Keywords: زنجیره سنگین; Botulinum neurotoxin; 3,4-Diaminopyridine; Isometric muscle contractions; Endplate recordings; Neurotransmission; Release probability; BoNT; botulinum neurotoxin; DAP; 3,4-diaminopyridine; HC; heavy chain; LC; light chain; NMJ; neuromuscular junction; EPP
مقالات ISI زنجیره سنگین (ترجمه نشده)
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Keywords: زنجیره سنگین; CA; caprylic acid; mAb; monoclonal antibody; Ig; immunoglobulin; HCP; host cell protein; CHO; Chinese hamster ovary; LC; light chain; HC; heavy chain; MCBS; multi-component buffer system; TCID50; 50% tissue culture infectious dose; MuLV; murine leukemia v
Comparability study of Rituximab originator and follow-on biopharmaceutical
Keywords: زنجیره سنگین; AA; amino acid; ABC; ammonium bicarbonate; ACN; acetonitrile; ADCC; antibody-dependent cellular cytotoxicity; CD; circular dichroism; CDC; complement-dependent cytotoxicity; CDRs; complementarity determining regions; CH; constant region of heavy chain; CH
Identification and characterization of monoclonal antibody fragments cleaved at the complementarity determining region using orthogonal analytical methods
Keywords: زنجیره سنگین; CE-SDS; sodium dodecyl sulfate capillary electrophoresis; mAb; monoclonal antibody; RP-LC-MS; reversed phase liquid chromatography mass spectrometry; CDR; complementarity determining region; SEC-HPLC; size exclusion liquid chromatography; dSEC-HPLC; d
Keywords: زنجیره سنگین; BCA; bicinchoninic acid; CDR1; 2complementarity determining regions 1, 2; CFA; complete Freund's adjuvant; Cκ; constant kappa light chain; Cλ; constant lambda light chain; DH; heavy diversity; DNase; deoxyribonuclease; ELISA; direct enzyme-linked immu
Keywords: زنجیره سنگین; Disulfide linkage; Disulfide scrambling; Therapeutic mAbs; Peptide mapping; Nonreducing; LC-MS; mAb; monoclonal antibody; IgG; immunoglobulin G; HC; heavy chain; LC; light chain; VL; variable domain of light chain; CL; constant domain of light chain; VH
Keywords: زنجیره سنگین; Light chain subisotype; Heavy chain; IgM; IgT; Preferential combination; Rainbow trout; Ab; antibody; BCR; B cell receptor; C domain; constant domain; CH; heavy chain constant domain; CL; light chain constant domain; DN; double negative; D segment; divers
Keywords: زنجیره سنگین; Ag; antigen; bnAb; broadly neutralizing anti-HIV Ig; CLL; chronic lymphocytic leukemia; EBV; Epstein Barr virus; GBM; glomerular basement membrane; GN; glomerulonephritis; GP; Goodpasture; GPS; GP syndrome; HC; heavy chain; HCDR3; heavy chain complementar
Keywords: زنجیره سنگین; IgG; immunoglobulin G; mAb; monoclonal antibody; CHO; Chinese hamster ovary; HCP; host cell proteins; nh-HCP; non-histone host cell proteins; HC; heavy chain; LC; light chain; CCS; cell culture supernatant; c-d CCS; chromatin-directed clarified CCS; CV; c
Keywords: زنجیره سنگین; Biological toxins; Ricin; Botulinum neurotoxin; Staphylococcal enterotoxin; Saxitoxin; Standardization; Proficiency testing; AOAC; AOAC International; BoNT; Botulinum neurotoxin; CRM; Certified reference material; CWC; Chemical Weapons Convention; EFSA; E
Keywords: زنجیره سنگین; 2D-LC; two-dimensional liquid chromatography; AA; amino acid; AC; affinity chromatography; ADC; antibody-drug conjugates; ADCC; antibody-dependent cellular cytotoxicity; AF4; asymmetric flow field fractionation; APTS; 1-aminopyrene-3,6,8-trisulfonate; Asn
Keywords: زنجیره سنگین; amniotic membrane; anti-inflammation; anti-angiogenesis; antiscarring; heavy chain; hyaluronan; inter-α-inhibitor; limbus; stem cell niche; stem cells; umbilical cord;
Keywords: زنجیره سنگین; Botulinum neurotoxin; Botulism; Synaptotagmin; Synaptic vesicle glycoprotein 2; Protein complex; Host-pathogen recognition; botulinum neurotoxin; BoNT; light chain; LC; heavy chain; HC; N-terminal domain of HC; HN; C-terminal domain of HC; HC; N-terminal
Keywords: زنجیره سنگین; Polysialic acid; Tegaserod; Mimetic; Peripheral nerve; Regeneration; Glycan; Drug repurposing; CDR; complementary determining region; cGN; cerebellar granule neuron; DRG; dorsal root ganglion; ELISA; enzyme-linked immunosorbent assay; FBA; foot base angle
Keywords: زنجیره سنگین; Protein translocase; Biological weapons; Botulism; Antibotulinal agents; Modular nanomachine; βME; beta-mercaptoethanol; ÎpH; pH gradient across the cis and trans compartments; γ; single channel conductance; BoNT; botulinum neurotoxin; BTD; beltless tr
Keywords: زنجیره سنگین; AP-1; activator protein-1; BLNK; B cell linker protein; BTK; Bruton's tyrosine kinase; CCT; choline cytidylyltransferase; CDP-choline; cytidine diphosphocholine; CEPT1; choline/ethanolamine phosphotransferase 1; Cer; ceramide; CK; choline kinase; CPT1; ch
In vitro potency determination of botulinum neurotoxin serotype A based on its receptor-binding and proteolytic characteristics
Keywords: زنجیره سنگین; Botulinum neurotoxin serotype A (BoNT/A); In vitro assay; Binding and cleavage assay (BINACLE assay); Activity determination; BINACLE; Binding and cleavage assay; BoNT; Botulinum neurotoxin; BSA; Bovine serum albumin; GT1b; Trisialoganglioside GT1b; H-cha
Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy
Keywords: زنجیره سنگین; bsAb; bispecific antibody; CHO; chinese hamster ovary; ER; endoplasmic reticulum; IgG; Immunoglobulin G; DTE; difficult-to-express; DHFR; dihydrofolate reductase; MTX; Methotrexate; VCD; viable cell density; qRT-PCR; quantitative real-time polymerase chai
A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2
Keywords: زنجیره سنگین; Calcium; Calcium-binding protein; Microtubule-associated protein; Endoplasmic reticulum exit site; MAP1B; microtubule-associated protein 1B; HC; heavy chain; LC1; light chain 1; ALG-2; apoptosis-linked gene 2; ABM; ALG-2 binding motif; KO; knockout; Nluc;
Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds
Keywords: زنجیره سنگین; MPER; membrane-proximal external region; TMD; transmembrane domain; Env; HIV-1 envelope glycoprotein; MD; molecular dynamics; bNAb; broadly neutralizing antibody; CDR-H3; complementarity-determining region three of the heavy chain; HC; heavy chain; WT; wi
Comparison of SEC and CE-SDS methods for monitoring hinge fragmentation in IgG1 monoclonal antibodies
Keywords: زنجیره سنگین; CE-SDS; SEC; Fragmentation; Antibody; Electrophoresis; IgG; immunoglobulin; HC; heavy chain; LC; light Chain; HL; heavy-light; HH; heavy-heavy; HHL; heavy-heavy-light; NGH; non-glycosylated heavy chain; LMW; low molecular weight; mAb; monoclonal antibody;
Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants
Keywords: زنجیره سنگین; FCRL5; Fc receptor-like 5; H chain; heavy chain; SPR; surface plasmon resonance; RU; relative unit; Charge variants; Deamidation; IgG2; Disulfide isoform; Surface plasmon resonance;
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
Keywords: زنجیره سنگین; BoNTs; botulinum neurotoxins; BoNT/A; botulinum neurotoxin serotype A; HC; heavy chain; LC; light chain; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; SNAP-25; 25Â kDa synaptosomal-associated protein; BIG-IV; Botulism Immun
A novel therapeutic with two SNAP-25 inactivating proteases shows long-lasting anti-hyperalgesic activity in a rat model of neuropathic pain
Keywords: زنجیره سنگین; Neuropathic pain; Botulinum neurotoxin; SNAREs; Analgesics; BoNT; botulinum neurotoxin; BoTIM/A; protease-inactive mutant of BoNT/A; CGRP; calcitonin gene-related peptide; DAS; digit abduction score; DC; di-chain; DTT; dithiothreitol; HC; heavy chain; HN;
Immuno-detection of cleaved SNAP-25 from differentiated mouse embryonic stem cells provides a sensitive assay for determination of botulinum A toxin and antitoxin potency
Keywords: زنجیره سنگین; BoNT/A; botulinum neurotoxin A; SNAP-25; synaptosomal protein of molecular mass 25Â kDa; EB; embryoid bodies; ESDN; embryonic stem cell-derived neurons; mESC; mouse embryonic stem cells; HC; heavy chain; LC; light chain; LHn/A; recombinant endopeptidase f
Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis
Keywords: زنجیره سنگین; Ab; Antibodies; ADCC; Antibody-dependent cellular cytotoxicity; Ag; Antigen; BLAST; Basic local alignment search tool; BSA; Bovine serum albumin; CDC; Complement-dependent cytotoxicity; CDRs; Complementarity determining regions; CHO; Chinese hamster ovary
Sequential screening by ClonePix FL and intracellular staining facilitate isolation of high producer cell lines for monoclonal antibody manufacturing
Keywords: زنجیره سنگین; ClonePix FL; NS0; Chinese hamster ovary cells; Intracellular staining; Flow cytometry high throughput screening; IgG expression; Heavy chain; Light chain; Probability of monoclonality; Semi-solid media;
In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics
Keywords: زنجیره سنگین; BINACLE; binding and cleavage assay; BoNT; botulinum neurotoxin; BSA; bovine serum albumin; GT1b; ganglioside GT1b; H-chain; heavy chain; HCc; C-terminal region of the H-chain; L-chain; light chain; LD50; lethal dose for 50% of test animals; NAP; neurotox
ReviewBotulinum neurotoxin type A: Actions beyond SNAP-25?
Keywords: زنجیره سنگین; BoNT/A; botulinum neurotoxin type A; HC; heavy chain; LC; light chain; SNAP-25; synaptosomal-associated protein of 25Â kDa; SV2; synaptic vesicle protein 2; SNARE; soluble N-ethylmaleimide-sensitive factor attachment protein receptor; VAMP; vesicle-associ
Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein
Keywords: زنجیره سنگین; rFVIIIFc; Human cell line; HEK 293H; Hemophilia A; Manufacturing; Recombinant; aPTT; activated partial thromboplastin time; α-Gal; galactose-α-1,3-galactose; BDD; B domain-deleted; FcRn; neonatal Fc receptor; FVIII; factor VIII; HC; heavy chain; HCP; ho
Characterization of cysteine related variants in an IgG2 antibody by LC-MS with an automated data analysis approach
Keywords: زنجیره سنگین; IgG2; Monoclonal antibody; Disulfide; Free sulfhydryls and cysteine; LC-MS; nrRP-HPLC; Pinpoint software; ACN; acetonitrile; AEX; anion-exchange chromatography; CEX; cation-exchange chromatography; CHO; Chinese hamster ovary; ESI; electrospray ionizatio
Transcriptome analysis of a CHO cell line expressing a recombinant therapeutic protein treated with inducers of protein expression
Keywords: زنجیره سنگین; CHO; Chinese hamster ovary; DHFR; dihydrofolate reductase; GO; gene ontology; GS; glutamine synthetase; GSEA; gene set enrichment analysis; HC; heavy chain; HMBA; hexamethylene bisacetamide; IgG1; human immunoglobulin G1; IRES; internal ribosome entry sit
Distribution of the LDL receptor within clathrin-coated pits and caveolae in rat and human liver
Keywords: زنجیره سنگین; LDL; low density lipoprotein; VLDL; very low density lipoprotein; LDLRAP1; LDL receptor adaptor protein-1; CH; cholesterol; ZA; zaragozic acid A; HC; heavy chain; TS; Triton soluble; TI; Triton insoluble; LDL receptor; Clathrin; Caveolin-1; Rat liver; Hum
Progress in HIV-1 vaccine development
Keywords: زنجیره سنگین; HIV-1; vaccine; T cells; B cells; broadly neutralizing antibodies; ADCC; Antibody-dependent cellular cytotoxicity; BCR; B-cell antigen receptor; bnAb; Broad neutralizing antibody; Env; Envelope; gp; Glycoprotein; HC; Heavy chain; HCDR3; Immunoglobulin thi
Assessment of naturally occurring covalent and total dimer levels in human IgG1 and IgG2
Keywords: زنجیره سنگین; DTT; dithiothreitol; EDTA; ethylene diamine tetraacetic acid; GFB; glufibrinopeptide B; HC; heavy chain; HL; half molecule; LC; light chain; LC/MS; liquid chromatography/mass spectrometry; NEM; N-ethylmaleimide; SDS-PAGE; sodium dodecyl sulfate-polyacryla
Retrocyte Display® technology: Generation and screening of a high diversity cellular antibody library
Keywords: زنجیره سنگین; A-MuLV; Abelson murine leukemia virus; BCR; B cell receptor; BiP; binding immunoglobulin protein; CDR; complementarity determining region; DR6; death receptor 6; FACS; fluorescence activated cell sorting; FCS; fetal calf serum; IRES; internal ribosome ent
Human leukocyte antigen (HLA)-G and cervical cancer immunoediting: A candidate molecule for therapeutic intervention and prognostic biomarker?
Keywords: زنجیره سنگین; 3â²UTR; untranslated region; 5â²URR; upstream regulatory region; ADC; cervical adenocarcinoma; AGUS; atypical glandular cells; APC; antigen presenting cells; ATG; start codon; Cd; cytoplasmatic domain; CD; cluster of differentiation; CIN; cervical intra
Hemorrhagin VaH4, a covalent heterodimeric P-III metalloproteinase from Vipera ammodytes ammodytes with a potential antitumour activity
Keywords: زنجیره سنگین; Vipera ammodytes ammodytes; Snake venom; Hemorrhagin; Metalloproteinase; Structure; Antitumour; ACN; acetonitrile; ADAM; a disintegrin and metalloproteinase; ADAMTS; ADAM with thrombospondin type-1 motif; BM; basement membrane; BSA; bovine serum albumin;
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Keywords: زنجیره سنگین; BafA1; bafilomycin A1; BoNT/X; botulinum neurotoxin/serotype X; CGNs; cerebellar granule neurons; FBS; foetal bovine serum; HC; heavy chain; HC; C-terminal half of HC; HCC; C-terminal domain of the HC-fragment; HCN; N-terminal domain of the HC-fragment; H
Easy expression of the C-terminal heavy chain domain of botulinum neurotoxin serotype A as a vaccine candidate using a bi-cistronic baculovirus system
Keywords: زنجیره سنگین; ACh; acetylcholine; AcMNPV; Autographa californica multiple polyhedrosis virus; BEVS; baculovirus expression vector system; BoNT/A; botulinum toxin A; EGFP; enhanced green fluorescent protein; ELISA; enzyme-linked immunosorbent assay; HC; heavy chain; IMA
Effects of enzymatically inactive recombinant botulinum neurotoxin type A at the mouse neuromuscular junctions
Keywords: زنجیره سنگین; Non-toxic botulinum neurotoxin A; Neuromuscular junction; Acetylcholine release; Nerve muscle preparation; Deactivated; Recombinant botulinum neurotoxin A; BoNT/A; Botulinum neurotoxin A; DrBoNT/A; deactivated recombinant BoNT/A; ACh; acetylcholine; NMPs;
B-cell biology and development
Keywords: زنجیره سنگین; B cell; B lymphocyte; immunodeficiency; development; humoral immunity; autoimmunity; tolerance; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B-cell activator of the TNF-α family (aka BLYS); BAFF-R; BAFF recept
The bovine genomic DNA sequence data reveal three IGHV subgroups, only one of which is functionally expressed
Keywords: زنجیره سنگین; BTA, Bos taurus chromosome; HTGS, unfinished high throughput genomic sequences; WGS, whole genome shotgun; EST, expressed sequence tagImmunoglobulin; Heavy chain; Variable segment; Germline repertoire; Bovine; Cattle; Genome
Production and characterization of monoclonal antibodies to IgM of Pacific herring (Clupea pallasii)
Keywords: زنجیره سنگین; Monoclonal antibody; IgM; Heavy chain; Clupeidae
Integrated control of axonemal dynein AAA+ motors
Keywords: زنجیره سنگین; HC; heavy chain; LC; light chain; IC; intermediate chain; AAA+ domain; Cilia; Dynein; Flagella; Microtubule;
The role of classical and non-classical HLA class I antigens in human tumors
Keywords: زنجیره سنگین; APM; antigen processing machinery; β2-m; β2-microglobulin; CALR; calreticulin; CANX; calnexin; CTL; cytotoxic T lymphocyte; DAC; 5-aza-2â²-deoxycytidine; ER; endoplasmic reticulum; ERAP; ER aminopeptidase associated with antigen processing; HC; heavy c
Monoclonal antibody to serum immunoglobulins of Clarias batrachus and its application in immunoassays
Keywords: زنجیره سنگین; APES; 3-aminopropyltriethoxysilane; BSA; bovine serum albumin; c-ELISA; competitive ELISA; Cb-Ig; Clarias batrachus immunoglobulins; DAB; 3â3â² diaminobenzidine; DMEM; Dulbecco's Modified Eagle Medium; FITC; fluorescein isothiocyanate; FSC; forward sca
B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients
Keywords: زنجیره سنگین; L-chain; light chain; H-chain; heavy chain; VL gene; light chain V gene; SLE; systemic lupus erythematosus; Receptor editing; Light chain; B cell repertoire; SLE;
B lymphopoiesis is characterized by pre-B cell marker gene expression in fetal cattle and declines in adults
Keywords: زنجیره سنگین; BREC; B cell recombination excision circle; HC; heavy chain; IGLL1; immunoglobulin lambda like polypeptide-1; IPP; ileal Peyer's patch; LC; light chain; RT-qPCR; reverse transcription qPCR; VPREB; pre-B lymphocyte gene; B lymphopoiesis; Pre-B cell; Surr
Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)
Keywords: زنجیره سنگین; aa; amino acid; C; Ig constant region; H; heavy chain; Ig; immunoglobulin; L; light chain; mAb; monoclonal antibody; MYA; million years ago; Sec; secretory tail; Tm; transmembrane region; V; Ig variable region; Evolution; Cartilaginous fish; Adaptive immu