Keywords: Euscaphis japonica; Triterpene acid; HepG2; Triglyceride accumulation
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Keywords: Anticancer agents; Apoptosis; HepG2; Integrated therapy; X-ray sensitization
Synthesis, biological evaluation, molecular docking and DFT calculations of novel benzenesulfonamide derivatives
Keywords: Sulphonamide; MCF-7; HepG2; KSHV thymidylate synthase complex; Computational calculations.;
Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines
Keywords: 5-Aminolevulinic acid; Photodynamic therapy; Genotoxicity; Cytotoxicity; MCF-7; HepG2; Micronucleus test; Comet assay;
Iridoids and sfingolipids from Hedyotis diffusa
Keywords: Hedyotis diffusa; Cytotoxicity; Iridoid glycosides; Cerebrosides; Ceramides; Geniposidic acid (PubChem CID: 443354); Asperulosidic acid (PubChem CID: 44423083); Scandoside (PubChem CID: 21602023); Asperuloside (PubChem CID: 84298); H. diffusa; Hedyotis di
Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes
Keywords: Drug-metabolizing enzymes; Hep3B; HepG2; Huh7; Human livers; MRM-HR; SWATH;
Anti-invasion and anti-metastasis effects of Valjatrate E via reduction of matrix metalloproteinases expression and suppression of MAPK/ERK signaling pathway
Keywords: Valjatrate E; HepG2; Invasion; Metastasis; MAPK/ERK signaling pathway;
Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide
Keywords: [C8mim]Br; HepG2; ROS; Apoptosis; Cytotoxicity mechanism;
Antitumor activity of Pinoresinol in vitro: Inducing apoptosis and inhibiting HepG2 invasion
Keywords: Pin; Pinoresinol; HepG2 cells; human hepatocellular carcinoma cell line; L02 cells; normal hepatocellular cell line; MMP; mitochondrial membrane potential; VCAM-1; vascular cell adhesion molecule-1; ICAM-1; intercellular cell adhesion molecule-1; MMP-9; m
Antihyperlipidemic effect of a Rhamnus alaternus leaf extract in Triton-induced hyperlipidemic rats and human HepG2 cells
Keywords: Rhamnus alaternus; Rhamnaceae; Hyperlipidemia; Flavonoids; HepG2; Fatty acid oxidation;
α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells
Keywords: αT; α-tocopherol; αT3; α-tocotrienol; γT; γ-tocopherol; γT3; γ-tocotrienol; αTTP; α-tocopherol transfer protein; AUC; are under the concentration-time curve; HepG2; human hepatoma cultured cell; HepG2-TTP; HepG2 cell line expressing the human TT
EFLDO induces apoptosis in hepatic cancer cells by caspase activation in vitro and suppresses tumor growth in vivo
Keywords: EFLDO; Euphorbia lunulata Bge; HepG2; Apoptosis; Caspase; Xenograft; ki67;
Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq
Keywords: Tris (2-butoxyethyl) phosphate; HepG2; RNA-seq; Toxicogenomics; Mode of action;
Oxidative stress-mediated p53/p21WAF1/CIP1 pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells
Keywords: Microcystin-LR; HepG2; Oxidative stress; p53; p21; Proto-oncogene;
Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells
Keywords: Tetrahydrocurcumin; Steatosis; HepG2; AMPK; Insulin resistance;
Cratoxylum formosum ssp. pruniflorum activates the TRAIL death receptor complex and inhibits topoisomerase I
Keywords: Bax; Bcl-2 associated X protein; Bcl-2; B cells lymphoma-2 protein; Bid; Bcl-2 homology interacting domain death against; CFP; Cratoxylum formosum (Jack.) Dyer ssp. pruniflorum (Kurz) Gogel; DISC; Death inducing signaling complex; FADD; Fas associated dea
Putting xanthine oxidoreductase and aldehyde oxidase on the NO metabolism map: Nitrite reduction by molybdoenzymes
Keywords: AO; aldehyde oxidase; AFR; activity-to-flavin ratio; Cb; cytoglobin; Cc; cytochrome c; CcO; cytochrome c oxidase; DAF-FM; 4-amino-5-methylamino-2â²,7â²-difluorofluorescein; DAF-FM DA; DAF-FM diacetate; DPI; diphenyleneiodonium chloride; EPR; electron pa
Novel thioureido-benzenesulfonamide derivatives with enaminone linker as potent anticancer, radiosensitizers and VEGFR2 inhibitors
Keywords: Benzenesulfonamides; HEPG2; VEGFR2;
Indirubin 3â²-oxime inhibits anticancer agent-induced YB-1 nuclear translocation in HepG2 human hepatocellular carcinoma cells
Keywords: YB-1; Nuclear translocation; Inhibitor; Indirubin 3â²-oxime; HepG2;
Purification, chemical structure and antioxidant activity of active ingredient (LPT-3d) separated from Lachnum sp.
Keywords: PDA; potato dextrose agar; TLC; thin layer chromatography; HPLC; high-pressure liquid chromatography; FT-IR; Fourier transform infrared; ESI-MS; electrospray ionization mass spectrometry; NMR; nuclear magnetic resonance; DPPH; 2, 2-diphenyl-1-picrylhydraz
Biological applications of Ru(II) polypyridyl complexes
Keywords: FDA; United States Food and Drug Administration; PDT; photodynamic therapy; PS; photosensitizer; ROS; reactive oxygen species; PACT; photodynamic antimicrobial chemotherapy; NKP-1339; sodium salt of indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(I
In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw. on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes
Keywords: AC; (A.cominia, Allophylus cominia); PTP1B; (Protein Tyrosine Phosphatase 1B); DPPIV; (Dipeptidyl peptidase-4); HepG2; (Hepatocellular liver carcinoma); MTT; (2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide); Ki; (inhibitory const
Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway
Keywords: Atorvastatin; HepG2; miRNA-145; PI3K/Akt;
Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells
Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; IGF-1; insulin-like growth factor 1; IGFBP1; insulin-like growth factor binding protein 1; STS; staurosporine; TG; thapsigargin; HBs; viral surface protei
Micronucleus induction and cell cycle alterations produced by deoxynivalenol and its acetylated derivatives in individual and combined exposure on HepG2 cells
Keywords: Deoxynivalenol; 3-ADON; 15-ADON; HepG2; Cell cycle; Genotoxicity;
In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells
Keywords: Botanical mixtures; Estragole; Foeniculum vulgare; Genotoxicity; HepG2; Toxicity; NQO; 4-nitroquinoline N-oxide; AO; acridine orange; CBMN assay; cytokinesis-block micronucleus assay; DAPI; 4â²-6-diamidino-2-phenylindole; EtOH; ethanol; FSEO; fennel seed
Suppression of p53R2 gene expression with specific siRNA sensitizes HepG2 cells to doxorubicin
Keywords: dNTP; deoxynucleotide; HHC; hepatocellular carcinoma; PI; propidium iodide; qRT-PCR; quantitative real-time PCR; p53R2; siRNA; Doxorubicin; Chemotherapy; HepG2;
Antioxidant and anticancer activities of α-aminophosphonates containing thiadiazole moiety
Keywords: α-Aminophosphonates; Thiadiazole; Heterocyclic; Anticancer; Antioxidant; HepG2; MCF7;
The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target
Keywords: Aak2; 5â²AMP-activated protein kinase catalytic subunit alpha-2; ACC; acetyl CoA carboxylase; Acly; ATP citrate lyase; Adipo-IR; adipose tissue insulin resistance index; ADME; absorption, distribution, metabolism, excretion; AGA; appropriate-for-gestatio
Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ
Keywords: C3; PPARγ; PPARα; HNF4α; Insulin; HepG2;
Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate-induced HepG2 cells
Keywords: Sulfated polysaccharides; Hyperlipidemia; AMPK; Triglycerides; Total cholesterol; HepG2;
Chitin synthesis inhibitors promote liver cancer cell metastasis via interfering with hypoxia-inducible factor 1α
Keywords: Chitin synthesis inhibitors (CSIs); Cancer cell metastasis; Hypoxia-inducible factor 1α (HIF-1α); CSIs; chitin synthesis inhibitors; HIF-1α; hypoxia-inducible factor 1α; RLA; the relative luciferase activity; EMT; epithelial-to-mesenchymal transition;
Acridone alkaloids from the stem bark of Citrus aurantium display selective cytotoxicity against breast, liver, lung and prostate human carcinoma cells
Keywords: A549; human lung adenocarcinoma; ANOVA; one-way analysis of variance; ATCC; American type culture collection; CDCl3; chloroform; DMSO; dimethyl sulfoxide; ECACC; European collection of authenticated cell cultures; HepG2; human liver adenocarcinoma; HPLC;
Chemical characterization and cytotoxic, genotoxic, and mutagenic properties of Baccharis trinervis (Lam, Persoon) from Colombia and Brazil
Keywords: CHO; Chinese Hamster Ovary; AE; Aqueous extracts; B; Brazil; C; Colombia; EAF; Ethyl Acetate Fraction; BF; Butanol Extract; ARF; Aqueous Residue Fraction; HPLC; High Performance Liquid Chromatography; HRMS; High Resolution Mass Spectrometry; MTT; 3-(4.5-d
Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release
Keywords: A549; A549 lung cancer cells; AAO; anodized alumina substrates; Ad; adamantane; ALMA; allyl methacrylate; ATRP; atom transfer radical polymerization; AuNPs; gold nanoparticles; CAC; critical aggregation concentration; CB[7]; cucurbituril; β-CD; β-cyclod
Review fantastic medical implications of 3D-printing in liver surgeries, liver regeneration, liver transplantation and drug hepatotoxicity testing: A review
Keywords: 3D printing; Liver constructs; Surgical simulation; Liver regeneration; Liver transplantation; Hepatotoxicity; 3D-printing; three-dimensional printing; 3D Bio-printing; 3D cell printing technology; ALF; acute liver failure; CLD; chronic liver disease; CT;
Microcystin induction small Maf protein involve in transcriptional regulation of GST from freshwater mussel Cristaria plicata
Keywords: Maf; musculoaponeurotic fibrosarcoma; GST; glutathione S-transferase; ARE; antioxidant response element; EpRE; electrophile response element; CNC; cap “n” collar; bZIP; basic region leucine zipper; Nrf2; nuclear factor erythroid-2p45-related factor 2;
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model
Keywords: cFLIP; cellular FLICE-inhibitory protein; CHB; chronic hepatitis B; ER; endoplasmic reticulum; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; MOMP; mitochondrial outer membrane permeabilization; SODD; silencer of death domains;
Comprehensive review on flavonoids biological activities of Erythrina plant species
Keywords: 5-LOX; 5-lipoxygenase; AMPK; adenosine monophosphate-activated protein kinase; Bax; Bcl-2-associated X protein; BC; lymphoma cell line; Bcl-2; B-cell CLL/lymphoma 2; Caco2; human epithelial colorectal adenocarcinoma cells; CCRF-CEM; T lymphoblastoid cell
Chronic exposure of nanomolar MC-LR caused oxidative stress and inflammatory responses in HepG2 cells
Keywords: MC-LR; HepG2; Oxidative stress; Inflammatory reaction; Cytotoxicity;
New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
Keywords: Antibacterial; DNA gyrase; GyrB; Inhibitor; N-phenylpyrrolamide; ParE; Topoisomerase IV; ATCC; American type culture collection; ATR; attenuated total reflectance; CDI; 1,1â²-carbonyldiimidazole; CFU; colony-forming unit; CLSI; Clinical and Laboratory St
Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy
Keywords: A2058; human metastatic melanoma cell; A2780; human ovarian carcinoma cell; A2780cisR; cisplatin-resistant A2780; A375; human melanoma cell; A549; human lung adenocarcinoma epithelial cell; A549R; cisplatin-resistant A549 cell; Aβ; beta-amyloid; acac; ac
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Impact of glutathione modulation on the toxicity of the Fusarium mycotoxins deoxynivalenol (DON), NX-3 and butenolide in human liver cells
Keywords: 2-VP; 2-vinylpyridine; BSO; l-buthionine sulfoximine; BUT; butenolide; CDDO-Im; 1[2-cyano-312-dioxooleana-1,9(11)-dien-28-oyl]imidazolide; CTG; CellTracker⢠Green; DCF; 2â²7â²-dichlorofluorescein; DMEM; Dulbecco's Modified Eagle Medium; DON; deoxyni
A review on the ethnomedicinal uses, phytochemistry and pharmacology of Alpinia officinarum Hance
Keywords: ABS; Akaferd blood stopper; AN; Aspergillus niger; AO; Alpinia officinarum; BC; Bacillus cereus; B16-F10; Mouse melanoma cell line; CA; Candida albicans; CAR; Constitutive androstane receptor; CH2CL2; Dichloromethane; DPPH; Diphenylpicrylhydrazyl; EA; Eth
DNA binding and in vitro anticarcinogenic activity of a series of newfashioned Cu(II)-complexes based on tricationic metalloporphyrin salicyloylhydrazone ligands
Keywords: CT-DNA; calf-thymus-DNA; EtBr; ethidium bromide; DMF; N, N-dimethylformamide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; A549; non-small cell lung cancer; HepG2; liver hepatocellular carcinoma; Hs 578Bst; human normal breast cells;
Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies
Keywords: Curculigo orchioides Gaertn; Antioxidant; HepG2; HeLa; Anticancer; Molecular docking; GC-MS; Gas Chromatography Mass Spectrometry; L-AA; l-ascorbate; SOD; Superoxide Dismutase; CAT; Catalase; GR; Glutathione Reductase; GST; Glutathione S Transferase; GPx;
Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells
Keywords: Persea americana; Triterpenoid; MCF-7; HepG2; Cancer cells;
In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant
Keywords: Aurea helianthus; Antioxidative; Anti-inflammatory; HepG2; Raw 264.7;
Detection of HepG2 Cells in Artificial Samples by Multifunctional Microfluidic Chip
Keywords: Microfluidic chip; Multi-orifice flow fractionation; Magnetic capture; Fluorescence visualization; HepG2;