کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4323757 | 1613812 | 2015 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: β1-and β2-adrenoceptors in hippocampal CA3 region are required for long-term memory consolidation in rats β1-and β2-adrenoceptors in hippocampal CA3 region are required for long-term memory consolidation in rats](/preview/png/4323757.png)
• β1-AR is required for the hippocampus dependent memory consolidation.
• β2-AR is involved in the hippocampus dependent memory consolidation.
• The expression of β1-AR is increased during the consolidation of contextual fear memory.
The existence of β-adrenoceptors (ARs) in the hippocampus and the importance of β-ARs in regulating synaptic plasticity and learning/memory function are well documented. As known, β-ARs in area cornu ammonis 1 (CA1) are involved in regulating memory consolidation. However, little is known about the functional roles of the β-ARs subtypes, β1- and β2-ARs, in the hippocampal cornu ammonis 3 (CA3) region. To address this question, we firstly locally infused the β1- or β2-ARs antagonist into the CA3 region and observed that blockage of either β1-AR or β2-AR impaired long-term contextual fear memory and water-maze spatial memory. We also found that, following the contextual fear conditioning, the expression of β1-AR in the CA3 region significantly increased, whereas β2-AR was unchanged. Then intra-CA3 infusion of recombinant lentiviral RNAi vectors for β1 or β2-ARs also produced deficit in contextual memory consolidation. Taken together, the results suggested that the β1- and β2-ARs in the CA3 region were involved in hippocampus dependent memory consolidation.
Journal: Brain Research - Volume 1627, 19 November 2015, Pages 109–118