miRNA-144 induces microglial autophagy and inflammation following intracerebral hemorrhage
Keywords: من; miRNA-144; Microglia; Autophagy; Inflammation; ICH;
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Shunts: Is Surgical Education Safe?
Keywords: من; Complication; Hydrocephalus; Outcome; Resident training; Risk; Safety; Shunt; Surgical education; BCFN; Board-certified faculty neurosurgeons; CI; Confidence interval; CSF; Cerebrospinal fluid; HR; Hazard ratio; HUG; University Hospital Geneva; ICH; Intra
Tim-3 enhances brain inflammation by promoting M1 macrophage polarization following intracerebral hemorrhage in mice
Keywords: من; Tim-3; Inflammation; M1 polarization; ICH;
Provision of food and water in rodent whole body plethysmography safety pharmacology respiratory studies - Impact on animal welfare and data quality
Keywords: من; bpm; breaths per minute; ICH; International Conference on Harmonisation; p.o.; oral gavage administration; MV; minute volume; f; respiratory rate; S.E.M.; standard error of the mean; TV; tidal volume; WBP; whole body plethysmography; Food; Water; Whole-bo
Endovascular Stroke Treatment of Acute Tandem Occlusion: A Single-Center Experience
Keywords: من; ASPECTS; Alberta Stroke Program early computed tomography score; CI; confidence interval; ICA; internal carotid artery; ICH; intracranial hemorrhage; mRS; modified Rankin scale; NIHSS; National Institutes of Health Stroke Scale; OR; odds ratio; sICH; symp
Target Embolization of Associated Aneurysms in Ruptured Arteriovenous Malformations
Keywords: من; Associated aneurysm; Complication; Rehemorrhage; Ruptured brain arteriovenous malformations; Target embolization; AN; Aneurysm; BAVM; Brain arteriovenous malformation; ICH; Intracranial hemorrhage; mRS; Modified Rankin Scale; NBCA; N-butyl cyanoacrylate;
Clinical Features of Hemorrhagic Moyamoya Disease in China
Keywords: من; Clinical features; Hemorrhage; Moyamoya disease; Rebleeding; CT; Computed tomography; ICA; Internal carotid artery; ICH; Intracerebral hemorrhage; IVH; Intraventricular hemorrhage; MMD; Moyamoya disease; PCA; Posterior cerebral artery; SAH; Subarachnoid h
Antiplatelet Resumption after Antiplatelet-Related Intracerebral Hemorrhage: AÂ Retrospective Hospital-Based Study
Keywords: من; Antiplatelet medication; Intracerebral hemorrhage; BP; blood pressure; CAA; cerebral amyloid angiopathy; CI; confidence interval; CT; computed tomography; DBP; diastolic blood pressure; HR; hazard ratio; ICH; intracerebral hemorrhage; IQR; interquartile r
Detection of high serum concentration of CXC chemokine ligand-12 in acute intracerebral hemorrhage
Keywords: من; ICH; intracerebral hemorrhage; AUC; area under curve; CI; confidence interval; CT; computerized tomography; CXCL12; CXC chemokine ligand-12; NIHSS; National Institutes of Health Stroke Scale; HR; hazard ratio; OR; odds ratio; ROC; receiver operating chara
Original ArticleCorrelation of Circulating T Lymphocytes and Intracranial Hypertension in Intracerebral Hemorrhage
Keywords: من; Hypertensive intracerebral hemorrhage; Indicator; Intracranial pressure; Ratio; T lymphocytes; AUC; area under the curve; GCS; Glasgow Coma Scale; GOS; Glasgow Outcome Scale; ICH; intracerebral hemorrhage; ICP; intracranial pressure;
Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage
Keywords: من; GFAP; glial fibrillary acidic protein; HO; heme oxygenase; ICH; intracerebral hemorrhage; MTT; Methylthiazolyldiphenyl-tetrazolium; Nrf2; nuclear factor erythroid 2-related factor 2; Tg; transgenic; Glia; Intracerebral hemorrhage; Nrf2; Stroke; Subarachno
Technical Note & Surgical TechniqueEarly microsurgery in a paradigm of “intervention first” for skull base Cognard grade IV dural arteriovenous fistulas
Keywords: من; CSF; cerebrospinal fluid; CT; computed tomography; CVR; cortical venous reflux.; DAVFs; dural arteriovenous fistulas; DSA; digital subtraction angiography; GCS; Glasgow coma scale; ICH; intracerebral hemorrhage; IVH; intraventricular hemorrhage; mRS; modi
Identification of appropriate QTc formula in beagle dogs for nonclinical safety assessment
Keywords: من; Beagle dogs; Electrocardiogram; Heart rate; QT correction formula; Preclinical assessment; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ECG; Electrocardiogram; GLP; Good Laboratory Practice; HR; Heart Rate; ICH; Internat
Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
Keywords: من; Silymarin; ICH; NLRP3; Inflammasome; NF-κB-P65; Nrf-2;
Original ArticleComparison of Grading Scales Regarding Perioperative Complications and Clinical Outcomes of Brain Arteriovenous Malformations After Endovascular Therapy-Multicenter Study
Keywords: من; Brain arteriovenous malformations; Endovascular therapy; Grading scales; AN; Aneurysm; AUC; Area under the curve; AUROC; Area under the receiver operating characteristic curve; AVF; Arteriovenous fistula; bAVM; Brain arteriovenous malformation; ICH; Intra
Association of ACVRL1 Genetic Polymorphisms with Arteriovenous Malformations: A Case-Control Study and Meta-Analysis
Keywords: من; ACVRL1; Arteriovenous malformations; Single nucleotide polymorphism; ACVRL1; Activin receptorlike kinase 1; BAVM; Brain arteriovenous malformation; CI; Confidence interval; ICH; Intracranial hemorrhage; OR; Odds ratio; PCR; Polymerase chain reaction; SNP;
Stentriever Thrombectomy Failure: A Challenge in Stroke Management
Keywords: من; Mechanical thrombectomy; Stent; Stroke; Tirofiban; CT; Computed tomography; CTA; Cerebral tomography angiography; CTp; Perfusion computed tomography; DSA; Digital subtraction angiography; ICA; Internal cerebral artery; ICH; Intracerebral hemorrhage; LAO;
Research paperIn-line monitoring of multi-layered film-coating on pellets using Raman spectroscopy by MCR and PLS analyses
Keywords: من; PAT; process analytical technology; EMA; European medicines agency; FDA; food and drug administration; ICH; international conference for harmonization of technical requirements for registration of pharmaceuticals for human use; PLS; partial least squares;
Patterns of Stroke Between University Hospitals and Nonuniversity Hospitals in Mainland China: Prospective Multicenter Hospital-Based Registry Study
Keywords: من; Acute stroke patterns; China; Multicenter; Nonuniversity hospitals; University hospitals; CT; Computed tomography; ICH; Intracranial hemorrhage; MRI; Magnetic resonance imaging; mRS; Modified Rankin Scale;
Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infants
Keywords: من; BPD; bronchopulmonary dysplasia; BW; birth weight; GA; gestational age; ICH; intracranial hemorrhage; NDI; neurodevelopmental impairment; NEC; necrotizing enterocolitis; NRN; Neonatal Research Network; OR; adjusted odds ratio; PDA; patent ductus arteriosu
Safety evaluation of Astragalus extract mixture HT042 and its constituent herbs in Sprague-Dawley rats
Keywords: من; Astragalus extract mixture; HT042; Astragalus membranaceus; Eleutherococcus senticosus; Phlomis umbrosa; Toxicity; RBC; red blood cell; ALT; alanine aminotransferase; ICH; International Council for Harmonisation;
Determination of genotoxic impurity in atazanavir sulphate drug substance by LC-MS
Keywords: من; GTI; Atazanavir; LC-MS; ICH; QL; DL;
Original ArticlesMarkers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation
Keywords: من; extubation; extremely preterm; neonatal morbidity; bronchopulmonary dysplasia; BPD; Bronchopulmonary dysplasia; CPAP; Continuous positive airway pressure; EPT; Extremely preterm; FiO2; Fraction of inspired oxygen; GA; Gestational age; ICH; Intracranial he
Surgical Evacuation of Spontaneous Supratentorial Lobar Intracerebral Hemorrhage: Comparison of Safety and Efficacy of Stereotactic Aspiration, Endoscopic Surgery, and Craniotomy
Keywords: من; Craniotomy; Endoscopic surgery; Intracerebral hemorrhage; Stereotactic aspiration; CT; Computed tomography; ER; Evacuation rate; ES; Endoscopic surgery; GCS; Glasgow Coma Scale; GOS; Glasgow Outcome Scale; HV; Hematoma volume; ICH; Intracerebral hemorrhag
Predicting Subclinical Atherosclerosis in Low-Risk Individuals
Keywords: من; cardiovascular risk; Fuster-BEWAT score; ideal cardiovascular health; predictive tools; subclinical atherosclerosis; CACS; coronary artery calcium score; CT; computed tomography; CV; cardiovascular; CVD; cardiovascular disease; FBS; Fuster-BEWAT (blood pr
MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage
Keywords: من; miR-124; M2 polarization; Microglia; Inflammation; C/EBP-α; ICH;
Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood-brain barrier dysfunction in vitro
Keywords: من; AD; Alzheimer's disease; AP; activating peptide; BBB; blood-brain barrier; BMEC; brain microvascular endothelial cell; DMEM; Dulbecco's modified Eagle's medium; EDTA; ethylenediaminetetraacetic acid; ERK; extracellular signal-regulated kinase; FBS
Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia
Keywords: من; DAPI; 4/6-diamidino-2-phenylindole; FBS; fetal bovine serum; HP-β-CD; hydroxypropyl-β-cyclodextrin; ICH; intracerebral hemorrhage; IKK; IκB kinase; IL-1β; interleukin-1β; IL-6; interleukin-6; IκB; Inhibitor of κB; LPS; lipopolysaccharide; MACS; mag
ReviewGenotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations
Keywords: من; COL4A1; collagen type IV alpha 1; COL4A2; collagen type IV alpha 2; CVD; cerebrovascular disease; HANAC; hereditary angiopathy with nephropathy, aneurysms and muscle cramps; ICH; intracerebral hemorrhages; OI; Osteogenesis imperfecta; NC1; non collagenous
Antiplatelet Agents for the Treatment and Prevention of Coronary Atherothrombosis
Keywords: من; aspirin; cangrelor; clopidogrel; prasugrel; ticagrelor; vorapaxar; ACS; acute coronary syndromes; CABG; coronary artery bypass graft; CAD; coronary artery disease; COX; cyclooxygenase; DAPT; dual antiplatelet therapy; ICH; intracranial hemorrhage; MI; myo
The Role of ABO Blood Group in Cerebral Vasospasm, Associated Intracranial Hemorrhage, and Delayed Cerebral Ischemia in 470 Patients with Subarachnoid Hemorrhage
Keywords: من; Cerebral vasospasm; Delayed cerebral ischemia; Hemostasis; Nitric oxide; Stroke and blood coagulation; CT; Computed tomography; CVS; Cerebral vasospasms; DCI; Delayed cerebral ischemia; eNOS; Endothelial nitric oxide synthase; ICH; Intracerebral hemorrhag
Characterization of N-Acetyl-Tryptophan Degradation in Protein Therapeutic Formulations
Keywords: من; HPLC (high-performance/pressure liquid chromatography); oxidation; excipients; chemical stability; formulation; analytical chemistry; AAPH; 2,2â²-Azobis(2-amidinopropane) dihydrochloride; DiOia; dioxyindolylalanine; HSA; human serum albumin; ICH; Interna
Photostability testing using online reactor HPLC hyphenation and mass spectrometric compound identification illustrated by ketoprofen as model compound
Keywords: من; API; active pharmaceutical ingredient; DAD; diode array detection; EI; electron ionization; ESI; electrospray ionization; ESI+; positive electrospray ionization; FDA; US Food and Drug Administration; GC; gas chromatography; HPLC; high performance liquid c
ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia
Keywords: من; ICH; Thrombin; ROS/TXNIP pathway; NLRP3 inflammasome; Apoptosis;
Reverse phase HPLC method for detection and quantification of lupin seed γ-conglutin
Keywords: من; HPLC; high pressure liquid chromatography; TFA; trifluoroacetic acid; MS/MS; mass spectroscopy; SDS-PAGE; sodium dodecyl sulphate polyacrylamide gel electrophoresis; ELISA; enzyme-linked immunosorbent assay; MRM; multiple reaction monitoring; RP-HPLC; rev
Cerebral microbleeds, cognitive impairment, and MRI in patients with diabetes mellitus
Keywords: من; BOMBS; Brain Observer Micro-Bleed Scale; CAA; cerebral amyloid angiopathy; CBF; cerebral blood flow; CSVD; cerebral small vessel disease; CMBs; cerebral microbleeds; CT; computed tomography; DM; diabetes mellitus; ESWAN; enhanced gradient echo T2*-weighte
Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments
Keywords: من; 3T3 NRU PT; 3T3 neutral red uptake phototoxicity testing; AOP; adverse outcome pathway; DEREK; deductive estimation of risk from existing knowledge; HOMO-LUMO gap; energy gap between the highest occupied molecular orbital and the lowest unoccupied molecul
Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity
Keywords: من; ACN; acetonitrile; AHP; American Herbal Pharmacopoeia; AMB; Amphotericin B; ANOVA; analysis of Variance; ATCC; American Type Culture Collection; CCC; CEREMIC culture collection; CEREMIC; Centro de Referencia de MicologÃa; CFU; colony-forming units; CLSI;
Formation Mechanism and In Vitro Evaluation of Risperidone-Containing PLGA Microspheres Fabricated by Ultrafine Particle Processing System
Keywords: من; microspheres; dissolution; material science; drug delivery systems; controlled release; RIS; risperidone; PLGA; poly(d, l-lactic-co-glycolic acid); UPPS; ultrafine particle processing system; MS; microsphere; DCM; dichloromethane; DMC; dimethyl carbonate;
Impurity profiling of l-asparagine monohydrate by ion pair chromatography applying low wavelength UV detection
Keywords: من; AA; amino acid; FMOC; 9-fluorenylmethyl chloroformate; ICH; International Council for Harmonization; LOQ; limit of quantitation; Ph. Eur.; European Pharmacopoeia; R2; regression coefficient; RSD; relative standard deviation; S/N; signal-to-noise ratio; RR
Gene silencing of MCP-1 prevents microglial activation and inflammatory injury after intracerebral hemorrhage
Keywords: من; MCP-1; Microglia; Activation; Inflammation; ICH
Research articleMild hypothermia protects rat neuronal injury after intracerebral hemorrhage via attenuating endoplasmic reticulum response induced neuron apoptosis
Keywords: من; ICH; intracerebral hemorrhage; ER; endoplasmic reticulum; NT; normothermic; HT; hypothermic; qRT- PCR; quantificational real-time polymerase chain reaction; TUNEL; terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; Intracerebral hemorr
IL-17A promotes microglial activation and neuroinflammation in mouse models of intracerebral haemorrhage
Keywords: من; IL-17A; Microglia; Neuroinflammation; ICH;
Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage
Keywords: من; Sinomenine; Microglia; M2 polarization; Inflammatory injury; ICH;
Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant
Keywords: من; (2R,4R)-Monatin; QT prolongation; QTc; TQT study; Food ingredient; ADME; absorption, distribution, metabolism, and elimination; AE; adverse event; Ae; amounts excreted; AUC0-inf; area under the plasma concentration-time curve to infinite time; AUC0-t; a
Research PaperRole of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model
Keywords: من; PDGF-D; PDGFR-β; ICH; Neuroinflammation;
Quantitative measurement of amoxicillin in Ibuprofen tablets using UPLC
Keywords: من; UPLC; Amoxicillin; Ibuprofen tablets; Quantitative determination; Penicillin traces; Pharmaceutical analysis; UPLC; ultra performance liquid chromatography; cGMP; current good manufacturing practices; ICH; international conference of harmonization; RSD; r
Programmed death (PD)-1 attenuates macrophage activation and brain inflammation via regulation of fibrinogen-like protein 2 (Fgl-2) after intracerebral hemorrhage in mice
Keywords: من; PD-1; Macrophage; Inflammation; Fgl-2; ICH;
An FDA oncology analysis of immune activating products and first-in-human dose selection
Keywords: من; MABEL; Immune oncology; First-in-human dose; ADCC; antibody-dependent cellular cytotoxicity; CRA; cytokine release assay; CRS; cytokine release syndrome; DLT; dose limiting toxicity; EMA; European Medicines Agency; FIH; first-in-human; HHD; highest human
Size of monodispersed nanomaterials evaluated by dynamic light scattering: Protocol validated for measurements of 60 and 203Â nm diameter nanomaterials is now extended to 100 and 400Â nm
Keywords: من; ANOVA; analysis of variance; AT; ambient temperature; CRM; certified reference material; CV; coefficient of variation; DLS; dynamic light scattering; ERM; European reference materials; GUM; guide to the expression of uncertainty in measurement; ICH; Inter