Keywords: هس 1; ACTB; actin-β; ACTG1; actin-γ1; ADA; American Diabetes Association; Ascl1; achaete-scute homolog 1; BMPR2; bone morphogenetic protein receptor type 2; CCNG2; cyclin G2; CNS; central nervous system; CRKL; CRK-like proto-oncogene adaptor protein; CSNK2A2;
مقالات ISI هس 1 (ترجمه نشده)
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Keywords: هس 1; AAV; adeno-associated virus; Arx; aristaless-related homeobox; BA; biliary atresia; BAC; bacterial artificial chromosome; BDL; bile duct ligation; CD; campomelic dysplasia; CDE; choline-deficient ethionine-supplemented diet; Cdx2; caudal type homeobox 2;
Keywords: هس 1; 2210010C04Rik; RIKEN cDNA 2210010C04 gene; 5330417C22Rik; RIKEN cDNA 5330417C22 gene; A1AT; alpha1-antitrypsin; Ago1; argonaute RISC catalytic component 1; Amy2a5; amylase 2a5; Amy2b; amylase, alpha 2B; AP1/JUN; jun proto-oncogene; Bmp; bone morphogenetic
Keywords: هس 1; Acaca; Acetyl-Coenzyme A carboxylase 1; Acly; ATP citrate lyase; Actb; Beta-actin; ANOVA; Analysis of variance; AUC; Area under the curve; Bax; Bcl2-associated X protein; Bcl2; B cell leukemia/lymphoma 2; Bscl2; Berardinelli-Seip congenital lipodystroph
Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1
Keywords: هس 1; Diabetic nephropathy; Autophagy; Fibrosis; PTEN; Notch1; Hes1;
MicroRNA-374b promotes the proliferation and differentiation of neural stem cells through targeting Hes1
Keywords: هس 1; Hes1; miR-374b; Neurogenesis; Neuronal stem cells;
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Keywords: هس 1; Mouse Model; Type 2 Diabetes; Enteroendocrine Cells; Signal Transduction; CCK; cholecystokinin; Ctgf; connective tissue growth factor; Cyr61; cysteine-rich angiogenic inducer 61; Dll1; delta-like protein 1; DBZ; dibenzazepine; EdU; 5-ethynyl-2â²-deoxyuri
Nuclear Factor I Represses the Notch Effector HEY1 in Glioblastoma
Keywords: هس 1; APCDD1; adenomatosis polyposis coli downregulated 1; AP2; activating protein 2; bHLH; basic helix-loop-helix; B-FABP; brain fatty acid-binding protein; CoRE; composite response element; EZH2; enhancer of zest homolog 2; GBM; glioblastoma; GO; gene ontolog
Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)
Keywords: هس 1; miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH
MiR-182 alleviates the development of cyanotic congenital heart disease by suppressing HES1
Keywords: هس 1; Cyanotic congenital heart disease (CHD); miR-182; HES1; Hypoxia;
The implication of Numb-induced Notch signaling in endothelial-mesenchymal transition of diabetic nephropathy
Keywords: هس 1; Diabetic nephropathy; Endothelial-mesenchymal transition; Numb; Notch signaling; Hes1;
Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway
Keywords: هس 1; Dioscin; Hepatocyte proliferation; γ-secretase; Liver regeneration; Notch1/Jagged1 signal pathway; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BrdU; 5-bromo-2-deoxy-uridine; CDK2; cyclin D-cyclin dependent kinase 2; CDK4; cyclin D-cyc
Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ αβ T-cells
Keywords: هس 1; TCR; T cell receptor; Dll; delta-like ligand; GSI-X; γ-secretase inhibitor; HES1; hairy enhancer of split1; IFN-γi; nterferon-γ; NICD; Notch intracellular domain; Jag; jagged; NRARP; Notch-regulated ankyrin repeat protein; αβ T cells; T cell anergy;
HES1 in immunity and cancer
Keywords: هس 1; HES1; NOTCH; Cancer; Immunity; Cytokine; Therapy;
Loss of Hes1 expression is associated with poor prognosis in colorectal adenocarcinoma
Keywords: هس 1; HES1; Notch; Colorectal carcinoma; Biomarker; Immunohistochemistry;
Steroid receptor RNA activator: Biologic function and role in disease
Keywords: هس 1; AF-2; activation function-2; AR; androgen receptor; C/EBPα; ccaat-enhancer-binding protein α; CTCF; CCCTC-binding factor; Ddx5; DEAD box protein 5; ERα; estrogen receptor α; GR; glucocorticoid receptor; Hes1; hairy and enhancer of split-1; HP1γ; hete
Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway
Keywords: هس 1; PAH, pulmonary arterial hypertension; PAP, pulmonary arterial pressure; PASMCs, pulmonary arterial smooth muscle cellsPASMCs; Proliferation; NICD3; Hes1; P27Kip1
Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression
Keywords: هس 1; Baicalin; Neurogenesis; Notch; Hes1; Ascl1; Human iPS cells;
Exploring the potential relationship between Notch pathway genes expression and their promoter methylation in mice hippocampal neurogenesis
Keywords: هس 1; Notch1; Hes1; Neurogenin2; DNA methylation; Hippocampal neurogenesis
HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44+/CD24â/low tumor-initiating subpopulation in basal-like breast cancer
Keywords: هس 1; ER; estrogen receptor; GFP; green fluorescent protein; CD44s; standard form of CD44; CD44v; variant form of CD44; MCF10DCIS; MCF10DCIS.com; DCIS; GFP-unlabeled control MCF10DCIS; DCIS-HES1; GFP-labeled HES1 overexpressing MCF10DCIS; qPCR; quantitative pol
Redox-regulated fate of neural stem progenitor cells
Keywords: هس 1; ARE; antioxidant response element; bHLH; basic helix-loop-helix; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CtBPs; C-terminal binding proteins; DLL4; delta-like protein 4; DVL; disheveled; DOUX; dual oxidases; ES; embryonic stem cells; EGFR; epid
Research ReportHes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development
Keywords: هس 1; Hes1; Hes5; Neurohypophysis; Pituicyte; Pituitary development;
Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate
Keywords: هس 1; ALS; amyotrophic lateral sclerosis; Cyt C; cytochrome c; DAPT; N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester; EV; empty vector; fALS; familial amyotrophic lateral sclerosis; GSK3; glycogen synthase kinase 3; Hes1; the Hairy and Enh
Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure-activity relationship study
Keywords: هس 1; YM155; DNA intercalation; Redox cycling; Cell viability; Survivin suppressant; Apoptosis; p54nrb; nuclear RNA-binding protein; ILF3/NF110; interleukin enhancer binding factor 3/nuclear factor 110; SP1; specificity factor 1; STAT3; signal transducer and ac
Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity
Keywords: هس 1; Hippocampus; Alzheimer's disease; Cerebellin 4; Amyloid β; NGF; Hes1;
Clinical Application of Basic ScienceNotch signaling and new therapeutic options in liver disease
Keywords: هس 1; Jag-1; Jagged-1; Dll; Delta-like; NICD; Notch intracellular domain; RBP-Jκ; recombination signal binding protein immunoglobulin kappa J; MAML1; mastermind-like 1; Hes1; hairy enhancer of split-1; Hey1; hairy enhancer of split-related with YRPW motif1; So
Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells
Keywords: هس 1; ALS; amyotrophic lateral sclerosis; Ccnd2; cyclin D2; Dlx2; distal-less homeobox 2; epSPCs; ependymal stem/progenitor cells; FALS; familial ALS; GAD 67; glutamic acid decarboxylase 67; GFAP; glial fibrillary acidic protein; Hes1; hairy and enhancer of spl
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: هس 1; ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury
Keywords: هس 1; Hes1; Notch signaling; Adult neurogenesis; Dentate gyrus; Traumatic brain injury
Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development
Keywords: هس 1; Hes1; Hes5; Notch; Vascular remodeling; Arterial specification; Brain vascular development;
Role for Lhx2 in corticogenesis through regulation of progenitor differentiation
Keywords: هس 1; cKO; conditional knockout; dTel; dorsal telencephalon; SVZ; subventricular zone; VZ; ventricular zone; WT; wild type; Cortical neurogenesis; Lhx2; Hes1; Notch; floxed Lhx2;
Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway
Keywords: هس 1; CSLCs; cancer stem-like cells; GBM; glioblastoma multiforme; ATO; arsenic trioxide; GSI; γ-secretase inhibitors; Hes1; hairy enhancer of split 1; Hey1; Hes-related protein 1; APL; acute promyelocytic leukemia; GSLCs; glioblastoma stem like cells; NICD; N
Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice
Keywords: هس 1; BDNF; brain-derived neurotrophic factor; BrdU; 5-bromo-2â²-deoxyuridine; CC; corpus callosum; CD45; cluster of differentiation number 45 or leukocyte common antigen; CNTF; ciliary neurotrophic factor; Dll3; delta-like 3; ECA; external carotid artery; EGF
Neuroscience Forefront ReviewProneural genes in neocortical development
Keywords: هس 1; Ascl1; Achaete scute-like 1; AS-C; achaete-scute complex; BAF; Brahma-associated factors; bHLH; basic-helix-loop-helix; CGE; caudal ganglionic eminences; GABA+; GABAergic; glu+; glutamatergic; GSK3; glycogen synthase kinase 3; Hes1; hairy and enha
HES1 inhibits adipogenesis of porcine mesenchymal stem cells via transcriptional repression of FAD24
Keywords: هس 1; HES1; FAD24; Adipogenesis; Mesenchymal stem cell; Promoter
The expression of NOTCH2, HES1 and SOX9 during mouse retinal development
Keywords: هس 1; Notch; Hes1; Sox9; Retina; Development; Mouse
C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades
Keywords: هس 1; C/EBPα; Hepatocellular carcinoma; Hes1; Notch3
Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation
Keywords: هس 1; Mouse; Ovary; Notch pathway; Hes1; Oocytes; Fertility
Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment
Keywords: هس 1; Pancreas; Notch; Ngn3 stability; Hes1
Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition
Keywords: هس 1; OSI; oxidative stress injury; H2O2; hydrogen peroxide; HUVECs; human umbilical vein endothelial cells; ROS; reactive oxygen species; EC; endothelial cell; Hes1; Hairy and enhancer of split 1; HRT; Hairy-related transcription; MTT; 3-(4,5-dimethylthiazol-2
TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells
Keywords: هس 1; TNFα; OSCC; Cancer stem cells; Notch; Hes1
Research ReportBaicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression
Keywords: هس 1; NPCs; neural progenitor cells; MAP-2; microtubule associated protein; GFAP; glial fibrillary acidic protein; Stat3; signal transducer and activator of transcription 3; bHLH; basic helix-loop-helix; Hes1; Hairy enhancer of split 1; Baicalin; Neural pro
Functional recovery and neuronal regeneration of a rat model of epilepsy by transplantation of Hes1-down regulated bone marrow stromal cells
Keywords: هس 1; bHLH; basic helix-loop-helix; BMSCs; bone marrow stromal cells; BrdU; 5-bromo-2â²-deoxyuridine; Bt2cAMP; N6, O2â²-dibutyryladenosine 3â²:5â²-cyclic monophosphate; CCM; complete culture medium; DG; dentate gyrus; DAPI; 4â²,6-diamidino-2-phenylindo
Stem cells as the root of pancreatic ductal adenocarcinoma
Keywords: هس 1; ABC; ATP binding cassette; ALDH1; Aldehyde dehydrogenase 1a1; Arx; Aristalless-related homeobox; EMT; Epithelial-to-mesenchymal transition; CAC; Centroacinar cells; CD; Cluster of differentiation; CDKN2A; Cyclin-dependent kinase inhibitor 2A; CSC; Cancer
Origin of the brush cell lineage in the mouse intestinal epithelium
Keywords: هس 1; Brush cell; Tuft cell; Hes1; Atoh1; Gfi1b; Notch signaling; Intestinal stem cell;
The hallmarks of CDKN1C (p57, KIP2) in cancer
Keywords: هس 1; AML; acute myeloid leukemia; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-x long; BCR-ABL; breakpoint cluster region-V-abl Abelson murine leukemia viral oncogene homolog 1; bHLH; basic helix-loop-helix; BWS; Beckwith-Wiedemann Syndrome; CDK; cy
Delta-like 1-Lysine613 regulates notch signaling
Keywords: هس 1; Dll1; Delta-like 1; DSL; Delta/Serrate/Lag2; Notch-ICD; Notch intracellular domain; Notch-ECD; Notch extracellular domain; HES1; Hairy/enhancer of Split 1; HEY1; Hairy/enhancer of split related with YRPW motif protein 1; CSL; Suppressor of Hairless/Lag1;
The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary
Keywords: هس 1; Hypothalamus; Development; Notch; Hes1; AVP; SS; PVN; SON;
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
Keywords: هس 1; Hair cell; Supporting cell; Hes1; Hes5; Hey1; Developing cochlea;
FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors
Keywords: هس 1; Fibroblast growth factor; Isthmic organizer; Neuronal stem cell; Hes1; Neurogenesis; Basal lamina;