دانلود مقالات ISI درباره Ikr + ترجمه فارسی

ویرایش ژن از سلول های بنیادی منجر به انقباض سلول های بنیادی برای رمزگشایی قلب و عروق

Genome Editing of Induced Pluripotent Stem Cells to Decipher Cardiac Channelopathy Variant

Keywords: arrhythmia; genome editing; induced pluripotent stem cells; long QT syndrome; variant of uncertain significance; AP; action potential; APD; action potential duration; Cas9; CRISPR-associated protein 9; CRISPR; clustered regularly interspaced short palindr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

رویکرد علمی ترجمه برای ارزیابی اثرات قلبی عروقی و پرواریتریوژنیک میترآگین آگونیست بتا-3 آدرنرژیک

Translational science approach for assessment of cardiovascular effects and proarrhythmogenic potential of the beta-3 adrenergic agonist mirabegron

Keywords: APD90; action potential duration measured at 90% repolarization; ICa,L; calcium activated current via L-channel; INa; sodium activated current; IKr; rapidly activating delayed rectifier potassium current; IKs; slowly activating delayer rectifier potassium

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

هدف قرار دادن انتخاب انتخابی قبل از مرحله فاکتور آریتی مغز 3 زود پس از دپولاریزاسیون در میوسیت های انسانی

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

Keywords: ACh; acetylcholine; AF; atrial fibrillation; AP; action potential; APD; action potential duration; [Ca2 +]i; intracellular Ca2 + concentration; CaMKII; Ca2 +/calmodulin-dependent protein kinase II; DAD; delayed afterdepolarization; EAD; early afterdepo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

سندرم برادیکاردی و بی کفایتی کرونوتروپیک در ارتباط با درمان ضد قارچی آنتی بادی تک آنترواکونازول: گزارش مورد

Sinus bradycardia and chronotropic incompetence associated with single-agent itraconazole antifungal therapy: A case report

Keywords: CYP2C19; cytochrome P450 C19; CYP2C9; cytochrome P450 C9; CYP3A4; cytochrome P450 3A4; HERG; human ether-à-go-go-related gene; HPLC; high-pressure liquid chromatography; IKr; rapid component of delayed rectifier potassium current; IKur; ultrarapid acti

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

اثرات افتراق آنتی آنیوم های ترییدازین بر مدت فعالیت بالقوه ای در عضله پاپیلری خرگوش

Differential effects of thioridazine enantiomers on action potential duration in rabbit papillary muscle

Keywords: APD; action potential duration; ΔΔ-APD; drug effect on APD compared to control; APD90; 90% action potential duration; AAP; amplitude of the action potential; Vrest; resting membrane potential; IKr; rapid component of delayed rectifier potassium current;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

هیدروکسی کلروکین موجب کاهش ضربان قلب توسط تعدیل جریان جبرانی شده با هیپرپلاریزاسیون میشود: بینش الکتروفیزیولوژیک و پتانسیل درمانی

Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

Keywords: ANOVA; analysis of variance; AP; action potential; HCQ; hydroxychloroquine; HR; heart rate; ICaL; L-type calcium ion current; If; funny current; IKr; rapid delayed rectifier potassium current; LV; left ventricle; PSS; physiological saline solution; SAN; s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

چشم انداز: طبقه بندی مبتنی بر پویایی آریتمی های بطنی

Perspective: A dynamics-based classification of ventricular arrhythmias

Keywords: AP; Action potential; APD; AP duration; BS; Brugada syndrome; CaMKII; Ca-calmodulin kinase II; CPVT; Catecholaminergic polymorphic ventricular tachycardia; CV; Conduction velocity; DAD; Delayed afterdepolarization; EAD; Early afterdepolarization; ERS; Ear

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

مکانیزم سلولی از کاردیومیوپاتی ناشی از انقباض بطنی زودرس

Cellular mechanism of premature ventricular contraction-induced cardiomyopathy

Keywords: AP; action potential; APD; action potential duration; [Ca2+]i; intracellular Ca2+ concentrations; CM; cardiomyopathy; CON; control; E-C; excitation-contraction; ICaL; L-type Ca current; IK1; inward rectifier current; IKr; rapid delayed rectifier current;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

مهار انتخابی از سدیم سرکوب کننده تاکی کاردی بطنی و فیبریلاسیون در قلب موش های نامحدود

Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts

Keywords: AP; action potential; APA; action potential amplitude; APD; action potential duration; CL; cycle length; DAD; delayed afterdepolarization; EAD; early afterdepolarization; H2O2; hydrogen peroxide; IC50; concentration for 50% inhibition; INa-L; late inward

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

هیپوکالمی ترویج فاز دیر 3 پس از دپولاریزاسیون و فیبریلاسیون بطنی مجدد در طی تزریق ایزوپروترنول در بطن های خرگوش پرفشار لانگندورف

Hypokalemia promotes late phase 3 early afterdepolarization and recurrent ventricular fibrillation during isoproterenol infusion in Langendorff perfused rabbit ventricles

Keywords: AP; action potential; APD; action potential duration; Cai; intracellular calcium; CaiTD; duration of Cai transient; EAD; early afterdepolarization; ES; electrical storm; ICFTR; cystic fibrosis transmembrane regulator chloride current; IKAS; small conducta

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

رانولازین باعث بهبود بی اختیاری الکتریکی و اختلال قوام مغز در پسوریازیس و بهبودی بقای با بهبودی عصبی خوب در یک مدل موشهای قلب

Ranolazine ameliorates postresuscitation electrical instability and myocardial dysfunction and improves survival with good neurologic recovery in a rat model of cardiac arrest

Keywords: AMSA; amplitude spectrum area; Ca2+; calcium ion; CPP; coronary perfusion pressure; CPR; cardiopulmonary resuscitation; ECG; electrocardiogram; EF; ejection fraction; hs-cTnT; plasma high-sensitivity cardiac troponin T; IKr; delayed rectifying potassium c

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2014 سفارش ترجمه

رانولازین فتوتریو و فیبریلاسیون دهلیزی را در یک مدل سگ پایان می دهد

Ranolazine terminates atrial flutter and fibrillation in a canine model

Keywords: AERP; atrial effective refractory period; AF; atrial fibrillation; AFL; atrial flutter; BB; Bachmann bundle; CL; cycle length; CT; conduction time; ECG; electrocardiographic; IKr; rapidly activating delayed rectifier potassium current; INa; sodium current

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2014 سفارش ترجمه

عملکرد و تنظیم سرین / ترئونین فسفاتاز در قلب سالم و بیمار

Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

Keywords: AF; atrial fibrillation; AKAP; A-kinase-anchoring protein; AP; action potential; β-AR; β-adrenoceptor; CaMKII; Ca2 +/calmodulin-dependent protein kinase type-II; CKIP-1; casein kinase-2 interacting protein-1; cMyBP-C; cardiac myosin-binding protein-C;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

مقاله اصلی در دسترس بودن داده های غربالگری کانال یون بالا و پیامدهای آن برای ارزیابی ایمنی قلب

Original articleVariability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Keywords: AP(D); Action Potential (Duration); AZ; AstraZeneca; FLIPR; FLuorometric Imaging Plate Reader; GSK; GlaxoSmithKline; HTS; High Throughput Screening [assays]; IC50; Concentration for 50% Inhibition; ICaL; L-type calcium current; IKr; rapid delayed rectifie

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Suppression of hERG K+ current and cardiac action potential prolongation by 4-hydroxynonenal via dual mechanisms

Keywords: IKr; rapidly activating delayed rectifier potassium current in cardiomyocyte; IKs; slowly activating delayed rectifier potassium current in cardiomyocyte; ICa,L; , L-type calcium current in cardiomyocyte; IhERG; outward K+ current in hERG overexpressed co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

Keywords: DHE; dehydroevodiamine; IKr; rapid delayed rectifier current; APD; action potential duration; EAD; early afterdepolarization; cAVB; chronic atrioventricular block; TdP; Torsade de Pointes arrhythmia; hiPSC-CM; human induced pluripotent stem cell-derived c

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay

Keywords: Human stem cell cardiomyocytes; Calcium fluorescent dye; Calcium transient; Preclinical cardiac safety; Amp; amplitude; bpm; beats per minute; BR; beat rate; CiPA; Comprehensive in Vitro Proarrhythmia Assay; CTD; calcium transient duration; DMSO; dimethyl

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters

Keywords: Brugada syndrome; hiPSC-cardiomyocytes; Ajmaline; INa; IKr; Activation-recovery interval; AP; Action Potential; APD; Action Potential Duration; Br1; Brugada Type 1 ECG; BrS; Brugada Syndrome; cFPD; Corrected Field Potential Duration (Bazett's formula); CM

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome

Keywords: channelopathy; genetics; short QT syndrome; sudden cardiac death; therapy; AF; atrial fibrillation; AP; action potential; ECG; electrocardiogram; ER; early repolarization; GWAS; genome-wide association studies; ICD; implantable cardioverter-defibrillator;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Attenuation of ischemia/reperfusion-induced inhibition of the rapid component of delayed rectifier potassium current by Isosteviol through scavenging reactive oxygen species

Keywords: I/R; ischemia/reperfusion; ROS; reactive oxygen species; IKr; rapid component of delayed rectifier potassium; APD; action potential duration; ECG; electrocardiogram; STVNa; Isosteviol sodium; Ito; transient outward potassium channel current; ISS; steady-s

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

The prospective IQ-CSRC trial: A prototype early clinical proarrhythmia assessment investigation for replacing the ICH E14 thorough QTc (TQT) study

Keywords: AP; cardiac action potential; CiPA; comprehensive in vitro proarrhythmia assay; CSRC; Cardiac Safety Research Consortium; Cmax; maximal plasma concentration; CTWG; clinical translational working group; DRest; rate-normalized Tpeak − Tend = Tpe inter

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes

Keywords: LQTS; long-QT syndrome; VM; ventricular myocyte; APD; Action potential duration; IKr; rapidly activating delayed rectifier current; IKs; slowly activating delayed rectifier current; INaL; late (persistent) sodium current; ICaL; L-type calcium current; NCX

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Keywords: hERG 1a; hERG 1b; KCNH2; IKr; LQT2; HEK293; Cardiomyocytes; Guinea pig; Potassium channel; Truncation mutants

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

HIV-Tat induces a decrease in IKr and IKsvia reduction in phosphatidylinositol-(4,5)-bisphosphate availability

Keywords: IKr; IKs; Phosphatidylinositol-(4,5)-bisphosphate; HIV-Tat protein; Induced pluripotent stem cell-derived cardiomyocytes; Long QT syndrome;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation

Keywords: Comprehensive in vitro Proarrhythmia Assay (CiPA); Field potential data sampling and analysis; Induced pluripotent cell cardiomyocytes (hiPSC-CMs); Multi electrode array (MEA); Patch clamp technologies; Pending issues and solutions; Validation; Voltage se

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

“QT clock” to improve detection of QT prolongation in long QT syndrome patients

Keywords: C-loop; cytoplasmic loop; IKr; rapid component of the late repolarizing potassium current; IKs; slow component of the late repolarizing potassium current; LQT1; long QT syndrome type 1; LQT2; long QT syndrome type 2; LQT3; long QT syndrome type 3; LQTS; l

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Carnitine deficiency induces a short QT syndrome

Keywords: ECG; electrocardiogram/electrocardiographic; IKr; rapid potassium current; LCFA; long-chain fatty acid; LV; left ventricular; OCTN2; organic cation transport Na+; PCD; primary carnitine deficiency; Carnitine deficiency; Short QT syndrome; Electrophysiolog

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS

Keywords: Acquired long QT syndrome; Kinetics; Kv11.1; Arrhythmia; Simulation; hERG; IKr; rapid delayed rectifier potassium current; AP; action potential; APD90; action potential duration at 90% maximal repolarisation; IKr50; 50% reduction in conductance of the rap

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2016 سفارش ترجمه

Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet

Keywords: IKr; iPS cell-derived cardiomyocytes; Field potential

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

KN-93 inhibits IKr in mammalian cardiomyocytes

Keywords: KN-93; IKr; CaMKII; Ventricular myocytes; Off target effect; Pharmacology;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

Keywords: AP; action potential; APD; action potential duration; ATX-II; anemone toxin II; [Ca2+]i; intracellular calcium concentration; CaMKII; Ca2+/calmodulin-dependent protein kinase II; DAD; delayed afterdepolarization; EAD; early afterdepolarization; ICa-L; L-t

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation

Keywords: ACh; acetylcholine; AF; atrial fibrillation; AP; action potential; APD; action potential duration; APD50, APD70, APD90, and APD95; action potential duration measured at 50, 70, 90, and 95% repolarization, respectively; CL; cycle length; DI; diastolic inte

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

QT interval correction assessment in the anesthetized guinea pig

Keywords: ANES GP; anesthetized guinea pig; BP; blood pressure; BT; body temperature; GP; guinea pig; hERG; human ether-a-go-go related gene; IKr; rapidly-activating delayed rectifier potassium current; IKs; slowly-activating delayed rectifier potassium current; MA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Keywords: aLQTS; drug-induced or acquired long-QT syndrome; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; C1; closed state 1; C2; closed state 2; C3; closed state 3; EAD; early-afterdepolarization; ECG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

The cardiomyocyte molecular clock regulates the circadian expression of Kcnh2 and contributes to ventricular repolarization

Keywords: ECG; electrocardiographic; BMAL1; brain muscle arnt-like1; CLOCK; circadian locomotor output control kaput; iCSΔBmal1; inducible cardiomyocyte-specific deletion of Bmal1; IKr; rapidly activating delayed-rectifier K+ current; Klf15; Krüppel-like factor 1

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2015 سفارش ترجمه

Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome

Keywords: ACA; aborted cardiac arrest; CE; cardiac event; HR; hazard ratio; IKr; rapid component of cardiac K+ channel; IKs; slow component of cardiac K+ channel; LQTS; long QT syndrome; LQT#; long QT syndrome genotype #; OC; oral contraceptive; PWP; Prentice-Willi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

PQ segment depression in patients with short QT syndrome: A novel marker for diagnosing short QT syndrome?

Keywords: ECG; electrocardiogram/electrocardiographic; IKr; inward-rectifier potassium ion channel; PQD; PQ segment depression; QTc; corrected QT; SQTS; short QT syndrome; TDR; transmural dispersion of repolarization; PQ segment depression; Short QT syndrome; Sudde

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of the cardiac ATP-dependent potassium current by KB-R7943

Keywords: IKir; total inward rectifier K+ current; IKr; delayed rectifier K+ current; IK1; background inward rectifier K+ current; IKACh; acetylcholine-activated inward K+ rectifier current; IKATP; ATP-sensitive K+ current; NCX; sodium-calcium exchanger; INCX; Na

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Prediction of Thorough QT study results using action potential simulations based on ion channel screens

Keywords: AP(D); action potential (duration); AZ; AstraZeneca; B&Q2; IonWorks Barracuda and second Quattro screening dataset; GLP; good laboratory practice; GSK; GlaxoSmithKline; IC50; concentration for 50% inhibition; ICaL; long-lasting-type calcium current; IKr;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

Keywords: APD; action potential duration; EAD; early afterdepolarization; ICa,L; L-type Ca2+ current; IK1; inward rectifier K+ current; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; KCNE1; β-subunit to KvLQT1 to form slow delayed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Keywords: aLQTS; drug-induced or acquired long-QT syndrome; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; C1; closed state 1; C2; closed state 2; C3; closed state 3; EAD; early-afterdepolarization; ECG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

A public-private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Keywords: ADRs; adverse drug reactions; CDER; Center for Drug Evaluation and Research; cTn; cardiac troponin; CV; cardiovascular; EMA; European Medicines Agency; EWG; Expert Working Group; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; h

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of the cardiac inward rectifier potassium currents by KB-R7943

Keywords: ACh; acetylcholine; CCh; carbamylcholine chloride; IKir; total inward rectifier K+ current; IKr; delayed rectifier K+ current, IK1, background inward rectifier K+ current; IKACh; acetylcholine-activated inward rectifier current; IKATP; the ATP-sensitive c

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs

Keywords: Arsenic trioxide; α-lipoic acid; hERG; IKr; IKs; QT prolongation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Deciphering hERG channels: Molecular basis of the rapid component of the delayed rectifier potassium current

Keywords: AP; action potential; CNB domain; cyclic nucleotide binding domain; ER; endoplasmatic reticulum; ERG; ether-a-go-go-related gene; HEK cells; human embryonic kidney cells; IKr; delayed rectifier potassium current; PAS domain; Per-Arnt-Sim domain; hERG chan

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo

Keywords: Short-term variability; Torsades de pointes; Chronic AV block dog; Drugs; Long QT syndrome; Repolarization; Biomarkers; APD; action potential duration; BVR; beat-to-beat variability of repolarization; cAVB; chronic atrioventricular block; ECG; electrocard

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

Keywords: QT; Tp-e; Tp-e/QT ratio; proarrhythmias; ionic channels; IKr; IKs; ICa,L; INa; IKATPECG, electrocardiogram; ICa,L, inward L-type calcium current; IKATP, ATP-sensitive potassium current; IKr, delayed rectifier potassium current with its rapid; IKs, slow co

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Metabolic stress, reactive oxygen species, and arrhythmia

Keywords: ∆Ψm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5′-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Molecular determinants of hERG potassium channel inhibition by disopyramide

Keywords: Antiarrhythmic; Docking; Disopyramide; hERG; IKr; Short QT; Long QT; QT interval; Rapid delayed rectifier;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه