Diabetes and fragility fractures - A burgeoning epidemic?
Keywords: Diabetes; Osteoporosis; Fragility fractures; Neuropathy thiazolidinediones; Insulin; Obesity; IGF-1;
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Measurement of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 after delayed separation of whole blood samples
Keywords: IGF-1; IGFBP-3; Storage; Stability; Serum; Plasma; Whole blood
Low intensity exercise attenuates disease progression and stimulates cell proliferation in the spinal cord of a mouse model with progressive motor neuronopathy
Keywords: exercise; pmn mice; neuroprotection; IGF-1; motoneuronsBrdU, bromodeoxyuridine; IGF-1, insulin-like-growth factor 1; L-VF, lateral and ventral funiculi; PF, posterior funiculus; pmn, progressive motor neuronopathy
Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children
Keywords: Children; Adenotonsillectomy; Growth; Adenotonsillar hypertrophy; IGF-1; Sleep disorders
BCAR3 regulates EGF-induced DNA synthesis in normal human breast MCF-12A cells
Keywords: BCAR3; Cas; Microinjection; EGF; Insulin; IGF-1; DNA synthesis; SH2 domain
Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression
Keywords: YY1; CHOP-10; Adipocyte differentiation; IGF-1; FBS
Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
Keywords: Glucose; IGF-1; microRNA; Apoptosis; Cytochrome-c; Mitochondria
Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor
Keywords: Statin; Simvastatin; IGF-1; IGF-1 receptor; PC-3
Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep
Keywords: Fetal; Undernutrition; Overnutrition; Heart; CNTFR; STAT3; IGF-1
Ghrelin treatment suppresses neutrophil-dominant inflammation in airways of patients with chronic respiratory infection
Keywords: Ghrelin; Respiratory tract infection; Neutrophil; Cachectic state; IGF-1; Translational research
A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells
Keywords: Mesenchymal stem cells; PI3K; p38; TGF-β1; IGF-1; Collagen-GAG scaffold; Chondrogenic differentiation
Anabolic effects of PTH in cyclooxygenase-2 knockout osteoblasts in vitro
Keywords: Prostaglandin; Nonsteroidal anti-inflammatory drugs; Sclerostin; IGF-1; MKP-1
The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: Findings from the prospective British Women's Heart and Health Study
Keywords: IGF-1; CHD; Epidemiology; Women;
Changes in total ghrelin within the somatotropic axis in severe burn patients: Comparison of those with inhalation injury and those without inhalation injury
Keywords: Growth hormone; IGF-1; Ghrelin; IGFBP-3; Severe burn; Inhalation injury
Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K/PTEN/Akt pathway
Keywords: MSTN; Myostatin; TGF-β; Transforming growth factor-β; PI3K; Phosphatidylinositol 3-kinase; PTEN; Phosphatase and tensin homolog deleted on chromosome 10; MAPK; Mitogen-activated protein kinase; ERK; Extracelluar signal-regulated kinase; JNK; c-Jun N-ter
Differentiation of endothelial cells derived from mouse embryoid bodies: A possible in vitro vasculogenesis model
Keywords: mES cells; mouse embryonic stem cells; EBs; embryoid bodies; EGM-2; endothelial growth medium-2; LIF; leukaemia inhibitory factor; VEGF; vascular endothelial growth factor; bFGF; basic fibroblast growth factor; IL-6; interleukin-6; EPO; erythropoietin; IG
Relationship between antidepressants and IGF-1 system in the brain: Possible role in cognition
Keywords: IGF-1; Fluoxetine; Antidepressants; Cognition; Frontal Cortex; Hippocampus
Physiological levels of insulin and IGF-1 synergistically enhance the differentiation of mesenteric adipocytes.
Keywords: Mesenteric adipocytes; Differentiation; Insulin; IGF-1; Insulin resistance;
Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system
Keywords: Ghrelin; GHS-R; Aging; Pituitary; GH; IGF-1; Prolactin; Pit-1; Thymus
Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin
Keywords: Wnt; cat/TCF; Insulin; IGF-1; FOXO; mTOR
Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1α activity
Keywords: Chondrogenesis; Cartilage repair; Hypoxia; HIF-1α; BMP-2; IGF-1
Selective inhibition of SCLC growth by the A12 anti-IGF-1R monoclonal antibody correlates with inhibition of Akt
Keywords: IGF-1; IGF-1R antibody; Akt; Small cell lung cancer
Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells
Keywords: AS160; AKT substrate 160 kDa; AS160_v2; AS160_variant 2; AICAR; 5-aminoimidozole-4-carboxamide 1 β-D-ribonucleoside; AMPK; 5'AMP-activated protein kinase; IGF-1; insulin like growth factor-1; GAP; GTPase-activating protein; PTB; phospho-tyrosine binding
Th2 Cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages
Keywords: 5-HT; 5-hydroxytryptamine; AAMÏ; alternatively activated macrophage; BEC; S-(2-boronoethyl)-I-cysteine; CAMÏ; classically activated macrophage; Cl2MDP; clodronate; FIZZ; found in inflammatory zone; IFN-γ; interferon-γ; IGF-1; insulin-like growth facto
Molecular and ultrastructural characterization of endothelial cells differentiated from human bone marrow mesenchymal stem cells
Keywords: Mesenchymal stem cell; Endothelial cells; Angiogenesis; Differentiation; IGF-1; Weible-Palade body;
NBS1 is required for IGF-1 induced cellular proliferation through the Ras/Raf/MEK/ERK cascade
Keywords: NBS1; Ras/Raf/MEK/ERK; MAPK; IGF-1; Cell cycle progression;
Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: Results of the Study of Health in Pomerania (SHIP)
Keywords: References ranges; IGF-1; IGFBP-3; Quantile regression; Study of Health in Pomerania (SHIP)
Nitric oxide mediates the survival action of IGF-1 and insulin in pancreatic β cells
Keywords: Beta cell survival; Nitric oxide; Insulin; IGF-1
Insulin-Like Growth Factor-1 Restores Erectile Function in Aged Rats: Modulation the Integrity of Smooth Muscle and Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Activity
Keywords: IGF-1; Aging; Erectile Dysfunction; Gene Therapy;
Role of platelets on liver regeneration after 90% hepatectomy in mice
Keywords: PH; partial hepatectomy; LR; liver regeneration; HGF; hepatocyte growth factor; IGF-1; insulin-like growth factor; TGFβ1; transforming growth factor beta 1; PDGF; platelet-derived growth factor; PEG-rHuMGDF; pegylated recombinant human megacaryocyte grow
FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
Keywords: EGF; IGF-1; FGF2; Real-time PCR; Endometrial cancer
Peripheral elevation of IGF-1 fails to alter Aβ clearance in multiple in vivo models
Keywords: Aβ; Alzheimer's disease; IGF-1; Clearance; Tg2576; Tau
Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women
Keywords: Menopause; Muscle strength; Resistance training; Estrogen; IGF-1;
How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
Keywords: DNA damage; IGF-1; Aging; Cancer; p53; Stem cells; p16INK4A
Growth Hormone Treatment for Growth Failure in Pediatric Patients with Crohn's Disease
Keywords: BP3; Binding protein 3; CD; Crohn's disease; DEXA; Dual-energy x-ray absorptiometry; GH; Growth hormone; IBD; Inflammatory bowel disease; IGF-1; Insulin-like growth factor 1; PCDAI; Pediatric Crohn's Disease Activity Index; RDA; Recommended Dietary Allowa
Temperature and ration effects on components of the IGF system and growth performance of rainbow trout (Oncorhynchus mykiss) during the transition from late stage embryos to early stage juveniles
Keywords: Rainbow trout; Incubation temperature; Ration levels; Transitional feeding period; Late stage embryos (LSEs); Early stage juveniles (ESJs); IGF-1; IGF-2; IGF-RIa; IGF-RIb
Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
Keywords: p53; Mammary gland; Mouse; Ductal morphogenesis; IGF-1
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament
Keywords: Anterior cruciate ligament; Collagen hydrogel; Gene transfer; IGF-1; Adenovirus
IGF-1 receptor signaling pathways and effects of AMPK activation on IGF-1-induced progesterone secretion in hen granulosa cells
Keywords: IGF-1; Steroidogenesis; Energy metabolism; Follicle
Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis
Keywords: amyotrophic lateral sclerosis; insulin; free oxygen radicals; endplate innervation; behavior testing; electrophysiology; ALS; amyotrophic lateral sclerosis; ChAT; choline acetyltransferase; CMAP; compound motor action potential; CREB; cAMP response elemen
Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice
Keywords: IGF-1; GH; GHRH; Grip strength test; Somatostatin; Soleus; VGF
The presence of EGF- and IGF-1-receptors in the small intestine of fetal, neonatal and weaned piglets
Keywords: EGF; IGF-1; Development; Intestine; Pig
Hypertrophy and atrophy inversely regulate Caveolin-3 expression in myoblasts
Keywords: DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; HS; horse serum; PBS; phosphate buffer solution; BSA; bovine serum albumin; Caveolin 3; Hypertrophy; AKT; Igf-1; Vasopressin; Atrophy; Starvation; Dexamethasone;
Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells
Keywords: IGF-1; Stem cell; CXCR4; Migration; SDF-1
The neuroprotective effects of a locally acting IGF-1 isoform
Keywords: IGF-1; Neuromuscular diseases; Muscle; Brain; Neuroprotection
Discrepancy in IGF-1 and GH response to submaximal exercise in young male subjects
Keywords: Submaximal exercise; IGF-1; GH-independent; IGFBP-3; InsulinExercice submaximal; IGF-1; GH-indépendant; IGFBP-3; Insuline
Evaluation of IGF-1 levels in cats with transient and permanent diabetes mellitus
Keywords: Cat; Diabetes mellitus; IGF-1; Diabetic remission
Relationships between leptin, insulin, IGF-1 and IGFBP-3 in children with energy malnutrition
Keywords: Children; Malnutrition; IGF-1; IGFBP-3; Leptin; Insulin
Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cells
Keywords: STAT, signal transducers and activators of transcription; IGF-1, insulin-like growth factor-1; EMSA, electrophoretic mobility shift assayHypoxia; IGF-1; STAT5b; HepG2; Gene expression; Binding site; Solid tumor cell
Freeze-dried platelets promote hepatocyte proliferation in mice
Keywords: Freeze-dried; Platelet; IGF-1; PDGF; Hepatocyte; Heat of crystallization; Adenine nucleotides; Mouse