Keywords: SL; sarcolemma; SR; saroplasmic reticulum; SERCA; sarcoplasmic/endoplasmic reticulum calcium ATPase; NCX; Na+/Ca2+ exchanger; EC; excitation-contraction; AP; action potential; LCC; L-type calcium channel; HIP; human amylin transgenic; NFAT; nuclear fact
مقالات ISI (ترجمه نشده)
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Keywords: Atrial fibrillation; Atrial neuropathy; Early diagnosis; Prediction; Therapy; Fibrillation atriale; Neuropathie atriale; Diagnostic précoce; Prédiction; Thérapie; AF; atrial fibrillation; ANS; autonomic nervous system; GP; ganglionated plexus; If; hype
Keywords: APD90; action potential duration measured at 90% repolarization; ICa,L; calcium activated current via L-channel; INa; sodium activated current; IKr; rapidly activating delayed rectifier potassium current; IKs; slowly activating delayer rectifier potassium
Keywords: AEN; agronomic efficiency of applied N; FP; farmers' fertilizer practice; IKS; indigenous potassium supply; INS; indigenous nitrogen supply; IPS; indigenous phosphorus supply; NE; Nutrient Expert; ST; soil testing; PFPN; partial factor productivity of a
Keywords: AE; agronomic efficiency; FP; farmers' practice; IKS; indigenous potassium supply; INS; indigenous nitrogen supply; IPS; indigenous phosphorus supply; NUE; nutrient use efficiency; OPT; optimum management; PFP; partial factor productivity; RE; recovery
Keywords: APD; action potential duration; ÎÎ-APD; drug effect on APD compared to control; APD90; 90% action potential duration; AAP; amplitude of the action potential; Vrest; resting membrane potential; IKr; rapid component of delayed rectifier potassium current;
Keywords: BFNS; benign familial neonatal seizures; CMAP; compound muscle action potential; EA1; episodic ataxia type 1; HCN; hyperpolarization-activated cyclic nucleotide-gated; Ih; HCN current; IKf; fast K+ conductance; IKs; slow K+ conductance; INap; persistent N
Keywords: AP; Action potential; APD; AP duration; BS; Brugada syndrome; CaMKII; Ca-calmodulin kinase II; CPVT; Catecholaminergic polymorphic ventricular tachycardia; CV; Conduction velocity; DAD; Delayed afterdepolarization; EAD; Early afterdepolarization; ERS; Ear
Keywords: AEN; Agronomic efficiency of applied N; FP; Farmers' fertilizer practice; GRF; Gross return above fertilizer cost; IKS; Indigenous potassium supply; INS; Indigenous nitrogen supply; IPS; Indigenous phosphorus supply; NE; Nutrient Expert; PFPN; Partial f
Keywords: AP; action potential; APD; action potential duration; [Ca2+]i; intracellular Ca2+ concentrations; CM; cardiomyopathy; CON; control; E-C; excitation-contraction; ICaL; L-type Ca current; IK1; inward rectifier current; IKr; rapid delayed rectifier current;
Keywords: AF; atrial fibrillation; AKAP; A-kinase-anchoring protein; AP; action potential; β-AR; β-adrenoceptor; CaMKII; Ca2 +/calmodulin-dependent protein kinase type-II; CKIP-1; casein kinase-2 interacting protein-1; cMyBP-C; cardiac myosin-binding protein-C;
Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current
Keywords: KCNE1; IKs; Early repolarization syndrome;
Suppression of hERG K+ current and cardiac action potential prolongation by 4-hydroxynonenal via dual mechanisms
Keywords: IKr; rapidly activating delayed rectifier potassium current in cardiomyocyte; IKs; slowly activating delayed rectifier potassium current in cardiomyocyte; ICa,L; , L-type calcium current in cardiomyocyte; IhERG; outward K+ current in hERG overexpressed co
Calcium/calmodulin-dependent protein kinase II regulation of IKs during sustained β-adrenergic receptor stimulation
Keywords: Calcium/calmodulin-dependent protein kinase II; CaMKII; Delayed rectifier; Heart failure; IKs; KCNQ1; β-Adrenergic receptor;
Nanomedicine for the cardiac myocyte: Where are we?
Keywords: 7KC; 7-ketocholesterol; Ang II; Angiotensin II; AT1; Angiotensin II type 1; AT1R; Ang II type 1 receptor; Au; Gold; BIO; 6-Bromoindirubin-3 oxine.; CeO2; Cerium oxide/ceria; CLIO; Cross-linked iron oxide; CNF; Carbon nanofiber; CNT; Carbon nanotube; CsA;
The northeast regional SPS meeting update: Safety pharmacology innovations and applications
Keywords: Fatty acid acyl hydrolase (FAAH); Stem cell; Cardiomyocyte; EEG; Hearing loss; BIA 10-2474; CGF166; hERG (IKr); IKs; Organs on chip; Rat telemetry; Suicidal ideation and behavior;
Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative
Keywords: Action potential (AP); Action potential duration (APD); Cardiac voltage-gated ion channels; INa; Ito; IK1; hERG; IKs; In-vitro study; Cardiac action potential; Early afterdepolarization (EAD); Delayed afterdepolarization (DAD); Cardiac arrhythmias; QT pro
The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome
Keywords: channelopathy; genetics; short QT syndrome; sudden cardiac death; therapy; AF; atrial fibrillation; AP; action potential; ECG; electrocardiogram; ER; early repolarization; GWAS; genome-wide association studies; ICD; implantable cardioverter-defibrillator;
Molecular cloning and functional expression of the K+ channel KV7.1 and the regulatory subunit KCNE1 from equine myocardium
Keywords: KV7.1; KCNQ1; KCNE1; Equine; Horse; Cardiac electrophysiology; IKs; slow delayed rectifier current; LQT1; long QT syndrome; SCD; sudden cardiac death;
Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes
Keywords: LQTS; long-QT syndrome; VM; ventricular myocyte; APD; Action potential duration; IKr; rapidly activating delayed rectifier current; IKs; slowly activating delayed rectifier current; INaL; late (persistent) sodium current; ICaL; L-type calcium current; NCX
JPH-2 interacts with Cai-handling proteins and ion channels in dyads: Contribution to premature ventricular contraction-induced cardiomyopathy
Keywords: Ab; antibody; BIN-1; bridging integrator-1; Cavβ2; voltage-gated Ca channel β subunit 2; CICR; Ca-induced Ca release; CON; control; CSQ2; calsequestrin 2; ICaL; L-type Ca channel current; IKs; slow delayed rectifier current; IP; immunoprecipitate; JPH-2
Rabbit models as tools for preclinical cardiac electrophysiological safety testing: Importance of repolarization reserve
Keywords: Pre-clinical safety testing; Cardiac arrhythmias; Repolarization reserve; IKs; Species differences; Rabbit;
HIV-Tat induces a decrease in IKr and IKsvia reduction in phosphatidylinositol-(4,5)-bisphosphate availability
Keywords: IKr; IKs; Phosphatidylinositol-(4,5)-bisphosphate; HIV-Tat protein; Induced pluripotent stem cell-derived cardiomyocytes; Long QT syndrome;
Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation
Keywords: Comprehensive in vitro Proarrhythmia Assay (CiPA); Field potential data sampling and analysis; Induced pluripotent cell cardiomyocytes (hiPSC-CMs); Multi electrode array (MEA); Patch clamp technologies; Pending issues and solutions; Validation; Voltage se
Stop-codon and C-terminal nonsense mutations are associated with a lower risk of cardiac events in patients with long QT syndrome type 1
Keywords: ACA; aborted cardiac arrest; CI; confidence interval; c-loop; cytoplasmic loop; C-term; C-terminal; HR; hazard ratio; ICD; implantable cardioverter-defibrillator; IKS; slow delayed rectifier current; IVS; intron intervening sequence; LQT1; long QT syndrom
Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+-activated Clâ current in canine ventricular myocytes
Keywords: 9-AC; 9-anthracene carboxylic acid; AP; action potential; APVC; action potential voltage-clamp; APD90; action potential duration at 90% of repolarization; BKCa; large-conductance Ca2+-activated K+ channels; CaT; calcium transient; Cav1.2; pore forming sub
“QT clock” to improve detection of QT prolongation in long QT syndrome patients
Keywords: C-loop; cytoplasmic loop; IKr; rapid component of the late repolarizing potassium current; IKs; slow component of the late repolarizing potassium current; LQT1; long QT syndrome type 1; LQT2; long QT syndrome type 2; LQT3; long QT syndrome type 3; LQTS; l
Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress
Keywords: AP; action potential; APD; action potential duration; ATX-II; anemone toxin II; [Ca2+]i; intracellular calcium concentration; CaMKII; Ca2+/calmodulin-dependent protein kinase II; DAD; delayed afterdepolarization; EAD; early afterdepolarization; ICa-L; L-t
Microscopic mechanisms for long QT syndrome type 1 revealed by single-channel analysis of IKs with S3 domain mutations in KCNQ1
Keywords: Cf, Ci, Cs; fast, intermediate, slow closed state; G-V; voltage dependence of opening; IKs; slowly activating delayed rectifier potassium current; LQTS; long QT syndrome; O1, O2; short and longer open states; Po; open probability; S2, S3, S4; second, thir
QT interval correction assessment in the anesthetized guinea pig
Keywords: ANES GP; anesthetized guinea pig; BP; blood pressure; BT; body temperature; GP; guinea pig; hERG; human ether-a-go-go related gene; IKr; rapidly-activating delayed rectifier potassium current; IKs; slowly-activating delayed rectifier potassium current; MA
Melatonin affects voltage-dependent calcium and potassium currents in MCF-7 cell line cultured either in growth or differentiation medium
Keywords: α-DTX; α-dendrotoxin; Chr; chromanol; HP; holding potential; IbTx; iberiotoxin; IBK; voltage- and Ca2+-dependent delayed-rectifier iberiotoxin-sensitive K+ current; IKCa; intermediate-conductance Ca2+-activated K+ channels; ICa,L; L-type Ca2+ current; I
BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs)
Keywords: AP; action potential; APP; amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; DMEM; Dulbecco's modified Eagle's medium; DTT; dithiothreitol; EGFP; enhanced green fluorescent protein; FRAP; fluorescence recovery after photobleaching; HEK293T;
Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome
Keywords: ACA; aborted cardiac arrest; CE; cardiac event; HR; hazard ratio; IKr; rapid component of cardiac K+ channel; IKs; slow component of cardiac K+ channel; LQTS; long QT syndrome; LQT#; long QT syndrome genotype #; OC; oral contraceptive; PWP; Prentice-Willi
A590T mutation in KCNQ1 C-terminal helix D decreases IKs channel trafficking and function but not Yotiao interaction
Keywords: KV7.1; KCNQ1; KCNE1; IKs; LQT; Yotiao;
In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation
Keywords: Atrial fibrillation; AF; IKs; Inherited arrhythmia; KCNQ1; Modelling; Re-entry; Simulation; Spiral wave
How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity
Keywords: APD; action potential duration; EAD; early afterdepolarization; ICa,L; L-type Ca2+ current; IK1; inward rectifier K+ current; IKr; rapid delayed rectifier K+ current; IKs; slow delayed rectifier K+ current; KCNE1; β-subunit to KvLQT1 to form slow delayed
Prediction of Thorough QT study results using action potential simulations based on ion channel screens
Keywords: AP(D); action potential (duration); AZ; AstraZeneca; B&Q2; IonWorks Barracuda and second Quattro screening dataset; GLP; good laboratory practice; GSK; GlaxoSmithKline; IC50; concentration for 50% inhibition; ICaL; long-lasting-type calcium current; IKr;
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
Keywords: AKAP9; A-kinase anchoring protein 9 (Yotiao); AP; action potential; APD90; steady-state action potential duration at 90% repolarization; ECG; electrocardiogram/electrocardiographic; HEK293; human embryonic kidney 293; IKs; slowly activating delayed rectif
Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for
Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization
Keywords: AP; action potential; APD; action potential duration; CL; cycle length; EAD; early afterdepolarization; ECG; electrocardiogram; Endo; endocardial; Epi; epicardial; ICaL; L-type calcium current; IKs; slow delayed-rectifier potassium current; ISO; isoproter
Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5
Keywords: Atrial fibrillation; Kv1.5; IKs; Diphenylphosphinic amides; Diphenylphosphine oxides
α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs
Keywords: Arsenic trioxide; α-lipoic acid; hERG; IKr; IKs; QT prolongation
Transcriptomic analysis reveals atrial KCNE1 downâregulation following lung lobectomy
Keywords: Arrhythmia; IKs; KCNQ1; MinK; Postoperative atrial fibrillation;
Deubiquitylating enzyme USP2 counteracts Nedd4-2–mediated downregulation of KCNQ1 potassium channels
Keywords: IKs; Kv7.1; minK; Potassium channels; Ubiquitylation; Deubiquitylation; Membrane protein regulationCA, changed to alanine; DUB, deubiquitylating enzyme; ENac, epithelial sodium channel; Nedd4, neuronal precursor cell–expressed developmentally downregulate
In Silico Cardiac Risk Assessment in Patients With Long QT Syndrome : Type 1: Clinical Predictability of Cardiac Models
Keywords: IKs; KCNQ1; KCNQ2; LQT; QTACA, aborted cardiac arrest; AP, action potential; ECG, electrocardiography; FGM, Flaim-Giles-McCulloch; IKs, rectifier potassium current; LQT1, long QT syndrome type 1; LQTS, long QT syndrome; Q4, upper quartile; QTc, QT interva
Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation
Keywords: QT; Tp-e; Tp-e/QT ratio; proarrhythmias; ionic channels; IKr; IKs; ICa,L; INa; IKATPECG, electrocardiogram; ICa,L, inward L-type calcium current; IKATP, ATP-sensitive potassium current; IKr, delayed rectifier potassium current with its rapid; IKs, slow co
Metabolic stress, reactive oxygen species, and arrhythmia
Keywords: âΨm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5â²-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI
Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome
Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm
Repolarizing cardiac potassium channels: Multiple sites and mechanisms for CaMKII-mediated regulation
Keywords: Kv channels; Kir channels; Kv4.3; macromolecular Kv channel complexes; posttranslational regulation/modulation; CaM; calcium calmodulin; CaMKII; calcium calmodulin-dependent protein kinase II; Ito,f; fast, transient voltage-dependent K+ current; IKr; rapi
Protein kinase C downregulates IKs by stimulating KCNQ1-KCNE1 potassium channel endocytosis
Keywords: Endocytosis; IKs; KCNE1; KCNQ1; PKC; TraffickingCHO, Chinese hamster ovary; IKs, slow-activating cardiac delayed rectifier K+ current; LQT, long QT; PBS, phosphate-buffered saline; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate