Keywords: AIns; iatrogenic insulin amyloid; ThT; thioflavin T; ANS; 8 anilinonaphthalene-1-sulfonic acid; APRs; aggregation prone regions; hIAPP; human islet amyloid polypeptide; CD; circular dichroism; TEM; transmission electron microscopy; PDB; protein data bank;
مقالات ISI (ترجمه نشده)
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Keywords: Aβ; amyloid-beta; AFM; atomic force microscopy; ANS; 8-anilino-1-naphthalenesulfonate; αSNWT; wild-type α-synuclein; αSN103; C-terminally truncated α-synuclein; CD; circular dichroism; CTR; C-terminal region; DHPC; 1,2-dihexanoyl-sn-glycero-3-phospho
Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid-β precursor protein; ApoE-ε4; apolipoprotein E-ε4; BBB; blood-brain barrier; CTF; C-terminal fragment; DMN; default mode network; ER; endoplasmic reticulum; GLP-1; glucagon-like peptide-1; GLP-
Disaggregation of human islet amyloid polypeptide fibril formation by ruthenium polypyridyl complexes
Keywords: hIAPP; Ru polypyridyl complex; Interaction; Disaggregation; hIAPP; Human islet amyloid poplypeptide; T2D; Type II diabetes; ThT; Thioflavine T; Tyr; Tyrosine; PrP106-126; Prion neuropeptide 106-126; bpy; 2,2â²-bipyridine; phen; 1,10-phenanthroline; dpq;
Inhibition of amyloid peptide fibril formation by gold-sulfur complexes
Keywords: PrP; prion protein; hIAPP; human islet amyloid polypeptide; Aβ; amyloid-β protein; T2DM; type 2 diabetes mellitus; His; histidine; Met; methionine; DDTC; diethyl dithiocarbamate; PDT; pyrrolidine dithiocarbamate; DMSO; dimethyl sulphoxide; ThT; thioflav
Keywords: IAPP; islet amyloid polypeptide; hIAPP; human IAPP; DEPC; diethylpyrocarbonate; DMI; DEPC-modified hIAPP; HFIP; 1,1,1,3,3,3-hexafluoro-2-propanol; ThT; thioflavin-T; Modification; Amyloid; hIAPP; Imidazole ring;
Keywords: DKD; diabetic kidney disease; ATR-FTIR; attenuated total reflectance-Fourier transform infrared; ANN; artificial neural network; HCA; hierarchical cluster analysis; PCA; principal component analysis; ESRD; end-stage renal disease; AGEs; advanced glycation
Keywords: hIAPP; All-d-amino-acid inhibitor; Phospholipid membrane; α-Helical intermediate; Fibrillogenesis;
Keywords: hIAPP; Solvent effect; Inhibitor; Phospholipid membrane; Fibrillogenesis;
Regulation of heteronuclear Pt-Ru complexes on the fibril formation and cytotoxicity of human islet amyloid polypeptide
Keywords: hIAPP; Fibril formation; Heteronuclear PtRu complexes; Inhibition;
Atomistic-level study of the interactions between hIAPP protofibrils and membranes: Influence of pH and lipid composition
Keywords: Amyloid oligomer; Type 2 diabetes; hIAPP; Membrane; MD simulation;
Schiff base oxovanadium complexes resist the assembly behavior of human islet amyloid polypeptide
Keywords: hIAPP; Schiff base oxovanadium complexes; Fibrillation; Interaction; Disaggregation;
Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy
Keywords: A2058; human metastatic melanoma cell; A2780; human ovarian carcinoma cell; A2780cisR; cisplatin-resistant A2780; A375; human melanoma cell; A549; human lung adenocarcinoma epithelial cell; A549R; cisplatin-resistant A549 cell; Aβ; beta-amyloid; acac; ac
Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells
Keywords: ASK1; apoptosis signal regulating kinase-1; BME; β-mercaptoethanol; GSH; glutathione; hA; human amylin; hIAPP; human islet amyloid polypeptide; HFIP; hexafluoride isopropanol; JNK; c-Jun N-terminal kinase; Lac; lactacystin; MAP; mitogen activated protein
IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies
Keywords: 2DIR; two-dimensional infra-red spectroscopy; AFM; atomic force microscopy; AGE; advanced glycation end; CD; circular dichroism; CGRP; calcitonin gene-related peptides; DMSO; Dimethyl Sulfoxide; EGCG; epigallocatechin gallate; EPR; electron paramagnetic r
Original ArticleAmyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets
Keywords: Islet amyloid; Amylin; Islet amyloid polypeptide; β-cell apoptosis; Interleukin-1β; Interleukin-1 receptor antagonist; Islet inflammation; Type 2 diabetes; BSA; bovine serum albumin; ER; endoplasmic reticulum; FBS; fetal bovine serum; hIAPP; human islet
Tracking the amyloidogenic core of IAPP amyloid fibrils: Insights from micro-Raman spectroscopy
Keywords: hIAPP; human IAPP; rIAPP; rat IAPP; APRs; aggregation-prone regions; STEM; scanning-transmission electron microscopy; ssNMR; solid-state Nuclear Magnetic Resonance; RMSF; root mean square fluctuation; ASA; accessible surface area; TERS; Tip-Enhanced Raman
Synthesis and characterization of oxidovanadium complexes as enzyme inhibitors targeting dipeptidyl peptidase IV
Keywords: DPP-IV; dipeptidyl peptidase IV; mg V·kgâ 1; mg Vanadium injected/weight of mice in kg; GLP-1; glucagon-like peptide-1; GIP; glucose-dependent insulinotropic peptide; BEOV; bis(ethylmaltolato)oxovanadium(IV); PTP1B; protein tyrosine phosphatase 1B; P
TRPV4 regulates insulin mRNA expression and INS-1E cell death via ERK1/2 and NO-dependent mechanisms
Keywords: 4α-PDD; 4α-phorbol 12,13-didecanoate; BrdU; 5-bromo-2â²-deoxyuridine; ERK1/2; extracellular signal-regulated kinase 1/2; GCK; glucokinase; GLP-1; glucagon-like peptide-1; hIAPP; human islet amyloid polypeptide; HPRT; hypoxanthine-guanine phosphoribos
ESI-IMS-MS: A method for rapid analysis of protein aggregation and its inhibition by small molecules
Keywords: Aβ; amyloid-β peptide; Aβ40; amyloid-β peptide residues 1-40; AD; Alzheimer's disease; ADH; alcohol dehydrogenase; AFM; atomic force microscopy; CCS; collision-cross sectional area; Cl-NQTrp; chloronaphthoquinine-tryptophan; CsI; caesium iodide; D
Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment
Keywords: AFM; Atomic force microscopy; CD; circular dichroism; CC; Critical concentration of fibrillation; CuAAC; Cu(I)-catalyzed alkyne-azide cycloaddition; αCD; α-cyclodextrin; N3P3; cyclotriphosphazene; DIC; Diisopropylcarbodiimide; DIPEA; N,N-diisopropylet
In Vitro Evaluation of Hypoglycemic Agents to Target Human Islet Amyloid Polypeptide: A Key Protein Involved in Amyloid Deposition and Beta-Cell Loss
Keywords: antiamyloidogenic agents; hIAPP; human islet amyloid polypeptide; repaglinide; troglitazone; type 2 diabetesagents antiamyloïdogènes; hIAPP (human islet amyloid polypeptide); polypeptide amyloïde d’îlots pancréatiques humains; répaglinide; troglitazone; d
Effects of gold complexes on the assembly behavior of human islet amyloid polypeptide
Keywords: hIAPP, amylin; human islet amyloid polypeptide; rIAPP; rat IAPP; AuNPs; gold nanoparticles; PAH; poly (allylamine hydrochloride); ThT; thioflavin T; H2TPP; tetraphenylporphyrin; hIAPP; Assembly; Gold complex; Interaction; Dimerization;
Stabilities and structures of islet amyloid polypeptide (IAPP22-28) oligomers: From dimer to 16-mer
Keywords: hIAPP; human islet amyloid polypeptide; MD; molecular dynamics; Nucleation; Amyloid fibril; Molecular dynamics simulation; Islet amyloid polypeptide (residues 22-28); Type II diabetes;
Human IAPP amyloidogenic properties and pancreatic β-cell death
Keywords: hIAPP; Human islet amyloid polypeptide; Amylin; Amyloid; β-Cell death; Ion-channels; Type 2 diabetes mellitus; T2DM
Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides
Keywords: Spectroscopy; Type 2 diabetes; Confocal microscopy; Mitochondria; Amyloid; Model membranes; hIAPP; human islet amyloid polypeptide; IAPP; islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; rIAPP; rodent islet amy
Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms
Keywords: 4α-PDD; the phorbol ester 4α-phorbol 12,13-didecanoate; cAMP; cyclic adenosine monophosphate; hIAPP; human islet amyloid polypeptide; KRHB; Krebs-Ringer-HEPES buffer; PKC; protein kinase C; siRNA; small interfering RNA; nt siRNA; non-targeting siRNA;
Proanthocyanidins are the major anti-diabetic components of cinnamon water extract
Keywords: CD; circular dichroism; CWE; cinnamon water extract; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PA; proanthocyanidins; PBS
ReviewMolecular links between Alzheimer's disease and diabetes mellitus
Keywords: AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase
Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide
Keywords: CD; circular dichroism; EGCG; (â)-epigallocatechin 3-gallate; HFIP; hexafluoroisopropanol; hIAPP; human islet amyloid polypeptide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; T2DM; type 2 diabetes mellitus; TEM; transmission elect
Probing ion channel activity of human islet amyloid polypeptide (amylin)
Keywords: hIAPP; Ion channel; Directional permeability; Molecular dynamic;
Comparing the structural properties of human and rat islet amyloid polypeptide by MD computer simulations
Keywords: hIAPP; rIAPP; MD simulation; Disulfide bond; Proline;
A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes
Keywords: Amylin; Amyloidogenesis; Diabetes mellitus type-2; Intrinsically disordered polypeptide; Ï-Ï stacking; AFM; atomic force microscopy; CFTR; cystic fibrosis transmembrane conductance regulator; CGRP; calcitonin gene related peptide; DM-2; type-2 diabete
Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin
Keywords: Oleuropein; Amylin; hIAPP; Amyloid cytotoxicity; Type two diabetes; Extra virgin olive oil