کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10585124 | 981362 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BioProfile-Extract knowledge from corporate databases to assess cross-reactivities of compounds
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
In the last 10-15Â years, many new technologies and approaches have been implemented in research in the pharmaceutical industry; these include high-throughput screening or combinatorial chemistry, which result in a rapidly growing amount of biological assay and structural data in the corporate databases. Efficient use of the data from this growing data mountain is a key success factor; 'provide as much knowledge as possible as early as possible and therefore enable research teams to make the best possible decision whenever this decision can be supported by stored data'. Here, an approach which started several years ago to obtain as much information as possible out of historical assay data stored in the corporate database is described. It will be shown how important a careful preprocessing of the stored data is to enhance its information. Different possibilities for accessing and to analyzing the preconditioned data are in place. Some of will be described in the examples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 18, 15 September 2012, Pages 5428-5435
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 18, 15 September 2012, Pages 5428-5435
نویسندگان
Bernd Beck,