کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1953284 1057262 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hedgehog and adipogenesis: Fat and fiction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Hedgehog and adipogenesis: Fat and fiction
چکیده انگلیسی

Morphogenes, abundantly described during embryogenesis have recently emerged as crucial modulators of cell differentiation processes. Hedgehog signaling, the dysregulation of which causing several pathologies such as congenital defects and cancer, is involved in several cell differentiation processes including adipogenesis. This review presents an overview of the relations between Hedgehog signaling, adipocyte differentiation and fat mass. While the anti-adipogenic role of Hedgehog signaling seems to be established, the effect of Hedgehog inhibition on adipocyte differentiation in vitro remains debated. Finally, Hedgehog potential as a pharmacological target to treat fat mass disorders is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 89, Issue 12, December 2007, Pages 1447–1453
نویسندگان
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