Keywords: α-SMA; α-smooth muscle actin; AIF; apoptosis inducing factor; AP-1; activator protein 1; ARE; antioxidant response element; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-xl; B cell lymphoma extra large; CDKCs; cyclin:CDK complexes; c-My
مقالات ISI (ترجمه نشده)
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Keywords: AGO; Argonaute; ARG1; arginase1; ATM; adipose tissue macrophage; BAT; brown adipose tissue; BMDM; bone marrow derived macrophage; C/EBP; CCAAT-enhancer-binding proteins; CCL2; C-C Motif Chemokine Ligand 2; CCR2; C-C Motif Chemokine Receptor 2; CLS; crown-
Keywords: ERK; extracellular signal regulated kinase; FXR; farsenoid X receptor; HCC; hepatocellular carcinoma; HSCs; hepatic stellate cells; IL1β; Interleukin 1 beta; IL18; Interleukin 18; IKKβ; inhibitor of nuclear factor kappa-B kinase subunit beta; JAK; Janus
Keywords: ALDH2; Aging; Autophagy; Cardiomyocyte; JNK; Bcl-2; IKKβ;
Keywords: 2-DG; 2-deoxyglucose; 2-HG; 2-hydroxyglutarate; 5mC; 5-methlycystosine; ACACA; acetyl-CoA carboxylase; AML; acute myeloid leukemia; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; ALDH; aldehyde dehydrogenase; ADCs; an
Keywords: ACOX; peroxisomal acyl-coenzyme A oxidase 1; BDNF; Brain-derived neurotrophic factor; BM; bardoxolone methyl; CDDO-Im; 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; FAS; fatty acid synthase; FOXO1; Forkhead box protein O1; HF; high fat; LC; l
Keywords: BALF; bronchoalveolar lavage fluid; ELISA; enzyme-linked immunosorbent assay; Foxp3; forkhead transcription factor 3; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HE; hematoxylin and eosin; IL; interleukin; IKKβ; inhibitor of IκB kinase β; IFN-γ;
Keywords: 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr
Bardoxolone methyl induces neuritogenesis in Neuro2a cells
Keywords: Akt; v-Akt Murine Thymoma Viral Oncogene; ARE; Antioxidant Responsive Element; BDNF; Brain Derived Neurotrophic Factor; CDDO; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CHOP; C/EBP homologous protein; DR5; Death Receptor 5; ERK; Extracellular signal Re
Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex
Keywords: IKKβ; SNARE machinery; CBM complex; Ubiquitination;
Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549â¯cells
Keywords: Nickel; Lung cancer cell; Quercetin; Chrysin; TLR4; NF-κB; IκB; inhibitor of NF-κB; IKKβ; IκB kinase β; Myd88; myeloid differentiation factor 88; MMP-9; metalloproteinases 2 and 9; TLR4; Toll-like receptor;
NF-κB pathways in the development and progression of colorectal cancer
Keywords: 5-FU; 5-fluorouracil; AMPK/mTOR; AMP-activated Protein Kinase/mammalian target of rapamycin; APC; adenomatous polyposis coli; BAFF; B-cell activating factor; COX-2; cyclooxygenase 2; CRC; Colorectal cancer; DD; Dimerization domain; EGFR; epidermal growth
NF-κB in the crosshairs: Rethinking an old riddle
Keywords: BCL-2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma-extra large; BFL-1; Bcl-2-related gene expressed in foetal liver; cIAP; cellular inhibitor of apoptosis; cFLIP; cellular FLICE-inhibitory protein; CLL; chronic lymphocytic leukaemia; DIABLO; direct inhibit
Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring
Keywords: ARC; arcuate nucleus; Ascl1; achaete-scute homolog 1; bHLH; basic helix-loop-helix; BMP; bone morphogenetic protein; BrDU; 5-bromo-2â²-deoxyuridine; BSA; bovine serum albumin; BW; body weight; Ct; comparative threshold cycle; Cy3; cyanine 3; DAB; 3,3â²-
Immunometabolic regulation by triterpenes of Eucalyptus tereticornis in adipose tissue cell line models
Keywords: Obesity; Inflammation; Adipose tissue; Natural products; Triterpenes; PPARγ; Peroxisome proliferator-activated receptor gamma; C/EBPα; CCAAT-enhancer-binding proteins; IL-6; Interleukin 6; IL-1β; Interleukin 1β; TNFα; Tumoral necrosis factor alpha; M
Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice
Keywords: Aβ; Amyloid-β; AD; Alzheimer's disease; ERK2; extracellular signal-regulated kinase 2; IKKβ; Inhibitor of NF-κB kinase β; IRS-1 pSer616; Insulin receptor substrate-1 phosphorylated at serine residue 616; MAPK; mitogen-activated protein kinase; mTOR
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice
Keywords: Tumor Microenvironment; Drug Development; Targeted Therapy; Pancreas; AE; anion exchanger; CA; carbonic anhydrase; GPCR; G protein-coupled receptor; GPX; glutathione peroxidase; GSH; glutathione; HCQ; hydroxychloroquine; HMGB1; high mobility group box 1;
Adipocytes promote nicotine-induced injury of endothelial cells via the NF-κB pathway
Keywords: PVAT; perivascular adipose tissue; VECs; vascular endothelial cells; HUVECs; human umbilical vein endothelial cells; NF-κB; nuclear factor kappa B; IKKβ; ikappa B kinaseβ; IkBα; ikappa B α; IL-6; interleukin-6; MCP-1; monocyte chemotactic protein-1;
Role of Rho-specific guanine nucleotide dissociation inhibitor α regulation in cell migration
Keywords: Rho GEFs; Rho guanine nucleotide exchange factors; Rho GAPs; Rho GTPases activating protein; RhoGDIs; Rho-specific guanine nucleotide dissociation inhibitors; ROCK; Rho kinase; ER; estrogen receptor; HCC; hepatocellular carcinoma; ERM; Ezrin-radixin-moesi
Leptin receptor knockout-induced depression-like behaviors and attenuated antidepressant effects of exercise are associated with STAT3/SOCS3 signaling
Keywords: FST; forced swim test; GSK-3β; glycogen synthase kinase-3β; HDL; high density lipoprotein; IKKβ; inhibitor of κB kinase β; IL; interleukin; LepRb; leptin receptor; NFκB; nuclear factor kappaB; OFT; open field test; PTP1B; protein tyrosine phosphatas
Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet
Keywords: High calorie diet; Hippocampus; Oxidative stress; Inflammation; Apigenin; Sitagliptin; HFFD; high fat-high fructose diet; API; apigenin; STG; sitagliptin; IKKβ; inhibitor of kappa B kinase beta; NF-κB; nuclear factor kappa B; JNK; c-Jun NH2 terminal kin
Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention
Keywords: 2h-PG; 2-hour postprandial glucose; ALT; alanine transaminase; AUC; area under the curve; AST; aspartate transaminase; JNK; C-Jun N-terminal kinase; DMEM; Dulbecco's modified Eagle's medium; FBG; fasting blood glucose; GPx; glutathione peroxidase; HDL
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND
Keywords: Astrocytes; Aging; HIV-associated neurocognitive disorders; Neuroinflammation; ER/Nucleolar/Oxidative stress; Excitotoxicity; Aβ; amyloid beta; AEG-1; astrocyte elevated gene-1; AD; Alzheimer's disease; AIDS; acquired immune deficiency syndrome; ARE; a
Regulatory role of NADPH oxidase 2 in the polarization dynamics and neurotoxicity of microglia/macrophages after traumatic brain injury
Keywords: TBI; traumatic brain injury; ROS; reactive oxygen species; NF-κB; Nuclear factor-kappa B; APO; apocynin; VE; vehicle; LPS; lipopolysaccharides; IFN-γ; interferon-γ, IL, interleukin; TNF; tumor necrosis factor; HEt; hydroethidine; ROI; regions of intere
Nrf2 signaling pathway: Pivotal roles in inflammation
Keywords: ARE; antioxidant response element; CBP; cAMP-response-element-binding protein binding protein; COX-2; cyclooxygenase 2; Gclc; glutamate cysteine ligase catalytic subunit; Gclm; glutamate cysteine ligase regulatory subunit; GSH; glutathione; HO-1; heme oxy
BRCA1-Associated Protein Increases Invasiveness of Esophageal Squamous Cell Carcinoma
Keywords: AHSG; Esophageal Cancer; Tumor Progression; Oncogene; BRAP; BRCA1-associated protein; cDNA; complementary DNA; CI; confidence interval; ESCC; esophageal squamous cell carcinoma; HR; hazard ratio; ICAM-1; intercellular adhesion molecule-1; IKKβ; inhibitor
Topical Application of Dieckol Ameliorates Atopic Dermatitis in NC/Nga Mice by Suppressing Thymic Stromal Lymphopoietin Production
Keywords: AD; atopic dermatitis; BMDC; bone marrow-derived dendritic cell; DC; dendritic cell; DNCB; 2,4-dinitrochlorobenzene; HDM; house dust mite; IKKβ; inhibitor of NF-κB kinase subunit beta; OX40L; OX40 ligand; TSLP; thymic stromal lymphopoietin;
Polyphenols from Cymbopogon citratus leaves as topical anti-inflammatory agents
Keywords: COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; NF-κB; nuclear factor kappa B; IKKβ; inhibitor of nuclear factor kappa-B kinase subunit beta; HPLC; high-performance liquid chromatography; PDA; photo-diode array; ESI/MSn; electro-spray io
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
Keywords: ALS; Amyotrophic lateral sclerosis; ARE; Antioxidant response element; FTLD; Frontotemporal lobar degeneration; IKKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; Keap1; Kelch-like ECH-associated protein 1; KIR; Keap1-interacting region; LIR;
Original ArticlepVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation
Keywords: IKKβ; pVHL; Ubiquitination;
LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex
Keywords: LRR; Leucine-rich repeat; LRRC; leucine-rich repeat containing; TLR; Toll-like receptor; NF-κB; nuclear factor-κB; TRAF6; TNFR-associated factor 6; IKK; IκB kinase; Leucine-rich repeat; Toll-like receptor; NF-κB; IKKβ; Phosphorylation;
Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects
Keywords: IKKβ; Inhibitor; Structure-activity relationship; NO reduction; Anti-inflammatory effect;
Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by inhibiting IKKβ expression
Keywords: Telmisartan; Vascular inflammation; Hyperglycemia; IKKβ; VCAM-1; Telmisartan (PubChem CID: 65,999); Losartan (PubChem CID: 3961); Fimasartan (PubChem CID: 9,870,652); VCAM-1; vascular cell adhesion molecule-1; ICAM-1; intercellular adhesion molecule-1; E
Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis
Keywords: Microenvironment; Immune Regulation; Transcription Factor; Gene Regulation; ESCC; esophageal squamous cell cancer; GM-CSF; granulocyte-macrophage colony-stimulating factor; HUVEC; human umbilical vein endothelial cell; IKKβ; IκB kinase-β; IKKβca; cons
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Cornus mas L. (cornelian cherry), an important European and Asian traditional food and medicine: Ethnomedicine, phytochemistry and pharmacology for its commercial utilization in drug industry
Keywords: AAE; ascorbic acid equivalent; AAPH; 2,2â²-Azobis(2-amidinopropane) dihydrochloride; ABTS; 2,2-Azinobis-3-ethylbenzothiazoline-6-sulfonic acid; AD; Alzheimer's disease; AFLP; Amplified fragment length polymorphism; AIP; Atherogenic index parameter; ALP;
A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ
Keywords: 4E-BP1; eukaryotic translation initiation factor 4E-binding protein; BMDM; bone marrow-derived macrophage; CM; conditioned medium; DMEM; Dulbecco's modified essential medium; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylen
Tetracyclines downregulate the production of LPS-induced cytokines and chemokines in THP-1 cells via ERK, p38, and nuclear factor-κB signaling pathways
Keywords: LPS; lipopolysaccharide; NF-κB; nuclear factor-kappa B; IκBα/β; inhibitor kappa B alpha and beta; IKKα; inhibitor kappa B kinase alpha; IKKβ; inhibitor kappa B kinase beta; Lipopolysaccharide (LPS); Cytokine; Chemokine; Tetracyclines; Nuclear factor
In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity
Keywords: A.U.; arbitrary units; DAG; diacylglycerol; EGP; endogenous glucose production; FFAs; free fatty acids; IKKβ; IκBα kinase β; LCFA-CoA; long-chain fatty acyl-CoA; LC/MSD; liquid chromatography/mass selective detector; MONO; monounsaturated; PKC; protei
A review on the possible molecular mechanism of action of N-acetylcysteine against insulin resistance and type-2 diabetes development
Keywords: N-acetyl-l-cysteine (NAC) (PubChem CID: 12035); AKT; protein kinase B; AP-1; activator protein 1; CCL2; chemokine (C-C motif) ligand 2; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; FFA; free fatty acid; GLUT; gluc
Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy
Keywords: Fat diet; Catalase; Autophagy; Cardiomyocyte; IKKβ; AMPK;
Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: The relationship to AMPK activation
Keywords: Triterpenoids; Cyclocarya paliurus; Inflammation; Insulin resistance; Glucose uptake; AMPK; Cyclocaric acid B (CAS No. 182315-46-4); Cyclocarioside H (CAS No. 1403937-87-0); Akt; Protein kinase B; AMPK; AMP-activated protein kinase; AUC; Area under the cu
Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IÎBα/NF-κB signaling pathway
Keywords: CXCL1/KC; chemokine (C-X-C motif) ligand 1; ECs; endothelial cells; FBS; fetal bovine serum; HUVECs; human umbilical vein endothelial cells; IKKβ; IκB kinase β; ICAM-1; intercellular adhesion molecule-1; IL-8; interleukin-8; MCP-1/JE; mouse/monocyte ch
MicroRNA-mediated mechanism of vitamin D regulation of innate immune response
Keywords: Vitamin D; Inflammation; Macrophage; miR-155; SOCS1; NF-kappaB; IKKβ; Negative feedback loop;
Aspirin augments the expression of Adenomatous Polyposis Coli protein by suppression of IKKβ
Keywords: Adenomatous Polyposis Coli; Aspirin; Cancer; Inflammation; IKKβ; NF-κB;
IKK-β/NF-κB p65 mediates p27Kip1 protein degradation in arsenite response
Keywords: IKKβ; IκB kinase β; NF-κB; nuclear factor κB; Skp2; S-phase kinase associated protein 2; Kpc; Kip1 ubiquitination-promoting complex; CHX; cyclohexamide; GSK3; glycogen synthase kinase 3; Cul4a; Culin 4A, a core component for a ubiquitin ligase; Ro52;
Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ
Keywords: NLK; NF-κB; TNFα; IKKβ; TAK1;
Purple sweet potato color ameliorates kidney damage via inhibiting oxidative stress mediated NLRP3 inflammasome activation in high fat diet mice
Keywords: ACR; urine albumin/creatinine ratio; AGEs; advanced glycation end products; ASC; apoptosis associated speck-like protein containing a CARD; Col IV; Collagen IV; COX-2; cyclooxygenase-2; HFD; high fat diet; IL-1β; interleukin-1β; iNOS; induce nitric oxid
Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling
Keywords: C5a; complement component 5a; HMGB1; High Mobility Group Box 1; HPF; high power field; IKK; Inhibitor of NF-κB kinase; MEFs; Mouse Embryo Fibroblasts; MΦ; mature macrophages; PDGF; platelet derived growth factor; RAGE; receptor for advanced glycation en