MC3R, melanocortin-3 receptor; MC4R, mel
Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts
Keywords: گیرندههای جفتشونده با پروتئین جی; ABC, ATP binding cassette; CerS, ceramide synthase; ELEM, equine leukoencephalomalacia; FB1, fumonisin B1; Gapdh, glyceraldehyde 3-phosphate dehydrogenase; GPCR, G protein-coupled receptor; HDAC, histone deacetylase; Lpp, lipid phosphate phosphatase; MEF,
Calcium sensing receptor suppresses human pancreatic tumorigenesis through a novel NCX1/Ca2+/β-catenin signaling pathway
Keywords: گیرندههای جفتشونده با پروتئین جی; CaSR; Pancreatic cancer; Ca2+ signaling; NCX1; β-cateninCaSR, calcium sensing receptor; NCX1, Na+/Ca2+ exchanger 1; [Ca2+]cyt, cytosolic Ca2+; GPCR, G protein-coupled receptor; PC, pancreatic cancer; CRC, colorectal cancer
Intrinsic plasticity induced by group II metabotropic glutamate receptors via enhancement of high-threshold KV currents in sound localizing neurons
Keywords: گیرندههای جفتشونده با پروتئین جی; ACSF, artificial cerebrospinal fluid; AP, action potential; CF, characteristic frequency; GPCR, G protein-coupled receptor; HF, high frequency; HTK, high-threshold potassium; ITD, interaural time difference; KV, voltage-gated potassium channel; LF, low fr
Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics
Keywords: گیرندههای جفتشونده با پروتئین جی; CID, collision induced dissociation; ETD, electron transfer dissociation; FTMS, Fourier transform mass spectrometry; GO, Gene Ontology; GPCR, G protein-coupled receptor; GSEA, geneset enrichment analysis; HpH RPLC, high pH reversed phase liquid chromatogr
Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors
Keywords: گیرندههای جفتشونده با پروتئین جی; AKT, protein kinase B; BCC, basal cell carcinoma; CNS, central nervous system; GPCR, G protein-coupled receptor; HBA, hydrogen bond acceptor; Hh, Hedgehog; MB, medulloblastoma; mTOR, mammalian target of rapamycin; N-G-L, NIH3T3-GRE-Luc reporter gene assay
Characterization of G protein coupling mediated by the conserved D1343.49 of DRY motif, M2416.34, and F2516.44 residues on human CXCR1
Keywords: گیرندههای جفتشونده با پروتئین جی; CXCR1, CXC receptor 1; GPCR, G protein-coupled receptor; DRY motif, Asp-Arg-Tyr motif; IL-8, interleukin 8; TMs, transmembrane domain; i2, intracellular loop 2; i3, intracellular loop 3; PLC, phospholipase C; WT, wild type; Kd, affinity constants; IP, ino
A new crystal structure fragment-based pharmacophore method for G protein-coupled receptors
Keywords: گیرندههای جفتشونده با پروتئین جی; 7TM, seven transmembrane domain; AFE, aromatic face-to-edge; AFF, aromatic face-to-face; AUC, area under the curve; ECL, extracellular loop; GPCR, G protein-coupled receptor; H1, histamine 1 receptor; H3, histamine 3 receptor; HBA, hydrogen bond acceptor;
Nanodomain organization of rhodopsin in native human and murine rod outer segment disc membranes
Keywords: گیرندههای جفتشونده با پروتئین جی; AFM, atomic force microscopy; GPCR, G protein-coupled receptor; ROS, rod outer segment(s)Atomic force microscopy; G protein-coupled receptor; Lipid raft; Membrane structure; Photoreceptor; Phototransduction
Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands
Keywords: گیرندههای جفتشونده با پروتئین جی; EL, extracellular loop; GPCR, G protein-coupled receptor; 2MeSADP, 2-methylthioadenosine 5′-diphosphate; SAR, structure-activity relationship; TM, transmembrane helical domain; UDP, uridine 5′-diphosphate; UDPG, uridine 5′-diphosphoglucoseG protein-couple
Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry
Keywords: گیرندههای جفتشونده با پروتئین جی; DDM, n-dodecyl-β-d-maltopyranoside; GPCR, G protein-coupled receptor; HDX-MS, hydrogen/deuterium exchange mass spectrometry; IPTG, isopropyl-thio-β-d-galactopyranoside; SEC, size exclusion chromatographyβ-Arrestin; Pre-activation; Inactivation; Conformati
β1-and β2-adrenoceptors in hippocampal CA3 region are required for long-term memory consolidation in rats
Keywords: گیرندههای جفتشونده با پروتئین جی; AC, Adenyl cyclase; AR, Adrenoceptor; BSA, Bovine serum albumin; CA1, Cornu ammonis 1; CA3, Cornu ammonis 3; GPCR, G Protein-coupled receptor; LC, Locus coeruleus; NE, Norepinephrine; PB, Phosphate buffer; PBS, Phosphate-buffered saline; PKA, cAMP-depende
Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity
Keywords: گیرندههای جفتشونده با پروتئین جی; Gαs; VE-cadherin; S1PR1 signaling; adherens junctions; vascular integrityAJ, adherens junction; CTx, cholera toxin; EC, endothelial cell; FSK, Forskolin; GPCR, G protein-coupled receptor; HUVEC, human umbilical vein endothelial cell; KD, knockdown; KO, kn
The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis
Keywords: گیرندههای جفتشونده با پروتئین جی; Ab, antibody; AV, annexin V; CHX, cycloheximide; EGF, epidermal growth factor; GAIN, GPCR autoproteolysis-inducing; GPCR, G protein-coupled receptor; GPS, GPCR proteolysis site; mAb, monoclonal antibody; pAb, polyclonal antibody; PI, propidium iodide; SEM
Structure and function of serotonin G protein-coupled receptors
Keywords: گیرندههای جفتشونده با پروتئین جی; Serotonin; GPCR; 5-HT1B; 5-HT2B; Functional selectivity; β-Arrestin5-HT, 5-hydroxytryptamine, serotonin; GPCR, G protein-coupled receptor; CNS, central nervous system; GI, gastrointestinal; IP3, inositol triphosphate; DAG, diacylglycerol; GRK, G protein r
Annexin A3 plays a role in cytoplasmic calcium oscillation by extracellular calcium in the human promyelocytic leukemia HL-60 cells differentiated by phorbol-12-myristate-13-acetate
Keywords: گیرندههای جفتشونده با پروتئین جی; ANXA3, annexin A3; BEL, 4-bromoenol lactone; C5aR, C5a receptor; iPLA2, calcium-independent phospholipase A2; cPLA2, calcium-dependent cytoplasmic phospholipase A2; GPCR, G protein-coupled receptor; HL-60 macrophage-like cells, differentiated from human p
Tricyclic antidepressants exhibit variable pharmacological profiles at the α2A adrenergic receptor
Keywords: گیرندههای جفتشونده با پروتئین جی; AMI, amitriptyline; AR, adrenergic receptor; Arr, arrestin; CFP, cyan fluorescent protein; DMI, desipramine; ESC, escitalopram; FLIM, fluorescence lifetime imaging microscopy; FRET, fluorescence resonance energy transfer; GPCR, G protein-coupled receptor;
Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation
Keywords: گیرندههای جفتشونده با پروتئین جی; FFA, free fatty acid; GPCR, G protein-coupled receptor; PKC, protein kinase C; DHA, docosahexaenoic acid; α-LA, α-linolenic acid; TIRF, total internal reflection fluorescenceGPR120; Free fatty acid receptor 4; Receptor phosphorylation; Protein kinase C
Dynamics of apelin receptor/G protein coupling in living cells
Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; APJ, apelin receptor; HEK, human embryonic kidney; BRET, bioluminescence resonance energy transfer; FRET, Förster resonance energy transfer; Rluc, Renilla reniformis luciferase; YFP, yellow fluorescent protein; CFP, cyan
TSH signaling pathways that regulate MCP-1 in human differentiated adipocytes
Keywords: گیرندههای جفتشونده با پروتئین جی; BSA, bovine serum albumin; CHO, Chinese hamster ovarian; CREB, cAMP response element-binding protein; DMEM, Modified Eagle’s Medium; DPI, diphenyleneiodonium; FBS, fetal bovine serum; FFA, free fatty acids; GPCR, G protein-coupled receptor; IκB, inhibitor
REEP1 and REEP2 proteins are preferentially expressed in neuronal and neuronal-like exocytotic tissues
Keywords: گیرندههای جفتشونده با پروتئین جی; AR, adrenergic receptor; dHMN-V, distal hereditary motor neuropathy type V; GPCR, G protein-coupled receptor; HSP, hereditary spastic paraplegia; mAb, monoclonal antibody; NGF, nerve growth factor; OR, olfactory receptor; REEP, receptor expression enhanci
Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor
Keywords: گیرندههای جفتشونده با پروتئین جی; Salvinorin A and B; Michael acceptor-type ligands; Kappa, delta, and mu opioid receptors; Molecular modelingDOR, δ-opioid receptor; GPCR, G protein-coupled receptor; KOR, κ-opioid receptor; MOR, μ-opioid receptor; TM, transmembrane; PDB, protein data bank
Src family kinases involved in CXCL12-induced loss of acute morphine analgesia
Keywords: گیرندههای جفتشونده با پروتئین جی; DOR, delta-opioid receptor; DRG, dorsal root ganglia; GPCR, G protein-coupled receptor; IR, immunoreactivity; i.t., intrathecal; MOR, mu-opioid receptor; PAG, periaqueductal gray matter; PBS, phosphate-buffered saline; s.c., subcutaneously; SFK, Src famil
Solid-state NMR spectroscopy to study protein–lipid interactions
Keywords: گیرندههای جفتشونده با پروتئین جی; AFM, atomic force microscopy; CP, cross-polarization; CSA, chemical shift anisotropy; DHA, docosahexaenoic acid; GPCR, G protein-coupled receptor; MAS, magic-angle spinning; NOE, nuclear Overhauser effect; NOESY, nuclear Overhauser enhancement spectroscop
Molecular mechanisms of the action of miraculin, a taste-modifying protein
Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; hT1R, human T1R; MCL, miraculinSweet protein; Taste-modifying activity; Miracle fruit; Sweet taste receptor
Functional diversification of taste cells in vertebrates
Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; PLC-β2, phospholipase C-β2; TRPM5, transient receptor potential M5; ENaC, epithelial sodium channelTaste cells; Taste receptors; PLC-β2; G proteins; Transcription factors; Differentiation
Identification of raloxifene as a novel CB2 inverse agonist
Keywords: گیرندههای جفتشونده با پروتئین جی; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; GPCR, G protein-coupled receptor; FDA, food and drug administration; HTRF, homogenous time-resolved fluorescenceCannabinoid receptor; Inverse agonist; Drug repurposing; Raloxifene; Osteoporosis
Chemo-attractant N-acetyl proline–glycine–proline induces CD11b/CD18-dependent neutrophil adhesion
Keywords: گیرندههای جفتشونده با پروتئین جی; COPD, chronic obstructive pulmonary disease; FBS, fetal bovine serum; fMLP, formyl-Methionyl-Leucyl-Phenylalanine; GPCR, G protein-coupled receptor; HUVEC, human umbilical vein endothelial cell; LFA-1, lymphocyte Function-associated Antigen 1, CD11a/CD18,
From neuroepithelial cells to neurons: Changes in the physiological properties of neuroepithelial stem cells
Keywords: گیرندههای جفتشونده با پروتئین جی; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cAMP, cyclic AMP; CCh, carbamylcholine; ERK, extracellular signal-regulated kinase; GABA, gamma-aminobutyric acid; GPCR, G protein-coupled receptor; InsP3, inositol 1,4,5-trisphosphate; KA, kaina
Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast
Keywords: گیرندههای جفتشونده با پروتئین جی; flp, FMRFamide-like protein gene; FLP, FMRFamide-like peptide; FLP2-R, receptor for peptides encoded on flp-2; FLIPR, fluorescence imaging plate reader; GPCR, G protein-coupled receptor; nlp, neuropeptide-like protein geneFLP; Caenorhabditis elegans; flp2
A bZIP protein, VIP1, interacts with Arabidopsis heterotrimeric G protein β subunit, AGB1
Keywords: گیرندههای جفتشونده با پروتئین جی; Arabidopsis thaliana; Heterotrimeric G protein β subunit; Transcription factor; Osmosensory signaling; Protein–protein interactionsBiFC, bimolecular fluorescence complementation; GPCR, G protein-coupled receptor; ABA, abscisic acid; AC, adenylate cyclase;
Intrathecal P/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression
Keywords: گیرندههای جفتشونده با پروتئین جی; Voltage sensitive calcium channels; SNX-482; ω-Agatoxin IVA; Neurokinin 1 receptor; c-Fos; Spinal cordCGRP, calcitonin gene-related peptide; GPCR, G protein-coupled receptor; DRG, dorsal root ganglia; IB4, isolectin B4; IT, intrathecal; NK1r, neurokinin 1
Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface
Keywords: گیرندههای جفتشونده با پروتئین جی; B1R, kinin B1 receptor; B2R, kinin B2 receptor; GPCR, G protein-coupled receptor; ER, endoplasmatic reticulum; BK, bradykinin; ERAD, ER-associated degradation; HEK293, human embryonic kidney 293; FCS, fetal calf serum; DMEM, Dulbecco's modified Eagle's me
Regulation of G protein signaling by the 70 kDa heat shock protein
Keywords: گیرندههای جفتشونده با پروتئین جی; GPCR, G protein-coupled receptor; G proteins, heterotrimeric guanine nucleotide-binding regulatory proteins; A1-R, adenosine A1 receptor; HSP, heat shock protein; HSP70/hsp70, 70 kDa family of heat shock proteins; 5-HT1A-R, 5-hydroxytryptamine1A receptor;
Frizzled receptors signal through G proteins
Keywords: گیرندههای جفتشونده با پروتئین جی; Frz, frizzled; GPCR, G protein-coupled receptor; MAPK, mitogen-activated protein kinase; GEF, guanine nucleotide exchange factor; GDI, guanine nucleotide dissociation inhibitorFrizzled; G protein; GPCR; Wnt signaling; Planar cell polarity; GDI
An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation
Keywords: گیرندههای جفتشونده با پروتئین جی; CSF-1, colony stimulating factor-1; CSF-1 Mϕ, monocytes differentiated to HMDM with CSF-1; GM-CSF, granulocyte macrophage colony stimulating factor; GM-CSF Mϕ, monocytes differentiated to HMDM with GM-CSF; GPCR, G protein-coupled receptor; HMDM, human mon
Does complement play a role in bone development and regeneration?
Keywords: گیرندههای جفتشونده با پروتئین جی; BMP, bone morphogenetic protein; C3aR, C3a receptor; C5aR, C5a receptor; DAF, decay accelerating factor, CD55; DAMP, danger associated molecular pattern; ERK, extracellular-signal related kinase; GPCR, G protein-coupled receptor; IGF, insulin-like growth