دانلود مقالات ISI درباره چگونه + ترجمه فارسی

Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells

Keywords: چگونه; Chordoma; β-β-dimethylacrylshikonin; Silibinin; Apoptosis; ACTB; actin beta; AKT; AKT serine/threonine kinase; BAD; BCL2 associated agonist of cell death; BAK; BCL2 antagonist/killer; BAX; BCL2 associated X protein; BCL-2; B cell leukemia/lymphoma 2; BH

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

Keywords: چگونه; BMSCs; bone marrow stem cells; BrdU; 5-bromo-2′-deoxyuridine; CMs; cardiomyocytes; CSCs; cardiac stem cells; DAPI; 4′,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FITC; fluo

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Mahuang decoction mitigates airway inflammation and regulates IL-21/STAT3 signaling pathway in rat asthma model

Keywords: چگونه; 6-keto-PGF1a; 6-ketone-prostaglandin F1a; ANOVA; one-way analysis of variance; BALF; bronchoalveolar lavage fluid; ECL; electro-chemi-luminescence; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EOS; eosinophilic granulocyte; EP; epp

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma

Keywords: چگونه; DAPI; 4′,6-diamidino-2-phenylindole; DMSO; dimethylsulfoxide; FCS; foetal calf serum; HSP; heat shock protein; IB; immunoblotting; IF; immunofluorescence; IL; interleukin; JAK; Janus kinase; NES; nuclear export signal; NLS; nuclear localisation signal;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Emerging therapies for atopic dermatitis: JAK inhibitors

Keywords: چگونه; atopic dermatitis; baricitinib; eczema; JAK inhibitor; ruxolitinib; systemic therapy; tofacitinib; CPK; creatine phosphokinase; Cr; creatinine; EASI; Eczema Area and Severity Index; JAK; Janus kinase; PASI; Psoriasis Area and Severity Index; STAT; signal

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation

Keywords: چگونه; IFN-γ; interferon gamma; IL; interleukin; JAK; Janus kinase; T-LGL; T cell large granular lymphocyte; T-LGLL; T cell large granular lymphocytic leukemia; MTS; 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; PBMC;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Extensive and functional overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte derived differentiating macrophages

Keywords: چگونه; Interleukin-4; STAT6; Retinoid X receptor; Macrophage; Chromatin immunoprecipitation; Trancriptome; Cistrome; JAK; Janus tyrosine kinases; STAT; Signal Transducer and Activator of Transcription; IL-4; Interleukin 4; TNFα; tumor necrosis factor alpha; IFN

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Jageum-Jung improves 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice and suppresses pro-inflammatory chemokine production by inhibiting TNF-α/IFN-γ-induced STAT-1 and NFκB signaling in HaCaT cells

Keywords: چگونه; AD; atopic dermatitis; DAD; diode array UV/VIS detector; DMSO; dimethyl sulfoxide; DNCB; 2,4-dinitrochlorobenzene; DNP-HAS; dinitrophenyl-human serum albumin; ELISA; Enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinases; FBS; fe

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

STAT3 Mediates Nilotinib Response in KIT-Altered Melanoma: A Phase II Multicenter Trial of the French Skin Cancer Network

Keywords: چگونه; AE; adverse event; AKT; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; CI; confidence interval; CR; complete response; GIST; gastrointestinal stromal tumors; JAK; Janus kinase; MAPK; mitogen-activated protein kinase; OS; overall survival;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

JAK and STAT members in channel catfish: Identification, phylogenetic analysis and expression profiling after Edwardsiella ictaluri infection

Keywords: چگونه; JAK/STAT signaling pathway; JAK; STAT; Catfish; Edwardsiella ictaluri; Immunity;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Imatinib prevents lung cancer metastasis by inhibiting M2-like polarization of macrophages

Keywords: چگونه; TAM; tumor associated macrophage; CD206; cluster of differentiation 206; BMDMs; bone marrow derived macrophages; Arg1; arginase 1; Mgl2; macrophage galactose N-acetyl-galactosamine specific lectin 2; Mrc1; mannose receptor C-type 1; CDH1; cadherin 1; CCL2

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

A change in structural integrity of c-Kit mutant D816V causes constitutive signaling

Keywords: چگونه; JAK; Janus kinase; JM region; juxtamembrane region; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MD; molecular dynamics; MIHC; Myb-immortalized haemopoietic cells; WT; wild-type c-Kit; WTp; wild-type phosphorylated c-Kit; MT_D816V

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Nesfatin-1 functions as a switch for phenotype transformation and proliferation of VSMCs in hypertensive vascular remodeling

Keywords: چگونه; α-SMA; α-smooth muscle actin; BCA; Bicinchoninic acid; CCK-8; Cell counting kit-8; CDK2; cyclin dependent kinase 2; DAPI; 4′,6-diamidino-2-phenylindole; DBP; diastolic blood pressure; DMEM; Dulbecco's modified Eagle's medium; DHE; dhydroethidium; EdU;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

The proinflammatory effects of macrophage-derived NADPH oxidase function in autoimmune diabetes

Keywords: چگونه; ABIS; All Babies in Southwest Sweden study; APC; Antigen presenting cells; Arg-1; Arginase 1; CB3; Coxsackievirus strain B3; CB4; Coxsackievirus strain B4; CGD; Chronic granulomatous disease; CSF-1; Colony-stimulating factor 1; AISY; Diabetes Autoimmunity

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia

Keywords: چگونه; TGFi; TGF induced factor homeobox; TGF; transforming growth factor; IL1; interleukin 1; IL1i; IL1 inhibitors; IL1RL1; interleukin 1 receptor like 1; TNF; tumor necrosis factor; Nogo; reticulon 4 (RTN4/Nogo); NGF; nerve growth factor; STC; stanniocalcin 1;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical variables and ethnicity may influenced by polymorphism of CAT −262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications

Keywords: چگونه; T1D; type1 diabetes; CAT; Catalase; MnSOD; manganese superoxide dismutase; SOD; superoxide dismutase; WHO; World Health Organization; TAHINA; survey Transition And Health Impact in North Africa; INSP; National Institute of Public Health; ROS; Reactive oxy

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Keywords: چگونه; Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

Keywords: چگونه; MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development

Keywords: چگونه; AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

Protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1-derived peptide recombinant protein tyrosine phosphatase (AP-rPTP), alleviates both atopic dermatitis-like and psoriasis-like dermatitis

Keywords: چگونه; Atopic dermatitis; psoriasis; transdermal delivery peptide; protein tyrosine phosphatase; T-cell protein tyrosine phosphatase; transcutaneous drug; immunomodulatory protein; AD; Atopic dermatitis; AP; Astrotactin 1-derived peptide; CHS; Contact hypersen

دانلود رایگان متن کامل مقاله ISI 75 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy as a pharmacological target in hematopoiesis and hematological disorders

Keywords: چگونه; 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5′-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus

Keywords: چگونه; STAT2; signal transducer and activator of transcription 2; JAK; Janus kinase; IL-10; interleukin-10; TYK2; tyrosine kinase 2; IFN; interferon; ISGF3; IFN-stimulated gene factor 3; ISG; IFN-stimulated gene; CREB; cyclic AMP-response element-binding protein

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: Inspired by functional and structural genomics

Keywords: چگونه; JAK/STAT; T-cell malignancy; JAK inhibitor; ATLL; adult T-cell leukemia/lymphoma; γc; common gamma receptor dependent cytokine; HTLV-1; human T-cell lymphotropic virus-1; IL-2/IL-2R; interleukin 2/interleukin 2 receptor; JAK; Janus kinase; JAK3i; Janus k

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Spinal dorsal horn astrocytes: New players in chronic itch

Keywords: چگونه; Astrocytes; Spinal dorsal horn; STAT3; Lipocalin-2; Mouse; ATF3; activating transcription factor 3; CNS; central nervous system; CV; conventional; GRP; gastrin-releasing peptide; GRPR; GRP receptor; GFAP; glial fibrillary acidic protein; JAK; Janus kinase

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing

Keywords: چگونه; AP; activator protein; ATP; adenosine triphosphate; Ca2+; calcium ions; cAMP; cyclic adenosine monophosphate; Cox; cytochrome c oxidase; Cu; copper; Cyto c; cytochrome c; DNA; deoxyribonucleic acid; ECM; extracellular matrix; EGF; epidermal growth factor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts

Keywords: چگونه; JAK; Inhibitor; Cardiac transplantation; Allograft rejection; Vasculopathy; Tacrolimus;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of Gastric Carcinogenesis by Inflammatory Cytokines

Keywords: چگونه; Gastric Cancer; Inflammation; Cytokines; ATPase; adenosine triphosphatase; IFN; interferon; IL; interleukin; JAK; Janus-activated kinase; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor kappa B; SPEM; spasmolytic polypeptide-expressing meta

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

STAT3 activation in infection and infection-associated cancer

Keywords: چگونه; Bacteria; Colon cancer; Inflammation; Infection; JAK; Salmonella; STAT; STAT3; STAT5; Virus;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Cinnamic acid derivatives inhibit hepatitis C virus replication via the induction of oxidative stress

Keywords: چگونه; Hepatitis C virus; Cinnamic acid; STAT3; Reactive oxygen species; HCV; hepatitis C virus; IFN; interferon; ROS; reactive oxygen species; STAT3; signal transducer and activator of transcription 3; JAK; Janus kinase; IL-6; interleukin-6; OAS3; 2′-5′-oli

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Interleukin-10 inhibits neuroinflammation-mediated apoptosis of ventral mesencephalic neurons via JAK-STAT3 pathway

Keywords: چگونه; PD; Parkinson's disease; IL-10; interleukin-10; IL-10R; interleukin-10 receptor; LPS; lipopolysaccharide; TH; tyrosine hydroxylase; TNF-α; tumor necrosis factor-α; BDNF; brain derived neurotrophic factor; JAK; Janus kinase; STAT; signal transducer and a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS

Keywords: چگونه; JAK; Inhaled LPS rat model; Tofacitinib; Lung inflammation; BALF; STAT3; BALF; bronchoalveolar lavage fluid; JAK; janus kinase; LPS; lipopolysaccharide; pSTAT3; phosphorylated STAT3; STAT; signal transducers and activators of transcription; TLR; toll-like

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure

Keywords: چگونه; JAK; Janus kinase; narrowband ultraviolet B; nbUVB; phototherapy; ruxolitinib; tofacitinib; vitiligo; BSA; body surface area; CXCL9; C-X-C motif chemokine ligand 9; ELISA; enzyme-linked immunosorbent assay; IFN-γ; interferon gamma; JAK; Janus kinase; nbU

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The deposition of anti-DNA IgG contributes to the development of cutaneous lupus erythematosus

Keywords: چگونه; CCL; chemokine (C C motif) ligand; CLE; cutaneous lupus erythematosus; ELISA; enzyme-linked immunosorbent assay; Fn14; fibroblast growth factor inducible 14; JAK; janus-activated kinase; IP-10; interferon gamma-induced protein 10; MCP-1; monocyte chemotac

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

JAK/STAT disruption induces immuno-deficiency: Rationale for the development of JAK inhibitors as immunosuppressive drugs

Keywords: چگونه; JAK; STAT; Immunosuppression; Myeloproliferative neoplasia; Autoimmunity; GVHD;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Short communicationDocosahexaenoic acid inhibits IL-6 expression via PPARγ-mediated expression of catalase in cerulein-stimulated pancreatic acinar cells

Keywords: چگونه; DAPI; 4′,6-diamidino-2-phenylindole; DCF-DA; dichlorofluorescein diacetate; DHA; docosahexaenoic acid; JAK; Janus kinase; NADPH; nicotinamide adenine dinucleotide phosphate; NF-κB; nuclear factor kappa-B; PPARγ; peroxisome proliferator-activated recep

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells

Keywords: چگونه; Kaempferol glucopyranoside; Saussurea stella; Interferon; JAK/STAT; SOCS3; CML; chronic myelogenous leukemia; ERK; extracellular signal-regulated kinase; HCC; hepatocellular carcinoma; JAK; janus kinase; IFN; interferon; ISRE; interferon-sensitive respons

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The good and the bad faces of STAT1 in solid tumours

Keywords: چگونه; BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The evolutionary divergence of STAT transcription factor in different Anopheles species

Keywords: چگونه; STAT; Signal Transducer and Activator of Transcription; JAK; Janus kinase; NJ; Neighbor-Joining; An.; Anopheles; MEGA; Molecular Evolutionary Genetics Analysis; UTR; untranslated region; MYA; million years ago; P. berghei; Plasmodium berghei; SOCS; suppre

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Research reportPoly-dimensional network comparative analysis reveals the pure pharmacological mechanism of baicalin in the targeted network of mouse cerebral ischemia

Keywords: چگونه; Akt; Serine/threonine kinase; BA; Baicalin/baicalein; CM; Concha margaritifera; CNS; Central nervous system; ERK; Extracellular signal-regulated kinase; GPCRs; Caspase-2 and Galpha (q)-specific amine G-protein-coupled receptors; JAK; Janus kinase; JNK; c-

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Age-related remodeling of the JAK/STAT/SOCS signaling pathway and associated myocardial changes: From histological to molecular level

Keywords: چگونه; JAK; STAT; Aging; Histology; Immunohistochemistry;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperInnovative drug vehicle for local treatment of inflammatory skin diseases: Ex vivo and in vivo screening of five topical formulations containing poly(lactic acid) (PLA) nanoparticles

Keywords: چگونه; PLA; poly(lactic acid); AD; atopic dermatitis; JAK; janus kinase; PBS; phosphate-buffered saline; BSA; bovine serum albumin; PFA; paraformaldehyde; PDI; polydispersity index; NP; nanoparticle; fluoNP; fluorescent nanoparticle; rpm; rotation per minute; EE

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia

Keywords: چگونه; Mnk inhibitor; FLT3 inhibitor; Dual inhibitor; AML; Drug discovery; Anti-leukaemic agent; AML; acute myeloid leukaemia; CDK; cyclin-dependent kinase; eIF; eukaryotic initiation factor; Erk; extracellular signal-regulated kinase; FLT3; Fms-like tyrosine ki

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin-Sensitive Late-LTP is Enhanced in the Hippocampus of IL-6 Transgenic Mice

Keywords: چگونه; ANOVA; analysis of variance; ACSF; artificial cerebral-spinal fluid; CNS; central nervous system; DNA; deoxyribonucleic acid; ERK; extracellularly regulated kinase; fEPSP; field excitatory postsynaptic potential; HFS; high-frequency stimulation; I/O; inpu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa

Keywords: چگونه; CMV; cytomegalovirus; HCV; hepatitis C virus; IFNα; interferon alpha; JAK; Janus kinase; PBMC; peripheral blood mononuclear cells; PDCs; plasmacytoid dendritic cells; RA; rheumatoid arthritis; RASFs; rheumatoid arthritis synovial fibroblasts; SLE; system

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3

Keywords: چگونه; PcG; Colon Cancer; Ulcerative Colitis; PAP; AOM; azoxymethane; BMI1; BMI1 proto-oncogene, polycomb ring finger; BrdU; 5-bromo-2-deoxyuridine; CAC; colitis-associated cancer; ChIP; chromatin immunoprecipitation; Co-IP; co-immunoprecipitation; DSS; dextran

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex

Keywords: چگونه; JAK; Janus kinase; STAT; signal transducer and activator of transcription; SOCS; suppressor of cytokine signaling; TYK2; tyrosine kinase 2; NF-κB; nuclear factor kappa B; C/EBP; CCAAT-enhancer-binding proteins; GATA-1; GATA-binding factor 1; AP-1; Activa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation

Keywords: چگونه; STAT1 gain of function; IFN-γ; ruxolitinib; autoimmunity; TH1 cell; TH17 cell; follicular T helper cell; T helper cell polarization; ATG; Anti-thymocyte globulin; BSA; Body surface area; GOF; Gain of function; IC50; Half-maximal inhibitory concentration

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Treatment of Hypereosinophilic Syndrome with Cutaneous Involvement with the JAK Inhibitors Tofacitinib and Ruxolitinib

Keywords: چگونه; HES; hypereosinophilic syndrome; JAK; Janus kinase; L-HES; lymphocytic variant HES; STAT; signal transducer and activator of transcription; Th2; T helper type 2;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleMACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers

Keywords: چگونه; Solid cancers; MACC1; STAT signaling; Fas mediated apoptosis; Bcl-2 family proteins; MACC1; Metastasis associated in colon cancer 1; CRC; Colorectal cancer; STAT; Signal transducers and activators of transcription; JAK; Janus kinase; Mcl-1; Myeloid cell l

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

The 20 kDa and 22 kDa forms of human growth hormone (hGH) exhibit different intracellular signalling profiles and properties

Keywords: چگونه; 22K-GH; 22 kDa growth hormone; 20K-GH; 20 kDa growth hormone; GHR; growth hormone receptor; JAK; Janus kinase; STAT; signal transducers and activators of transcription; 22 kDa GH; 20 kDa GH; Signalling pathway; JAK2-STAT5;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه