Keywords: مسیر سیگنالینگ یخچال; α-CGRP; alpha-calcitonin gene related peptide; Ang; angiopoietin; AE2; anion exchanger 2; ADP; adenosine diphosphate; ADPKD; autosomal dominant polycystic kidney disease; ATP; adenosine triphosphate; ASBT; sodium-dependent bile acid transporter; AQP; aqu
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Keywords: مسیر سیگنالینگ یخچال; Cyclopamine; Tumor extracellular matrix; Nanotherapeutics; Pancreatic cancer; Hedgehog signaling pathway;
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Smoothened; Antagonist; GPCR; Scaffold hopping; Cancer therapyAUC, area under curve; CE, collision energy; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; DP, declus
Keywords: مسیر سیگنالینگ یخچال; AKT inhibitor; autoimmune adverse effects; autoimmune dermopathies; B-RAF; dabrafenib; dermatitis; dual inhibitor; dysgeusia; everolimus; hair loss; hedgehog signaling pathway; immunotherapy; immune-related toxicities; ipilimumab; keratoacanthoma; keratos
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Inhibitors; SAR; Pharmacokinetic properties;
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Inhibitors; Five-membered heteroaromatic ring fused-pyrimidine; Synthesis;
Keywords: مسیر سیگنالینگ یخچال; Resveratrol; Epithelial-to-mesenchymal transition (EMT); Renal fibrosis; Hedgehog signaling pathway;
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Inhibitors; Anti-tumor agents; Benzylphthalazines
Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties
Keywords: مسیر سیگنالینگ یخچال; Vismodegib; Hedgehog signaling pathway; Basal cell carcinoma; Deuterated drug; Deuterium-hydrogen replacement; Pharmacokinetic properties;
LncRNA ASAP1-IT1 positively modulates the development of cholangiocarcinoma via hedgehog signaling pathway
Keywords: مسیر سیگنالینگ یخچال; CCA; ASAP1-IT1; Proliferation; Migration; Hedgehog signaling pathway;
Smoothened stabilizes and protects TRAF6 from degradation: A novel non-canonical role of smoothened with implications in lymphoma biology
Keywords: مسیر سیگنالینگ یخچال; SMO; TRAF6; Diffuse large B cell lymphoma; Hedgehog signaling pathway;
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor
Keywords: مسیر سیگنالینگ یخچال; Wnt signaling pathway; Hedgehog signaling pathway; Porcupine; Smoothened; Antagonist; Stem cell; Cancer therapy; AUC; area under the plasma time-concentration curve; BCC; basal cell carcinoma; BPO; benzoyl peroxide; CL; clearance; CSC; cancer stem cells;
Studies directed toward synthesis of taepeenin D: construction of the C4 stereogenic center and the CD benzofuran rings
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Taepeenin D; Cyclic ether formation; Regioselective C-C bond formation; Benzofuran;
A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Phase 1; Cetuximab; Combination therapy; Head and neck squamous cell carcinoma;
Aldehyde dehydrogenase 1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular cancer
Keywords: مسیر سیگنالینگ یخچال; Aldehyde dehydrogenase 1A1; Transcription factor Gli2; Hedgehog signaling pathway; Hepatocellular cancer;
Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism
Keywords: مسیر سیگنالینگ یخچال; NIMA-related expressed kinase 2A; Suppressor of fused; Phosphorylation; Transcription factor Gli2; Hedgehog signaling pathway;
Chondroprotective effects of palmatine on osteoarthritis in vivo and in vitro: A possible mechanism of inhibiting the Wnt/β-catenin and Hedgehog signaling pathways
Keywords: مسیر سیگنالینگ یخچال; Osteoarthritis; Palmatine; Wnt signaling pathway; Hedgehog signaling pathway; Interleukin-1β; Matrix metalloproteinase
Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives
Keywords: مسیر سیگنالینگ یخچال; Stem cells; Smoothened agonists; Structure-activity relationships; Osteogenic activity; Heterocycle; Synthesis; Pharmacophore; Hedgehog signaling pathway;
Hedgehog inhibitors from Withania somnifera
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Inhibitor; Natural product; Withania somnifera
Vitamin D3 analogues that contain modified A- and seco-B-rings as hedgehog pathway inhibitors
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Vitamin D3; Gli; Basal cell carcinoma; MedulloblastomaHh, Hedgehog; Gli, glioblastoma associated oncogene; Cyp24a1, 1,25-dihydroxyvitamin D3 24-hydroxylase; VD3, vitamin D3; VDR, vitamin D receptor
Stable knockdown of protein kinase CK2-alpha (CK2α) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells
Keywords: مسیر سیگنالینگ یخچال; HCC; CK2α; MMPs; EMT process; Hedgehog signaling pathway;
Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Inhibitors; Pyrrolo[2,1-f][1,2,4]triazine; Novel
Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer
Keywords: مسیر سیگنالینگ یخچال; Hedgehog Signaling Pathway; Non-small cell lung cancer; ALDH1A1; Immunohistochemistry; Clinical outcome
Nonmelanoma Skin Cancer of the Head and Neck
Keywords: مسیر سیگنالینگ یخچال; Molecular; Genetic; Cancer genetics; Carcinogenesis; Ultraviolet radiation; Hedgehog signaling pathway;
Mechanisms of Disease Progression in NASH
Keywords: مسیر سیگنالینگ یخچال; NASH; Nonalcoholic steatohepatitis; Hedgehog signaling pathway; Hepatocellular carcinoma; Cirrhosis; Hepatic fibrosis;
Hedgehog signal inhibitor forskolin suppresses cell proliferation and tumor growth of human rhabdomyosarcoma xenograft
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Gli1; Forskolin; Rhabdomyosarcoma; Xenograft
Resveratrol Inhibits Proliferation and Induces Apoptosis through the Hedgehog Signaling Pathway in Pancreatic Cancer Cell
Keywords: مسیر سیگنالینگ یخچال; Resveratrol; Pancreatic cancer; Hedgehog signaling pathway; Proliferation; Apoptosis;
Potent agonists of the Hedgehog signaling pathway
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Agonist; SAR study; Small molecule;
Hedgehog and adipogenesis: Fat and fiction
Keywords: مسیر سیگنالینگ یخچال; Hedgehog signaling pathway; Gli1; Ihh; Adipocyte differentiation; Fat mass; Obesity; Lipodystrophy
Hedgehog signaling in small-cell lung cancer: Frequent in vivo but a rare event in vitro
Keywords: مسیر سیگنالینگ یخچال; Small-cell lung cancer; SCLC; Hedgehog signaling pathway; Cyclopamine; siRNA; HH; hedgehog; HHIP; hedgehog interacting protein; NSCLC; non-SCLC; PTCH; Patched; RNAi; RNA interference; SCLC; small-cell lung cancer; SHH; Sonic hedgehog; siRNA; small interfe
Role of apoptosis in basal cell and squamous cell carcinoma formation
Keywords: مسیر سیگنالینگ یخچال; Skin tumors; Basal cell carcinoma; Apoptosis; p53; Hedgehog signaling pathway; RNA interference;