کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1951971 1538415 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic modifications by histone deacetylases: Biological implications and therapeutic potential in liver fibrosis
ترجمه فارسی عنوان
تغییرات اپیژنتیک توسط هیستون دیازتیلاس: پیامدهای بیولوژیکی و پتانسیل درمانی در فیبروز کبدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


• Multiple roles of HDACs in liver fibrosis.
• Therapeutic effects of HDAC inhibitors.
• Transcriptional regulation of specific target genes in HSCs by HDACs.
• Emerging signal pathways regulated in HSCs by HDACs.

Liver fibrosis is an important pathological repair process in reaction to liver injury characterized by progressive accumulation of extracellular matrix (ECM) components. Mechanism that orchestrates this fibrotic disorder is the activation of hepatic stellate cell (HSC) that requires extensive alterations in gene expression. Reversible deacetylation of histone proteins is one of the most abundant epigenetic modifications and is crucial in modulating gene expression. Recent evidence has highlighted a pathological imbalance between the acetylation and deacetylation of histone proteins regulated by histone deacetylases (HDACs). In the past several years, the role of HDACs in liver fibrosis initiation and progression, as well as the therapeutic effects of HDAC inhibitors, has been well studied. Here, the innovative aspects of histone deacetylation will be presented, with respect to the roles of HDACs in liver fibrosis, the affected genes and signal pathways involved in HSCs activation, as well as significant data emerging from the field in support of HDAC inhibitors as potential therapeutic targets for the treatment of liver fibrosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 116, September 2015, Pages 61–69
نویسندگان
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