Reactive oxygen species mediate nitric oxide production through ERK/JNK MAPK signaling in HAPI microglia after PFOS exposure
Keywords: PFOS; Microglia; ROS; iNOS; NO; ERK/JNK MAPK;
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Research ReportSynergistic anti-tumor actions of luteolin and silibinin prevented cell migration and invasion and induced apoptosis in glioblastoma SNB19 cells and glioblastoma stem cells
Keywords: CDK; cyclin-dependent kinase; DMSO; dimethyl sulfoxide; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; GSC; glioblastoma stem cells; ICAD; inhibitor of caspase activated DNase; IgG; immunoglobulin G; iNOS; inducible nitric oxide synthase; LUT;
The effect of neuronal conditional knock-out of peroxisome proliferator-activated receptors in the MPTP mouse model of Parkinson's disease
Keywords: 6-OHDA; 6-hydroxydopamine; ANOVA; analysis of variance; DOPAC; 3,4-dihydrophenylacetic acid; HPLC; high-performance liquid chromatography; IL; interleukin; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MPP; 1-methyl-4-phenylpyridinium; M
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
Keywords: Aβ; β-amyloid; AD; Alzheimer's Disease; AICD; APP Intracellular Domain; APP; Amyloid Precursor Protein; ARG1; Arginase 1; CHF5074; 1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropanecarboxylic acid; FIZZ1; Found in Inflammatory Zone; GS
Anti-osmotic and antioxidant activities of gigantol from Dendrobium aurantiacum var. denneanum against cataractogenesis in galactosemic rats
Keywords: DC; diabetic cataracts; AR; aldose reductase; NO; nitric oxide; iNOS; inducible nitric oxide synthase; ARI; aldose reductase inhibitors; PBS; phosphate buffer saline; FBS; fetal bovine serum; NIH; National Institute of Health; MD; molecular docking; PDB;
Li-Gan-Shi-Liu-Ba-Wei-San improves non-alcoholic fatty liver disease through enhancing lipid oxidation and alleviating oxidation stress
Keywords: ALT; alanine aminotransferase; AST; aspartate transaminase; DMSO; Dimethyl Sulphoxide; FFA; free fatty acid; HDL-C; high density lipoprotein cholesterol; IκBα; inhibitor of nuclear factor κB α; iNOS; inducible nitric oxide synthase; KRP; Krebs-Ringer
Blocking the mitogen activated protein kinase-p38 pathway is associated with increase expression of nitric oxide synthase and higher production of nitric oxide by bovine macrophages infected with Mycobacterium avium subsp paratuberculosis
Keywords: Paratuberculosis; Bovine macrophages; Nitric oxide; iNOS; Mycobacterium;
Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide
Keywords: COX-2; cyclooxygenase-2; DN; desoxo-narchinol-A; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; EtOAc; ethyl acetate; FBS; fetal bovine serum; H&E; hematoxylin and eosin; HPRT; hypoxanthine guanine phosphoribosyl-tra
Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW 264.7 macrophages
Keywords: LPS; lipopolysaccharide; P. gingivalis; Porphyromonas gingivalis; HO-1; heme oxygenase-1; ROS; reactive oxygen species; RANKL; receptor activator of nuclear factor-κB (RANKL); NF-Îb; nuclear factor-kappa B; Nrf-2; nuclear factor-erythroid 2-related fact
Lysophosphatidylcholine exacerbates Leishmania major-dendritic cell infection through interleukin-10 and a burst in arginase1 and indoleamine 2,3-dioxygenase activities
Keywords: BMDC; Bone marrow-derived dendritic cells; IDO; Indoleamine 2,3-dioxygenase; iNOS; inducible nitric oxide synthase; IL-6; Interleukin-6; IL-10; Interleukin-10; kyn; kynurenine; Leish; Leishmania; LIPA; Leishmania Institut Pasteur Alger; LPS; Lipopolysacch
Effects of the non-commensal Methylococcus capsulatus Bath on mammalian immune cells
Keywords: BP; BioProtein; DC; dendritic cells; DSS; dextran sulfate sodium; IECs; intestinal epithelial cells; IBD; inflammatory bowel diseases; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; moDCs; monocyte-derived DCs; MNC; mononuclear cells; PRR
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes
Keywords: ANOVA; analysis of variance; COX-2; cyclooxygenase-2; CNS; central nervous system; COSY; Correlation Spectroscopy; DMEM; Dulbecco's Modified Eagle's Medium; EDTA; ethylenediaminetetraacetate; FBS; fetal bovine serum; HMBC; heteronuclear multiple bond corr
Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
Keywords: CDKL5; cyclin-dependent kinase-like 5; GCLC; glutamate-cysteine ligase catalytic subunit; HNE; 4-hydroxy-2-nonenal; HNE-PA; HNE-protein adduct; iNOS; inducible NO synthase; MECP2; methyl-CpG binding protein 2; Nrf2; nuclear factor erythroid 2-relate
Inhibition of mTOR pathway restrains astrocyte proliferation, migration and production of inflammatory mediators after oxygen-glucose deprivation and reoxygenation
Keywords: Mammalian target of rapamycin; Reactive astrogliosis; Oxygen-glucose deprivation; Proliferation; Migration; Inflammation mediator; EdU; 5-ethynyl-29-deoxyuridine; mTOR; mammalian target of rapamycin; p-mTOR; phosphorylated mammalian target of rapamycin;
Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS
Keywords: Atorvastatin; Indomethacin-induced gastric ulcer; PGE2; TNF-a; Neutrophil infiltration; iNOS
E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression
Keywords: BMDM; bone marrow-derived macrophage; IFN; interferon; iNOS; inducible nitric oxide synthase; KO; NKLAM-knockout; LPS; lipopolysaccharide; NK; natural killer cell; NKLAM; natural killer lytic-associated molecule; NO; nitric oxide; RBR; RING in between RIN
The dual role of iNOS in cancer
Keywords: Nitric oxide; iNOS; Cancer; Apoptosis; Stroma; Cell situation
Quercetin modulates iNOS, eNOS and NOSTRIN expressions and attenuates oxidative stress in warm hepatic ischemia-reperfusion injury in rats
Keywords: eNOS; Hepatic ischemia/reperfusion; iNOS; NOSTRIN; Oxidative stress and quercetin
Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman
Keywords: LCM; long-chain metabolite; TOH; tocopherol; T3; tocotrienol; TQ; tocopheryl quinone; α-13â²-OH; α-13â²-(6-hydroxy-2,5,7,8,-tetramethylchroman-2-yl)-2,6,10-trimethyltridecanol; α-13â²-COOH; α-13â²-(6-hydroxy-2,5,7,8, -tetramethylchroman-2-yl)-2,6,
Angiotensin II-induced mouse hippocampal neuronal HT22 cell apoptosis was inhibited by propofol: Role of neuronal nitric oxide synthase and metallothinonein-3
Keywords: Ang II; angiotensin II; APAF-1; apoptotic protease activating factor-1; AT1R; angiotensin type 1 receptor; AT2R; angiotensin type 2 receptor; Bcl-2; B-cell lymphoma-2; BID; BH3-interacting domain; cIAP-1; cellular inhibitor of apoptosis protein-1; c-FLIP;
CD8+ T activation attenuates CD4+ T proliferation through dendritic cells modification
Keywords: 1-MT; 1-methyl-tryptophan; BAL; bronchoalveolar lavage; CFSE; 5(6)-carboxyfluorescein diacetate N-succinimidyl ester; CMFDA; 5-chloromethylfluorescein diacetate; DC; dendritic cell; Far-Red; CELLTRACE(TM) FAR RED DDAO-SE; HE; hematoxylin and eosin; IDO; i
ThoracicThe effect of methylene blue treatment on aspiration pneumonia
Keywords: iNOS; Methylene blue; Pulmonary aspiration; Surfactant protein D; TUNEL;
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease
Keywords: GFAP; OX-42; iNOS; Glial cells; 6-OHDA lesion; Neuroinflammation;
MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death
Keywords: CNS; central nervous system; COX-2; cyclooxygenase-2; iNOS; inducible nitric oxide synthase; IL; interleukin; KO; knockout; LPS; lipopolysaccharide; MMPs; matrix metalloproteases; NO; nitric oxide; OGD/RO; oxygen glucose deprivation/reoxygenation; p38MAPK
Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice
Keywords: CNS; central nervous system; Hipp; hippocampus; Striat; striatum; MidBr; midbrain; iG; intragastric; EtOH; ethanol; HCFD; high fat diet; ATP; adenosine triphosphate; NO; nitric oxide; iNOS; inducible NO synthase; IL-1β; interleukin 1 beta; IL-6; interleu
The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis
Keywords: ALS; amyotrophic lateral sclerosis; SOD1; superoxide dismutase 1; VIP; vasoactive intestinal peptide; PACAP; pituitary adenylate cyclase-activating polypeptide; SNV; stearyl-norleucine-VIP; PBS; phosphate-buffered saline; GFAP; glial fibrillary acidic pro
Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease
Keywords: Parkinson's disease; Microglia; NADPH oxidase; iNOS; Tanshinone IIA; MPTP
3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages
Keywords: RAW264.7 cells; TLR-4; Didox; Oxidative stress; Inflammation; iNOS;
Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling
Keywords: AngII; angiotensin II; ACE; angiotensin converting enzyme; AT1R; AT1 receptor; CVD; cardiovascular disease; DAG; diacylglycerol; DBP; diastolic blood pressure; ED; endothelial dysfunction; eNOS; endothelial nitric oxide synthase; ERK1/2; extracellular sig
Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice
Keywords: ANP; atrial natriuretic peptide; AU; arbitrary unit; β-MHC; beta-myosin heavy chain; BNP; brain natriuretic peptide; cDNA; complementary deoxyribonucleic acid; DOX; doxorubicin; ECG; electrocardiogram; ESR; electron spin resonance; ET; ventricular ejecti
Adrenomedullin attenuates interleukin-1β-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway
Keywords: IL-1β; Interleukin-1β; NF-κB; Nuclear factor-kappa B; ADM; Adrenomedullin; DMEM; Dulbecco's modified Eagle's medium; FBS; Fetal bovine serum; DAPI; 6-Dianidino-2-phenylindole dihydrochlor; PARP; Poly adenosine diphosphate-ribose polymerase; PBS; phosph
Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner
Keywords: COX-2; cyclooxygenase-2; ECM; extracellular matrix; iNOS; inducible nitric oxide synthase; IκBα; inhibitor of nuclear factor-kappaB α subunit; IKK; IκB kinase; MAPK; mitogen-activated protein kinase; MMP; matrix metalloproteinase; NF-κB; nuclear fact
Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro
Keywords: BALF; bronchoalveolar lavage fluid; COPD; chronic obstructive pulmonary disease; COX-2; cyclooxygenase-2; CS; cigarette smoke; iNOS; inducible nitric oxide synthase; MAPKs; mitogen-activated protein kinases; MCP-1; monocyte chemoattractant protein-1; MMP-
Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
Keywords: Nrf2; nuclear factor erythroid-2 related factor 2; Am. G; American ginseng; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MCP-1; monocyte chemotactic protein-1; MIP-1β; macrophage inflammatory protein-1 beta; IL-1β; interleukin-1 beta;
Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential
Keywords: AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; ÎΨm; mitochondrial membrane potential; iNOS; inducible nitric oxide synthase; P450; cytochrome P450; PAH; polycyclic aromatic hydrocarbon; Benzo[a]pyrene; Nitric oxide; Mitochondrial membrane hyperp
Cardiac-specific overexpression of catalase prevents diabetes-induced pathological changes by inhibiting NF-κB signaling activation in the heart
Keywords: CAT-TG; cardiac-specific catalase overexpression transgenic; WT; wild type; α-KGD; α-oxoglutarate dehydrogenase E1 component; KGDHC; α-ketoglutarate dehydrogenase complex; ATP-α; ATP synthase α subunit; ATP-β; ATP synthase β subunit; ROS; reactive
In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract
Keywords: Pa-ME; methanolic extract of Phyllanthus acidus; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; Akt; prot
Neuronal effects of a nickel-piperazine/NO donor complex in rodents
Keywords: Nitric oxide; Central nervous system; Locomotor behavior; Anxiety; Memory; Depression; pbm; beats per minutes; HR; heart rate; iNOS; inducible nitric oxide synthase; i.p.; intraperitoneal; NO; nitric oxide; NORT; novel object recognition test; PKC; protei
Splenectomy attenuates obesity and decreases insulin hypersecretion in hypothalamic obese rats
Keywords: AUC; area under the curve; BSA; bovine albumin serum; bw; body weight; CON; control; CRP; C-reactive protein; GK; glucokinase; H&E; hematoxylin and eosin; Hct; hematocrit; IL1β; interleukin 1 beta; IL6; interleukin 6; iNOS; inducible oxide synthase; ITT;
Tranilast: A review of its therapeutic applications
Keywords: ARH; aryl hydrocarbon receptor; bFGF; basic fibroblast growth factor; cAMP; cyclic AMP; CDK; cyclin-dependent kinase; COX-2; cyclooxsygenase-2; CTGF; connective tissue growth factor; CXCL; CX chemokine ligand; CXCR; CX chemokine receptor; EMT; epithelial-
CD200+ and CD200− macrophages accumulated in ischemic lesions of rat brain: The two populations cannot be classified as either M1 or M2 macrophages
Keywords: Alternative; TLR4; iNOS; TGFβ; Ki67; CD68; CD86; NG2
Platycodon grandiflorus - An Ethnopharmacological, phytochemical and pharmacological review
Keywords: (2R, 3R) taxifolin (Pubchem CID: 439533); quercetin-7-O-glucoside (Pubchem CID: 5282160); luteolin-7-O-glucoside (Pubchem CID: 5280637); apigenin-7-O-glucoside (Pubchem CID: 5280704); luteolin (Pubchem CID: 5280445); apigenin (Pubchem CID: 5280443); palmi
Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
Keywords: Bd-EE; Boerhavia diffusa L. ethanol extract; HPLC; high performance liquid chromatography; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TLR; Toll-like receptor (TLR); NF-κB; nuclear factor-κB; AP-1; Activat
Gingerols and shogaols: Important nutraceutical principles from ginger
Keywords: BSA; bovine serum albumin; COX; cyclooxygenase; GN; gingerol; HepG2; human hepatoma G2; iNOS; inducible NO synthase; LPS; lipopolysaccharide; MBC; minimum bactericidal concentration; MIC; minimal inhibitory concentration; NF-κB; nuclear factor-kappa B; N
6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria
Keywords: iNOS; LPS; 6-OHDA; Caspase-3; DNA damage; Aminoguanidine;
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
Keywords: Nuclear Factor κB; Immune system; Cellular radiation response; Linear energy transfer; Bystander effect; Chemokines; A20 (TNFAIP3); tumor necrosis factor inducible protein 3; ARD; ankyrin repeat domain; ATM; ataxia telangiectasia mutated protein; β-TrCP
Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat
Keywords: Autophagy; HDAC inhibitor; Diabetic nephropathy; NF-κB/iNOS signaling; Proteinuria; Sodium valproate; Ac-H3/Ac-H4; acetylated histone H3/H4; CaB; calbindin; CaM; calmodulin; DN; diabetic nephropathy; FITC; fluorescein isothiocyanate; HDACs; histone deace
TNF-α inhibitor protects against myocardial ischemia/reperfusion injury via Notch1-mediated suppression of oxidative/nitrative stress
Keywords: iNOS; inducible nitric oxide synthase; I/R; ischemia/reperfusion; MI/R; myocardial ischemia/reperfusion; Notch1 ICD; Notch1 intracellular domain; ROS; reactive oxygen species; siRNA; small interfering RNA; TACE; TNF-α converting enzyme; TNF-α; tumor nec
Redox modulation of mitochondriogenesis in exercise. Does antioxidant supplementation blunt the benefits of exercise training?
Keywords: Akt; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; AP-1; activator protein 1; COX IV; cytochrome c oxidase; CuZnSOD; copper/zinc superoxide dismutase; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric oxide synthase; ERK; extracellular signa