Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis
Keywords: PGE; Tumor necrosis factor-α; iNOS; Nuclear factor-κB
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Pure Î9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Î9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages
Keywords: BSA; albumin bovine serum; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CBC; cannabichromene; CBD; cannabidiol; CBG; cannabigerol; COX-2; cyclooxygenase-2; DAN; 2,3-diaminonaphthalene; DMSO; dimethyl sulfoxide (DMSO); DTT; 1,4-dithi
Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice
Keywords: ACh; acetylcholine; DBP; diastolic blood pressure; eNOS; endothelial nitric oxide synthase; GSH; glutathione; GSSG; Glutathione disulfide; HO-1; heme oxygenase-1; HR; heart rate; iNOS; inducible nitric oxide synthase; MDA; malondialdehyde; NADPH oxidase;
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways
Keywords: MED27; Melanoma; AKT; MAPK; NF-κB; iNOS;
Glycoprotein isolated from Styrax japonica Siebold et al. Zuccarini inhibits oxidative and pro-inflammatory responses in HCT116 colonic epithelial cells and dextran sulfate sodium-treated ICR mice
Keywords: SJSZ glycoprotein; Dextran sodium sulfate; Colonic epithelial cells; Hydroxyl radicals; Mouse colitis; COX-2; cyclooxygenase-2; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; DSS; dextran sulfate sodium; DAI; disease activity index; iNOS; inducible nit
Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain
Keywords: Gelatin nanoparticles; iNOS; siRNA; MCAO; Intranasal delivery
Intestinal anti-inflammatory activity of calcium pyruvate in the TNBS model of rat colitis: Comparison with ethyl pyruvate
Keywords: CPM; calcium pyruvate monohydrate; EP; ethyl pyruvate; GSH; glutathione; IBD; inflammatory bowel disease; ICAM-1; intercellular adhesion molecule-1; IFNγ; interferon γ; IL; interleukin; iNOS; inducible nitric oxide synthase; LTB4; leukotriene B4; MCP-1;
Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats
Keywords: Black raspberries; Anthocyanin; Oesophageal cancer; Cancer prevention; NMBA (PubChem CID: 13643); PBIT (PubChem CID: 935415); Celecoxib (PubChem CID: 2662); SCC; squamous cell carcinoma; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; PBIT
The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling
Keywords: arg; arginine; BH4; tetrahydrobiopterin; CW; continuous wave; ED-EPR; echo-detected EPR; ENDOR; electron nuclear double resonance; EPR; electron paramagnetic resonance, also known as ESR or electron spin resonance; HYSCORE; hyperfine sublevel correlation
LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis
Keywords: Ad; adenovirus; BCA; bicinchoninic acid; BSA; bovine serum albumin; CAT1H; 1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride; DMEM; Dulbecco's modified Eagle's medium; DynK44A; dominant-negative dynamin; eGFP; enhanced green fluoresce
Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response
Keywords: BER; base excision repair; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase-2; EAE; experimental autoimmune encephalomyelitis; faPyG; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; GAS; gamma-interferon activation site; iNOS; inducible nitric oxid
Dietary (-)-epicatechin mitigates oxidative stress, NO metabolism alterations, and inflammation in renal cortex from fructose-fed rats
Keywords: CAT; catalase; CuZnSOD; copper, zinc superoxide dismutase; eNOS; endothelial nitric oxide synthase; GPx; glutathione peroxidase; GSH; reduced glutathione; IL-6; interleukin-6; 4-HNE; 4-hydroxynonenal; hnRNP; heterogeneous nuclear ribonucleoprotein A1; iNO
Imipramine and amitriptyline ameliorate the rotenone model of Parkinson's disease in rats
Keywords: 5-HT; serotonin; AMI; amitriptyline; BDNF; brain-derived neurotrophic factor; CAT; catalase; CREB; cAMP-response element-binding protein; DMSO; dimethyl sulfoxide; DA; dopamine; IMI; imipramine; iNOS; inducible nitric oxide synthase; MDA; malondialdehyde;
Spirostanol saponins from Chinese onion (Allium chinense) exert pronounced anti-inflammatory and anti-proliferative activities
Keywords: Chinese onion; Allium chinense; Spirostanol saponins; Anti-inflammatory; Antiproliferative; Laxogenin (PubChem CID: 10950057); Neogitogenin (PubChem CID: 44630243); A549; human lung cancer cells; CNE-1; human nasopharyngeal carcinoma; DEPT; distortionless
Reciprocal interaction among gasotransmitters in isolated pancreatic β-cells
Keywords: AOAA; amino-oxyacetic acid; [Ca2+]i; intracellular Ca2+ concentration; 3MST; 3-mercatopyruvate sulfurtransferase; CaM; calmodulin; CBS; Cystathionine-β-synthetase; CO; carbon monoxide; CSE; cystathionine-γ-lyase; deoxy-Mb; deoxymyoglobin; DTZ; dithizone
Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway
Keywords: COX-2; cyclooxygenase-2; DAPI; 4,6-diamino-2-phenyl indole; DHA; docosahexaenoic acid; EBI; early brain injury; EMSA; electrophoretic mobility shift assays; EPA; eicosapentaenoic acid; FJB; Fluoro-Jade B; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; G
Basic ScienceSoluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate
Keywords: BMDM; bone-marrow-derived macrophage; DPP-4; dipeptidyl peptidase-4; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; IκB-α; NF-kappa-B inhibitor alpha; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; M6P; mannose-6-phosphate; NO; nitric
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Keywords: Apoptosis; Cytokines; iNOS; STAT3; TRAF2; Type 1 diabetes;
Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice
Keywords: SCFA; short-chain fatty acid; HDAC; histone deacetylases; GPR41 and GPR43 respectively; free fatty acid receptor (FFAR)-2 and 3; PPARs; peroxisome proliferator-activated receptors; MTC1; monocarboxylate transporter 1; CCI; chronic constriction injury; FBA
Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling
Keywords: AhR; aryl hydrocarbon receptor; ATF2; activating transcription factor 2; BPDE; benzo(a)pyrene-7,8-diol-9,10-epoxide; CYP11A1; cytochrome P450 11A1; CYP1A1; cytochrome P450 1A1; iNOS; inducible nitric oxide synthase; MDA; malondialdehyde; PARP; poly-ADP ri
Inhibition of coagulation proteases Xa and IIa decreases ischemia-reperfusion injuries in a preclinical renal transplantation model
Keywords: α-SMA; α-smooth muscle actin; DCD; donors deceased after cardiac death; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HAEC; human aortic endothelial cell; HES; hematoxylin-eosin-s
Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages
Keywords: Mycobacterium tuberculosis; esxO; Rv2346c; Survival; Macrophages; Oxidative stress; Genomic instability; WT; Wild Type; Msm; Mycobacterium smegmatis; Mtb; Mycobacterium tuberculosis; MsmRv2346c; Mycobacterium smegmatis expressing Rv2346c; MOI; multiplicit
Myeloid-derived suppressor cells in murine AIDS inhibit B-cell responses in part via soluble mediators including reactive oxygen and nitrogen species, and TGF-β
Keywords: Monocytic MDSC; B cell; Reactive oxygen species; Reactive nitrogen species; INOS; Superoxide; Peroxynitrite; Nitric oxide; Breg; Suppression;
Rat aorta as a pharmacological tool for in vitro and in vivo studies
Keywords: BH4; tetrahydrobiopterin; cGMP; cyclic guanine monophosphate; COX; cyclooxygenase; cNOS; constitutive NOS; DAG; diacylglycerol; DMEM; Dulbecco's modified eagle's medium; eNOS; endothelial NOS; EDHF; endothelium dependent hyperpolarization factor; EGTA; et
Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic-pituitary-adrenal axis function
Keywords: AG; aminoguanidine; FST; forced swimming test; GC; glucocorticoid; HBT; hole-board test; HIPP; hippocampus; HPA; hypothalamic-pituitary-adrenal axis; hprt1; hypoxanthine phosphoribosyl transferase1; i.p.; intraperitoneal; iNOS; inducible NOS; IC; isol
Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2)
Keywords: BDNF; brain-derived neurotropic factor; cAMP; cyclic adenosine monophosphate; CGS21680; 3-[4-[2-[[6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]purin-2-yl]amino]ethyl]phenyl]propanoic acid - selective adenosine A2A agonist; Cyt.
4â²-O-β-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats
Keywords: 4â²-O-β-D-glucosyl-5-O-methylvisamminol; Phosphatidylinositol-3-kinase; Protein kinase B; Transient middle cerebral artery occlusion; Tumor necrotic factor-α; Bad; Bcl-2-associated death promoter; BrdU; 5-Bromo-2â²-deoxyuridine; BWI; Brain water ind
Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies
Keywords: AP-1; activator protein-1; ARE; antioxidant response element; ATF2; activating transcription factor 2; CoQ0; coenzyme Q0; COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; GSH; glutathione; HO-1; heme oxygenase-1; I-κB; inhibitor-κB;
Epigallocatechin gallate and mitochondria-A story of life and death
Keywords: ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; ALT; alanine aminotransferase; AMP; adenosine monophosphate; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; ATP; adenosine triphosphate; Bax; BCL2-Associated X Protein; Bc
Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics
Keywords: ASR; Angelica sinensis radix; BBB; Blood Brain Barrier; BDPH; Butylidenephthalide; CD; circular dichroism; CO; Cnidium officinale; EC; endothelial cells; EO; essential oils; FA; ferulic acid; GC/MS; gas chromatography/mass spectroscopy; H2O2; hydrogen per
Herbal extracts, lichens and biomolecules as natural photo-protection alternatives to synthetic UV filters. A systematic review
Keywords: BCC; basal cell melanoma; CoQ10; coenzyme Q10; CPDs; cyclobutane pyrimidine dimers; COX-2; cyclooxygenase-2; DDE; D. Don herbal extract; GSH; endogenous reduced glutathione; EGCG; epigallocathetin gallate; GAE; gallic acid and ethyl gallate; GTP; green te
Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death
Keywords: I/R; ischemia and reperfusion; RNS; reactive nitrogen species; ROS; reactive oxygen species; O2â¢â; superoxide; ONOOâ; peroxynitrite; SOD; superoxide dismutase; NOS; nitric oxide synthases; iNOS; inducible nitric oxide synthases; NO; nitric oxide; EG
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
Keywords: Mucin-Type O-Glycans; Mucus Barrier; Ulcerative Colitis; Mouse Model; ASC; apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain; BM; bone marrow; C3GnT; core 3 β1,3-N-acetylglucosaminyltransferase; DKO; double knock-
The essential oil from the twigs of Cinnamomum cassia Presl alleviates pain and inflammation in mice
Keywords: EO; essential oil; PGE2; prostaglandin E 2; COX-2; cyclooxygenase-2; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CFA; complete Freund's adjuvan; NC; normal control group; IL-1β; interleukin 1β; TNF-α; tumor necrosis factor-alpha; GC-MS; ga
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Keywords: ALI; acute lung injury; APCs; antigen-presenting cells; ARE; antioxidant responsive element; Bach1; Broad complex-Tramtrack-Bric-a-brac (BNB) and Cap'n'collar (CNC) homolog 1; BAL; bronchoalveolar lavage; BR; bilirubin-IXα; BV; biliverdin-IXα; BVR;
Effect of asymmetric dimethylarginine (ADMA) on heart failure development
Keywords: Nitric oxide; Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase-1; Heart failure; CHF; chronic Heart failure; ADMA; Asymmetric dimethylarginine; BH4; tetrahydrobiopterin; DDAH1; dimethylarginine dimethylaminohydrolase 1; PRMT1; type 1 p
Features of endothelial dysfunction and morphofunctional changes of the uteroplacental complex in experimentally induced pre-eclampsia
Keywords: VEGF; vascular endothelial growth factor; eNOS; endothelial NO-synthase; iNOS; inducible NO-synthase; APTT; activated partial thromboplastin time; PT; prothrombin time; TT; thrombin time; vWF; von Willebrand factor; Experimental model pre-eclampsia endoth
Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase
Keywords: Aβ; amyloid beta; AEBSF; 4-(2-aminoethyl)-benzenesulfonyl fluoride; cRGD; cyclic peptide arginine-glycine-aspartate-d-phenylalanine-valine; fMLP; N-formylmethionyl-leucyl-phenylalanine; iNOS; inducible NO synthase; LME; l-leucine methyl ester; LPS; lipop
Astrocytes in physiological aging and Alzheimer's disease
Keywords: 3xTg-AD; triple transgenic mice model of Alzheimer's disease; AD; Alzheimer's disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; CA1; Cornu Ammonis 1; CNS; Central nervous system; DG; dentate gyrus; GABA; γ-aminobutyric acid; GFAP;
Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca2+-ATPase in diabetic rats
Keywords: Iron; Diabetic heart complications; Tyrosine nitration; SERCA2a; DFO; deferoxamine; DNP; dinitrophenol; DTT; dithiothreitol; HFD; high-fat diet; iNOS; inducible nitric oxide synthase; i.p.; intraperitoneally; NO; nitric oxide; NPD; normal pellet diet; ONO
Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides
Keywords: SEPAc; standardized extract of polymethoxyflavones obtained A. conyzoides; PGE2; prostaglandin E2; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; RA; rheumatoid arthritis; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; 5,6,7,3
Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling
Keywords: I-R; ischemia-reperfusion; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; MMP-9; matrix metalloproteinase-9; TLR4; toll-like receptor 4; e-PA; extrinsic plasminogen activator; t-PA; tissue plasminogen activator; HR; heart rate; BP; arteri
Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; ANOVA; analysis of variance; BEs; behavioral evaluations; GABA; glutamate and gamma aminobutyric acid; iNOS; inducible nitric oxide synthase; LTP; long-term potentiation; m-CPBG; m-chlorophenylbiguanide; PTZ
Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway
Keywords: Interleukin-17A; Cardiomyocyte; Apoptosis; Stat3; iNOS; Ischemia/reperfusion injury;
Enhanced XOR activity in eNOS-deficient mice
Keywords: CLU; chemiluminescence units; DAF-FM DA; 4-amino-5-methylamino-2â²,7â²-difluorescein diacetate; EDTA; ethylene diamine tetra-acetic acid; eNOS; endothelial NO synthase; iNOS; inducible NO synthase; nNOS; neuronal NO synthase; Febuxostat; 2-(3-Cyano-4-is
S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway
Keywords: SPRC; S-propargyl-cysteine; CSE; cystathionine γ-synthase; FLS; fibroblast-like synoviocytes; AIA; adjuvant-induced arthritis; Nrf2; nuclear factor erythroid-2-related factor 2; ARE; antioxidant response element; Keap1; kelch-like ECH-associated protein
Gastroprotective potential of Pentahydroxy flavone isolated from Madhuca indica J. F. Gmel. leaves against acetic acid-induced ulcer in rats: The role of oxido-inflammatory and prostaglandins markers
Keywords: Gastroprotective; Acetic acid; Madhuca indica; Pentahydroxy flavone; TNF-α; IL-1; iNOs; COX-II;
DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells
Keywords: PM2.5; DDAH1; Nrf2; iNOS; ROS;
Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling
Keywords: NO; nitric oxide; PGE2; prostaglandin E2; NSAIDs; non-steroidal anti-inflammatory drugs; qRT-PCR; quantitative real-time polymerase chain reaction; LPS; lipopolysaccharide; IFN-γ; interferon γ; G-CSF; granulocyte colony stimulating factor; TNF-α; tumor
Myeloid-derived suppressor cells expressing a self-antigen ameliorate experimental autoimmune encephalomyelitis
Keywords: 7-AAD; 7-aminoactinomycin D; DMEM; Dulbecco's modified Eagle's medium; EGFP; enhanced green fluorescent protein; EAE; experimental autoimmune encephalomyelitis; EU; European Union; FBS; fetal bovine serum; GEE; generalized estimating equation; GFAP; glial