دانلود مقالات ISI درباره غربالگری بالا + ترجمه فارسی

Protein engineering of aldolase LbDERA for enhanced activity toward real substrates with a high-throughput screening method coupled with an aldehyde dehydrogenase

Keywords: غربالگری بالا; Aldehyde dehydrogenase; Crystal structure; 2-Deoxyribose-5-phosphate aldolase; High-throughput screening; Protein engineering; Statin side chains;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

A rapid screening platform for catalyst discovery in azide-alkyne cycloaddition by ICP-MS/MS

Keywords: غربالگری بالا; Azide-alkyne cycloaddition; Catalyst; High-throughput screening; ICP-MS/MS; Monovalence metal ions;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening

Keywords: غربالگری بالا; C. elegans; Caspase; CED-3; High-throughput screening; Small molecule inhibitor; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

An enzyme-mediated protein-fragment complementation assay for substrate screening of sortase A

Keywords: غربالگری بالا; High-throughput screening; NanoLuc luciferase; Protein-fragment complementation assay; Sortase A; Substrate profiling; ESI; electrospray ionization; HPLC; high performance liquid chromatography; IPTG; isopropyl β-d-1-thiogalactopyranoside; LgBiT; large f

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Monitoring in vivo metabolic flux with a designed whole-cell metabolite biosensor of shikimic acid

Keywords: غربالگری بالا; Whole-cell biosensor; High-throughput screening; Metabolic flux; Regulatory protein; Shikimic acid;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

NMR in drug design

Keywords: غربالگری بالا; Fragment-based drug design; Fragment-based screening; Ligand binding; NMR spectroscopy; Temperature shift coefficients; Saturation transfer difference; Chemical shift perturbation; WaterLOGSY; T2 difference; Millamolecule; Ligand-protein interaction; Hit

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

High-throughput screening for drugs of abuse and pharmaceutical drugs in hair by liquid-chromatography-high resolution mass spectrometry (LC-HRMS)

Keywords: غربالگری بالا; Hair analysis; Drugs of abuse; Therapeutic drugs; NPS; UHPLC-HRMS; Forensic toxicology; Clinical toxicology; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Lipidomics in translational research and the clinical significance of lipid-based biomarkers

Keywords: غربالگری بالا; 5-HETE; 5-hydroxyicosatetraenoic acid; 12-HETE; 12-hydroxyicosatetraenoic acid; 15-HETE; 15-hydroxyicosatetraenoic acid; aa; diacyl; ae; acyl-alkyl; ACs; acylcarnitines; ACOG; The American College of Obstetricians and Gynecologists; AD; Alzheimer's dise

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Targeted pharmacotherapies for defective ABC transporters

Keywords: غربالگری بالا; 4-PBA; 4-phenylbutyrate; ABC; ATP-Binding Cassette; BRIC2; Benign Recurrent Intrahepatic Cholestasis type 2; BSEP; Bile Salt Export Pump; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane conductance Regulator; CsA; Cyclosporin A; DMSO; DiMethylSul

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies

Keywords: غربالگری بالا; Ap3A; diadenosine triphosphate; Ap4A; diadenosine tetraphosphate; Ap5A; diadenosine pentaphosphate; AR-C67085MX; 2-propylthio-β,γ-dichloromethylene-ATP; PSB0412; 2-propargylthio-β,γ-dichloromethylene-ATP; 5-BDBD; 5-(3-bromophenyl)-1,3-dihydro-2H-benzo

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening

Keywords: غربالگری بالا; Kinase; MAP3K; High-throughput screening; Autophagy; Drug discovery; Inhibitor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach

Keywords: غربالگری بالا; Quinolinone; Vaccinia; Adenovirus; Click chemistry; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor

Keywords: غربالگری بالا; Trypanosoma brucei; Mitogen-activated protein kinase (MAPK); High-throughput screening; Extracellular-signal regulated kinase (ERK); AZ960;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Genome-scale functional analysis of the human genes modulating p53 activity by regulating MDM2 expression in a p53-independent manner

Keywords: غربالگری بالا; High-throughput screening; MDM2; p53; Leukemia; MDM2-modulating gene;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Comparative genomics analysis of a series of Yarrowia lipolytica WSH-Z06 mutants with varied capacity for α-ketoglutarate production

Keywords: غربالگری بالا; Yarrowia lipolytica; α-Ketoglutarate; High-throughput screening; Carboxylic acid; Keto acid; Genomics sequencing;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

High-throughput screening and radioligand binding studies reveal monoamine oxidase-B as the primary binding target for d-deprenyl

Keywords: غربالگری بالا; d-deprenyl; High-throughput screening; Binding site

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development of novel functional ingredients: Need for testing systems and solutions with Caenorhabditis elegans

Keywords: غربالگری بالا; Functional food; Functional nutrition; Functional ingredients; High-throughput screening; Mechanistic studies; Caenorhabditis elegans

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Zebrafish small molecule screens: Taking the phenotypic plunge

Keywords: غربالگری بالا; High-throughput screening; Whole-organism screening; Phenotypic screening; Phenome-wide association study;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase

Keywords: غربالگری بالا; H-PGDS; High-throughput screening; Inhibitor; SPACOX, cyclooxygenase; DTT, dithiothreitol; GST, glutathione S-transferase; H-PGDS, hematopoietic prostaglandin D2 synthase; HTS, high-throughput screening; L-PGDS, lipocalin-type prostaglandin D2 synthase; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A novel cell-based duplex high-throughput screening assay combining fluorescent Ca2+ measurement with homogeneous time-resolved fluorescence technology

Keywords: غربالگری بالا; Cell-based assays; High-throughput screening; Multiplex assays and technology; Fluorescent Ca2+ measurement; HTRF technologyGPCR, G-protein-coupled receptor; HTS, high-throughput screening; HCS, high-content screening; FRET, fluorescence resonance energy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

DNA shuffling of uricase gene leads to a more “human like” chimeric uricase with increased uricolytic activity

Keywords: غربالگری بالا; Urate oxidase; DNA shuffling; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Mechanisms of Antigen Adsorption Onto an Aluminum-Hydroxide Adjuvant Evaluated by High-Throughput Screening

Keywords: غربالگری بالا; aluminum hydroxide; adsorption; vaccine adjuvants; vaccines; automation; high-throughput screening; adsorption isotherm; antigen; adsorption mechanisms; phosphophilicity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry

Keywords: غربالگری بالا; Prostaglandins; Cell-based inflammatory reaction system; TFC LC-HRMS; Natural products; High-throughput screening; Potency evaluation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Classical density functional theory for gas separation in nanoporous materials and its application to CH4/H2 separation

Keywords: غربالگری بالا; Gas separation; Classical density functional theory; Metal-organic frameworks; Hydrogen purification; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A simpler sampling interface of venturi easy ambient sonic-spray ionization mass spectrometry for high-throughput screening enzyme inhibitors

Keywords: غربالگری بالا; High-throughput screening; Angiotensin converting enzyme inhibitors; Venturi easy ambient sonic-spray ionization mass spectrometry; Sampling interface

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Design of a microfluidic strategy for trapping and screening single cells

Keywords: غربالگری بالا; Microfluidics; Single cell; High-throughput screening; Chaotic mixing;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A natural component from Euphorbia humifusa Willd displays novel, broad-spectrum anti-influenza activity by blocking nuclear export of viral ribonucleoprotein

Keywords: غربالگری بالا; Influenza virus; Antiviral; Natural component; High-throughput screening; Nuclear export;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Cyclopiazonic acid, an inhibitor of calcium-dependent ATPases with antiviral activity against human respiratory syncytial virus

Keywords: غربالگری بالا; Respiratory syncytial virus; High-throughput screening; Natural product; Cyclopiazonic acid; Calcium ATPases;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro dioxin-like potencies of HO- and MeO-PBDEs and inter-species sensitivity variation in birds

Keywords: غربالگری بالا; Emerging chemicals; Species sensitivity; High-throughput screening; Prioritization; Relative potency

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

A high-throughput screening system targeting the nuclear export pathway via the third nuclear export signal of influenza A virus nucleoprotein

Keywords: غربالگری بالا; IAV; influenza virus; NP; nucleoprotein; vRNA; viral RNA; vRNP; viral ribonucleoprotein; NLS; nuclear localization signal; NES; nuclear export signal; CRM1; chromosome region maintenance 1; LMB; leptomycin B; HTS; high-throughput screening; AcGFP; green f

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Optimizing multi-dimensional high throughput screening using zebrafish

Keywords: غربالگری بالا; hpf; hours post fertilization; DMSO; Dimethyl sulfoxide; HTS; high-throughput screening; Zebrafish; High throughput screening; Developmental toxicity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Arrays of 3D double-network hydrogels for the high-throughput discovery of materials with enhanced physical and biological properties

Keywords: غربالگری بالا; Hydrogel; Biomaterial; Microarray; High-throughput screening; Double-network; Polymer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of compounds that modulate retinol signaling using a cell-based qHTS assay

Keywords: غربالگری بالا; Retinol signaling; Developmental toxicant; High-throughput screening; Stem cell; LOPAC; Tox21;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Prediction of salt effects on protein phase behavior by HIC retention and thermal stability

Keywords: غربالگری بالا; Protein phase diagram; High-throughput screening; Hydrophobic interaction chromatography; Thermal stability;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Intermediate-sensor assisted push–pull strategy and its application in heterologous deoxyviolacein production in Escherichia coli

Keywords: غربالگری بالا; Pathway engineering; High-throughput screening; Biosensor; Deoxyviolacein biosynthesis; Sequential optimization

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of Constipation

Keywords: غربالگری بالا; CFTR; Constipation; High-Throughput Screening; LoperamidecAMP, cyclic adenosine monophosphate; CFTR, cystic fibrosis transmembrane conductance regulator; CSBM, complete spontaneous bowel movement; DMSO, dimethyl sulfoxide; EC50, half-maximal effective con

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

High-throughput process development of an alternative platform for the production of virus-like particles in Escherichia coli

Keywords: غربالگری بالا; Virus-like particles; Escherichia coli; Micro-scale cultivation; BioLector; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back

Keywords: غربالگری بالا; bioavailability; cancer therapeutics; Drosophila; FDA-approved drugs; high-throughput screening; signaling pathways

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of pyrrolo[3,2-c]pyridin-4-amine compounds as a new class of entry inhibitors against influenza viruses in vitro

Keywords: غربالگری بالا; Influenza virus; Antiviral drugs; High-throughput screening; Entry inhibitor; Pyrrolopyridinamine;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Structural, dielectric and ferroelectric properties of (Bi,Na)TiO3-BaTiO3 system studied by high throughput screening

Keywords: غربالگری بالا; Lead-free piezoelectric; High-throughput screening; PVD; Ferroelectric thin films; Perovskite;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Bioluminescent kinase strips: A novel approach to targeted and flexible kinase inhibitor profiling

Keywords: غربالگری بالا; Kinase profiling; Bioluminescence; ADP detection; Selectivity profiles; Kinase assay; Kinase inhibitor; PTM; post-translational modification; FDA; U.S. Food and Drug Administration; BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; TK; tyrosine kinase

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

High-throughput screening assays for antibacterial and antifungal activities of Lactobacillus species

Keywords: غربالگری بالا; Antibacterial; Antifungal; Bacteriocin; High-throughput screening; Lactobacillus

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors

Keywords: غربالگری بالا; Sodium-dependent glucose co-transporter; Type 2 diabetes mellitus; Non-glycoside; High-throughput screening; Click chemistry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

NMR relaxation and exchange in metal–organic frameworks for surface area screening

Keywords: غربالگری بالا; Metal–organic frameworks; NMR relaxometry; Exchange; High-throughput screening

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Temperature-controlled microintaglio printing for high-resolution micropatterning of RNA molecules

Keywords: غربالگری بالا; Microarray; Intaglio printing; RNA patterning; in situ synthesis; Parallel spotting; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach

Keywords: غربالگری بالا; Radix Salviae Miltiorrhizae; Thrombin inhibitor; Peak fractionation; QTOF mass spectrometry; High-throughput screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

A qualitative and quantitative high-throughput assay for screening of gluconate high-yield strains by Aspergillus niger

Keywords: غربالگری بالا; Aspergillus niger; Gluconate production; Colorimetric; High-throughput screening

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Effect of lysozyme solid-phase PEGylation on reaction kinetics and isoform distribution

Keywords: غربالگری بالا; PEGylation; Lysozyme; On-column; Solid-phase PEGylation; High-throughput screening

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of the effects of amyloid β aggregation from seaweed extracts by a microliter-scale high-throughput screening system with a quantum dot nanoprobe

Keywords: غربالگری بالا; Alzheimer's disease; Amyloid; Quantum dots; Seaweed; High-throughput screening

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

Keywords: غربالگری بالا; Aldehyde dehydrogenase; High-throughput screening; Inhibition

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه