Keywords: مانع از HDAC; 5-Aza; 5-Aza-2-deoxycytidine; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; BIR; baculoviral inhibitor of apoptosis repeat; CAD; caspase-activated deoxyribonuclease; CDK; cyclin-dependent kinase; cIAP; cellular inhibitor of apoptosis; CL
مقالات ISI مانع از HDAC (ترجمه نشده)
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Keywords: مانع از HDAC; CDK inhibitors; HDAC inhibitors; Hypomethylating agents; Imetelstat; JAK inhibitors; KIT inhibitors; MDM2 inhibitors; MPN; PRM-151; Sotatercept;
Keywords: مانع از HDAC; Urothelial carcinoma; Chicken chorioallantoic membrane (CAM) model; HDAC inhibitors; Cisplatin; Romidepsin; Vorinostat;
Keywords: مانع از HDAC; DAC; 5-Aza-2â²-deoxycytydine; DNMT; DNA methyltransferase; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACì; HDAC inhibitors; IL-2; interleukin-2; INS; insulin; LADA; latent autoimmune diabetes in adults; miRNA; microRNA; PBMCs; peripher
Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors
Keywords: مانع از HDAC; Chalcone; Histone deacetylase; Docking; Anti-proliferative; HDAC inhibitors;
Keywords: مانع از HDAC; Epigenetics; Histone deacetylases (HDACs); HDAC inhibitors; Photolabile protecting group; Caged compounds;
Keywords: مانع از HDAC; Insulin resistance; Type 2 diabetes; Histone deacetylases; HDAC inhibitors;
Keywords: مانع از HDAC; Autophagy; Acetylation; Diabetic nephropathy and SIRTs; HDACs; HDAC inhibitors
Keywords: مانع از HDAC; AP-1; activator protein 1; APC; antigen-presenting cells; ARE; AU-rich element; ASK; Apoptosis Signal regulating Kinase; ATF-2; Activating Transcription Factor 2; CRE; Cyclic AMP Responsive Element; CBP; CREB binding protein; CsA; ciclosporin A; ERK; Extr
Keywords: مانع از HDAC; Histone deacetylase; Anticancer activity; HDAC inhibitors; Short chain fatty acids; Hydroxamic acidsADP, adenosine diphosphate; Arg, arginine; Asp, aspartic acid; Cys, cysteine; DNA, deoxyribonucleic acid; Gly, glycine; HAT, histone acetyl transferase; HD
Keywords: مانع از HDAC; Histone deacetylases; HDAC inhibitors; Liver fibrosis; Hepatic stellate cellECM, extracellular matrix; HSC, hepatic stellate cell; TGF-β, transforming growth factor-β; PDGF, platelet-derived growth factor; α-SMA, α-smooth muscle actin; MMPs, matrix metall
Keywords: مانع از HDAC; Neural crest; Migration; Read-across; Chemical grouping; Gene expression; HDAC inhibitors; Pesticides; Metals; PCBs; Pathways of toxicity; Toxicology
Keywords: مانع از HDAC; Histone deacetylases; HDAC inhibitors; Pancreatic cancer; Combination therapy
Keywords: مانع از HDAC; Histone-acetylation; Alzheimer; Gene-expression; Memomry; HDAC inhibitors
Keywords: مانع از HDAC; Inflammatory lung diseases; Epithelial damage; Fibrosis; TFF2; Relaxin; HDAC inhibitors; Stem cells
Keywords: مانع از HDAC; Systemic lupus erythematosus (SLE); Biomarkers; Pharmacoepigenetics; HDAC inhibitors; DNA methylation; microRNA;
Keywords: مانع از HDAC; HDAC inhibitors; Cell context; Cell cycle arrest; Histone modification; Apoptosis;
Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A
Keywords: مانع از HDAC; Marine natural product; Largazole; Psammaplin A; Hybrid; HDAC inhibitors;
Epigenetic crosstalk: Pharmacological inhibition of HDACs can rescue defective synaptic morphology and neurotransmission phenotypes associated with loss of the chromatin reader Kismet
Keywords: مانع از HDAC; Drosophila; Kismet; HDAC; HDAC inhibitors; CHARGE syndrome; CHD7;
Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap
Keywords: مانع از HDAC; HDAC inhibitors; Y-shaped cap; Antiproliferative activity; Molecular docking;
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma
Keywords: مانع از HDAC; XNBWKNWCSWBFRL-UHFFFAOYSA-N; WOGPSXAJPRAXBA-UHFFFAOYSA-N; RHUMXXCHLQENCI-UHFFFAOYSA-N; HDAC inhibitors; Squaramide; CTCL; Topical; Mycosis fungoides;
Mechanisms controlling the anti-neoplastic functions of FoxO proteins
Keywords: مانع از HDAC; ATM; ataxia telangiectasia mutated; cHL; classical hodgkin lymphoma; CML; chronic myelogenous leukemia; CSC; cancer stem cell; ERK; the extracellular signal-regulated kinase; ERα; the nuclear receptor estrogen receptor α; FoxO; forkhead box O; G6PC; glu
HDAC inhibitors as epigenetic regulators for cancer immunotherapy
Keywords: مانع از HDAC; AICD; activation-induced cell death; AML; acute myeloid leukemia; APC; antigen-presenting cells; CAR; coxsackie- and adenovirus receptor; CDKs; cyclin-dependent kinases; CG; cancer germline; DCs; dendritic cells; HAT; histone acetyltransferase; HDAC; hist
The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity
Keywords: مانع از HDAC; Histone deacetylase; HDAC inhibitors; Vorinostat; Isoform selectivity; HDAC6/8 selective inhibitor;
Cutaneous T-cell lymphomas: Focusing on novel agents in relapsed and refractory disease
Keywords: مانع از HDAC; ARGX-110; Brentuximab vedotin; Bortezomib; Copanlisib; cutaneous T-cell lymphoma; Forodesine; Gemcitabine; HDAC inhibitors; Ipilimumab; IPH4102; Mogamulizumab; Nivolumab; NM-IL-12; Panobinostat; Pegylated liposomal doxorubicin; Pentostatin; Pralatrexate;
Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa
Keywords: مانع از HDAC; HDAC inhibitors; Pseudomonas aeruginosa; Perfluorinated hydroxamic acids; Selectivity;
Design, synthesis and tumor cell growth inhibitory activity of 3-nitro-2H-cheromene derivatives as histone deacetylaes inhibitors
Keywords: مانع از HDAC; HDACs; HDAC inhibitors; 3-Nitro-2H-chromenes; Coumarins; Anticancer agents; Zinc-dependent hydrolases; Isoform selective;
Design, synthesis and anti-tumor activity study of novel histone deacetylase inhibitors containing isatin-based caps and o-phenylenediamine-based zinc binding groups
Keywords: مانع از HDAC; Anticancer; Epigenetics; HDAC inhibitors; Isatin;
Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation
Keywords: مانع از HDAC; Atrial fibrillation; Histone deacetylases; HDAC inhibitors; Non-histone proteins
Update on rational targeted therapy in AML
Keywords: مانع از HDAC; High-risk AML; IDH; BET; HDAC inhibitors; LSD1; DOT1L; Flavopiridol; Palbociclib; Volasertib; Wee1; Idasanutlin; Aurora kinase; Rigosertib; Hedgehog; BH3-mimetic; Venetoclax; Pevonedistat; Tosedostat
HACE1 is a putative tumor suppressor gene in B-cell lymphomagenesis and is down-regulated by both deletion and epigenetic alterations
Keywords: مانع از HDAC; Tumor suppressor gene; Epigenetic; Lymphoma; HDAC inhibitors; Deletions
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity
Keywords: مانع از HDAC; Hydroxamic acids; HDAC inhibitors; Antiproliferative activity; Antitumor activity; Synthesis;
Inside HDACs with more selective HDAC inhibitors
Keywords: مانع از HDAC; Epigenetics; HDAC inhibitors; Synthesis; Molecular modelling; Histone acetylation;
Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease
Keywords: مانع از HDAC; Abdil solution; antibody dilution solution; A.U.; arbitrary units; BBB; blood brain barrier; BSA; bovine serum albumin; DCPIP; 2,6-dichlorophenolindophenol; DD; deacetylase domain; dpf; days post fertilization; DMB; dynein motor binding; HAD; HDAC associa
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity
Keywords: مانع از HDAC; RGFP966 (PubChem CID: 56650312); N,N-Dimethylformamide (PubChem CID: 6228); Suberoylanilide hydroxamic acid (PubChem CID: 5311); Lysine acetylation; HDACs; Inflammation; NF-κB p65; HDAC inhibitors; Lung disease;
Epigenetic-based therapies in the preclinical and clinical treatment of Huntington's disease
Keywords: مانع از HDAC; Neurodegenerative; Epigenetics; Transcription; HDAC inhibitors; Clinical trials;
Antidepressant action of HDAC inhibition in the prefrontal cortex
Keywords: مانع از HDAC; HDACs; histone deacetylases; PBS; phosphate-buffered saline; MS-275; HDAC inhibitors; depression; gene expression;
Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: Modulation of histone deacetylase activity
Keywords: مانع از HDAC; Histone acetylation; Histone deacetylases; HDAC inhibitors; Parkinson’s disease; Sodium butyrate; 6-OHDA
Interplay between histone acetylation/deacetylation and poly(ADP-ribosyl)ation in the development of ischemic tolerance in vitro
Keywords: مانع از HDAC; Ischemia tolerance; Preconditioning; NMDA; Histone acetylation/deacetylation; Poly(ADPribosyl)ation; HDAC inhibitors; HAT; histone acetyl transferase; HDAC; histone deacetylase; OGD; oxygen-glucose deprivation; SAHA; suberoylanilide hydroxamic acid; PARP;
Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites
Keywords: مانع از HDAC; Plasmodium falciparum; Trypanosoma brucei; Malaria; African sleeping sickness; Histone; HDAC inhibitors
DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells
Keywords: مانع از HDAC; HDAC inhibitors; Glioblastoma; Radiation; Chek2; Bcl-XL;
In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma
Keywords: مانع از HDAC; ACFs; aberrant crypt foci; AO/EB; acridine orange/ethidium bromide; CPCSEA; Committee for the Purpose of Control and Supervision of Experiments on Animals; CMC; carboxymethylcellulose; DMEM; Dulbecco's minimum essential media; DMSO; dimethyl sulfoxide;
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: مانع از HDAC; Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors
Keywords: مانع از HDAC; Indoline-2,3-dione derivatives; HDAC inhibitors; Synthesis; Biological evaluation; QSAR;
NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease
Keywords: مانع از HDAC; NRSF; Target genes; Epigenetic mechanisms; HDAC inhibitors; Parkinson's disease;
Mcl-1 dependence predicts response to vorinostat and gemtuzumab ozogamicin in acute myeloid leukemia ★
Keywords: مانع از HDAC; AML; Biomarker; Personalized medicine; HDAC inhibitors; Gemtuzumab ozogamicin
HDAC inhibitors induce apoptosis but not cellular senescence in Gadd45α-deficient E1A+Ras cells
Keywords: مانع از HDAC; Transformed cells; Gadd45α inactivation; Apoptosis; Senescence; HDAC inhibitors;
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors
Keywords: مانع از HDAC; Adamantyl moiety; Hydroxamic acids; HDAC inhibitors; Antiproliferative activity
Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
Keywords: مانع از HDAC; Cancer; HDAC inhibitors; HDAC2; p53; RLIM; Sumoylation;
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents
Keywords: مانع از HDAC; Benzimidazole; HDAC inhibitors; Structure-activity relationship; Anticancer agents;