Efficient production of recombinant adeno-associated viral vector, serotype DJ/8, carrying the GFP gene
Keywords: hepatocytes; AAV; GFP; serotype DJ/8; Hepatocytes;
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Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP
Keywords: hepatocytes; Type 2 inositol 1,4,5-trisphosphate receptor; Calcium signaling; Hepatocytes; Bile secretion; Cyclic AMP;
Hepatobiliary transport kinetics of the conjugated bile acid tracer 11C-CSar quantified in healthy humans and patients by positron emission tomography
Keywords: hepatocytes; Functional molecular imaging of the liver; Cholestasis; Hepatic transport kinetics; Bile acid transporter; Hepatocytes; Bile acids and salts; Kinetics; Positron-emission tomography;
The Delivery of Small Interfering RNA to Hepatic Stellate Cells Using a Lipid Nanoparticle Composed of a Vitamin A-Scaffold Lipid-Like Material
Keywords: hepatocytes; siRNA; drug delivery systems; site-specific delivery; liposomes; hepatocytes;
Pharmacokinetics and pharmacodynamics of thiopurines in an in vitro model of human hepatocytes: Insights from an innovative mass spectrometry assay
Keywords: hepatocytes; Hepatocytes; Azathioprine; Mercaptopurine; Thiopurines metabolites; LC-MS/MS;
Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men
Keywords: hepatocytes; Chemerin; Hepatocytes; Inflammation; TNF; Type 2 diabetes;
Antioxidant and anti-inflammatory effects of Chinese propolis during palmitic acid-induced lipotoxicity in cultured hepatocytes
Keywords: hepatocytes; Propolis; Polyphenols; Lipoapoptosis; Hepatocytes; NAFLD;
Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism
Keywords: hepatocytes; albumin-mediated uptake; clearance; DDI; drug interaction; hepatocytes; IVIVE; IPRL; pharmacokinetics; PBPK models;
Muscarinic receptor mediated signaling pathways in hepatocytes from CCL4 - induced liver fibrotic rat
Keywords: hepatocytes; Muscarinic acetylcholine receptors; Hepatocytes; Hepatic fibrosis; Cell signaling pathway;
In vitro metabolism of [14C]-benalaxyl in hepatocytes of rats, dogs and humans
Keywords: hepatocytes; Benalaxyl; Comparative in vitro metabolism; Cryopreserved; Hepatocytes;
Controlling the selective and directional migration of hepatocytes by a complementary density gradient of glycosylated hyperbranched polymers and poly(ethylene glycol) molecules
Keywords: hepatocytes; Directional cell migration; Selective cell adhesion; Complementary gradient; Hepatocytes; Carbohydrate-protein interaction;
Cross-interference of two model peroxisome proliferators in peroxisomal and estrogenic pathways in brown trout hepatocytes
Keywords: hepatocytes; PPARα; Estrogens; Peroxisomes; Hepatocytes; Brown trout;
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
Keywords: hepatocytes; NAFLD; NLRP3; Inflammasomes; Cholesterol crystals; Kupffer cells; Hepatocytes; Interleukin-1β; Fibrosis; Diet, atherogenic; Methionine; NLR proteins;
Cytotoxicity and apoptosis induced by mixed mycotoxins (T-2 and HT-2 toxin) on primary hepatocytes of broilers in vitro
Keywords: hepatocytes; T-2/HT-2 toxin; Cytotoxicity; Apoptosis; Liver toxicity; Hepatocytes; T-2; T-2 toxin; HT-2; HT-2 toxin; Bcl-2; B-cell lymphoma 2; Bax; Bcl-2 Associated X protein; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; TUNEL; Terminal transfera
Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis
Keywords: hepatocytes; Microcystin; Apoptosis; Hepatocytes; Transporters; Necrosis; Primary human hepatocytes;
Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes
Keywords: hepatocytes; Celastrol; Mitochondrial dysfunction; Inflammation; Insulin resistance; Hepatocytes;
Oxygen transport in hollow fibre membrane bioreactors for hepatic 3D cell culture: A parametric study
Keywords: hepatocytes; Hollow fibre membrane bioreactor; Oxygen uptake; Mass transport; Hepatocytes; Spheroids;
A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures
Keywords: hepatocytes; Animal alternatives; Fish; Morphology; Hepatocytes; Cytochrome P450 1A (Cyp1a); Polycyclic aromatic hydrocarbons (PAHs);
Concept: The Use of Targeted Immunoaffinity Proteomics for Routine Assessment of In Vitro Enzyme Induction
Keywords: hepatocytes; drug interactions; cytochrome P450; CYP enzymes; induction; hepatocytes; in vitro models; in vitro-in vivo correlations (IVIVC); proteomics;
Hepatotoxicity of fusariotoxins, alone and in combination, towards the HepaRG human hepatocyte cell line
Keywords: hepatocytes; Co-exposure; Cytotoxicity; Fusariotoxins; Hepatocytes; Human; Molecular markers;
Annexin A6 in the liver: From the endocytic compartment to cellular physiology
Keywords: hepatocytes; ABC; adenosine triphosphate binding cassette transporters; AEE; apical early endosomes; AnxA6; annexin group A; ARE; apical recycling endosomes; ASGP; asialoglycoprotein receptor; BFA; Brefeldin A; BEE; basolateral early endosomes; CaM; calmodulin; Cav-1;
Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?
Keywords: hepatocytes; transporters; drug interaction; hepatocytes; pharmacokinetics/pharmacodynamics; protein binding; AFE; average fold error; AUC; area under the curve; BSA; bovine serum albumin; CLBile; biliary clearance; CLBL; basolateral efflux clearance; CLUptake; uptake
Oxidative and ER stress-dependent ASK1 activation in steatotic hepatocytes and Kupffer cells sensitizes mice fatty liver to ischemia/reperfusion injury
Keywords: hepatocytes; HP; hepatocytes; KC; Kupffer cells; I/R; ischemia-reperfusion; OS; oxidant species; PA; palmitic acid; ND; normal diet; HFD; high fat diet; ANOVA; analysis of variance; CD; control diet; JNK; c-Jun N-terminal kinase-1/2; ASK1; Apoptosis signal-regulating
Comparative whole genome analysis of dengue virus serotype-2 strains differing in trans-endothelial cell leakage induction in vitro
Keywords: hepatocytes; Vascular leakage; Dengue virus serotype 2; Endothelial cells; Hepatocytes; Infectivity; Genetic changes; Secretory NS1;
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data
Keywords: hepatocytes; clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b
Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations
Keywords: hepatocytes; hepatic clearance; hepatic transport; hepatobiliary disposition; hepatocytes; transporters; ABT; 1-aminobenzotriazole; Bcrp; breast cancer resistance protein; BDDCS; Biopharmaceutial Drug Disposition Classification System; BEI; biliary excretion index; Ca
Testosterone-induced modulation of peroxisomal morphology and peroxisome-related gene expression in brown trout (Salmo trutta f. fario) primary hepatocytes
Keywords: hepatocytes; Fish; Flutamide; Hepatocytes; ICI 182,780; Peroxisomes; Testosterone;
Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Keywords: hepatocytes; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c
Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches
Keywords: hepatocytes; active transport; cytochrome P450; glucuronosyltransferase (UGT); hepatic clearance; hepatic transport; hepatocytes; membrane transport/transporters; organic anion transporting polypeptide transporters; transporters; AUC; area under the plasma concentrati
Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions
Keywords: hepatocytes; Hepatitis B virus; Stem cell; Model; Antivirals; Antiviral agents; Hepatocytes; DNA; Viral;
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
Keywords: hepatocytes; Transmembrane 6 superfamily member 2; Triglycerides; Cholesterol esters; Arachidonic acid; Phosphatidylcholines; Non-alcoholic fatty liver disease; Lipogenesis; Genotype; Hepatocytes; Fatty acids;
Pretreatment With Rifampicin and Tyrosine Kinase Inhibitor Dasatinib Potentiates the Inhibitory Effects Toward OATP1B1- and OATP1B3-Mediated Transport
Keywords: hepatocytes; drug transport; drug interactions; organic anion-transporting polypeptide transporters; hepatocytes; hepatic transport; pharmacokinetics; physiologically based pharmacokinetic modeling; AUC; area under the plasma concentration-time curve; CsA; cyclosporin
Influence of Novosibirsk Terahertz free Electron Laser Radiation on the Morphology of Chicken Hepatocytes
Keywords: hepatocytes; hepatocytes; erythrocytes; THz laser radiation; atomic-force microscopy ;;
Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification
Keywords: hepatocytes; High content screening; Image analysis; Open-source software; Assay development; Co-culture; Hepatocytes;
Homocysteine upregulates hepcidin expression through BMP6/SMAD signaling pathway in hepatocytes
Keywords: hepatocytes; Hyperhomocysteinemia; Homocysteine; Hepcidin; BMP6/SMAD; Hepatocytes; ALK2; activin receptor-like kinase 2; ALK3; activin receptor-like kinase 3; ALK6; activin receptor-like kinase 6; BMP4; bone morphogenetic protein 4; BMP6; bone morphogenetic protein 6;
Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation
Keywords: hepatocytes; celastrol; interleukin-1 receptor-associated kinases; nuclear factor-kappa B; Toll-like receptor 4; hepatocytes;
Differential effect of fructose on fat metabolism and clock gene expression in hepatocytes vs. myotubes
Keywords: hepatocytes; Fructose; Clock; Metabolism; Fat; Hepatocytes; C2C12
ATP-consuming processes in hepatocytes of river lamprey Lampetra fluviatilis on the course of prespawning starvation
Keywords: hepatocytes; Lamprey; Hepatocytes; Prespawning starvation; Metabolic depression; Mitochondrial membrane potential; Protein synthesis; Na+-K+-pump; Aminotransferases;
β2-Adrenergic receptor ablation modulates hepatic lipid accumulation and glucose tolerance in aging mice
Keywords: hepatocytes; Lipid; Hepatocytes; Cide; Triglycerides; Metabolism; Nonalcoholic fatty liver disease;
The transcription factor Prep1 controls hepatic insulin sensitivity and gluconeogenesis by targeting nuclear localization of FOXO1
Keywords: hepatocytes; Hepatocytes; Gluconeogenesis; Prep1; Insulin sensitivity; T2DM; type 2 diabetes; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase;
Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes
Keywords: hepatocytes; TG; triglyceride; VLDL; very low-density lipoprotein; apoB100; apolipoprotein B100; ELISA; enzyme-linked immunosorbent assay; CPT1; carnitine palmitoyl transferase 1; SREBP1; sterol regulatory element binding protein-1; MTP; microsomal triglyceride transf
Curcumin inhibits activation of TRPM2 channels in rat hepatocytes
Keywords: hepatocytes; Curcumin; TRPM2 channel; Patch clamping; Oxidative stress; Hepatocytes;
In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines
Keywords: hepatocytes; Drug delivery systems; Liposomes; Micelles; In vitro toxicology; Nanomedicine; Hepatocytes; Lung epithelial cells; Comet assay;
QSARs for estimating intrinsic hepatic clearance of organic chemicals in humans
Keywords: hepatocytes; Quantitative structure-activity relationship; Biotransformation; Clearance (CLINT); Hepatocytes; Microsomes;
Rosiglitazone attenuates angiotensin II-induced C-reactive protein expression in hepatocytes via inhibiting AT1/ROS/MAPK signal pathway
Keywords: hepatocytes; C-reactive protein; Rosiglitazone; Inflammation; Hepatocytes; Angiotensin II;
Propolis induce cytotoxicity on cancerous hepatocytes isolated from rat model of hepatocellular carcinoma: Involvement of ROS-mediated mitochondrial targeting
Keywords: hepatocytes; Propolis; Apoptosis; Hepatocytes; Mitochondria; Hepatocellular carcinoma;
In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review
Keywords: hepatocytes; Bile salt export pump (BSEP); In vitro assay; Membrane vesicle; Hepatocytes; Cholestasis; Liver injuryABC, ATP-binding cassette transporters; BCRP, breast cancer resistance protein (ABCG2); BSEP, bile salt export pump (ABCB11) human protein; Bsep, bile sa
Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway
Keywords: hepatocytes; Angiotensin II; Liver cancer; AT1R antagonist; Candesartan; Tumor angiogenesis; Hepatocytes;
Exogenous FABP4 induces endoplasmic reticulum stress in HepG2 liver cells
Keywords: hepatocytes; Fatty acid/binding protein; Fatty acid/transport; Fatty acid; Linoleate; Signal transduction; Apoptosis; Hepatocytes; ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; eFABP4; exogenous fatty acid binding protein 4; EA; elaidic acid
Hepatoprotective and antioxidant potential of Asphodeline lutea (L.) Rchb. roots extract in experimental models in vitro/in vivo
Keywords: hepatocytes; Anthraquinones; Asphodeline lutea; CCl4; Cytochrome P450; Hepatocytes; Oxidative stress