Keywords: همبستگی برونتن-درونتن; Dissolution and absorption; IVIVC; Formulation additives; Flux; In vivo predictive; Bioequivalence; Bioavailability;
مقالات ISI همبستگی برونتن-درونتن (ترجمه نشده)
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Keywords: همبستگی برونتن-درونتن; BCS; biopharmaceutics classification system; DoE; design of experiment; FASSIF; fasted simulated intestinal fluid; FESSIF; fed simulated intestinal fluid; IVIVC; in vitro in vivo correlation; GIT; gastrointestinal tract; API; active pharmaceutical ingredi
Keywords: همبستگی برونتن-درونتن; Mucus; Cell-based models; Mucosal model; Epithelium model; Permeation; Absorption; 2D; two-dimension; 3D; three-dimension; ALI; air-liquid culture; BCS; biopharmaceutics classification system; CV; cervicovaginal; CVM; cervicovaginal mucus; DDS; drug deliv
Keywords: همبستگی برونتن-درونتن; ÎCN; acetonitrile; API; active pharmaceutical ingredient; BCS; biopharmaceutics classification system; FeSSGF; fed state simulated gastric fluid; FeSSGFhf; fed state simulated gastric fluid prepared with high fat milk (5% w/v); FeSSGFsk; fed state simula
Keywords: همبستگی برونتن-درونتن; A4D; adapter 4 dialysis; API; active pharmaceutical ingredient; DLS; dynamic light scattering; EP; European Pharmacopoeia; FaSSGF; fasted state simulated gastric fluid; FaSSIF; fasted state simulated intestinal fluid; FaSSIF-V2; fasted state simulated int
Keywords: همبستگی برونتن-درونتن; ADME; absorption distribution metabolism elimination; ASEs; aerosols solvent extractions; AUC; area under curve; BBB; blood-brain barrier; BCS; Biopharmaceutical Classification System; BDP; beclomethasone dipropionate; CFC; critical flocculation concent
Keywords: همبستگی برونتن-درونتن; QbD; Biorelevant dissolution; IVIVC; Ethanol; Design of experiments; Multivariate data analysis;
Keywords: همبستگی برونتن-درونتن; BCS; Biopharmaceutics Classification System; DoE; Design of Experiment; FASSIF; Fasted Simulated Intestinal Fluid; FESSIF; Fed Simulated Intestinal Fluid; IVIVC; In vitro In vivo correlation; Fed simulated intestinal fluid; Design of experiment; Biopharma
Keywords: همبستگی برونتن-درونتن; population pharmacokinetics; covariate models; automatic modeling; gene expression programming; genetic algorithm; ELS; extended nonlinear least squares; GA; genetic algorithm; GEP; gene expression programming; IVIVC; in vitro-in vivo correlation;
Keywords: همبستگی برونتن-درونتن; ANN; artificial neural networks; API; active pharmaceutical Ingredient; CFD; computational fluid dynamics; CMA; critical material attribute; CQA; critical quality attribute; CPP; critical process parameter; DEM; discrete element Method; DoDE; design of dy
Keywords: همبستگی برونتن-درونتن; API; active pharmaceutical ingredient; BE; bioequivalence; CLSM; confocal laser scanning microscopy; DDS; drug delivery system; ELISA; enzyme-linked immunosorbent assay; EMA; European Medicines Agency; FDA; U.S. Food & Drug Administration; FITC; fluoresce
Keywords: همبستگی برونتن-درونتن; ACAT; Advanced Compartmental Absorption and Transit; BCS; biopharmaceutical drug classification system; CAT; Compartmental Absorption and Transit; FD; fast dissolving; GR; gastric release; IR; immediate release; IVIVC; in vivo/in vitro correlations; MAE;
Keywords: همبستگی برونتن-درونتن; AIC; Akaike information criteria; BCS; Biopharmaceutics Classification System; BLQ; below the limit of quantification; CI; confidence interval; CYP2D6; cytochrome P450 2D6; GC-MS; gas chromatography coupled to mass spectrometry; IIV; interindividual var
Keywords: همبستگی برونتن-درونتن; Biopharmaceutics; Biopharmaceutical classification system; PBPK; IVIVC; Dissolution; Drug absorption;
Keywords: همبستگی برونتن-درونتن; modified release; bimodal release; dissolution; kinetics; absorption; disposition; pharmacokinetics; IVIVC; simulation; superposition;
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mech
Keywords: همبستگی برونتن-درونتن; DMPK; hepatocytes; IVIVC; PBPK modeling; pharmacokinetics; unbound fraction;
Effect of amorphous phase separation and crystallization on the in vitro and in vivo performance of an amorphous solid dispersion
Keywords: همبستگی برونتن-درونتن; Amorphous solid dispersion; Bioavailability; Phase separation; Crystallization; IVIVC;
In vitro and ex vivo correlation of drug release from ophthalmic ointments
Keywords: همبستگی برونتن-درونتن; Q1/Q2 equivalent; qualitative and quantitative sameness; RLD; reference listed drug, Lotemax®; CM; crossover modulus; K value; Power law consistency index; HP-β-CD; Hydroxypropyl-beta-cyclodextrin; IVIVC; in vitro-in vivo correlation; Ophthalmic ointmen
Identify super quality markers from prototype-based pharmacokinetic markers of Tangzhiqing tablet (TZQ) based on in vitro dissolution/ permeation and in vivo absorption correlations
Keywords: همبستگی برونتن-درونتن; Tangzhiqing tablet (TZQ); Quality marker (Q-marker); Pharmacokinetic marker (PK-marker); Nuciferine; Paeoniflorin; In vitro-in vivo correlation (IVIVC); CHM; Chinese herbal medicine; DDASS; drug dissolution/ absorption simulating system; IVIVC; in vitro-i
Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation
Keywords: همبستگی برونتن-درونتن; AUC; area under the curve; BE; bioequivalence; CI; confidence interval; CL; clearance; Cmax; maximum plasma concentration; CR; controlled release; CV; coefficient of variation; f2; similarity factor; FTFF; the fastest tablet of the fastest dissolving form
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: همبستگی برونتن-درونتن; 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
Keywords: همبستگی برونتن-درونتن; Pulmonary delivery; Dry powder inhalation; Solubility; Dissolution methods; Biopharmaceutical classification; API; Active pharmaceutical ingredient; ACI; Andersen cascade impactor; ALF; alveolar lung fluid; BCS; Biopharmaceutics Classification System; iBC
Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption
Keywords: همبستگی برونتن-درونتن; Biorelevant dissolution; Weak base; PBPK modeling; BCS class II; pH dependent solubility; ACAT; advanced compartmental absorption and transit model; ADAM; advanced dissolution, absorption and metabolism model; API; active pharmaceutical ingredient; ASD;
Research review paperIn-vitro in-vivo correlation (IVIVC) in nanomedicine: Is protein corona the missing link?
Keywords: همبستگی برونتن-درونتن; Nanoparticles; Protein corona; Targeting; Bio-nano interface; IVIVC; Physicochemical property; Inflammation; Cell uptake;
In Vitro and In Vivo Evaluation of a Hydrogel-Based Microneedle Device for Transdermal Electro-Modulated Analgesia
Keywords: همبستگی برونتن-درونتن; Hydrogels; skin; responsive drug delivery; transdermal drug delivery; IVIVC; pharmacokinetics; EMH; electro-modulated hydrogel; EMHM; electro-modulated hydrogel-microneedle array; IVIVC; in vitro-in vivo correlation;
Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine
Keywords: همبستگی برونتن-درونتن; renal transporter; drug interactions; in vitro-in vivo correlation; renal clearance; inhibition; AUC; area under the concentration curve; CLcr; creatinine renal clearance; Cmax; maximal total plasma concentration; Cmax,u; maximal unbound plasma concen
Application of an NLME-Stochastic Deconvolution Approach to Level A IVIVC Modeling
Keywords: همبستگی برونتن-درونتن; 2-stage; level A in vitro/in vivo correlation (IVIVC); numerical/stochastic deconvolution; population pharmacokinetics; nonlinear mixed-effects (NLME) modeling; BA; bioavailability; DTC; deconvolution through convolution; ER; extended release; FID; form
Use of Permeapad® for prediction of buccal absorption: A comparison to in vitro, ex vivo and in vivo method
Keywords: همبستگی برونتن-درونتن; Permeapad®; Metoprolol; Buccal absorption; IVIVC; pH; In vitro; Permeability;
Influence of polymer molecular weight on in vitro dissolution behavior and in vivo performance of celecoxib:PVP amorphous solid dispersions
Keywords: همبستگی برونتن-درونتن; PVP; Molecular weight; Amorphous solid dispersion; âIn vitro; Non-sink dissolution; Celecoxib; In vivo; IVIVC;
Evaluation of dose-dependent oral absorption of a newly developed drug candidate: In vitro-in vivo correlation
Keywords: همبستگی برونتن-درونتن; Non-linear oral absorption; Food effect; Solubility; Membrane permeability; IVIVC; Maximum absorbable dose (MAD)
Transdermal Delivery of Etoposide Phosphate II: In Vitro In Vivo Correlations (IVIVC)
Keywords: همبستگی برونتن-درونتن; etoposide; microdialysis; iontophoresis; rabbit; IVIVC; transdermal
Effect of polymer type and drug dose on the in vitro and in vivo behavior of amorphous solid dispersions
Keywords: همبستگی برونتن-درونتن; Non-sink dissolution; Amorphous solid dispersion; Bioavailability; Dose-dependence; Polymers; In vitro; In vivo; IVIVC; Supersaturation; Poorly soluble drugs; Solubility enhancement; Celecoxib; PVP; HPMC; PVA
Validation of a cage implant system for assessing in vivo performance of long-acting release microspheres
Keywords: همبستگی برونتن-درونتن; IVIVC; Controlled release; Cage model; PLGA; Release kinetics;
Can dosage form-dependent food effects be predicted using biorelevant dissolution tests? Case example extended release nifedipine
Keywords: همبستگی برونتن-درونتن; Biorelevant dissolution testing; USP apparatus III (BioDis); USP apparatus IV (flow through cell); Food effects; Nifedipine; Clinical study; IVIVC; Extended release
Production, applications and in vivo fate of drug nanocrystals
Keywords: همبستگی برونتن-درونتن; Drug nanocrystals; Formulation; IVIVC; Poor solubility
Characterizing release mechanisms of leuprolide acetate-loaded PLGA microspheres for IVIVC development I: In vitro evaluation
Keywords: همبستگی برونتن-درونتن; PLGA; Leuprolide; Microspheres; Release mechanisms; IVIVC;
An in vitro-in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics
Keywords: همبستگی برونتن-درونتن; Nifedipine (PubChem CID: 4485); IVIVC; Biorelevant dissolution; Capsule rupture time; Nifedipine; Immediate release; Hydrodynamics; Special dissolution media; Non-alcoholic beverages; Alcoholic beverages;
Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques
Keywords: همبستگی برونتن-درونتن; DLS; Dynamic light scattering; DOL; Degree of labeling; FCS; Fetal calf serum; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; HA; Hyaluronan; IFN; Interferon; i.m.; Intramuscular; ISG; Interferon stimulated gene; IVIVC; In vitro-in vivo-correlation; LN;
Development of pH sensitive microparticles of Karaya gum: By response surface methodology
Keywords: همبستگی برونتن-درونتن; Microparticles; Aqueous solvent; Optimization; Validation; In vivo studies; IVIVC; Frusemide (PubChemCID: 3440); Glutaraldehyde (PubChemCID: 110991); Sodium chloride (PubChem: CID 5234); Hydrochloric acid (PubChem: CID 313); Methanol (PubChemCID: 887); 1;
Development and validation of an in vitro–in vivo correlation (IVIVC) model for propranolol hydrochloride extended-release matrix formulations
Keywords: همبستگی برونتن-درونتن; IVIVC; Extended-release dosage; Propranolol
Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo
Keywords: همبستگی برونتن-درونتن; BCS; PBPK; IVIVC; Dissolution; Drug absorption; Permeability;
Prediction of the in vivo performance of enteric coated pellets in the fasted state under selected biorelevant dissolution conditions
Keywords: همبستگی برونتن-درونتن; Biorelevant dissolution; Gastric emptying; Non-compendial system; Enteric coated pellets; IVIVC
Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation
Keywords: همبستگی برونتن-درونتن; PVP; polyvinylpyrrolidone;; IVIVC; in vitro-in vivo correlation;; TEM; transmission electron microscopy;; EE; encapsulation efficiency;; CMCâNa; sodium carboxymethylcellulose;; MRT; mean residence time;; DLS; dynamic light scattering; Capsaicin; Micel
In vitro & in vivo correlation of release behavior of andrographolide from silica and PEG assisted silica gel matrix
Keywords: همبستگی برونتن-درونتن; Nano porous silica gel; Andrographolide; PEG; Sustained release; IVIVC;
Pharmacokinetic aspects and in vitro–in vivo correlation potential for lipid-based formulations
Keywords: همبستگی برونتن-درونتن; Pharmacokinetics; Lipolysis; IVIVC; Efflux transporters; Lymphatic delivery; Food effectADME, absorption/distribution/metabolism/elimination; AUC, area under the curve; BCS, biopharmaceutics classification system; BDDCS, biopharmaceutics drug disposition
In vitro models for the prediction of in vivo performance of oral dosage forms
Keywords: همبستگی برونتن-درونتن; BCS; biopharmaceutics classification system; ER; extended release; IR; immediate release; IMI; innovative medicines initiative; IVIVC; in vitro in vivo Correlation; MR; modified release; OrBiTo; oral biopharmaceutical tools; PK; pharmacokinetics; PBPK; ph
Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS
Keywords: همبستگی برونتن-درونتن; Lipid-based drug delivery systems; IVIVC; Lipid hydrolysis; Food interaction; SNEDDS; Low-soluble compounds;
In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs
Keywords: همبستگی برونتن-درونتن; Metoprolol; Buccal absorption; IVIVC; Mini-pigs; pH; TR146 cell culture;
Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs
Keywords: همبستگی برونتن-درونتن; Agomelatine; Polymorphs; Intrinsic dissolution rate; Pharmacokinetics; IVIVC
Cyclodextrin-water soluble polymer ternary complexes enhance the solubility and dissolution behaviour of poorly soluble drugs. Case example: Itraconazole
Keywords: همبستگی برونتن-درونتن; Ternary cyclodextrin complexes; Solubility enhancement; Transfer experiments; Intestinal drug precipitation; PBPK modelling; IVIVC