IL-11 expression in retinal and corneal cells is regulated by interferon-γ
Keywords: IL-11; IFN-γ; TNF-α; IL-1; TGF-β; Retina; Cornea;
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Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes
Keywords: AD, Alzheimer's disease; Aβ, amyloid β; IL-1, interleukin1; TNF-α, tumor necrosis factor α; iNOS, inducible nitric oxide synthase; COX-2, cyclooxigenase; PPAR-γ, peroxisome proliferator activated receptor γAlzheimer's disease; IL-1; PPAR; TNF; iNOS; COX-2
Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist
Keywords: [18F]rhIL-1RA; IL-1; Inflammation; [18F]fluoroacetaldehyde; PET.
A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases
Keywords: 8-OHdG, 8-hydroxy-2′-deoxyguanosine; BER, base excision repair; IL-1, interleukin-1; MYH, human MutY glycosylase homologMYH gene; 8-OHdG; Hypermethylation; Inflammation; Oxidative DNA damage; IL-1; Free radicals
Interleukin-1, inflammasomes and the skin
Keywords: AIM; absent in melanoma; ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; CAPS; cryopyrin-associated periodic syndrome; CH; contact hypersensitivity; DAMPs; damage-associated molecular patterns; DC; dendritic cells; DI
Connection between inflammatory processes and transmittor function-Modulatory effects of interleukin-1
Keywords: AD; Alzheimer's disease; Arc; activity-regulated cytoskeleton-associated protein; Aβ; β-amyloid; BDNF; brain-derived neurotrophic factor; CSF; cerebrospinal fluid; IL-1; interleukin-1; IL-1F; interleukin-1 family; IL-1R; interleukin-1 receptor; IL-1ra;
Refractory ulcers: The role of tumor necrosis factor-α
Keywords: EGF; epidermal growth factor; IL-1; interleukin 1; MMP; matrix metalloproteinase; PG; pyoderma gangrenosum; PMN; polymorphonuclear leukocyte; PTX; pentoxifylline; TGF; transforming growth factor; TNF; tumor necrosis factor;
Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage
Keywords: Cartilage; Mechanobiology; Load; IL-1; MMPs; ADAMTS
A new regulation of IL-6 production in adult cardiomyocytes by β-adrenergic and IL-1β receptors and induction of cellular hypertrophy by IL-6 trans-signalling
Keywords: β-Adrenergic receptors; cAMP; IL-6; IL-1; STAT3; Cardiac hypertrophy;
Noradrenaline acting at β-adrenoceptors induces expression of IL-1β and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex
Keywords: Noradrenaline; β-Adrenoceptor; IL-1; IL-1ra; IL-1RII; Neuroinflammation; LPS
Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals
Keywords: IL-1; Autoinflammatory diseases; NOMID/CINCA; DIRA; NLRP3; IL1RN; IL-1Ra; NOD like receptors; Anakinra; Neonatal disorder; Genetic disease
Suppression of interleukin-6-induced C-reactive protein expression by FXR agonists
Keywords: FXR; farnesoid X receptor; SHP; small heterodimer partner; CRP; C-reactive protein; SAP; serum amyloid P component; SAA; serum amyloid A; APP; acute-phase protein; IL-6; interleukin-6; IL-1; interleukin-1; PPAR-α; peroxisome proliferator-activated recept
IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice
Keywords: Constitutive expression; Cholesterol; Cyp7a1; HMG-CoA reductase; Inflammatory cytokine; Liver; IL-1; Mouse; Sex difference;
IL-17 and Th17 cells in human inflammatory diseases
Keywords: IL-17; Cytokines; Inflammation; Destruction; TNFα; IL-1
The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy
Keywords: Multiple sclerosis; IL-1; IL-1Ra; Acp; IL-1RII; Corticosteroid treatment
Inhibition of prostaglandin E2 signaling through the EP1 receptor does not affect prostacyclin production in human endothelial cells
Keywords: EP; prostanoid E receptor; COX; cyclooxygenase; PG; prostaglandin; PGI2; prostacyclin; HUVECs; human umbilical vein endothelial cells; PGIS; PGI2 synthase; ACF; aberrant crypt foci; AOM; azoxymethane; TxA2; thromboxane A2; TNF; tumor necrosis factor-α; I
Meniscal tissue explants response depends on level of dynamic compressive strain
Keywords: MMP; IL-1; Meniscus; Knee; Osteoarthritis; ADAMTS;
CCL20 produced in the cytokine network of rheumatoid arthritis recruits CCR6+ mononuclear cells and enhances the production of IL-6
Keywords: Rheumatoid arthritis; CCL20; IL-1; IL-17; IL-6
Etiology and site of temporal lobe epilepsy influence postictal cytokine release
Keywords: Temporal lobe epilepsy; IL-1; IL-6; TNF-alpha; Cytokines; Seizure
Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation
Keywords: Mesenchymal stem cells; IL-1; TNF; Osteoblasts and differentiation;
Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling
Keywords: Cytokine; Down syndrome; Down Syndrome Critical Region; IL-1; Inflammation; Tollip
Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide
Keywords: BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; CM; conditioned medium; CNS; central nervous system; ELISA; enzyme linked immunosorbent assay; HGF; hepatocyte growth factor; hMSCs; human MSCs; IGF-1; insulin-like growth factor-1; IFNγ;
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
Keywords: PTH; parathyroid hormone; IL-1; interleukin-1; IL-6; interleukin-6; IL-11; interleukin-11; M-CSF; macrophage colony-stimulating factor; RANKL; receptor activator of NFκB ligand; TGF-β; transforming growth factor β; IGF-1; insulin-like growth factor; FP
Autoinflammation: The prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses
Keywords: Autoinflammatory diseases; neonatal-onset multisystem inflammatory disease (NOMID)/chronic infantile neurologic, cutaneous, and arthritis (CINCA); cryopin-associated periodic syndromes (CAPS); deficiency of the IL-1 receptor antagonist; NLRP3; IL1RN; IL-1
Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component
Keywords: cDNA; complementary DNA; FI; fold increase; hs-CRP; high-sensitivity C-reactive protein; IL-1; interleukin 1; IL-6; interleukin 6; IL-1Ra; IL-1 receptor antagonist; IMM; indolent multiple myeloma; ISR; injection site reaction; MGUS; monoclonal gammopathy
Systemic JIA: new developments in the understanding of the pathophysiology and therapy
Keywords: systemic juvenile idiopathic arthritis; innate immunity; myeloid related proteins (MRPs); IL-1; IL-6; macrophage activation syndrome (MAS)
Therapy of autoinflammatory syndromes
Keywords: Autoinflammatory; IL-1; inflammasomeCAPS, Cryopyrin-associated periodic syndromes; CRP, C-reactive protein; FCAS, Familial cold autoinflammatory syndrome; FDA, US Food and Drug Administration; FMF, Familial Mediterranean fever; MWS, Muckle-Wells syndrome;
Rac1 regulates peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
Keywords: COX; cyclooxygenase; DMEM/F-12; Dulbecco's modified Eagle's medium/Ham's F-12; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; GFP; green fluorescence protein; IKK; IκB kinase; IL-1; interleukin-1; ILR;
High force reaching task induces widespread inflammation, increased spinal cord neurochemicals and neuropathic pain
Keywords: spinal cord; macrophages; cytokines; musculoskeletal disorder; nerve injury; repetitive strain injury; ED1+; ED1-positive activated macrophages; HRNF; high repetition, negligible force; H&E; hematoxylin and eosin; IFNγ; interferon gamma; IL-1; interleuki
Cardiac fibroblasts: At the heart of myocardial remodeling
Keywords: 15d-PGJ2; 15-deoxy-δ12,14-prostaglandin J2; α-SMA; Alpha smooth muscle actin; ACE; angiotensin converting enzyme; Ang II; angiotensin II; ANP; A-type (atrial) natriuretic peptide; ARB; angiotensin receptor blocker; AT1R/AT2R; angiotensin receptor type 1
Thalidomide decreases the plasma levels of IL-1 and TNF following burn injury: Is it a new drug for modulation of systemic inflammatory response
Keywords: TNF; IL-1; Thalidomide; Burn injury; Systemic inflammatory response
Therapeutic effects of daphnetin on adjuvant-induced arthritic rats
Keywords: Daphnetin; Adjuvant arthritic; IL-1; TNF-α; MIF
IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines
Keywords: IRAK; IRAK-4; IRAK-4 inhibitor; Kinase; Kinase inhibitor; Imidazo[1,2-a]pyridine; Inflammation; Anti-inflammatory; Ligand efficiency; IL-1; TNF-alpha; TNFα; Immunity
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38α MAP kinase inhibitors
Keywords: p38; Kinase; Inflammation; Pyrrolotriazines; TNF-α; IL-1
IFN-γ acts as anti-angiogenic cytokine in the human cornea by regulating the expression of VEGF-A and sVEGF-R1
Keywords: IFN-γ; VEGF-A; sVEGF-R1; Cornea; Fibroblasts; Corneal neovascularization; Inflammation; IL-1; TNF-α
The other side of the medal: How chemokines promote analgesia
Keywords: CFA; complete Freund's adjuvant; CCL2, MCP-1; monocyte chemoattractant protein 1; CCL3, MIP-1α; macrophage inflammatory protein-1α; CXCL1, KC; keratinocyte derived chemokine; CXCL2/3, MIP-2; macrophage inflammatory protein-2; CXCL8; interleukin-8; DRG;
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M
Keywords: Aggrecanase; ADAMTS; MMP; Hyaluronidase; IL-1; TNFα
Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome
Keywords: cannabinoids; inflammation; amyloid; immunohistochemistry; AA; arachidonic acid; Aβ; β-amyloid; AD; Alzheimer's disease; AEA; arachidonoylethanolamide (anandamide); DS; Down's syndrome; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase;
Effects of CpG-oligonucleotides, poly I:C and LPS on Atlantic cod scavenger endothelial cells (SEC)
Keywords: Scavenger endothelial cells; Reticuloendothelial system; CpG-oligonucleotides; Poly I:C; LPS; IL-1; Atlantic cod; Gadus morhua L.
IRAK1: A critical signaling mediator of innate immunity
Keywords: IRAK; IL-1; TLR; IL-1R; IL-18; IL-33; Splice variant; Signal transduction; Kinase; Adaptor protein; Phosphorylation; Ubiquitination; Protein degradation; Autoimmune disease; Endotoxin tolerance
Protective effect of Ginkgolids (A + B) is associated with inhibition of NIK/IKK/IκB/NF-κB signaling pathway in a rat model of permanent focal cerebral ischemia
Keywords: GKAB; Ginkgolid A and B, Ginkgolids (A + B); IKK; IκBα kinase; NIK; NF-κB-inducing kinase; NF-κB; nuclear factor kappaB; LPS; lipopolysaccharide; pMCAO; permanent middle cerebral artery occlusion; p-NIK,; phosphorylated NIK; p-IKKα,; phosphorylated
Changtai granule, a traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions
Keywords: CD; Crohn's disease; IBD; inflammatory bowel disease; TNBS; 2,4,6-trinitrobenzene sulfonic acid; i.g.; intragastric administration; IL-1; interleukin-1; MIP-2; macrophage inflammatory protein-2; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide syntha
Role of central β-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge
Keywords: Catecholamine; Brain; E. coli; Norepinephrine; Propranolol; IL-1
Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: Involvement of AP-1 transcription factors
Keywords: IL-6; IL-1; cAMP; Stabilization; AP-1; Thyroid cell
Inflammatory cytokine gene polymorphisms in gastric cancer cases’ and controls’ family members from Chinese areas at high cancer prevalence
Keywords: Polymorphisms; IL-1; Gastric cancer; H. pylori; Haplotype analysis
Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375
Keywords: CDK, cyclin-dependent kinase; ERK, extracellular signal-regulated kinase; ODC, ornithine decarboxylaseCytokines; Melanoma; IL-1; ERK1/2; E2F; CDK; p21; RB
Exposure-dependent effects of ethanol on the innate immune system
Keywords: Alcohol; Macrophage; Acute alcohol; Chronic alcohol; Phagocytosis; Cytokine; MAPK; TLR; NFκB; Lipid rafts; TNF-α; IL-6; IL-1
Dendritic cells and cytokines in human inflammatory and autoimmune diseases
Keywords: Dendritic cells; IL-1; IL-12; IL-23; TNF-α; IFN-α;
Analysis of innate immune signal transduction with autocatalytic expression vectors
Keywords: IL-1; interleukin-1; IL8; interleukin-8; TLR; toll-like receptor; IL-1RI; type 1 interleukin-1 receptor; TIR; Toll/interleukin-1 receptor; miR; micro-ribonucleic acid; LPS; lipopolysaccharide: NF-κB, Nuclear Factor kappa B(see also RelA); RelA; reticuloe
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat
Keywords: Brain; Caspase-1; Cerebral ischemia; IL-1