کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8260551 1534663 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring
ترجمه فارسی عنوان
قرار گرفتن در معرض مواجهه پرایسینژیک باعث برنامه ریزی برنامه های خاص جنسیتی از حساسیت های بیماری در نوزادان موش بالغ
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Vulnerability of the fetus upon maternal obesity can potentially occur during all developmental phases. We aimed at elaborating longer-term health outcomes of fetal overnutrition during the earliest stages of development. We utilized Naval Medical Research Institute (NMRI) mice to induce pre-conceptional and gestational obesity and followed offspring outcomes in the absence of any postnatal obesogenic influences. Male adult offspring developed overweight, insulin resistance, hyperleptinemia, hyperuricemia and hepatic steatosis; all these features were not observed in females. Instead, they showed impaired fasting glucose and a reduced fat mass and adipocyte size. Influences of the interaction of maternal diet ∗ sex concerned offspring genes involved in fatty liver disease, lipid droplet size regulation and fat mass expansion. These data suggest that a peri-conceptional obesogenic exposure is sufficient to shape offspring gene expression patterns and health outcomes in a sex- and organ-specific manner, indicating varying developmental vulnerabilities between sexes towards metabolic disease in response to maternal overnutrition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 2, February 2014, Pages 304-317
نویسندگان
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