دانلود مقالات ISI درباره غربالگری بالا + ترجمه فارسی

Screening of rare-earth-lean intermetallic 1-11 and 1-11-X compounds of YNi9In2-type for hard-magnetic applications

Keywords: غربالگری بالا; Permanent magnets; Density functional theory; High throughput screening; Ferromagnetic intermetallics; Intrinsic magnetic properties;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Detection of respiratory bacterial pathogens causing atypical pneumonia by multiplex Lightmix® RT-PCR

Keywords: غربالگری بالا; Respiratory pathogens; Molecular detection; Multiplex RT-PCR; Atypical pneumonia; High throughput screening; Lightmix® kit;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

A comparison of in vitro cytotoxicity assays in medical device regulatory studies

Keywords: غربالگری بالا; Cytotoxicity; Medical device; Qualitative and quantitative; MTT/XTT; tetrazolium; NR; neutral red; CFA; colony formation assay; MEM; minimal essential medium; HTS; high throughput screening; MHLW; Japan Ministry of Health Labour and Welfare; USP; United S

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

High throughput screening of β-glucuronidase (GUS) reporter in transgenic microalgae transformed by Agrobacterium tumefaciens

Keywords: غربالگری بالا; β-Glucuronidase; Agrobacterium tumefaciens; High throughput screening; 4-MUG; 4-MU; Chlorella vulgaris;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Utilizing Threshold of Toxicological Concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals

Keywords: غربالگری بالا; AOPs; Adverse Outcome Pathways; FSANZ; Food Standards Australia New Zealand; HTE; High Throughput Exposure; HTS; high throughput screening; ILSI; International Life Sciences Institute; HESI; Health and Environmental Sciences Institute; RISK21; Risk Assess

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

N-Acylhydrazones as drugs

Keywords: غربالگری بالا; ADME; absorption, distribution, metabolism, excretion; BBNH; N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone; BISH; boronyl salicylaldehyde isonicotinoyl hydrazone; DB; drug bank; DHBNH; dihydroxy benzoyl naphthyl hydrazone; FDA; food and dru

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

MS methods to study macromolecule-ligand interaction: Applications in drug discovery

Keywords: غربالگری بالا; MS; mass spectrometry; IM-MS; ion mobility mass spectrometry; HR-MS; high resolution mass spectrometry; MS/MS; tandem mass spectrometry; ESI; electrospray ionization; NSI; nanoelectrospray ionization; MALDI; matrix assisted laser desorption ionization; FT

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2)

Keywords: غربالگری بالا; MEKK2; MAP3K2; Kinase; Inhibitor; DMSO; dimethyl sulfoxide; MAPK; mitogen-activated protein kinase; MS; mass spectrometry; ATP; adenosine triphosphate; ADP; adenosine diphosphate; SAR; structure-activity relationship; SD; standard deviation; TR-FRET; time

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening

Keywords: غربالگری بالا; Epigenetics; Histone acetyltransferase; GCN5; High throughput screening; 1,8-Acridinedione derivative;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of bisphenol A and its analogs on reproductive health: A mini review

Keywords: غربالگری بالا; 3β-HSD; 3β-hydroxysteroid dehydrogenase; AR; androgen receptor; BPA; bisphenol A; BPAF; bisphenol AF; BPF; bisphenol F; BPS; bisphenol S; CDC; the US Centers for Disease Control and Prevention; E2; estradiol; EC20; 20% maximal effect concentration; ER Î

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening

Keywords: غربالگری بالا; High throughput screening; Epigenetics; Histone acetyltransferase; MOF; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Multiplex flow cytometry-based assay to study the breadth of antibody responses against E1E2 glycoproteins of hepatitis C virus

Keywords: غربالگری بالا; HCV; Antibody response; High throughput screening; FACS assay; Fluorescent cell barcoding;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic

Keywords: غربالگری بالا; ANO; Anoctamin; BSA; bovine serum albumin; CaCC; calcium (Ca2+)-activated Cl- channel; CF; cystic fibrosis; CFBE; cystic fibrosis bronchial epithelial (cells); CFTR; cystic fibrosis transmembrane conductance regulator; Dox; doxycycline; ER; endoplasmic re

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Rapid mass calorimeter as a high-throughput screening method for the development of flame-retarded TPU

Keywords: غربالگری بالا; Thermoplastic polyurethane; Flame retardancy; Rapid mass calorimeter; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure

Keywords: غربالگری بالا; α/β-Cardiac Myosin; Heavy chain Alpha and Beta Cardiac Myosin; ABCG2; ATP-Binding Cassette sub-family G member 2; ANOVA; Analysis of Variance; DMEM; Dulbecco's Modified Eagle Medium; DMSO; Dimethyl Sulfoxide; DPBS; Dulbecco's Phosphate-Buffered Sali

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules

Keywords: غربالگری بالا; Nuclear receptor; Pregnane and xenobiotic receptor (PXR); Stable cell lines; Herbal drugs; High throughput screening; Promoter-reporter; Small molecules;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Deciphering the role of IspD (2‑C‑methyl‑D‑erythritol 4‑phosphate cytidyltransferase) enzyme as a potential therapeutic drug target against Plasmodium vivax

Keywords: غربالگری بالا; IspD; (2‑C‑methyl‑d-erythritol 4-phosphate cytidyltransferase); PvIspD; Plasmodium vivax IspD; PfIspD; Plasmodium falciparum IspD; AtIspD; Arabidopsis thaliana IspD; MEP; Methyl erythritol phosphate (Non-mevalonate); HTS; High Throughput Screening;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition

Keywords: غربالگری بالا; Idebenone (PubChem CID: 3686); acarbose (PubChem CID: 41774); BI78D3 (PubChem CID: 2747117); candesartan cilexetil (PubChem CID: 2540); PQ401 (PubChem CID: 9549305); Src I1 (PubChem CID: 1474853); 17a-Hydroxyprogesterone (PubChem CID: 6238); FPA 124 (PubC

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay

Keywords: غربالگری بالا; Neuropilin1/VEGFR2/VEGF165; Binding; HTRF; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2018 سفارش ترجمه

Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption

Keywords: غربالگری بالا; Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Autoencoder Predicting Estrogenic Chemical Substances (APECS): An improved approach for screening potentially estrogenic chemicals using in vitro assays and deep learning

Keywords: غربالگری بالا; Deep learning; Autoencoder; Endocrine disruptor; Estrogenic; Predictive toxicology; Computational toxicology; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of a compound isolated from German chamomile (Matricaria chamomilla) with dermal sensitization potential

Keywords: غربالگری بالا; ACN; Acetonitrile; DBN; 1,5-Diazabicyclo[4.3.0]non-5-ene; DCYA; Dansyl CYsteamine; DNE; 1,6-Dioxaspiro[4.4]non-3-en-2-one; DMSO; Dimethyl sulfoxide; DPRA; Direct Peptide Reactivity Assay; ESI; Electro spray ionization; HTS; High throughput screening; LLNA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore

Keywords: غربالگری بالا; CLK; cdc2-like kinase; MDM2; mouse double minute 2 homolog; Luc; luciferase; TEA; triethylamine; DIPEA; diisopropylethylamine; EtOAc; ethyl acetate; Cdc-like kinase (CLK) inhibitors; Modulators of pre-mRNA splicing; High throughput screening; Anti-tumor a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells

Keywords: غربالگری بالا; NanoBit; RGS; High throughput screening; Gαi1; Gαq;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi

Keywords: غربالگری بالا; Trypanosoma copemani; Trypanosoma cruzi; High throughput screening; Lead compounds; Woylie;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

A novel dual luciferase based high throughput assay to monitor autophagy in real time in yeast S. cerevisiae

Keywords: غربالگری بالا; Autophagy; Luciferase; High throughput screening; Pexophagy; Peroxisome; Small molecules;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Two low complexity ultra-high throughput methods to identify diverse chemically bioactive molecules using Saccharomyces cerevisiae

Keywords: غربالگری بالا; AlamarBlue®; Optical density; Yeast; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells

Keywords: غربالگری بالا; HTS; high throughput screening; ECs; endothelial cells; DA; dorsal aorta; PCV; posterior cardinal vein; hpf; hours post fertilization; ISVs; intersegmental vessels; DLAV; dorsal longitudinal anastomotic vessel; CV; caudal vein; CVP; caudal vein plexus; pV

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2 − in LPS/IFNγ activated glioma cells

Keywords: غربالگری بالا; C6 glioma; Astrocytes; Natural products; HTP; High throughput screening; Herbs;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Recent advances on the encoding and selection methods of DNA-encoded chemical library

Keywords: غربالگری بالا; DNA-encoded library; Drug discovery; High throughput screening; Combinatorial chemistry; Dynamic combinatorial library;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Tumor-targeting peptides from combinatorial libraries

Keywords: غربالگری بالا; Tumor-targeting peptide; Biological library; Phage-display peptide library; One-bead one-compound peptide library; High throughput screening; Cell surface receptor;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Mycoloyltransferases: A large and major family of enzymes shaping the cell envelope of Corynebacteriales

Keywords: غربالگری بالا; aa; amino acids; AG; arabinogalactan; Ag85; antigen 85; DEP; diethyl phosphate; DTT; dithiothreitol; ESI-MS; ElectroSpray Ionisation- Mass Spectrometry; Fbp(s); fibronectin-binding protein(s); FITC; fluorescein isothiocyanate; HTS; high throughput screeni

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8

Keywords: غربالگری بالا; MCT8; High throughput screening; Thyroid hormone disruptors; Bisphenol A (BPA);

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Simple image-based no-wash method for quantitative detection of surface expressed CFTR

Keywords: غربالگری بالا; F508del CFTR; Surface expression; Fluorogen activating protein tag; Corrector; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

A continuous flow reactor setup as a tool for rapid synthesis of micron sized NaA zeolite

Keywords: غربالگری بالا; Multiphase flow; LTA; NaA; Pilot scale; Continuous flow reactor; CFR; High throughput screening; Zeolite synthesis

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development of resazurin-based assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei rhodesiense strain STIB 900 for the identification of potential anti-trypanosomal agents

Keywords: غربالگری بالا; High throughput screening; Human African Trypanosomiasis (HAT); Trypanosoma brucei rhodesiense; 384-Well plate format;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Optimizing multi-dimensional high throughput screening using zebrafish

Keywords: غربالگری بالا; hpf; hours post fertilization; DMSO; Dimethyl sulfoxide; HTS; high-throughput screening; Zebrafish; High throughput screening; Developmental toxicity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity

Keywords: غربالگری بالا; Pharmacoperone; High throughput screening; Antagonism; Receptor trafficking; Receptor misfolding; Therapeutic targeting of trafficking

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Screening and characterization of molecules that modulate the biological activity of IFNs-I

Keywords: غربالگری بالا; APA; antiproliferative assay; AVA; antiviral assay; C+; positive control; C-; negative control; CC; compound control; CWT; cells without treatment; DMSO; dimethyl sulfoxide; EGFP; enhanced green fluorescent protein; EnE; enhancer effect; FCS; fetal calf s

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid–azapeptoid hybrid library

Keywords: غربالگری بالا; Peptoid; Serine hydrolase; PAFAH1B2; Combinatorial chemistry; High throughput screening

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic influence of collagen I and BMP 2 drives osteogenic differentiation of mesenchymal stem cells: A cell microarray analysis

Keywords: غربالگری بالا; High throughput screening; MSC differentiation; Osteogenesis; Collagen I; Bone morphogenetic protein 2;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Benzimidazole-core as an antimycobacterial agent

Keywords: غربالگری بالا; AIDS; acquired immunodeficiency syndrome; DNA; deoxyribonucleic acid; EMB; ethambuthol; GI; growth inhibition; HIV; human immunodeficiency virus; HTS; high throughput screening; INH; isoniazid; LTBI; latent tuberculosis infection; MABA; micro plate alamar

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators

Keywords: غربالگری بالا; Hepatitis B virus; cccDNA; HBeAg; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Patient-specific hiPSC bioprocessing for drug screening: Bioprocess economics and optimisation

Keywords: غربالگری بالا; COG; cost of goods; CTS; CompacT SelecTTM automated cell culture machine; FCI; fixed capital investment; hPSC; human pluripotent stem cell; HTS; high throughput screening; iPSC; induced pluripotent stem cell; PCA; patch-clamp analysis; NCE; novel chemical

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Microfluidics for cell-based high throughput screening platforms—A review

Keywords: غربالگری بالا; High throughput screening; Cell-based microfluidics; Drug discovery

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

Keywords: غربالگری بالا; Comprehensive in vitro Proarrhythmia Assay (CiPA); Field potential data sampling and analysis; Induced pluripotent cell cardiomyocytes (hiPSC-CMs); Multi electrode array (MEA); Patch clamp technologies; Pending issues and solutions; Validation; Voltage se

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets

Keywords: غربالگری بالا; High throughput screening; Gene therapy; Hammerhead ribozyme; RNAi; siRNA; shRNA; DNAzyme; RNA drug discovery; Hereditary retinal degenerations; Autosomal dominant retinitis pigmentosa; anova; analysis of variance; bp; base pair; CV; coefficient of variat

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of NF-κB inhibitors following Shenfu injection and bioactivity-integrated UPLC/Q-TOF-MS and screening for related anti-inflammatory targets in vitro and in silico

Keywords: غربالگری بالا; BMC; Benzoyl-mesaconine; CAD; Coronary artery disease; CHD; Coronary heart disease; DEX; Dexamethasone; DMEM; Dulbecco's modified Eagle's Medium; ELISA; Enzyme-linked immunosorbent assay; ESI; Electrospray ionization; FBS; Fetal bovine serum; FUZ; Fuzil

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

Rapid quantification of low level polymorph content in a solid dose form using transmission Raman spectroscopy

Keywords: غربالگری بالا; Transmission raman; Polymoprh; Stability analysis; High throughput screening; Chemometrics; DoE;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Nitrobenzofurazan derivatives of N′-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1

Keywords: غربالگری بالا; N′-hydroxyamidines; Mechanism-based drug design; IDO1 inhibition; High selectivity; Low cytotoxicity; IDO1; indoleamine 2,3-dioxygenase 1; TDO; tryptophan 2,3-dioxygenase; L-Trp; L-tryptophan; HTS; High throughput screening; UV-Vis; ultraviolet-visi

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه