کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7787103 | 1500624 | 2015 | 46 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of pH sensitive microparticles of Karaya gum: By response surface methodology
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of pH sensitive microparticles of Karaya gum: By response surface methodology Development of pH sensitive microparticles of Karaya gum: By response surface methodology](/preview/png/7787103.png)
چکیده انگلیسی
The objective of the proposed work was to prepare pH sensitive microparticles (MP) of Karaya gum using distilled water as a solvent by spray drying technique. Different formulations were designed, prepared and evaluated by employing response surface methodology and optimal design of experiment technique using Design Expert® ver 8.0.1 software. SEM photographs showed that MP were roughly spherical in shape and free from cracks. The particle size and encapsulation efficiency for optimized MP was found to be between 3.89 and 6.5 μm and 81-94% respectively with good flow properties. At the end of the 12th hour the in vitro drug release was found to be 96.9% for the optimized formulation in pH 5.6 phosphate buffer. Low prediction errors were observed for Cmax and AUC0-âwhich demonstrated that the Frusemide IVIVC model was valid. Hence it can be concluded that pH sensitive MP of Karaya gum were effectively prepared by spray drying technique using aqueous solvents and can be used for treating various diseases like chronic hypertension, Ulcerative Colitis and Diverticulitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 134, 10 December 2015, Pages 353-363
Journal: Carbohydrate Polymers - Volume 134, 10 December 2015, Pages 353-363
نویسندگان
Abhay Raizaday, Hemant K.S. Yadav, S. Hemanth Kumar, Susmitha Kasina, M. Navya, C. Tashi,