A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry
Keywords: GRAS; Drug likeness; QSAR; Molecular properties
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NtGRAS1, a novel stress-induced member of the GRAS family in tobacco, localizes to the nucleus
Keywords: GRAS; Mitochondria; Oxidative stress; Stress signaling; TobaccoDCF, dichlorofluorescein; DEPC, diethyl pyrocarbonate; GFP, green fluorescent protein; NO, nitric oxide; ROS, reactive oxygen species; SNP, sodium nitroprusside
Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin
Keywords: Licorice; Glycyrrhizin; Toxicity; GRAS; Additive; Burdock; Food; Flavor; FEMA; Generally recognized as safe; JECFA; Food additive; Sweetener; 11β-Hydroxysteroid dehydrogenase; Enzyme; Cortisol; Hypermineralocorticoid; Teratogen; Mutagen; Cytotoxicity; Ca
Lack of carcinogenicity of d-xylose given in the diet to F344 rats for two years
Keywords: GRAS; generally recognized as safe; Hb; hemoglobin; Ht; hematocrit; PLT; platelets; RBC; red blood cell count; WBC; white blood cell count; Carcinogenicity; d-Xylose; F344 rats;
Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells
Keywords: FDA; US Food and Drug Administration; NCI; National Cancer Institute; AI; Adequate Intake; GRAS; Generally Recognized As Safe; RDI; Reference Daily Intake; TK; Thymidine kinase; MMS; Methyl methanesulfonate; DMBA; 7,12-Dimethylbenzanthracene; TFT; Trifluo
Toxicological evaluation of glycerin as a cigarette ingredient
Keywords: °C; degrees centigrade; CAS; chemical abstract service; Cig; cigarette; CFR; Code of Federal Regulations; CPSC; US Consumer Product Safety Commission; CO; carbon monoxide; EC50; concentration that reduces the number of viable cells by 50% compared to the
Safety assessment of esters of p-hydroxybenzoic acid (parabens)
Keywords: DNCB; dinitrochlorobenzene; FEMA; flavor and extract manufacturers' association; GRAS; generally recognized as safe; MIC; minimum inhibitory concentration; NOAEL; no observed adverse effect level; NOEL; no observed effect level; OTC; over the counter; P
Criteria for the safety evaluation of flavoring substances
Keywords: ABS; chromosomal aberration; ADH; alcohol dehydrogenase; ALD; aldehyde dehydrogenase; AE; anethole epoxide; CYP450; Cytochrome P450; CHO; Chinese hamster ovary; CoA; coenzyme A; CoE; Council of Europe; CCK; cholecystokinin; DDA; detailed dietary analysis;