Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
Keywords: التهاب; Silymarin; ICH; NLRP3; Inflammasome; NF-κB-P65; Nrf-2;
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Cytokine expression levels in ALS: A potential link between inflammation and BMAA-triggered protein misfolding
Keywords: التهاب; Pro-inflammatory; BMAA; Neuroinflammation; Protein misfolding; Inflammasome; Amyotrophic lateral sclerosis;
Lithospermum erythrorhizon extract inhibits Der p2-induced inflammatory response through alleviation of thymic stromal lymphopoietin, nuclear factor Kappa B, and inflammasome expression in human bronchial epithelial cells
Keywords: التهاب; Lithospermum erythrorhizon; Angelica sinensis; Thymic Stromal Lymphopoietin; NF-κB; Inflammasome; Signal transducer and activator of transcription 3;
Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia
Keywords: التهاب; Cytokines; Immunohistochemistry; Inflammasome; Placenta; RT-qPCR;
SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis
Keywords: التهاب; SRT1720; Sirtuin 1; Organ injury; Inflammation; Inflammasome; Sepsis;
Liver X receptors agonists suppress NLRP3 inflammasome activation
Keywords: التهاب; LXRs; liver X receptors; LXRα; NR1H3; LXRβ; NR1H2; T0901317; T09; GW3965; GW; mtROS; mitochondria reactive oxygen species; NLRP3; the NLR family pyrin domain-containing protein 3; ASC; speck-like protein containing a caspase recruitment domain; PAMP; pa
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth
Keywords: التهاب; Apical periodontitis; Inflammasome; Immunohistochemistry; Microbial stimuli;
Enfermedades autoinflamatorias en el adulto. CaracterÃsticas clÃnicas e implicaciones pronósticas
Keywords: التهاب; Enfermedades autoinflamatorias hereditarias; Adulto; Fiebre periódica; Inflamasoma; Nod-like receptor; TNF; Hereditary autoinflammatory diseases; Adults; Periodic fever; Inflammasome; Nod-like receptor; TNF;
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia
Keywords: التهاب; Inflammasome; Ceramide; Acid sphingomyelinase; Atherosclerosis;
Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O157:H7
Keywords: التهاب; Quercetin; Inflammasome; E. coli O157:H7; Polyphenol; Inflammation; Epithelial cells; Mitochondria;
AIM2 inflammasome activation and regulation: A structural perspective
Keywords: التهاب; AIM2; Inflammasome; Helical filament; High-order assembly; Polymerization; ASC; Caspase-1; PYD; CARD; P202; INCA;
RIP3 AND pMLKL promote necroptosis-induced inflammation and alter membrane permeability in intestinal epithelial cells
Keywords: التهاب; Adhesion molecules; Inflammasome; Intestinal inflammation; Necroptosis;
Genipin protects d-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the necroptosis-mediated inflammasome signaling
Keywords: التهاب; Genipin (PubChem CID: 442424); Necrostatin-1 (PubChem CID: 2828334); Acute liver failure; Damage-associated molecular patterns; Genipin; Inflammasome; Necroptosis;
Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation
Keywords: التهاب; Inflammasome; Interleukin-1beta; Water dropwort; Hyperoside; Isorhamnetin; EWD; the extracts of water dropwort; IL; interleukin; NLR; NOD-like receptors; PAMPs; pathogen-associated molecular patterns; DAMPs; damage-associated molecular patterns; AIM2; abs
Original ArticleNanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides
Keywords: التهاب; Fullerene; Radiculopathy; DRG; Inflammasome; Hyperalgesia; Low back pain;
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
Keywords: التهاب; Microglia; Interleukin-1β; Caspase 1; Inflammasome; APP/PS1 mice; Alzheimer's disease; Neuroinflammation;
Targeting inflammasome by the inhibition of caspase-1 activity using capped mesoporous silica nanoparticles
Keywords: التهاب; Gated mesoporous silica nanoparticles; controlled release; inflammasome; VX-765; macrophages; air pouch mouse model;
Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages
Keywords: التهاب; Chitin/chitosan; Macrophage; Immunomodulation; Inflammasome; Type 1 interferon;
Ugonin U stimulates NLRP3 inflammasome activation and enhances inflammasome-mediated pathogen clearance
Keywords: التهاب; ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; [Ca2+]i; intracellular calcium concentration; DAMPs; danger-associated molecular patterns; IP3; inositol triphosphate; IP3R; inositol triphosphate receptor; LPS; lipopol
Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis
Keywords: التهاب; KL-6; Muc1 mucin; Silicosis; Lung injury; Pulmonary fibrosis; Inflammasome;
HIV-1-Associated Atherosclerosis
Keywords: التهاب; caspase-1; immune activation; inflammasome; inflammation; macrophage; Tg26 transgenic mice; ART; antiretroviral therapy; CVD; cardiovascular disease; ER; endoplasmic reticulum; HIV; human immunodeficiency virus; HIV+; human immunodeficiency virus-infected
SOHO State of the Art Update and Next Questions: Biology and Treatment of Myelodysplastic Syndromes
Keywords: التهاب; Inflammasome; MDS; Next-generation sequencing; Pyroptosis; Targeted therapy;
Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase
Keywords: التهاب; IL-1; ibrutinib; Bruton tyrosine kinase; NLRP3; inflammasome; macrophage; X-linked agammaglobulinemia; Staphylococcus aureus; Muckle-Wells syndrome; inflammation; APC; Allophycocyanin; ASC; Apoptosis-associated speck-like protein containing a CARD; BMDM;
Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome
Keywords: التهاب; cytokine; inflammasome; interleukin-1beta; Korean Red Ginseng extracts; NLRP3;
Absent in Melanoma 2 proteins in SLE
Keywords: التهاب; Lupus; AIM2; Inflammasome; Interferon; IFN-signature;
Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling
Keywords: التهاب; Free cholesterol; Liver sinusoidal endothelial cell; Acetaminophen; Liver injury; Rab7; Toll-like receptor 9; Endosome; Lysosome; Inflammasome; Metabolic syndrome;
Toxoplasma gondii mitogen-activated protein kinases are associated with inflammasome activation in infected mice
Keywords: التهاب; Toxoplasma gondii; Mitogen-activated protein kinase; Inflammasome; IL-18; IFN-β;
Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases
Keywords: التهاب; Inflammasome; Caspase-1; Caspase-4; Caspase-5; Inflammation;
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse
Keywords: التهاب; Ischemia; Reperfusion; Injury; Infarction; Inflammation; Inflammasome;
The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux
Keywords: التهاب; Inflammasome; Pyroptosis; Inflammation; Potassium; Tyrosine kinase; NLRP3; NLR family, pyrin domain-containing 3; IL-1β; interleukin-1 beta; ROS; reactive oxygen species; mROS; mitochondrial reactive oxygen species; LPS; lipopolysaccharide;
Rosmarinic acid inhibits poly(I:C)-induced inflammatory reaction of epidermal keratinocytes
Keywords: التهاب; Inflammasome; Keratinocyte; Poly(I:C); Rosmarinic acid
Original ArticleGenotyping and differential expression analysis of inflammasome genes in sporadic malignant melanoma reveal novel contribution of CARD8, IL1B and IL18 in melanoma susceptibility and progression
Keywords: التهاب; Melanoma; inflammasome; SNPs; CARD8; IL1B;
A translocator protein 18Â kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation
Keywords: التهاب; TSPO; Ro5-4864; NLRP3; Inflammasome; Mitochondria;
NLRP2 is highly expressed in a mouse model of ischemic stroke
Keywords: التهاب; Ischemic stroke; NLRP2; Inflammasome; Astrocyte;
Probenecid protects against oxygen–glucose deprivation injury in primary astrocytes by regulating inflammasome activity
Keywords: التهاب; Cerebral ischemia/reperfusion injury; Pannexin 1; Inflammasome; NLRP3; HMGB1
Newcastle disease virus infection induces activation of the NLRP3 inflammasome
Keywords: التهاب; Inflammasome; NDV; NLRP3; Caspase-1; THPâ1 cells;
Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome
Keywords: التهاب; Sulforaphane; NLRP3; NLRC4; AIM2; Inflammasome
Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy
Keywords: التهاب; S. aureus; IL-1β; TNF-α; Inflammasome; Cross reactivity;
Inflammasome Proteins in Cerebrospinal Fluid of Patients with Subarachnoid Hemorrhage are Biomarkers of Early Brain Injury and Functional Outcome
Keywords: التهاب; Biomarkers; Inflammasome; Subarachnoid hemorrhageCNS, Central nervous system; CSF, Cerebrospinal fluid; GOS, Glasgow Outcome Scale; SAH, Subarachnoid hemorrhage
Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells
Keywords: التهاب; Obesity; Placenta; Palmitic acid; Inflammasome; Reactive oxygen species;
Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation
Keywords: التهاب; Juniperus rigida; IL-1β; TRIF; Inflammasome; ASC; Type-II diabetes
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury
Keywords: التهاب; TLR4; Inflammasome; Proinflammatory cytokines; (+)-Naltrexone; Interleukin-1β; NLRP3; Tumor necrosis factor; Neuropathic pain; Rats;
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation
Keywords: التهاب; TLR4; Cardiac fibroblasts; Cardiac myofibroblasts; Inflammasome; IL-1β
Differential inflammasome activation signatures following intracellular infection of human macrophages with Mycobacterium bovis BCG or Trypanosoma cruzi
Keywords: التهاب; Inflammasome; Mycobacteria; T. cruzi; Inflammation; NLR; TLR;
Reviews and feature articleInterferons and inflammasomes: Cooperation and counterregulation in disease
Keywords: التهاب; Interferon; IL-1β; IL-18; gram-negative bacteria; inflammasome; NLRP3; caspase-1; caspase-11; guanylate-binding protein; pyroptosis; AIM2; tuberculosis; multiple sclerosis; experimental autoimmune encephalomyelitis; AIM2; Absent in melanoma 2; ALR; AIM2-
Functional characterization of apoptosis-associated speck-like protein (ASC) of the goldfish (Carassius auratus L.)
Keywords: التهاب; Macrophages; Fish; Inflammasome; ASC; Macrophage; Teleost
Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects
Keywords: التهاب; HIV-1; Inflammation; Metabolism; Inflammasome; Innate immunity
Purinergic signaling during Porphyromonas gingivalis infection
Keywords: التهاب; Purinergic receptors; Innate immunity; Porphyromonas gingivalis; P2X7 receptor; Oral microbes; Inflammasome;
The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Keywords: التهاب; NLRP3; Inflammasome; Alloimmunization; Conventional dendritic cells (cDCs); Red blood cell (RBC) storage
Inflammatory immune response by lipopolysaccharide-responsive nucleotide binding oligomerization domain (NOD)-like receptors in the Japanese pufferfish (Takifugu rubripes)
Keywords: التهاب; Inflammatory cytokines; Inflammasome; Intracellular PRRs; NLR; Japanese pufferfish; LPS recognitionASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; NADPH, nicotinamide adenine dinucleotide phosphate hydr