Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines
Keywords: Nuclear receptor; HCC; HBV; HDAC; Hepatocarcinogenesis
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Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats
Keywords: Black currant; Diethylnitrosamine; Hepatocarcinogenesis; Chemoprevention; Cell proliferation; Apoptosis
Hepatitis B and C virus hepatocarcinogenesis: Lessons learned and future challenges
Keywords: Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Hepatocarcinogenesis; Liver;
Supplementation of selenium reduces chemical hepatocarcinogenesis in male Sprague-Dawley rats
Keywords: DEN; Hepatocarcinogenesis; SeleniumDEN, diethyl nitrosamine; 2-AA F, 2-acetylaminofluorene; PH, partial hepatectomy; GST-P, glutathione S-transferase-placental
Absence of chemopreventive influence of propolis on the rat liver altered foci development
Keywords: Propolis; Diethylnitrosamine; Hexachlorobenzene; GST-P-positive foci; Hepatocarcinogenesis; Wistar rats
Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions
Keywords: Marker; Hepatocarcinogenesis; Proteomics; CK8/18-positive foci
Pfaffia paniculata (Brazilian ginseng) roots decrease proliferation and increase apoptosis but do not affect cell communication in murine hepatocarcinogenesis
Keywords: Cancer; Hepatocarcinogenesis; Chemoprevention; Proliferation; Apoptosis; Saponin; Phytochemicals; Medicinal plants; Brazilian ginseng; Pfaffia paniculata
Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
Keywords: Chemoprevention; Chemotherapy; Clinical study; Hepatocarcinogenesis; Hepatocellular carcinoma; In vitro; In vivo; Liver; Pharmacokinetics; Resveratrol
Basic-Liver, Pancreas, and Biliary TractIncreased Expression of iASPP, Regulated by Hepatitis B Virus X Protein-Mediated NF-κB Activation, in Hepatocellular Carcinoma
Keywords: Hepatocarcinogenesis; Transcriptional Regulation; Chemoresistance; Apoptosis; AFP; α-fetoprotein; ASPP; ankyrin-repeat-, SH3-domain- and proline-rich-region-containing protein; bp; base pair; ChIP; chromatin-immunoprecipitation; EMSA; electrophoretic mob
Human hepatocellular carcinoma: Expression profiles-based molecular interpretations and clinical applications
Keywords: Affymetrix microarrays; cDNA-spotted DNA microarray; Differential gene expression profiling; HBV; HCV; Hepatocellular carcinoma (HCC); Hepatocarcinogenesis; HSV-1 amplicon vector; Iron homeostasis; Liver-specific uncoupling protein; Prediction of recurren
Human health risk assessment for peroxisome proliferators: More than 30 years of research
Keywords: Peroxisome proliferator (PP); Peroxisome proliferator-activated receptor α (PPARα); Oxidative stress; Apoptosis; Cell proliferation; Hepatocarcinogenesis
Incidence of hepatocellular carcinoma in hepatitis C carriers with normal alanine aminotransferase levels
Keywords: Hepatocellular carcinoma; Hepatocarcinogenesis; Hepatitis C virus; Normal ALT; Average integration value;
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation
Keywords: 2-Acetylaminofluore; Hepatocarcinogenesis; Cell proliferation; Apoptosis; p53; MicroRNA
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas
Keywords: Proteomics; GST-P positive foci; Hepatocarcinogenesis
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: Inhibition of cell proliferation and induction of apoptosis
Keywords: Resveratrol; Diethylnitrosamine; Phenobarbital; Hepatocarcinogenesis; Chemoprevention; Cell proliferation; Apoptosis; Bax; Bcl-2; Rat; Liver;
Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis
Keywords: o-Aminoazotoluene; Hepatocarcinogenesis; Susceptibility; Mitoinhibition; p53
Tomato oleoresin inhibits DNA damage but not diethylnitrosamine-induced rat hepatocarcinogenesis
Keywords: Chemoprevention; Diethylnitrosamine; DNA damage; GST-P liver foci; Hepatocarcinogenesis; Tomato oleoresin; Lycopene;
Temporal treatment with interferon-β prevents hepatocellular carcinoma in hepatitis B virus X gene transgenic mice
Keywords: Interferon-β; Hepatocarcinogenesis; Temporal treatment; Hepatitis B virus X gene; Transgenic mouse; DNA synthesis; Cell cycle; Primary hepatocyte culture; WRL-68;
A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats
Keywords: Toxicogenomics; Rat; Liver; Hepatocarcinogenesis; Non-genotoxic
Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice
Keywords: Chelidonium majus; p-DAB; PB; Hepatocarcinogenesis; Anti-tumor; Toxicity marker enzymes; Anti-carcinogen; Mice
Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis
Keywords: Hydroquinone; Antioxidants; Hepatocarcinogenesis; DNA adducts; Cell proliferation; Hepatocellular altered foci
High sensitivity of fatty liver Shionogi (FLS) mice to diethylnitrosamine hepatocarcinogenesis: Comparison to C3H and C57 mice
Keywords: hepatocarcinogenesis; diethylnitrosamine; fatty liver; DNA oxidative stress
Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage
Keywords: Hepatocarcinogenesis; Chemoprevention; Lutein; Blocking agent; Suppressing agent; DNA damage
Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure
Keywords: MiRNAs; Tamoxifen; Rat; Hepatocarcinogenesis
Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis
Keywords: Tamoxifen; Rat; Hepatocarcinogenesis; Gene expression;
Cell proliferation and hepatocarcinogenesis in rat initiated by diethylnitrosamine and promoted by phenobarbital: Potential roles of early DNA damage and liver metallothionein expression
Keywords: Cell proliferation; Diethylnitrosamine; DNA-strand breaks; Hepatocarcinogenesis; Ki-67; Metallothionein;
Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: Chemopreventive role of vanadium on this process
Keywords: Vanadium; Hepatocarcinogenesis; DNA adduct; Ethylguanines; 8-OHdGs; DNA strand-break
Expression of inducible nitric oxide (NO) synthase but not prevention by its gene ablation of hepatocarcinogenesis with fibrosis caused by a choline-deficient, l-amino acid-defined diet in rats and mice
Keywords: iNOS expression; iNOS knockout; Hepatocarcinogenesis; Fibrosis; Choline-deficiency
Hepatocellular carcinoma development in cirrhosis
Keywords: hepatocellular carcinoma; cirrhosis; hepatitis B virus; hepatitis C virus; hepatocarcinogenesis
Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
Keywords: Hepatitis B virus; Hepatocellular carcinoma; Hepatitis B x antigen; Genetic changes; Oncogenes; Tumor suppressor genes; MicroRNAs; Loss of heterozygosity; Hepatocarcinogenesis; Fragile sites; Genetic instability; Tumor suppressors
Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats
Keywords: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline; Cancer risk assessment; Hepatocarcinogenesis; No-observed effect level; Strain differences; 2-AFF; 2-acetylaminofluorene; DEN; diethylnirtrosamine; GST-P; glutathione S-transferase placental form; MeIQx; 2-am
Oxidative stress and hepatitis C viral infection
Keywords: Oxidative stress; Hepatitis C virus; Hepatocarcinogenesis; Lipid peroxidation; Steatosis; Insulin resistance;
Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice
Keywords: Piperonyl butoxide; Non-genotoxic carcinogen; Hepatocarcinogenesis; Oxidative stress; Mouse
Molecular basis of anticlastogenic potential of vanadium in vivo during the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats
Keywords: 8-OHdG; DNA strand-breaks; DNA–protein crosslinks; Chromosomal aberrations; Vanadium; Hepatocarcinogenesis
Vanadium inhibits the development of 2-acetylaminofluorene-induced premalignant phenotype in a two-stage chemical rat hepatocarcinogenesis model
Keywords: Vanadium; Hepatocarcinogenesis; GGT; PCNA; Chromosomal aberrations
Gene Expression Profile Related to the Progression of Preneoplastic Nodules toward Hepatocellular Carcinoma in Rats
Keywords: Hepatocarcinogenesis; transcriptomic; redox control; cancer markers; glutathione metabolism; HCC; hepatocellular carcinoma; DEN; diethylnitrosamine; 2-AAF; 2-acetylaminofluorene; GSTP; glutathione S-transferase, placental form; GGT; γ-glutamyl transpepti
Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment
Keywords: Mutation model; Color-shift model; Hepatocarcinogenesis; Cramer–von-Mises distance; Foci of altered hepatocytes; GSTP staining
Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition
Keywords: Hepatocarcinogenesis; Genetic predisposition; Quantitative trait loci; Modifier genes; Polygenic disease; Redifferentiation
Hepatitis C as a metabolic disease: Implication for the pathogenesis of NASH
Keywords: Diabetes; Hepatitis C virus; Insulin resistance; NASH; Hepatocarcinogenesis; Transgenic mouse;
Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats
Keywords: Embelin; Curcumin; N-nitrosodiethylamine; Phenobarbital; Hepatocarcinogenesis;
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model
Keywords: Hepatocarcinogenesis; Pfaffia paniculata; Liver; Cancer; Chemoprevention; DEN; diethylnitrosamine; H and E; hematoxilin and eosin;
Oxidative stress in carcinogenesis. Correlation between lipid peroxidation and induction of preneoplastic lesions in rat hepatocarcinogenesis
Keywords: Oxidative stress; Initiation; Lipid peroxidation; Preneoplastic lesions; Hepatocarcinogenesis;
Cytotoxic and genotoxic effects of the azo-dye p-dimethylaminoazobenzene in mice: A time-course study
Keywords: Hepatocarcinogenesis; p-Dimethylaminoazobenzene; Genotoxicity; Tumour marker enzymes;
Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model
Keywords: 1H-NMR Spectroscopy; Hepatocarcinogenesis; Rat; Lipid; In vivo;
Celecoxib, a cyclooxygenase-2 inhibitor, prevents induction of liver preneoplastic lesions in rats
Keywords: Selective cyclooxygenase-2 inhibitor; Chemoprevention; Hepatocarcinogenesis; 2-AAF; 2-acetylaminofluorene; COX; cyclooxygenase; DEN; diethylnitrosamine; GGT; γ-glutamyltranspeptidase; GST-P; glutathione S-transferase placental form; HPT; hepatocarcinogen
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: Possible mechanisms
Keywords: DDT; 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane; DEN; N-diethylnitrosamine; GST-P; glutathione-S-transferase placental form; PCNA; proliferating cell nuclear antigen; ssDNA; single-stranded DNA; DAB; 3,3â²-diaminobenzidine; 8-OHdG; 8-hydroxy-2â²-deox
Lack of direct mitogenic activity of dichloroacetate and trichloroacetate in cultured rat hepatocytes
Keywords: Trichloroethylene; Dichloroacetate; Trichloroacetate; Hepatocyte replication; Hepatocarcinogenesis; Peroxisome proliferators;
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat
Keywords: Antioxidant; Diethylnitrosamine; Erythrocytes; Glutathione; Hepatocarcinogenesis; Phenobarbital; Solanum trilobatum; Solanine; Solamarine; Solasodine;
Role of PPARα in mediating the effects of phthalates and metabolites in the liver
Keywords: PPARα; Peroxisome proliferation; Phthalate esters; Activation; Hepatocarcinogenesis;
Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths
Keywords: Grape seed proanthocyanidins; DMN; Mice; Hepatocarcinogenesis; DNA damage; Apoptosis; Prevention;