کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2530953 1558899 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation
چکیده انگلیسی

Atrial fibrillation (AF) is a common cardiac arrhythmia associated with high mortality and morbidity. Current treatments of AF have limited efficacy and considerable side effects. Histone deacetylases (HDACs) play critical roles in the pathophysiology of cardiovascular diseases and contribute to the genesis of AF. Therefore, HDAC inhibition may prove a novel therapeutic strategy for AF through upstream therapy and modifications of AF electrical and structural remodeling. In this review, we provide an update of the knowledge of the effects of HDACs and HDAC inhibitors on AF, and dissect potential underlying mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 781, 15 June 2016, Pages 250–257
نویسندگان
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