Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors
Keywords: غربالگری بالا; Aldehyde dehydrogenase; High-throughput screening; Inhibition
مقالات ISI غربالگری بالا (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Significantly improving the yield of recombinant proteins in Bacillus subtilis by a novel powerful mutagenesis tool (ARTP): Alkaline α-amylase as a case study
Keywords: غربالگری بالا; Recombinant proteins; Expression level; Atmospheric and room temperature plasma; High-throughput screening; Bacillus subtilis;
Cloning, expression and characterization of the recombinant cold-active type-I pullulanase from Shewanella arctica
Keywords: غربالگری بالا; High-throughput screening; Maltotriose; Psychrophiles; Pullulan; Type-I pullulanase
Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment
Keywords: غربالگری بالا; Reverse dosimetry; High-throughput screening; Quantitative in vitro-to-in vivo extrapolation;
Acute and chronic alcohol administration: Effects on performance of zebrafish in a latent learning task
Keywords: غربالگری بالا; Latent learning; Memory; Alcohol; High-throughput screening; Zebrafish;
Determination of the lipophilicity (log Po/w) of organic compounds by microemulsion liquid chromatography
Keywords: غربالگری بالا; Microemulsion liquid chromatography; Lipophilicity; Octanol/water partition coefficient; Linear solvation energy relationship; high-throughput screening;
Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity
Keywords: غربالگری بالا; A260; UV absorbance at 260Â nm; AIR; 5-amino-imidazole ribonucleotide; Ba; Bacillus anthracis (ÎANR strain); CAIR; 4-carboxy-amino-imidazole ribonucleotide; CD; circular dichroism; DMSO; dimethyl sulfoxide; E. coli ÎTolC; E. coli efflux pump knockout st
Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors
Keywords: غربالگری بالا; Voltage-gated sodium channel; Pain; CNS side effects; High-throughput screening; Piperidine;
A method for the simultaneous extraction and quantitation of lipophilic antioxidants in Triticum sp. by HPLC-DAD/FLD-MSn
Keywords: غربالگری بالا; Einkorn; High-throughput screening; Fluorescence detection; Mass spectrometry; Cereals; Food analysis; Vitamin E; Phenolic lipids; Food composition;
A novel 3D method of locomotor analysis in adult zebrafish: Implications for automated detection of CNS drug-evoked phenotypes
Keywords: غربالگری بالا; Zebrafish; High-throughput screening; Drug discovery; Video tracking; Neurophenotype;
Chemical chronobiology: Toward drugs manipulating time
Keywords: غربالگری بالا; Circadian rhythm; Small molecule compound; High-throughput screening; Chemical biology;
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
Keywords: غربالگری بالا; Colorectal cancer; Cancer stem cell; Wnt signaling; Traf2- and Nck-interacting kinase (TNIK); Molecular targeting therapy; ABC; ATP-binding cassette; APC; adenomatous polyposis coli; CBP; cAMP response element binding protein (CREB)-binding protein; CK; c
A [32P]NAD+-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors
Keywords: غربالگری بالا; Enoyl ACP reductase; Residence time (tR); Methodology; Steady-state kinetics; High-throughput screening; Penefsky column
Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model
Keywords: غربالگری بالا; Drug combination scoring; Interaction landscape; Dose–response matrix; High-throughput screening
FAITH - Fast Assembly Inhibitor Test for HIV
Keywords: غربالگری بالا; Retrovirus; HIV; Assembly; Assay; Inhibitor; High-throughput screening; Capsid; CA;
Functional genomic screening approaches in mechanistic toxicology and potential future applications of CRISPR-Cas9
Keywords: غربالگری بالا; 3-BrPA; 3 bromopyruvate; AOP; adverse outcome pathway; ARF4; ADP-ribosylation factor 4; BFA; brefeldin A; BT; 1,2,4-benzenetriol; CML; chronic myeloid leukemia; COSMID; CRISPR off-target sites with mismatches, insertions, and deletions; CRISPR-Cas9; clust
In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3)
Keywords: غربالگری بالا; Xenotransplant; Zebrafish; Leukemia stem cell; High-throughput screening;
Cell-based assay for low- and high-scale screening of the Wnt/β-catenin signaling modulators
Keywords: غربالگری بالا; Wnt/β-catenin signaling; GSK-3 inhibitor; High-throughput screening; Luciferase reporter cell line; Alzheimer’s disease
4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site
Keywords: غربالگری بالا; AMP-PNP-5â²; adenylyl-β,γ-imidodiphosphate; AUC; area under the receiver operating characteristic curve; DMSO; dimethyl sulfoxide; EF; enrichment factor; Fnorm; normalized fluorescence [â°] (per mill); GA; genetic algorithm; GHKL; Gyrase; Hsp90; histi
(Q)SAR modelling of nanomaterial toxicity: A critical review
Keywords: غربالگری بالا; AES; Auger electron spectroscopy; AFM; atomic force microscopy; ANNs; artificial neural networks; APO or Apop.; apoptosis; ATP; adenosine triphosphate (ATP); BET; Brunauer-Emmett-Teller; BSAI; biological surface adsorption index; CNTs; carbon nanotube
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models
Keywords: غربالگری بالا; RBPs; RNA-binding proteins; ALS; amyotrophic lateral sclerosis; FTD; frontotemporal dementia; HTS; high-throughput screening; F.C.; fold change; S.I.; splicing index; GO; Gene Ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; WB; Western blot; TDP-
Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR
Keywords: غربالگری بالا; acetyl-CoA; acetyl coenzyme A; ALARM NMR; a La assay to detect reactive molecules by nuclear magnetic resonance; Asf1; anti-silencing function 1; AZ; AstraZeneca; BME; β-mercaptoethanol; BSA; bovine serum albumin; CoA; coenzyme A; CPM; N-[4-(7-diethylami
A biochemical screen for GroEL/GroES inhibitors
Keywords: غربالگری بالا; GroEL; GroES; Chaperonin; High-throughput screening; Small molecule inhibitors;
A fluorescence-based glycosyltransferase assay for high-throughput screening
Keywords: غربالگری بالا; Glycosyltransferase engineering; Glycosyltransferase assay; High-throughput screening; ATP sensor
Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells
Keywords: غربالگری بالا; CCCP; carbonyl cyanide m-chlorophenylhydrazone; CDAD; Clostridium difficile-associated diarrhoea; CDI; Clostridium difficile infection; DACC; Data Analysis and Coordination Centre; 2,4-DNP; 2,4-dinitrophenol; DMSO; dimethyl sulfoxide; FDA; US Food and Dru
An ultrasensitive system for measuring the USPs and OTULIN activity using Nanoluc as a reporter
Keywords: غربالگری بالا; Nluc; Nanoluc; AMC; 7-amino-4-methylcoumarin; DTT; dithiothreitol; DMSO; dimethylsulfoxide; HTS; high-throughput screening; USP; ubiquitin-specific protease; GST; glutathione s-transferase; EGFP; enhanced green fluorescence protein; FRET; fluorescence res
A high-throughput assay of NK cell activity in whole blood and its clinical application
Keywords: غربالگری بالا; NK cell activity; Simple assay; High-throughput screening; IFN-γ; ELISA
HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase
Keywords: غربالگری بالا; Xanthine oxidase; High-throughput screening; Hit-to-lead; Non-purine XO inhibitors; Pyrimidone
In vitro and in vivo enhanced osteogenesis by kaempferol found by a high-throughput assay using human mesenchymal stromal cells
Keywords: غربالگری بالا; Kaempferol; Ipriflavone; Flavonoids; High-throughput screening; Mesenchymal stem cell; Osteoporosis;
C. elegans in high-throughput drug discovery
Keywords: غربالگری بالا; Fluphenazine (PubChem CID: 3372); Nemadipine-A (PubChem CID: 2856102); Clozapine (PubChem CID: 2818)Whole organism model; High-throughput screening; Small molecules; Pharmaceuticals; Drug target identification; Phenotypic analysis; Human disease models
Ultrafast CEST imaging
Keywords: غربالگری بالا; Ultrafast CEST imaging; PARACEST agents; Chemical exchange; High-throughput screening;
Associate editor: O. BinahInduced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing
Keywords: غربالگری بالا; iPSC; Drug screening; High-throughput screening; QT prolongation; Drug toxicity;
Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors
Keywords: غربالگری بالا; PARP2; Inhibitor; High-throughput screening; Chemical quantification; Biotinylated NAD+; ELISA
A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis
Keywords: غربالگری بالا; Polysialyltransferase; Polysialic acid; GFP; Endosialidase; High-throughput screening; Click chemistry;
Continuous colorimetric screening assay for detection of d-amino acid aminotransferase mutants displaying altered substrate specificity
Keywords: غربالگری بالا; Transaminases; Coupled enzyme assay; High-throughput screening; Mutagenesis; Substrate specificity; Enzyme kinetics
Evaluation of luciferase and GFP-expressing Nipah viruses for rapid quantitative antiviral screening
Keywords: غربالگری بالا; Henipavirus; Nipah virus; Antiviral screening; Luciferase; GFP; High-throughput screening;
Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies
Keywords: غربالگری بالا; GPCR; G protein-coupled receptor; IMP; integral membrane protein; CHESS; cellular high-throughput encapsulation solubilization and screening; NT; neurotensin peptide; FACS; fluorescence-activated cell sorting; EDTA; ethylenediaminetetraacetic acid; DDM; n
A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening
Keywords: غربالگری بالا; Protein palmitoylation; High-throughput screening; Autopalmitoylation; Posttranslational modification; zDHHC proteins
Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators
Keywords: غربالگری بالا; AMPK; High-throughput screening; Regulatory fragment; Drug discovery; Dephosphorylation inhibition; Nucleotide analogsAICAR, 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside; AMPK, AMP-activated protein kinase; FBDD, fragment-based drug design; MANT, m
Protein solubilization: A novel approach
Keywords: غربالگری بالا; Self-interaction chromatography; Protein solubility; Physical stability; High-throughput screening; Neural network; Design of experiments; ANN; artificial neural network; BCA; bicinchoninic acid; DLS; dynamic light scattering; Fab; antibody fragment regio
A novel high-throughput nematicidal assay using embryo cells and larvae of Caenorhabditis elegans
Keywords: غربالگری بالا; Caenorhabditis elegans; Cytotoxicity; High-throughput screening; Nematicides;
pCAP-based peptide substrates: The new tool in the box of tyrosine phosphatase assays
Keywords: غربالگری بالا; Fluorogenic enzyme substrates; Peptide synthesis; High-throughput screening; Enzyme activity gel; Multiply phosphorylated peptides;
High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects
Keywords: غربالگری بالا; FXTAS; Fragile X syndrome; LHON; Leber's hereditary neuropathy; AMPK; AMP-activated protein kinase; OCR; oxygen consumption rate; ECAR; extracellular acidification rate; Mitochondrial disease; Oxygen; Bioenergetics; High-throughput screening;
Monitoring G protein-coupled receptor activation using an adenovirus-based β-arrestin bimolecular fluorescence complementation assay
Keywords: غربالگری بالا; G protein-coupled receptor (GPCR); β-Arrestin; Bimolecular fluorescence complementation (BiFC); Adenovirus; High-throughput screening
Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings
Keywords: غربالگری بالا; SARS-CoV; Severe Acute Respiratory Syndrome coronavirus; 3CLpro; 3 Chymotrypsin-like cysteine protease; MD; molecular dynamics; VS; virtual screening; CSM; computational solvent mapping; ROC; receiver operating characteristic; RMSD; root mean square devia
Microfluidic 3D models of cancer
Keywords: غربالگری بالا; Microfluidics; 3D in vitro system; Cancer; Tumor microenvironment; Biomimetics; High-throughput screening; Drug testing;
An efficient algorithm coupled with synthetic minority over-sampling technique to classify imbalanced PubChem BioAssay data
Keywords: غربالگری بالا; High-throughput screening; Under-sampling; Over-sampling; PubChem; Imbalanced classification
Evaluation of coumarin-based fluorogenic P450 BM3 substrates and prospects for competitive inhibition screenings
Keywords: غربالگری بالا; Cytochrome P450 BM3; Fluorescence-based assay; Microtiter plate; High-throughput screening; P450 inhibition
High yield of secondary B-side electron transfer in mutant Rhodobacter capsulatus reaction centers
Keywords: غربالگری بالا; Photosynthetic reaction center; Charge recombination; High-throughput screening; Ultrafast spectroscopy; Directed evolution; Transmembrane electron transfer;
CHIP-MYTH: A novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β2-adrenergic receptor
Keywords: غربالگری بالا; membrane two-hybrid assay; protein-protein interactions; G-protein coupled receptors; drug-dependent protein interactions; high-throughput screening; LUMIER assay; Ade; adenine; 3-AT; 3-amino-1,2,4-triazole; β2AR; beta2-adrenergic receptor; Cub; carboxy-