Keywords: HDAC، هیستون دیازتیلاز; COPD, chronic obstructive pulmonary disease; HDAC, histone deacetylase; PMA, phorbol 12-myristate 13-acetate; LPS, lipopolysaccharide; GSH, glutathione; qPCR, quantitative polymerase chain reaction; TNFα, tumor necrosis factor α; 4-HNE, 4-hydroxynonenal;
مقالات ISI HDAC، هیستون دیازتیلاز (ترجمه نشده)
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Keywords: HDAC، هیستون دیازتیلاز; Aryl hydrocarbon receptor; Curcumin; CYP1A1; Epigenetic; FICZAHR, aryl hydrocarbon receptor; CUR, curcumin; CYP1A1, cytochrome P4501A1; FICZ, 6-formylindolo[3,2-b]carbazole; HAT, histone acetyltransferase; HDAC, histone deacetylase; TSA, trichostatin A; 5
Keywords: HDAC، هیستون دیازتیلاز; CoMFA, comparative molecular field analysis; CoMSIA, comparative molecular similarity analysis; DS, discovery studio software; FT-IR, Fourier transform infrared spectroscopy; HDAC, histone deacetylase; HMBC, heteronuclear multiple bond correlation; MMP, m
Keywords: HDAC، هیستون دیازتیلاز; c log P, the calculated log octanol/water partition coefficient; tPSA, topological polar surface area; CO, carbonoxygen double bond; LiAlH4, lithium aluminum hydride; HDAC, histone deacetylase; DprE1, decaprenylphosphoryl-β-d-ribose 2′-epimerase; Mtb, Myc
Keywords: HDAC، هیستون دیازتیلاز; EMT, epithelial–mesenchymal transition; CSC, cancer stem cell; PSC, pancreatic stellate cell; TGF-β, transforming growth factor β; ZEB, zinc-finger E-box binding homeobox; HDAC, histone deacetylase; PDGF, platelet-derived growth factor; EGF, epidermal gro
Keywords: HDAC، هیستون دیازتیلاز; MDSC, myeloid derived suppressor cells; IMC, immature myeloid cells; HDAC, histone deacetylase; eGFP, enhanced green fluorescent protein; APCs, antigen presenting cells; ROS, reactive oxygen species; NO, nitric oxide; GVHD, graft vs host disease; PBMC, pe
Keywords: HDAC، هیستون دیازتیلاز; Oral cancer; DNA methylation; Histone modifications; microRNA; Biomarkers; EpidrugsHPV, Human Papilloma Virus; DNMT, DNA methyltransferase; HDAC, histone deacetylase; miRNA, microRNA; NNK, nicotine-derived nitrosamine ketone; EDNRB, endothelin receptor ty
Keywords: HDAC، هیستون دیازتیلاز; CDase, ceramidase; DHS, dihydrosphingosine; DHS1P, dihydrosphingosine 1-phosphate; ER, endoplasmic reticulum; FALDH, fatty aldehyde dehydrogenase; HDAC, histone deacetylase; LCB, long-chain base; LCBP, long-chain base 1-phosphate; PE, phosphatidylethanola
Keywords: HDAC، هیستون دیازتیلاز; AVP, arginine vasopressin; BNST, bed nucleus of the stria terminalis; DNMT, DNA methyltransferase; ERα, estrogen receptor alpha; ERβ, estrogen receptor beta; GnRH, gonadotropin-releasing hormone; HDAC, histone deacetylase; HPA, hypothalamic–pituitary–adre
Keywords: HDAC، هیستون دیازتیلاز; EMT, Epithelial–mesenchymal transition; ESC, Embryonic stem cell; F1, First filial generation; HDAC, Histone deacetylase; iPSC, Induced pluripotent stem cell; IRES, Internal ribosome entry site; GSK3β, Glycogen synthase kinase 3 beta; MEF, Mouse embryonic
Keywords: HDAC، هیستون دیازتیلاز; FDA, the food and drug administration; GEMMs, genetically enginereed mouse models; PDTX, patient-derived tumor xenograft; NSG, NOD scid gamma; MTA, Material Transfer Agreement; APL, Acute Promyelocytic Leukemia; HDAC, histone deacetylase; NSCLC, non-small
Keywords: HDAC، هیستون دیازتیلاز; EGCG, epigallocatechin gallate; NaB, sodium butyrate; HDAC, histone deacetylase; HAT, histone acetyltransferase; DMSO, dimethylsulfoxide; DNMT1, DNA methyltransferase 1; DNMT3A, DNA methyltransferase 3A; γ-H2AX, gamma-H2A histone family member X; NF-κB, n
Keywords: HDAC، هیستون دیازتیلاز; 5-Aza, 5-aza-2′deoxycytidine; BET, bromodomain and extraterminal; DZNep, 3-Deazaneplanocin A; FFPE, formalin-fixed paraffin embedded; H3K9, histone 3 lysine 9; HATs, histone lysine acetyltransferases; HDAC, histone deacetylase; HDMs, histone lysine demeth
Keywords: HDAC، هیستون دیازتیلاز; DEX, dexamethasone; HDAC, histone deacetylase; MEL, melatonin; MT1, melatonin receptor-1; MT2, melatonin receptor-2; RORα, retinoid acid receptor-α; RZRβ, retinoid Z receptor-βDevelopmental programming; Glucocorticoid; Hypertension; Melatonin; Melatonin r
Keywords: HDAC، هیستون دیازتیلاز; AGL15, AGAMOUS-LIKE 15; ARR, ARABIDOPSIS RESPONSE REGULATOR; BBM, BABY BOOM; CIM, callus-inducing medium; HDAC, HISTONE DEACETYLASE; HDT, HD-TUINS PROTEIN; LBD, LATERAL ORGAN BOUNDARIES DOMAIN; LEC1, LEAFY COTYLEDON 1; PcG, polycomb group; PRC, polycomb r
Combination of retinoid and histone deacetylase inhibitor produced an anti-tumor effect in cutaneous T-cell lymphoma by restoring tumor suppressor gene, retinoic acid receptorβ2, via histone acetylation
Keywords: HDAC، هیستون دیازتیلاز; RAR, retinoic acid receptor; CTCL, cutaneous T cell lymphoma; HDAC, histone deacetylase; RXR, retinoid X receptorsRetinoic acid receptor; Cutaneous T cell lymphoma; Histone acetylation; DNA methylation
Histone deacetylase inhibitor abexinostat affects chromatin organization and gene transcription in normal B cells and in mantle cell lymphoma
Keywords: HDAC، هیستون دیازتیلاز; BL, Burkitt's lymphoma; CCND1, cyclin D1 gene; DNA, deoxyribonucleic acid; FISH, fluorescence in situ hybridization; HDAC, histone deacetylase; HDACi, histone deacetylase inhibitor; LCL, lymphoblastoid cell line; MCL, mantle cell lymphoma; NBL, normal B-l
Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells
Keywords: HDAC، هیستون دیازتیلاز; ARE, Antioxidant Response Element; DNPH, 2,4-Dinitrophenylhydrazine; GAPDH, Glyceraldehyde 3-Phosphate Dehydrogenase; GCL, Glutamate Cysteine Ligase; GST, Glutathione S-Transferase; HDAC, Histone Deacetylase; HO-1, Heme Oxygenase 1; HSP, Heat Shock Protei
Elevated nuclear sphingoid base-1-phosphates and decreased histone deacetylase activity after fumonisin B1 treatment in mouse embryonic fibroblasts
Keywords: HDAC، هیستون دیازتیلاز; ABC, ATP binding cassette; CerS, ceramide synthase; ELEM, equine leukoencephalomalacia; FB1, fumonisin B1; Gapdh, glyceraldehyde 3-phosphate dehydrogenase; GPCR, G protein-coupled receptor; HDAC, histone deacetylase; Lpp, lipid phosphate phosphatase; MEF,
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
Keywords: HDAC، هیستون دیازتیلاز; C646 (PubChemCID: 1285941); SAHA (PubChemCID: 5311)HAT, histone acetyltransferase; HATi, HAT inhibitor; HDAC, histone deacetylase; PCAF, P300/CBP-associated factor; MOZ, monocytic leukemic zinc finger; COX-2, cyclooxygenase-2; NF-κB, nuclear factor kappa
Epigenetic regulation of G protein coupled receptor signaling and its implications in psychiatric disorders
Keywords: HDAC، هیستون دیازتیلاز; GPCRs, Gprotein-coupled receptors; HDAC, histone deacetylase; CNS, central nervous system; GWAS, genome-wide association studies; GEFs, guanine nucleotide exchange factors; GDP, guanosine diphosphate; GTP, guanosine triphosphate; WHO, world health organiz
Jmjd3 mediates blood–spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions
Keywords: HDAC، هیستون دیازتیلاز; AAV, adeno-associated virus; BBB, blood–brain barrier; CNS, central nervous system; ChIP, Chromatin Immunoprecipitation; Cox, cyclooxygenase; GM, gray matter; HDAC, histone deacetylase; MMP, matrix metalloprotease; OGD, oxygen–glucose deprivation;; shRNA,
Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction
Keywords: HDAC، هیستون دیازتیلاز; FBS, fetal bovine serum; Hdac, histone deacetylase; MTT, 3-(4,5-dimethyl-2-thiazolyl) 2,5-diphenyl-2H-tetrazolium bromide; NaBu, sodium butyrate; PI, propidium iodide; SDS, sodium dodecyl sulfatePhytanic acid; Histone deacetylase; Cell death; Mitochondria
Solution NMR Studies of an Alternative Mode of Sin3 Engagement by the Sds3 Subunit in the Histone Deacetylase-Associated Sin3L/Rpd3L Corepressor Complex
Keywords: HDAC، هیستون دیازتیلاز; HDAC, histone deacetylase; HID, HDAC interaction domain; HSQC, heteronuclear single quantum coherence; NOE, nuclear Overhauser effect; NOESY, nuclear Overhauser effect spectroscopy; SID, Sin3 interaction domainconformational exchange; conformational heter
Histone deacetylase inhibitor sodium butyrate attenuates gentamicin-induced hearing loss in vivo
Keywords: HDAC، هیستون دیازتیلاز; ABR, auditory brainstem response; ANOVA, analysis of variance; GelD, gelatin sponge diffusion; GM, gentamicin; HDAC, histone deacetylase; IHC, inner hair cell; NaB, sodium butyrate; OHC, outer hair cell; PBS, phosphate-buffered saline; TTI, transtympanic
In vitro ischemia decreases histone H4K16 acetylation in neural cells
Keywords: HDAC، هیستون دیازتیلاز; ACA, acetyl-CoA; BA, sodium butyrate; DCA, sodium dichloroacetate; GD, glucose deprivation; H4K16Ac, histone H4 acetylated at residue K16; HAT, histone acetyltransferase; HDAC, histone deacetylase; HDACi, inhibitor of histone deacetylase; HIF, hypoxia ind
Influence of the carbamate fungicide benomyl on the gene expression and activity of aromatase in the human breast carcinoma cell line MCF-7
Keywords: HDAC، هیستون دیازتیلاز; HDAC, histone deacetylase; cAMP, cyclic adenosine monophosphate; RT-PCR, reverse transcription polymerase chain reaction; FBS, fetal bovine serum; PBS, phosphate-buffered saline; ER, estrogen receptorBenomyl; Carbendazim; MCF-7; Inhibition of HDAC1; Acety
Investigating the effects of in utero benzene exposure on epigenetic modifications in maternal and fetal CD-1 mice
Keywords: HDAC، هیستون دیازتیلاز; γH2AX, phosphorylated histone H2A variant X; TSA, trichostatin A; Parp-1, poly[ADP-ribose] synthase 1; HAT, histone acetyltransferase; Pten, phosphatase and tensin homolog; MAGE1, melanoma antigen 1; HDAC, histone deacetylase; DNMT, DNA methyl transferase
ING3 protein expression profiling in normal human tissues suggest its role in cellular growth and self-renewal
Keywords: HDAC، هیستون دیازتیلاز; ING, INhibitor of Growth; HAT, histone acetyltransferase; HDAC, histone deacetylase; TMA, tissue microarray; ELISA, enzyme-linked immunoabsorbent assay; IHC, immunohistochemistryTumor suppressor; PHD protein; Epigenetic regulator; Monoclonal antibody; Tis
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A
Keywords: HDAC، هیستون دیازتیلاز; Lysine demethylase; Tranylcypromine; EpigeneticBOC, t-butyloxycarbonyl; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethyl formamide; DMSO, dimethylsulfoxide; HDAC, histone deacetylase; KDM1A, lysine-specific histone demethylase type 1; MAO, monoamine ox
c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication
Keywords: HDAC، هیستون دیازتیلاز; BrdU, 5-bromo-2′-deoxy-uridine; ChiP, chromatin immunoprecipitation; DMSO, dimethylsulfoxide; DNMT, DNA methyltransferase; EMSA, electrophoretic mobility shift assay; HAT, histone acetyltransferase; HDAC, histone deacetylase; MCM4, minichromosome maintena
Maternal high-zinc diet attenuates intestinal inflammation by reducing DNA methylation and elevating H3K9 acetylation in the A20 promoter of offspring chicks
Keywords: HDAC، هیستون دیازتیلاز; ZnMHA, methionine hydroxy analog chelated zinc; H3K9Ac, histone H3 acetylation at lysine-9 (K9); HDAC, histone deacetylase; HAT, histone acetyltransferase; DNMT, DNA methylation transferase; IL, interleukin; TNF, tumor necrosis factor; MUC, mucin; NF-κB,
4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide – A new pleiotropic HDAC inhibitor targeting cancer cell signalling and cytoskeletal organisation
Keywords: HDAC، هیستون دیازتیلاز; HDAC, histone deacetylase; HDACi, histone deacetylase inhibitor; Etacrox, 4-(1-ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide×HClImidazoles; Hydroxamic acids; Histone deacetylase inhibitors; Microtubule acetylation; Antimetastatic activity; Transwell mi
GCN5 is involved in regulation of immunoglobulin heavy chain gene expression in immature B cells
Keywords: HDAC، هیستون دیازتیلاز; ChIP, chromatin immunoprecipitation; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; H-chain, heavy chain; H3K14, Lys-14 of histone H3; H3K9, Lys-9 of histone H3; HAT, histone acetyltransferase; HDAC, histone deacetylase; L-chain, light chain; RT-PCR, re
Histone deacetylase expression in white matter oligodendrocytes after stroke
Keywords: HDAC، هیستون دیازتیلاز; Ac-HH, acetylated histone H; APC, adenomatous polyposis coli; BrdU, bromodeoxyuridine; DAPI, 4,6’-diamidino-2-phenylindole; HDAC, histone deacetylase; MBP, myelin basic protein; MCAO, middle cerebral artery occlusion; NG2, chondroitin sulfate proteoglycan
SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells
Keywords: HDAC، هیستون دیازتیلاز; SAHA, suberoylanilide hydroxamic acid; HPV, human papillomavirus; RT-PCR, reverse transcription-PCR; RNPII, RNA polymerase II; ChIP, chromatin immunoprecipitation; FACS, fluorescence activated cell sorting; HDAC, histone deacetylase; HDACi, histone deacet
Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses
Keywords: HDAC، هیستون دیازتیلاز; Ac-K, acetylated lysine residue; CAD, C-terminal transactivation domain; CBP, CREB-binding protein; DBD, DNA-binding domain; HDAC, histone deacetylase; HIF, hypoxia-inducible factor; PCAF, p300/CBP-associated factor; Sirt1, sirtuin 1Sirtuin 1; Lysine acet
MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast cancer
Keywords: HDAC، هیستون دیازتیلاز; CSCs, cancer stem cells; HDAC, histone deacetylase; HSP70, heat shock protein 70; 3′UTR, 3′ untranslated region; HDACi, histone deacetylase inhibitormicroRNA; Histone deacetylase; Deacetylation; HSP70
Human ATP-Binding Cassette transporters ABCB1 and ABCG2 confer resistance to CUDC-101, a multi-acting inhibitor of histone deacetylase, epidermal growth factor receptor and human epidermal growth factor receptor 2
Keywords: HDAC، هیستون دیازتیلاز; MDR, multidrug resistance; ABC, ATP-binding cassette; HDAC, histone deacetylase; EGFR, epidermal growth factor receptor; HER2, human epidermal growth factor receptor 2Multidrug resistance; EGFR; HDAC; HER2; CUDC-101
Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages
Keywords: HDAC، هیستون دیازتیلاز; Histone deacetylase inhibitor; Malaria; Liver stages; Asexual blood stages; Gametocyte stagesDIC, N,N′-diisopropylcarbodiimide; DMF, N,N-dimethylformamide; EEF, exo-erythrocytic form; HDAC, histone deacetylase; Pf, Plasmodium falciparum; Pf LSG, P. falcip
p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis
Keywords: HDAC، هیستون دیازتیلاز; RhoB, ras homolog gene family member B; FTIs, farnesyltransferase inhibitors; SAPK/JNK, stress-activated protein kinase/c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; HDAC, histone deacetylase; HAT, histone acetylase; PARP-1, poly(ADP-ri
The TWEAK-Fn14 pathway: A potent regulator of skeletal muscle biology in health and disease
Keywords: HDAC، هیستون دیازتیلاز; ALS, autophagy-lysosomal system; α-SMA, α-smooth muscle actin; Dnmt, DNA methyltransferase; ECM, extracellular matrix; Fn14, fibroblast growth factor-inducible 14; HDAC, histone deacetylase; IBM, inclusion-body myositis; KO, knockout; PGC-1α, peroxisome p
Identification of Tf1 integration events in S. pombe under nonselective conditions
Keywords: HDAC، هیستون دیازتیلاز; TSA, trichostatin A; HDAC, histone deacetylase; IPCR, inverse polymerase chain reaction; G418, geneticin; neo, neomycinRetrotransposon; Integration; Heterochromatin; Fission yeast; Trichostatin A
Spiruchostatin A and B, novel histone deacetylase inhibitors, induce apoptosis through reactive oxygen species-mitochondria pathway in human lymphoma U937 cells
Keywords: HDAC، هیستون دیازتیلاز; SP-A, Spiruchostatin A; SP-B, Spiruchostatin B; ROS, reactive oxygen species; HDAC, histone deacetylase; MMP, mitochondrial membrane potential; NAC, N-acetyl-l-cysteine; FITC, fluorescein isothiocyanate; HATs, histone acetyltransferases; HDACi, histone de
Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity
Keywords: HDAC، هیستون دیازتیلاز; RNAi, RNA interference; HDAC, Histone deacetylase; HDACi, Histone deacetylase inhibitor; mTOR, mechanistic target of rapamycin; mTORC1, mTOR complex 1; mTORC2, mTOR complex 2; LOF, loss-of-function; TRNBC, triple negative breast cancer; RSP6, ribosomal S6
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors
Keywords: HDAC، هیستون دیازتیلاز; SIRT2; Huntington's disease; 3-(Benzylsulfonamido)benzamides; Polyglutamine aggregation; ADMECNS, central nervous system; HD, Huntington's disease; HDAC, histone deacetylase; SIRT2, sirtuin-2; PolyQ, polyglutamine
Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer 1
Keywords: HDAC، هیستون دیازتیلاز; HDAC, histone deacetylase; HDACIs, Histone deacetylase inhibitors; SAHA, Suberoylanilide hydroxamic acid; LRR, local-regional recurrence; HATs, Histone acetyltransferases; VPA, Valproic acid; DAPI, 4, 6-diamidino-2-phenylindole; PCNA, proliferation cell n
Dual-acting histone deacetylase-topoisomerase I inhibitors
Keywords: HDAC، هیستون دیازتیلاز; HDAC, histone deacetylase; HAT, histone acetyltransferase; HDACi, histone deacetylase inhibitors; SAHA, suberoylanilide hydroxamic acid; TSA, trichostatin A; Topo I, topoisomerase I class of enzymesHistone deacetylase; Histone deacetylase inhibitors; Topo
Lipopolysaccharide prevents valproic acid-induced apoptosis via activation of nuclear factor-κB and inhibition of p53 activation
Keywords: HDAC، هیستون دیازتیلاز; Bax, Bcl-2-associated X protein; Bcl-2, B-cell lymphoma 2; Erk, extracellular signal-regulated kinase; HDAC, histone deacetylase; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; MTT, 3-(4,5-dimethylthiazol-2-
Histone deacetylase inhibitor AR42 regulates telomerase activity in human glioma cells via an Akt-dependent mechanism
Keywords: HDAC، هیستون دیازتیلاز; TRAP, telomeric repeat amplification protocol; HDAC, histone deacetylase; PI3K, phosphatidylinositol 3-kinase; RT-PCR, reverse transcriptase-polymerase chain reactionTelomerase reverse transcriptase; Histone deacetylase inhibitor; Glioma; PI3K/Akt pathway