کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5588569 | 1569104 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS
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کلمات کلیدی
IL-6SIRSIL-4DXANRSIFN-γinflammation - التهاب( توروم) ONS - ایالات متحدهinterferon-γ - اینترفرون-γinterleukin-4 - اینترلوکین -4interleukin-6 - اینترلوکین ۶tumor necrosis factor alpha - تومور نکروز عامل آلفاdual-energy X-ray absorptiometry - جذب اندازه گیری اشعه ایکس دوگانه انرژیSystemic inflammatory response syndrome - سندرم پاسخ سیستماتیک التهابیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیNutritional risk screening - غربالگری رژیم غذاییTNF-α - فاکتور نکروز توموری آلفاoral nutritional supplement - مکمل تغذیه ای خوراکیsuPAR - ناراحتC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Nutritional support - پشتیبانی تغذیهIntervention group - گروه مداخلهcontrol group - گروه کنترلSoluble urokinase plasminogen activator receptor - گیرنده فعال کننده پلاسمینوژن توبرینایس محلول است
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS A high-protein diet during hospitalization is associated with an accelerated decrease in soluble urokinase plasminogen activator receptor levels in acutely ill elderly medical patients with SIRS](/preview/png/5588569.png)
چکیده انگلیسی
Acute illness and hospitalization in elderly individuals are often accompanied by the systemic inflammatory response syndrome (SIRS) and malnutrition, both associated with wasting and mortality. Nutritional support and resistance training were shown to increase muscle anabolism and reduce inflammation in healthy elderly. We hypothesized that nutritional support and resistance training would accelerate the resolution of inflammation in hospitalized elderly patients with SIRS. Acutely admitted patients aged >65 years with SIRS were randomized to an intervention consisting of a high-protein diet (1.7 g/kg per day) during hospitalization, and daily protein supplement (18.8 g) and 3 weekly resistance training sessions for 12 weeks after discharge (Intervention, n = 14), or to standard-care (Control, n = 15). Plasma levels of the inflammatory biomarkers soluble urokinase plasminogen activator receptor (suPAR), interleukin-6, C-reactive protein (CRP), and albumin were measured at admission, discharge, and 4 and 13 weeks after discharge. The Intervention group had an earlier decrease in suPAR levels than the Control group: â15.4% vs. +14.5%, P = .007 during hospitalization, and â2.4% vs. â28.6%, P = .007 between discharge and 4 weeks. There were no significant effects of the intervention on the other biomarkers. All biomarkers improved significantly between admission and 13 weeks, although with different kinetics (suPAR: â22%, interleukin-6: â86%, CRP: â89%, albumin: +11%). Nutritional support during hospitalization was associated with an accelerated decrease in suPAR levels, whereas the combined nutrition and resistance training intervention after discharge did not appear to affect the inflammatory state. Our results indicate that improved nutritional care during hospitalization may accelerate recovery in acutely ill elderly medical patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 41, May 2017, Pages 56-64
Journal: Nutrition Research - Volume 41, May 2017, Pages 56-64
نویسندگان
Juliette Tavenier, Thomas H. Haupt, Aino L. Andersen, Sussi F. Buhl, Anne Langkilde, Jens R. Andersen, Jens-Erik B. Jensen, Mette M. Pedersen, Janne Petersen, Ove Andersen,