Enhanced TH2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP)
Keywords: JORRP; TH1; TH2; IFN-γ; IL-4;
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Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum
Keywords: Leishmania infantum; Biotherapy; Antimonium crudum; Megakaryocytes; BALB/c; Th1/Th2 response; Th1; T helper cell type 1; Th2; T helper cell type 2; IFN-γ; Interferon gama; IL-4; Interleukin 4; IL-10; Interleukin 10; IL-12; Interleukin 12; AVL; American v
T follicular helper and TH2 cells in allergic responses
Keywords: Allergen-specific T cell; IL-4; Immunoglobulin E (IgE); Th2; Th2 cytokines; AD; Atopic dermatitis; ASCL2; Achaete-scute homologue 2; BCL-6; B-cell lymphoma 6; BLIMP1; B lymphocyte-induced maturation protein 1; CCR6; CC chemokine receptor type 6; cDCs; Con
Selenoprotein K modulate intracellular free Ca2+ by regulating expression of calcium homoeostasis endoplasmic reticulum protein
Keywords: SelK; CHERP; Ca2+; IL-2Rα; IL-4;
Research paperBrazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis
Keywords: Th17; IL-4; IL-6; IL-10; Human PBMC; In vitro;
Association between interleukin-4 (IL-4), gene polymorphisms (C-589T, T+2979G, and C-33T) and migraine susceptibility in Iranian population: A case-control study
Keywords: IL-4; interleukin-4; IL-9; interleukin-9; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; CNS; central nervous system; CCR2; C-C chemokine receptor type 2; TGFB1; transforming growth factor-b1; NOS3; nitric oxide synthase 3; Th2; T helper type
Carica papaya ameliorates allergic asthma via down regulation of IL-4, IL-5, eotaxin, TNF-α, NF-ĸB, and iNOS levels
Keywords: Airway inflammation; Cytokines; Immunomodulation; Th2-type immunity; Eosinophilia; CPL; Carica papaya leaves; IL-4; Interleukin-4; IL-5; Interleukin-5; TNF-α; Tumor necrosis factor-α; NF-ĸB; Nuclear factor-kappaB; iNOS; inducible nitric oxide synthase;
IL-4R suppresses airway inflammation in bronchial asthma by inhibiting the IL-4/STAT6 pathway
Keywords: Bronchial asthma; Airway inflammation; IL-4; STAT6; IL-4R;
Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana
Keywords: Nanoliposomal amphotericin B; IFN-γ; IL-4; IL-10;
GM-CSF and IL-4 produced by NKT cells inversely regulate IL-1β production by macrophages
Keywords: NKT cells; Macrophages; IL-1b; GM-CSF; IL-4;
Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer
Keywords: PC; prostate cancer; DC; dendritic cell; FITC; fluorescein isothiocyanate; mGM-CSF; mouse granulocyte macrophage colony-stimulating factor; PBS; PHOSPHATE buffered saline; SA; streptavidin; Tregs; regulatory T cells; ICOS; inducible costimulator; Foxp3; f
T helper-2 cytokine/regulatory T-cell gene polymorphisms and their relation with risk of psoriasis in a South Indian Tamil cohort
Keywords: Psoriasis; Th-2 cytokines; IL-4; T-reg cytokines; IL-10; FOXP3;
MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia
Keywords: MST1; CD4+ T cell; B cell activation; IL-4; CD40L; Mammalian sterile-20 like kinase 1; (MST1); Severe combined immunodeficiency; (SCID); Regulatory T; (Treg); T follicular helper; (Tfh); Class-switch recombination; (CSR); T cell receptor; (TCR);
Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-γ
Keywords: Bronchial epithelial cells; Interferon-γ; MUC5AC; Mucin; Sp1; IFN-γ; interferon-γ; TGF-α; transforming growth factor-α; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; IL-4; interleukin-4; IL-13; interleukin-13; NH
CD14++ CD16â monocytes are the main source of 11β-HSD type 1 after IL-4 stimulation
Keywords: CD14; CD14++ CD16â;  CD16; CD14+ CD16+;  HTRF; Homogeneous Time-Resolved Fluorescence; 11β-HSDs; 11β-hydroxysteroid dehydrogenases; CFSE; carboxyfluorescein-diacetate-succimidyl-ester method; rMFI; median fluorescence intensity; Monocytes; IL-4; 11Î
Involvement of JNK signaling in IL4-induced M2 macrophage polarization
Keywords: JNK; Alternatively activation; IL-4; Macrophage;
Parvovirus B19 infection modulates the levels of cytokines in the plasma of rheumatoid arthritis patients
Keywords: Parvovirus B19; Rheumatoid arthritis; IFNᵧ; IL-4; RA; rheumatoid arthritis; B19V; parvovirus B19; B19+; parvovirus B19 DNA positive; B19â; parvovirus B19 DNA negative; WBC; white blood cells; HgB; hemoglobin; ESR; erythrocyte sedimentation rate; CRP;
Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells
Keywords: Glucocorticoids; Ym1; Ms4a8a; Macrophages; IL-4; M2;
Topical treatments of Saussurea costus root and Thuja orientalis L. synergistically alleviate atopic dermatitis-like skin lesions by inhibiting protease-activated receptor-2 and NF-κB signaling in HaCaT cells and Nc/Nga mice
Keywords: Atopic dermatitis; Ig E; Mast cells; IL-4; Aucklandiae radix; Saussurea costus root; Thuja orientalis L;
Leishmania infantum-specific IFN-γ production in stimulated blood from dogs with clinical leishmaniosis at diagnosis and during treatment
Keywords: CBC; complete blood cell count; ConA; concanavalin A; DNA; deoxyribonucleic acid; ELISA; enzyme-linked immunosorbent assay; EU; ELISA units; IFAT; indirect immunofluorescence technique; IFN-γ; interferon-gamma; IL-10; interleukin-10; IL-4; interleukin 4;
Murine IL-4Î2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation
Keywords: IL-4; IL-4delta2; Cytokine; Antagonist; Binding;
OncologyChemoimmunotherapeutic effect of combined treatment with ex vivo generated antigen-presenting immune cells and conventional antitumor agents in a mouse neuroblastoma model
Keywords: GM-CSF; granulocyte-macrophage colony stimulating factor; IL-4; interleukin-4; CpG-ODN; CpG-oligodeoxynucleotide; BMDA; bone marrow-derived adherent cells; Neuroblastoma; Anticancer agent; Antitumor immunity; Cell therapy; Chemoimmunotherapy; Immunogenic
A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS
Keywords: BMI; body mass index; CG; control group; CRP; C-reactive protein; DEMMI; de Morton Mobility Index; DXA; dual-energy x-ray absorptiometry; IG; intervention group; IL-4; interleukin-4; IL-6; interleukin-6; IFN-γ; interferon-γ; NRS; nutritional risk screen
Research reportIntraperitoneal injection of IL-4/IFN-γ modulates the proportions of microglial phenotypes and improves epilepsy outcomes in a pilocarpine model of acquired epilepsy
Keywords: Microglia; M1; M2; IL-4; IFN-γ; Epilepsy;
Vγ1+γδT, early cardiac infiltrated innate population dominantly producing IL-4, protect mice against CVB3 myocarditis by modulating IFNγ+ T response
Keywords: Viral myocarditis; CVB3; γδT; Vγ1; IL-4;
Hataedock treatment has preventive therapeutic effects for atopic dermatitis through skin barrier protection in Dermatophagoides farinae-induced NC/Nga mice
Keywords: AD; Atopic dermatitis; HTD; Hataedock; DfE; Dermatophagoides Farinae Extract; HPLC; High Performance Liquid Chromatography; M/T; Masson trichrome method; LXR; liver X receptor; FLG; Filaggrin; PKC; protein kinase C; IL-4; interleukin-4; IL-13; interleukin
Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing
Keywords: RNA-seq; RNA-sequencing; ERCC; external RNA control consortium; FDR; false discovery rate; GO; gene ontology; QC; quality control; IFNγ; interferon-γ; LPS; lipopolysaccharide; IL-4; interleukin-4; ELISA; enzyme-linked immunosorbent assay; MCSF; macropha
THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro
Keywords: ACTB; β-actin; CCL2; chemokine (C-C motif) ligand 2; CCL18; chemokine (C-C motif) ligand 18; CCL22; chemokine (C-C motif) ligand 22; CCR7; chemokine (C-C motif) receptor 7; CD; cluster of differentiation; COX2; cytochrome C oxidase-2; IFNγ; interferon-Î
Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage
Keywords: OA; osteoarthritis; PRP; Platelet rich plasma; TGFβ; Transforming growth factor β; IL-4; Interleukin 4; IL-10; Interleukin 10;; IL-13; Interleukin 13;; IL-1β; Interleukin 1β; IL-6; Interleukin 6; TNF-α; Tumor necrosis factor α; FOXO; Forkhead box pr
Suppression of CCL26 and CCL11 generation in human alveolar epithelial cells by apple extracts containing procyanidins
Keywords: A549; human alveolar epithelial cells; CCL11; chemokine (C-C motif) ligand eotaxin; CCL26; chemokine (C-C motif) ligand eotaxin-3; DMSO; dimethyl sulphoxide; DP; degree of polymerisation; ELISA; enzyme-linked immunosorbent assay; FBS; foetal bovine serum;
Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration
Keywords: Layer by layer coating; IL-4; Surgical mesh; Polypropylene; Macrophage; Foreign body reaction;
Role of PARL-PINK1-Parkin pathway in adipocyte differentiation
Keywords: Adipogenesis; Parkin; Peroxisome proliferator-activated receptor-γ (PPARγ); Presenilin associated rhomboid-like protein (PARL); PTEN-induced kinase 1 (PINK1); C/EBPα/β; CCAAT-enhancer-binding protein-α/â β; DRP1; dynamin-related protein-1; FABP4;
CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes
Keywords: CRISPR-Cas9; Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9; CTLA-4; cytotoxic T-lymphocyte-associated protein 4; KO; knock out; CTL; cytotoxic T lymphocytes; TNF-α; Tumor necrosis factor-α; IFN-γ; interferon
Protective effect of bacillopeptidase CFR5 from Bacillus subtilis CFR5 on cerulein-induced pancreatitis
Keywords: Pancreatitis; Interleukin; Bacillopeptidase; Cytokines; Tight junction protein; BPC; bacillopeptidase CFR5; CIP; cerulein induced acute pancreatitis; IL-1; interleukin-1; IL-6; interleukin-6; IL-2; interleukin-2; IL-4; interleukin-4; IL-5; interleukin-5;
Investigation of anti-asthmatic potential of Kanakasava in ovalbumin-induced bronchial asthma and airway inflammation in rats
Keywords: API; Ayurvedic Pharmacopoeia of India; AFI; Ayurvedic Formulary of India; HPTLC; high performance thin layer chromatography; TLC; thin layer chromatography; BALF; bronchoalveolar lavaged fluid; ELISA; enzyme-linked immunosorbent assay; IgE; immunoglobulin
Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors
Keywords: BLA; basolateral amygdala; CON; control, animal facility reared control group; COX-2; cyclodeoxygenase-2; COX-2I; cyclodeoxygenase-2 inhibitor; DMSO; dimethyl sulfoxide; D2; dopamine type 2 receptor; D3; dopamine type 3 receptor; DR; dorsal raphe nucleus;
Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex
Keywords: Arg1; Arginase 1; DH-PH domain; the diffuse B-cell lymphoma (Dbl) domain and pleckstrin-homology domain; GDP; guanosine diphosphate; GEF; guanine exchange factor; GM130; 130 kDa cis Golgi matrix protein; GTP; guanosine triphosphate; INF-γ; Interferonγ;
Increased of the hepatocytes and splenocytes apoptosis accompanies clinical improvement and higher survival in mice infected with Trypanosoma cruzi and treated with highly diluted Lycopodium clavatum
Keywords: Apoptosis; Cytokine; Homeopathy; Lycopodium clavatum; Trypanosoma cruzi; Th1; T helper cell type 1; Th2; T helper cell type 2; TNF-α; tumor necrosis factor alpha; IFN-γ; Intereferon gamma; IL-6; Interleukin 6; IL-4; Interleukin 4;
Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production
Keywords: Group 2 innate lymphoid cell; TH2; IL-4; IL-13; IL-5; CD154; IgE; Toll-like receptor; APRIL; A proliferation-inducing ligand; BAFF; BÂ cell-activating factor of the TNF family; CRS; Chronic rhinosinusitis; CRTH2; Chemoattractant receptor expressed on TH
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
In vivo IL-4 prevents allo-antigen driven CD8+ CTL development
Keywords: Graft-vs.-host disease; T cells; IL-4; CTL; Mouse; Cytokine; BDF1; B6D2F1; B6; C57Bl/6; GrB; granzyme B; HVG; host-vs.-graft; KO; knock out; p â F1; parent-into-F1; pfp; perforin; Tfh; T follicular helper; WT; wild type;
Follicular helper T cells mediate IgE antibody response to airborne allergens
Keywords: Follicular T cells; IL-4; IgE; allergy; allergens; TH2 cells; APC; Antigen-presenting cell; BAL; Bronchoalveolar lavage; eGFP; Enhanced green fluorescent protein; FACS; Fluorescence-activated cell sorting; GC; Germinal center; HDM; House dust mite; ICOS;
Short communicationPredominance of Th1 response, increase of megakaryocytes and Kupffer cells are related to survival in Trypanosoma cruzi infected mice treated with Lycopodium clavatum
Keywords: Trypanosoma cruzi; Lycopodium clavatum; Megakaryocytes; Kupffer cells; Th1 response; Th1; T helper cell type 1; Th2; T helper cell type 2; TNF-α; tumor necrosis factor alpha; IFN-γ; Interferon gama; IL-10; Interleukin 10; IL-4; Interleukin 4; IL-17; Int
Myocardial fibrosis seen through the lenses of T-cell biology
Keywords: Foxp3; Forkhead box P3; IFN-γ; Interferon-gamma; IL-4; Interleukin-4; IL-5; Interleukin-5; IL-10; Interleukin-10; IL-13; Interleukin-13; IL-17; Interleukin-17; NOS2; Inducible Nitric Oxide Synthase; Teff; Effector T-cell; Th; T-helper cell; Treg; Regulat
Recombinant carp IL-4/13B stimulates in vitro proliferation of carp IgM+ B cells
Keywords: Fish; Carp; IL-4/13B; Recombinat protein; B cell; Proliferation; IL-4;
Agreement of skin test with IL-4 production and CD40L expression by T cells upon immunotherapy of subjects with systemic reactions to Hymenoptera stings
Keywords: VIT; Hymenoptera venom immunotherapy; BAT; basophil activation test; IDT; intradermal test; sIgE; specific IgE antibodies; Hymenoptera venom allergy; Venom immunotherapy; IL-4; CTLA-4; Intradermal skin test; Basophil activation test;
Luteolin inhibits recruitment of monocytes and migration of Lewis lung carcinoma cells by suppressing chemokine (C-C motif) ligand 2 expression in tumor-associated macrophage
Keywords: TAMs; IL-4; Luteolin; STAT6; CCL2; Migration;
1-Methylnicotinamide protects against liver injury induced by concanavalin A via a prostacyclin-dependent mechanism: A possible involvement of IL-4 and TNF-α
Keywords: Con A; concanavalin A; RO3244794; prostacyclin receptor antagonist; IL-4; interleukin 4; IFN-γ; interferon gamma; TNF-α; tumor necrosis factor alpha; NKT; natural killer T; MNA; 1-methylnicotinamide; PGI2; prostacyclin; cPGI2; carbaprostacyclin; ALT; al
A higher frequency of CD4+Â CXCR5+ T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis
Keywords: TFH cell; Henoch-Schönlein purpura nephritis; IL-21; eGFR; IL-4;
Ginsenoside Rb1: The new treatment measure of myasthenia gravis
Keywords: Myasthenia gravis; Ginsenoside Rb1; Th17 cells; Treg cells; IL-10; IL-4;