دانلود مقالات ISI درباره غربالگری بالا + ترجمه فارسی

How well can in vitro data predict in vivo effects of chemicals? Rodent carcinogenicity as a case study

Keywords: غربالگری بالا; Carcinogenesis; Prediction modeling; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile

Keywords: غربالگری بالا; Staphylococcus aureus; MRSA; ESKAPE; C. elegans; High throughput screening; Liquid infection assay; Efflux pump inhibition; Synergism;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Nanomolar inhibitors of Mycobacterium tuberculosis glutamine synthetase 1: Synthesis, biological evaluation and X-ray crystallographic studies

Keywords: غربالگری بالا; Tuberculosis; High throughput screening; X-ray crystallography; Glutamine synthetase; GlnA1 inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Intra-molecular hydrogen bonding stabilization based-fluorescent chemosensor for CO2: Application to screen relative activities of CO2 absorbents

Keywords: غربالگری بالا; CO2; Amino acid; Fluorescent chemosensor; Intra-molecular hydrogen bonding; CO2 absorbent screening; High throughput screening

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Use of MiniColumns for linear isotherm parameter estimation and prediction of benchtop column performance

Keywords: غربالگری بالا; High throughput screening; MiniColumns; Parameter estimation; Column modeling; Scale-down models;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B

Keywords: غربالگری بالا; VWBVATUTVWMVIR-LJAQVGFWSA-N; ATG4B; autophagin 1; FRET; fluorescence resonance energy transfer; HTS; high throughput screening; LC3B; microtubule-associated protein 1 A/B light chain 3B; NEM; N-ethylmaleimide; LC-MS; liquid chromatography coupled mass s

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of HCV NS5B thumb site I inhibitors: Core-refining from benzimidazole to indole scaffold

Keywords: غربالگری بالا; HCV; RdRp; Thumb site I; Indole; Anti-viral; Heterocycle; HCV; hepatitis C virus; RdRp; RNA-depended-RNA-polymerase; WHO; World Health Organization; HCC; hepatocellular carcinoma; SOC; standard of care; PEG-IFN-α; pegalated α-interferon; RVB; Ribavi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening

Keywords: غربالگری بالا; Neuroprogenitor cells; Apoptosis; In vitro models; High throughput screening; Developmental neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: Implications for oral cancer therapy

Keywords: غربالگری بالا; Anticancer agent; High throughput screening; Pyrithione zinc; Oral cancer; Tumor xenografts;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor

Keywords: غربالگری بالا; Kinases; Tumor; CDK2; Modulator; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

A “plug-and-use” approach towards facile fabrication of capillary columns for high performance nanoflow liquid chromatography

Keywords: غربالگری بالا; Column technology; Chromatography; Proteomics; High throughput screening; Capillary column

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells

Keywords: غربالگری بالا; ANGII; angiotensin II; AT2; angiotensin II receptor type 2; DRG; dorsal root ganglion; E2; estradiol or estrogen; ER; estrogen receptor; GDNF; glial cell line derived neurotrophic factor; NGF; nerve growth factor; PGP9.5; protein gene product 9.5; ir; imm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

A new combination approach of CI jet and QESD to formulate pH-susceptible amorphous solid dispersions

Keywords: غربالگری بالا; ASDs; Amorphous solid dispersions; BCS; Biopharmaceutics classification system; BI; Boehringer Ingelheim Pharmaceuticals; CIJ; Confined impinging jet; CQAs; Critical quality attributes; DCM; Dicholoromethane; HP-55; Hydroxypropyl methylcellulose phthalate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

A fast and sensitive coupled enzyme assay for the measurement of l-threonine and application to high-throughput screening of threonine-overproducing strains

Keywords: غربالگری بالا; l-Threonine aldolase; Threonine determination; Coupled enzyme assay; High throughput screening

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Keywords: غربالگری بالا; AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Bioengineering 3D environments for cancer models

Keywords: غربالگری بالا; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; 2D; two-dimensional; 3D; three-dimensional; PEG; polyethylene glycol; PLG; poly(lactide-co-glycolide); PLA; polylactic acid; RGD; arginine-glycine-aspartate peptide sequence; MMPs; m

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Applications of NMR screening techniques to the pharmaceutical target Checkpoint kinase 1

Keywords: غربالگری بالا; AEBSF; 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride; Chk1; Checkpoint kinase 1; DIRECTION; Difference of Inversion REcovery rate with and without Target IrradiatiON; DSBs; double strand breaks; HEPES; 4-(2-HydroxyEthyl)-1-PiperazineEthaneSulfoni

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Keywords: غربالگری بالا; Cancer immunotherapy; Enzyme inhibition; High throughput screening; Indoleamine 2,3-dioxygenase; In silico drug design; Molecular dynamics simulations; Structure–activity relationship; Tryptophan metabolismIDO1, indoleamine 2,3-dioxygenase 1; MHC, Maybrid

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

Recent advances in RNA interference research in insects: Implications for future insect pest management strategies

Keywords: غربالگری بالا; RNA interference; Systemic RNAi; High throughput screening; Microbial insecticide; Transgenic crop plants;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Intestinal organoids as tissue surrogates for toxicological and pharmacological studies

Keywords: غربالگری بالا; Intestinal organoids; Embryonic stem cells; Induced pluripotent cells; Intestinal stem cells; High throughput screening;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Keywords: غربالگری بالا; PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of PEG/phosphate aqueous two-phase systems for the purification of the chicken egg white protein avidin by using high-throughput techniques

Keywords: غربالگری بالا; Aqueous two-phase systems; High throughput screening; Tandem-HPLC; Avidin; Egg white proteins;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Perspectives in targeting miRNA function

Keywords: غربالگری بالا; miRNA; Antagomirs; Small molecules; High throughput screening

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

High Throughput Screening of Tranquilizers in Dairy Products Using Ultra-Performance Liquid Chromatography Coupled to High Resolution Time-of-Flight Mass Spectrometry

Keywords: غربالگری بالا; Tranquilizer; Dairy product; Ultra performance liquid chromatography; Time-of-flight mass spectrometry; High throughput screening

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Keywords: غربالگری بالا; Pim kinases; Kinase inhibitor; Structure based drug design; High throughput screening; Lead optimization

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A high throughput screening strategy for the assessment of nitrile-hydrolyzing activity towards the production of enantiopure β-hydroxy acids

Keywords: غربالگری بالا; Biotransformation; Bacterial isolates; Nitrile hydrolysing activity; High throughput screening; Enantioselectivity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

A quantitative high throughput assay for identifying gametocytocidal compounds

Keywords: غربالگری بالا; Malaria; Gametocytes; AlamarBlue; High throughput screening; Malaria drug discovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Yeast surface display for the expression, purification and characterization of wild-type and B11 mutant glucose oxidases

Keywords: غربالگری بالا; Saccharomyces cerevisiae; Glucose oxidase; Directed evolution; High throughput screening; Chimera

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches

Keywords: غربالگری بالا; Yersinia virulence; YopH; High throughput screening; Virtual screening

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Spheroid culture as a tool for creating 3D complex tissues

Keywords: غربالگری بالا; spheroid; bioengineering; high throughput screening; biomimicry

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis

Keywords: غربالگری بالا; Autoantigen discovery; High throughput screening; PhIP-Seq; Proteomics

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Systematic evaluation of 640 FDA drugs for their effect on CD4+Foxp3+ regulatory T cells using a novel cell-based high throughput screening assay

Keywords: غربالگری بالا; Immunosuppressive drugs; Regulatory T cells; Immune tolerance; High throughput screening; Foxp3APC, antigen presenting cell; CSA, cyclosporine A; CTLA-4, Cytotoxic T-Lymphocyte Antigen 4; DMEM, Dulbecco's modified Eagle's medium; FACS, fluorescence activa

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: Gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs

Keywords: غربالگری بالا; Glutamate decarboxylase; GABA; Assay development; High throughput screening; Enzyme inhibitors; Pesticide discovery;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

Keywords: غربالگری بالا; Antitubercular drugs; High throughput screening; Membrane targets; Hydrophobic compounds; Genetic analysis

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2013 سفارش ترجمه

Long time monitoring of the respiratory activity of isolated mitochondria

Keywords: غربالگری بالا; Isolated mitochondria; Respiratory activity; Optical oxygen sensor; High throughput screening

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Fast mouse PK (Fast PK): A rapid screening method to increase pharmacokinetic throughput in pre-clinical drug discovery

Keywords: غربالگری بالا; PK; pharmacokinetics; PD; pharmacodynamics; PO; per oral; IV; intravenous; HTS; high throughput screening; DMPK; drug metabolism and pharmacokinetics; AUC; area under the curve; HPMC; hydroxypropylmethyl cellulose; CMC; carboxymethyl cellulose; Pharmacoki

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications

Keywords: غربالگری بالا; DNT; developmental neurotoxicity; NPC; neural progenitor cell; COPAS; complex object parametric analyzer and sorter; HTS; high throughput screening; ROS; reactive oxygen species; DCF; dichlorofluorescin; PDL; poly-d-lysin; AU; arbitrary units; TOF; time o

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

BACE1 in Alzheimer's disease

Keywords: غربالگری بالا; Aβ; β-amyloid; ACDL; acid-cluster dileucine motif; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain protein; AICD; amyloid precursor protein intracellular domain; APLP; amyloid precursor-like protein; ApoE; apolipoprotein E; APP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Fluorescence properties of the anti-tumour alkaloid luotonin A and new synthetic analogues: pH modulation as an approach to their fluorimetric quantitation in biological samples

Keywords: غربالگری بالا; CE; Capillary electrophoresis; ESPT; Excited state proton transfer reactions; HPLC; High performance liquid chromatography; HTS; High throughput screening; LOD; Limit of detection; LOQ; Limit of quantitation; NMR; Nuclear magnetic resonance; QY; Quantum y

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

BioProfile-Extract knowledge from corporate databases to assess cross-reactivities of compounds

Keywords: غربالگری بالا; HTS; high throughput screening; BI; Boehringer Ingelheim; POC; percent of control; DB; database; DR; dose response; Data mining; Cross reactivities; Frequent Hitter; BioProfile;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

Keywords: غربالگری بالا; Leishmania; Leishmaniasis; Drug discovery; High throughput screening

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis

Keywords: غربالگری بالا; Trypanosoma brucei brucei; High throughput screening; Hit-to-lead; Time to kill

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Screening for small molecule inhibitors of embryonic pathways: Sometimes you gotta crack a few eggs

Keywords: غربالگری بالا; Xenopus; Egg extract; Small molecule; High throughput screening; Wnt signaling; Notch signaling; Hedgehog signaling;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Assessing embryonic stem cell response to surface chemistry using plasma polymer gradients

Keywords: غربالگری بالا; Plasma polymer; Stem cell; Gradient; High throughput screening

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Novel peptide ligand with high binding capacity for antibody purification

Keywords: غربالگری بالا; Small synthetic peptide ligands; Mixed-mode chromatography; Monoclonal antibody purification; Isothermal titration calorimetry; High throughput screening

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

High-content screening of peptide-based non-viral gene delivery systems

Keywords: غربالگری بالا; High-content screening; Gene delivery; Non-viral; High throughput screening; Fluorescent microscopy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Optimisation of expression and purification of the feline and primate foamy virus transmembrane envelope proteins using a 96 deep well screen

Keywords: غربالگری بالا; Optimisation of protein expression; High throughput screening; Foamy viruses; Transmembrane envelope protein; HIV-1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro

Keywords: غربالگری بالا; G6PD; glucose-6-phosphate dehydrogenase; HEDS; hydroxyethyldisulfide; OPPC; oxidative pentose phosphate cycle; ME; mercaptoethanol; DTNB; dithiobisnitrobenzoicacid; HTS; high throughput screening; Glutathione; Glucose metabolism; Cytotoxicity; Cell prolif

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

High throughput screening based selection of phases for aqueous two-phase system-centrifugal partitioning chromatography of monoclonal antibodies

Keywords: غربالگری بالا; Centrifugal partitioning chromatography; Monoclonal antibody; Host cell protein; Process development; High throughput screening

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests

Keywords: غربالگری بالا; High throughput screening; Cytotoxicity; Acute oral toxicity; Validation; Safety assessment; Alternative methods;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه